The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Alterations in composition and diversity of the intestinal microbiota in patients with diarrhea‐predominant irritable bowel syndrome
Open accessAbstract
Background The intestinal microbiota has been implicated in the pathophysiology of irritable bowel syndrome (IBS). Due to the variable resolutions of techniques used to characterize the intestinal microbiota, and the heterogeneity of IBS, the defined alterations of the IBS intestinal microbiota are inconsistent. We analyzed the composition of the intestinal microbiota in a defined subgroup of IBS patients (diarrhea‐predominant IBS, D‐IBS) using a technique that provides the deepest characterization available for complex microbial communities. Methods Fecal DNA was isolated from 23 D‐IBS patients and 23 healthy controls (HC). Variable regions V1–V3 and V6 of the 16S rRNA gene were amplified from all samples. PCR products were sequenced using 454 high throughput sequencing. The composition, diversity and richness of microbial communities were determined and compared between D‐IBS and HC using the quantitative insights into microbial ecology pipeline. Key Results The contribution of bacterial groups to the composition of the intestinal microbiota differed between D‐IBS and HC. D‐IBS patients had significantly higher levels of Enterobacteriaceae (P = 0.03), and lower levels of Fecalibacterium genera (P = 0.04) compared to HC. β‐Diversity values demonstrated significantly lower levels of UniFrac distances in HC compared to D‐IBS patients. The richness of 16S rRNA sequences was significantly decreased in D‐IBS patients (P < 0.04). Conclusions & Inferences Our 16S rRNA sequence data demonstrates a community‐level dysbiosis in D‐IBS. The altered composition of the intestinal microbiota in D‐IBS is associated with significant increases in detrimental and decreases in beneficial bacterial groups, and a reduction in microbial richness.
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In the citing paper
“others have shown that the colonic microbiome is altered in patients with IBS, when compared with healthy controls. 15 - 18”
From Efficacy of Probiotics in Irritable Bowel Syndrome: Systematic Review and Meta-analysis (2023) · cites this paper as [16]
Experimental — accuracy not yet measuredIn the citing paper
“Nonetheless, emerging data support the existence of dysbiosis in a subset of IBS [59] : a decreased complexity in composition [60] , temporary instability [61] , and changes in the mucosa-associated microbiota, with an increase in Bacteroides and Clostridia and a reduction in Bifidobacterium [62] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [60]
In the citing paper
“Recent studies using these advanced molecular biology techniques have demonstrated quantitative alterations of specific bacterial groups (33, 34, 81, 85, 142, 154) and reduced diversity in gut microbial populations in patients with IBS compared with healthy controls (33, 40).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [34]
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Metadata
- Authors
- Carroll, I. M., Ringel‐Kulka, T., Siddle, J. P., & Ringel, Y.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Ringel, Y.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2012-02-20
- Volume
- 24
- Issue
- 6
- Pages
- 521
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- PMC
- PMC3975596
- OpenAlex
- W1487811474
- Cited by
- 425
- References
- 63
- Citations by year
- 2026: 12 · 2025: 18 · 2024: 28 · 2023: 30 · 2022: 39 · 2021: 40 · 2020: 33 · 2019: 35 · 2018: 30 · 2017: 32 · 2016: 31 · 2015: 27 · 2014: 37 · 2013: 25 · 2012: 7
- FWCI
- 12.33
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R03DK084294, DK075621, K23DK075621, K01DK092330, DK084294)
- National Center for Research Resources (UL1RR025747)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Microscopic Colitis
- Keywords
- diarrhea-predominant irritable bowel syndrome, gut microbiota, dysbiosis, microbial diversity, microbial richness, Enterobacteriaceae, 16S rRNA gene sequencing
- MeSH terms
- Adult, Aged, Diarrhea, DNA, Bacterial, Feces, Female, Humans, Intestines, Male, Middle Aged, Irritable Bowel Syndrome, Metagenome
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