The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Gastrointestinal-specific anxiety: an important factor for severity of GI symptoms and quality of life in IBS: GI-specific anxiety in IBS
Abstract
BACKGROUND: Gastrointestinal (GI)-specific anxiety (GSA) has been proposed to influence symptom severity and quality of life (QOL) in patients with irritable bowel syndrome (IBS). The Visceral Sensitivity Index (VSI) is a recently developed, reliable and valid measure of GSA. Our aim was to evaluate the association between GSA, GI symptom severity, and QOL in IBS patients. METHODS: Sixty healthy subjects and 306 patients fulfilling the Rome II criteria for IBS were studied. Demographic and disease-related factors were assessed. Patients completed VSI and GI Symptom Rating Scale (GSRS) and questionnaires to determine psychological symptom severity (Hospital Anxiety and Depression Scale), QOL (Short form 36), and presence of functional GI disorders (Rome II Modular Questionnaire). KEY RESULTS: Compared with healthy subjects, patients with IBS had more severe GSA (34.7 +/- 16.9 vs. 2.2 +/- 4.4 [mean +/- standard deviation]; P < 0.0001). In the IBS group, more severe GSA was seen in patients with more severe GI symptoms (P < 0.0001), general anxiety (P < 0.0001) and depression (P < 0.0001), and with lower socioeconomic status (P < 0.05). In a regression analysis, GSA was the strongest predictor for GI symptom severity (GSRS total score), followed by number of Rome II diagnoses, presence of meal-related IBS symptoms, and gender (R(2) = 0.34). Gastrointestinal-specific anxiety was also, together with general anxiety, depression, socioeconomic status, and gender, found to be independently associated with mental QOL (R(2) = 0.62). CONCLUSIONS & INFERENCES: Gastrointestinal-specific anxiety seems to be an important factor for GI symptom severity and QOL in patients with IBS.
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“GSA is a key feature in IBS symptom maintenance, by acting as an endogenous stressor, and higher levels of GSA have consistently been shown to be related to higher symptom severity and lower quality of life (Jerndal et al., 2010;Labus et al., 2004Labus et al., , 2007)).”
From Pilot study of acceptance and commitment therapy for irritable bowel syndrome: A preliminary analysis of treatment outcomes and processes of change. (2018) · cites this paper as Jerndal et al., 2010
In the citing paper
“Several studies have confirmed the impact of symptom-related fear and avoidance behaviors on symptom severity and quality of life in IBS [24,27-30].”
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Functional bowel disorders and functional abdominal pain
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Psychosocial Factors in the Irritable Bowel Syndrome
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Enck, P., Aziz, Q., Barbara, G., Farmer, A. D., Fukudo, S., Mayer, E. A., Niesler, B., Quigley, E. M. M., Rajilić-Stojanović, M. D., Schemann, M., et al. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.14 · Cited by 1,102
Self-citationBöhn, L., Störsrud, S., Törnblom, H., Bengtsson, U., & Simrén, M. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.105 · Cited by 655
Self-citationZamani, M., Alizadeh‐Tabari, S., & Zamani, V. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15325 · Cited by 496
Lee, C., Doo, E.-Y., Choi, J. M., Jang, S.-H., Ryu, H.-S., Lee, J. Y., Oh, J. H., Park, J. H., & Kim, Y. S. (2017) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm16220 · Cited by 260
Simrén, M., Törnblom, H., Palsson, O. S., van Tilburg, M. A. L., Van Oudenhove, L., Tack, J., & Whitehead, W. E. (2018) · Gut · doi:10.1136/gutjnl-2016-312361 · Cited by 254
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Metadata
- Authors
- Jerndal, P., Ringström, G., Agerforz, P., Karpefors, M., Akkermans, L. M., Bayati, A., & Simrén, M.
- Affiliations
- University of Gothenburg (SE)
- AstraZeneca (Sweden) (SE)
- University Medical Center Utrecht (NL)
- Corresponding author
- Simrén, M.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2010-02-16
- Volume
- 22
- Issue
- 6
- Pages
- 646-e179
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- OpenAlex
- W2147789313
- Cited by
- 192
- References
- 51
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 10 · 2023: 15 · 2022: 17 · 2021: 14 · 2020: 7 · 2019: 13 · 2018: 15 · 2017: 9 · 2016: 17 · 2015: 8 · 2014: 18 · 2013: 13 · 2012: 11
- FWCI
- 9.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- AstraZeneca
- Sahlgrenska Universitetssjukhuset
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- irritable bowel syndrome, quality of life, anxiety, depression, socioeconomic status
- MeSH terms
- Adult, Aged, Analysis of Variance, Anxiety, Data Interpretation, Statistical, Depression, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Quality of Life, Surveys and Questionnaires, Regression Analysis, Gastrointestinal Tract, Irritable Bowel Syndrome, Young Adult
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