Cited by 121Pain Mechanisms and TreatmentsIon channel regulation and functionIon Channels and Receptors

Inflammation-induced hyperexcitability of nociceptive gastrointestinal DRG neurones: the role of voltage-gated ion channels

Beyak, M. J., Vanner, S.·2005·Neurogastroenterology & Motility

Abstract

Gastrointestinal (GI) inflammation modulates the intrinsic properties of nociceptive dorsal root ganglia neurones, which innervate the GI tract and these changes are important in the genesis of abdominal pain and visceral hyperalgesia neurones exhibit hyperexcitability characterized by a decreased threshold for activation and increased firing rate, and changes in voltages-gated Na(+) and K(+) channels play a major role in this plasticity. This review highlights emerging evidence that specific subsets of channels and signalling pathways are involved and their potential to provide novel selective therapeutics targets for the treatment of abdominal pain.

Integrity signals

Registry

Crossref · 10.1111/j.1365-2982.2004.00596.x

Cites

94 of 94 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Beyak, M. J., & Vanner, S.
Affiliations
Queen's University (CA)
Corresponding author
Vanner, S.
Venue
Neurogastroenterology & Motility
Publisher
Wiley
Published
2004-11-11
Volume
17
Issue
2
Pages
175-186
ISSN
  • 1350-1925 (ISSN-L)
  • 1365-2982
OpenAlex
W1995965793
Cited by
121
References
94
Citations by year
2026: 2 · 2025: 3 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 8 · 2016: 5 · 2015: 1 · 2014: 4 · 2013: 6 · 2012: 13
FWCI
0.47
Type
journal article
Language
en
Open access
closed
Locations
  • Neurogastroenterology & Motility (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Canadian Association of Gastroenterology
  • Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords
gastrointestinal inflammation, visceral hypersensitivity, dorsal root ganglion neurons, nociceptors, neuronal hyperexcitability, voltage-gated sodium channels, voltage-gated potassium channels, abdominal pain, neuroplasticity, therapeutic target
MeSH terms
Ganglia, Spinal, Inflammation, Ion Channels, Neural Pathways, Neurons, Nociceptors, Ion Channel Gating, Abdominal Pain, Gastrointestinal Tract

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review