CoChat
Sign Up
Cited by 42Smoking Behavior and CessationPrenatal Substance Exposure EffectsPregnancy and Medication Impact

Maternal use of nicotine replacement therapy during pregnancy and offspring birthweight: a study within the Danish National Birth Cohort

Lassen, Tina H., Madsen, Mia, Skovgaard, Lene T., Strandberg‐Larsen, Katrine, Olsen, Jørn, Andersen, Anne‐Marie N.·2010·Paediatric and Perinatal Epidemiology
DOI 10.1111/j.1365-3016.2010.01104.x
Open this paper in CoChat — free account

Abstract

Smoking is a well-established risk factor for fetal growth restriction and other adverse pregnancy outcomes, and nicotine may be one of the chemical compounds that drive these associations. Nicotine replacement therapy (NRT) is a smoking cessation aid, which can facilitate smoking cessation. It is, however, unknown whether NRT used during pregnancy impairs fetal growth. The aim of this study was to estimate the association between the use of NRT during pregnancy and offspring birthweight. The study population consisted of 72 761 women enrolled in the Danish National Birth Cohort between 1996 and 2002. Information on NRT and potential confounders was obtained from two computer-assisted telephone interviews conducted in the second and third trimesters, respectively. Multiple linear regression in a multilevel model was used to estimate the association between NRT use and birthweight adjusted for gestational age and potential confounders. The adjusted analyses showed no significant association between the duration of NRT use and birthweight (b = 0.25 g per week of NRT use [95% CI -2.31, 2.81]) and neither was the type of NRT product (patch, gum, inhaler) associated with reduced birthweight. However, simultaneous use of more than one NRT product was associated with reduced birthweight (b = -10.73 g per week of NRT use [95% CI -26.51, 5.05]), although the association was not statistically significant. The results of this study suggest that maternal use of NRT in pregnancy does not seriously affect birthweight, but there could be a negative effect on birthweight associated with simultaneous use of more than one type of NRT product.

Integrity signals

Registry

Crossref · 10.1111/j.1365-3016.2010.01104.x

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Only two non-RCT studies adjusted for smoking behaviour; others could be subject to confounding of unknown magnitude.

    “Only two non-RCT studies adjusted for smoking behaviour [33,37]; others could be subject to confounding of unknown magnitude.”

    From Fetal safety of nicotine replacement therapy in pregnancy: systematic review and meta-analysis. (2021) · cites this paper as [37]

  • In a population-based cohort with multivariate analysis adjusted for reported smoking behaviour, there were no statistically significant associations between duration of NRT use and mean birth weight (β = 0.25 g per week, CI -2.31 to 2.81).

    “Within a multivariate analysis which adjusted for reported smoking behaviour, a population-based cohort found no statistically significant associations between duration of NRT use and mean birth weight (β = 0.25 g per week of NRT use, CI = -2.31 to 2.81) [37].”

    From Fetal safety of nicotine replacement therapy in pregnancy: systematic review and meta-analysis. (2021) · cites this paper as [37]

  • Products of nicotine replacement therapy do not affect birthweight reduction.

    “In human observational studies it is shown that products of nicotine replacement therapy do not affect birthweight reduction [16].”

    From The effect of swedish snuff (snus) on offspring birthweight: a sibling analysis (2013) · cites this paper as [16]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Lassen, T. H., Madsen, M., Skovgaard, L. T., Strandberg‐Larsen, K., Olsen, J., & Andersen, A. N.
Affiliations
  • University of Southern Denmark (DK)
  • University of Copenhagen (DK)
  • University of California, Los Angeles (US)
Corresponding author
Lassen, Tina H.
ORCID
Venue
Paediatric and Perinatal Epidemiology
Publisher
Wiley
Published
2010-04-08
Volume
24
Issue
3
Pages
272-281
ISSN
  • 0269-5022 (ISSN-L)
  • 1365-3016
DOI
10.1111/j.1365-3016.2010.01104.x
OpenAlex
W2108533975
Cited by
42
References
28
Citations by year
2026: 1 · 2021: 1 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 6 · 2013: 3 · 2012: 4
FWCI
2.82
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Paediatric and Perinatal Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
  • March of Dimes Foundation
  • Sundhed og Sygdom, Det Frie Forskningsråd
  • Danmarks Grundforskningsfond
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
Keywords
nicotine replacement therapy, pregnancy, birth weight, fetal growth, smoking cessation, nicotine patch, nicotine gum, nicotine inhaler, fetal growth restriction, maternal smoking
MeSH terms
Smoking Prevention, Adult, Birth Weight, Denmark, Female, Humans, Nicotine, Pregnancy, Surveys and Questionnaires, Regression Analysis, Cohort Studies, Nicotinic Agonists, Maternal Exposure

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review