Cited by 433Gut microbiota and healthGastrointestinal motility and disordersMicroscopic Colitis

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Alterations in composition and diversity of the intestinal microbiota in patients with diarrhea‐predominant irritable bowel syndrome

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Carroll, I. M., Ringel‐Kulka, T., Siddle, J. P., Ringel, Y.·2012·Neurogastroenterology & Motility

DOI 10.1111/j.1365-2982.2012.01891.xPMC PMC3975596

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Abstract

Background The intestinal microbiota has been implicated in the pathophysiology of irritable bowel syndrome (IBS). Due to the variable resolutions of techniques used to characterize the intestinal microbiota, and the heterogeneity of IBS, the defined alterations of the IBS intestinal microbiota are inconsistent. We analyzed the composition of the intestinal microbiota in a defined subgroup of IBS patients (diarrhea‐predominant IBS, D‐IBS) using a technique that provides the deepest characterization available for complex microbial communities. Methods Fecal DNA was isolated from 23 D‐IBS patients and 23 healthy controls (HC). Variable regions V1–V3 and V6 of the 16S rRNA gene were amplified from all samples. PCR products were sequenced using 454 high throughput sequencing. The composition, diversity and richness of microbial communities were determined and compared between D‐IBS and HC using the quantitative insights into microbial ecology pipeline. Key Results The contribution of bacterial groups to the composition of the intestinal microbiota differed between D‐IBS and HC. D‐IBS patients had significantly higher levels of Enterobacteriaceae (P = 0.03), and lower levels of Fecalibacterium genera (P = 0.04) compared to HC. β‐Diversity values demonstrated significantly lower levels of UniFrac distances in HC compared to D‐IBS patients. The richness of 16S rRNA sequences was significantly decreased in D‐IBS patients (P < 0.04). Conclusions & Inferences Our 16S rRNA sequence data demonstrates a community‐level dysbiosis in D‐IBS. The altered composition of the intestinal microbiota in D‐IBS is associated with significant increases in detrimental and decreases in beneficial bacterial groups, and a reduction in microbial richness.

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QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887
Search and clustering orders of magnitude faster than BLAST
Edgar, R. C. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq461 · Cited by 21,098
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 20,145
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Bergey's Manual of Determinative Bacteriology
S., F. A., Buchanan, R. E., Gibbons, N. E., & Bergey (1975) · Taxon · doi:10.2307/1218353 · Cited by 11,304
UniFrac: a New Phylogenetic Method for Comparing Microbial Communities
Lozupone, C., & Knight, R. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.12.8228-8235.2005 · Cited by 8,227
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277

Show all 63 references

Research works printed but not linked: 1

Ringel Y, 2008, Netter’s Textbook of Internal Medicine, 419

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Authors: Carroll, I. M., Ringel‐Kulka, T., Siddle, J. P., & Ringel, Y.
Affiliations: University of North Carolina at Chapel Hill (US)
Corresponding author: Ringel, Y.
ORCID: Carroll, I. M.
Ringel‐Kulka, T.
Venue: Neurogastroenterology & Motility
Publisher: Wiley
Published: 2012-02-20
Volume: 24
Issue: 6
Pages: 521
ISSN: 1350-1925 (ISSN-L)
1365-2982
DOI: 10.1111/j.1365-2982.2012.01891.x
PMC: PMC3975596
OpenAlex: W1487811474
Cited by: 425
References: 63
Citations by year: 2026: 12 · 2025: 18 · 2024: 28 · 2023: 30 · 2022: 39 · 2021: 40 · 2020: 33 · 2019: 35 · 2018: 30 · 2017: 32 · 2016: 31 · 2015: 27 · 2014: 37 · 2013: 25 · 2012: 7
FWCI: 12.33
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Neurogastroenterology & Motility (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (R03DK084294, DK075621, K23DK075621, K01DK092330, DK084294)
National Center for Research Resources (UL1RR025747)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Gastroenterology › Microscopic Colitis
Keywords: diarrhea-predominant irritable bowel syndrome, gut microbiota, dysbiosis, microbial diversity, microbial richness, Enterobacteriaceae, 16S rRNA gene sequencing
MeSH terms: Adult, Aged, Diarrhea, DNA, Bacterial, Feces, Female, Humans, Intestines, Male, Middle Aged, Irritable Bowel Syndrome, Metagenome

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Alterations in composition and diversity of the intestinal microbiota in patients with diarrhea‐predominant irritable bowel syndrome

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