Inflammation-induced hyperexcitability of nociceptive gastrointestinal DRG neurones: the role of voltage-gated ion channels
Abstract
Gastrointestinal (GI) inflammation modulates the intrinsic properties of nociceptive dorsal root ganglia neurones, which innervate the GI tract and these changes are important in the genesis of abdominal pain and visceral hyperalgesia neurones exhibit hyperexcitability characterized by a decreased threshold for activation and increased firing rate, and changes in voltages-gated Na(+) and K(+) channels play a major role in this plasticity. This review highlights emerging evidence that specific subsets of channels and signalling pathways are involved and their potential to provide novel selective therapeutics targets for the treatment of abdominal pain.
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Pain symptoms in IBD patients appear to be associated with inflammation of enteric neurons.
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Self-citation
- Authors
- Beyak, M. J., & Vanner, S.
- Affiliations
- Queen's University (CA)
- Corresponding author
- Vanner, S.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2004-11-11
- Volume
- 17
- Issue
- 2
- Pages
- 175-186
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- OpenAlex
- W1995965793
- Cited by
- 121
- References
- 94
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 8 · 2016: 5 · 2015: 1 · 2014: 4 · 2013: 6 · 2012: 13
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Association of Gastroenterology
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- gastrointestinal inflammation, visceral hypersensitivity, dorsal root ganglion neurons, nociceptors, neuronal hyperexcitability, voltage-gated sodium channels, voltage-gated potassium channels, abdominal pain, neuroplasticity, therapeutic target
- MeSH terms
- Ganglia, Spinal, Inflammation, Ion Channels, Neural Pathways, Neurons, Nociceptors, Ion Channel Gating, Abdominal Pain, Gastrointestinal Tract
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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