Pain management in patients with inflammatory bowel disease: insights for the clinician
Open accessAbstract
Abdominal pain is a common symptom in patients with inflammatory bowel disease (IBD) and has a profound negative impact on patients' lives. There are growing data suggesting that pain is variably related to the degree of active inflammation. Given the multifactorial etiologies underlying the pain, the treatment of abdominal pain in the IBD population is best accomplished by individualized plans. This review covers four clinically relevant categories of abdominal pain in patients with IBD, namely, inflammation, surgical complications, bacterial overgrowth, and neurobiological processes and how pain management can be addressed in each of these cases. The role of genetic factors, psychological factors, and psychosocial stress in pain perception and treatment will also be addressed. Lastly, psychosocial, pharmacological, and procedural pain management techniques will be discussed. An extensive review of the existing literature reveals a paucity of data regarding pain management specific to IBD. In addition, there is growing consensus suggesting a spectrum between IBD and irritable bowel syndrome (IBS) symptoms. Thus, this review for adult and pediatric clinicians also incorporates the literature for the treatment of functional abdominal pain and the clinical consensus from IBD and IBS experts on pharmacological, behavioral, and procedural methods to treat abdominal pain in this population.
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Intestinal inflammation may induce visceral hypersensitivity through the peripheral and central systems.
“Intestinal inflammation may induce visceral hypersensitivity through the peripheral and central systems (112).”
From Stress triggers flare of inflammatory bowel disease in children and adults (2019) · cites this paper as [112]
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- Authors
- Srinath, A. I., Walter, C., Newara, M. C., & Szigethy, E. M.
- Affiliations
- Children's Hospital of Pittsburgh (US)
- University of Pittsburgh (US)
- Venue
- Therapeutic Advances in Gastroenterology
- Publisher
- SAGE Publications
- Published
- 2012-05-17
- Volume
- 5
- Issue
- 5
- Pages
- 339-357
- ISSN
- 1756-283X (ISSN-L)
- 1756-2848
- PMC
- PMC3437534
- OpenAlex
- W2130155416
- Cited by
- 111
- References
- 138
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 6 · 2023: 6 · 2022: 10 · 2021: 10 · 2020: 16 · 2019: 14 · 2018: 7 · 2017: 7 · 2016: 4 · 2015: 10 · 2014: 10 · 2013: 3 · 2012: 1
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Therapeutic Advances in Gastroenterology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- University of Pittsburgh
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Pain Management Techniques
- Keywords
- inflammatory bowel disease, abdominal pain, pain management, irritable bowel syndrome, bacterial overgrowth, surgical complications, psychological factors, psychosocial stress, functional abdominal pain, pharmacological pain management, behavioral pain management, procedural pain management
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