The DOI matches its Crossref record.
Immunization against malaria with a recombinant protein
Abstract
SUMMARY: We have expressed in bacteria the C‐terminal part of Plasmodium yoelii merozoite surface protein‐1 (MSP1) containing the two epidermal growth factor‐like domains. The protein, either alone or fused to glutathione Stransferase, was highly effective as a vaccine and protected mice against challenge infection. Reduction and alkylation abolished the protection obtained with the protein. This shows for the first time the absolute requirement of the disulphide‐bonded conformation for immunogenicity. In a short term experiment, mice were protected against a massive challenge. The immunity was effective at the time of merozoite release/reinvasion. Recombinant protein based on this part of MSP1 may be suitable as a vaccine against malaria.
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Cited by
Egan, A. F., Morris, J., Barnish, G., Allen, S., Greenwood, B. M., Kaslow, D. C., Holder, A. A., & Riley, E. M. (1996) · Journal of Infectious Diseases · doi:10.1093/infdis/173.3.765 · Cited by 309
Self-citationMahanty, S., Mollis, S. N., Ravichandran, M., Abrams, J. S., Kumaraswami, V., Jayaraman, K., Ottesen, E. A., & Nutman, T. B. (1996) · Journal of Infectious Diseases · doi:10.1093/infdis/173.3.769 · Cited by 165
Metadata
- Authors
- LING, I. T., OGUN, S. A., & HOLDER, A. A.
- Venue
- Parasite Immunology
- Publisher
- Wiley
- Published
- 1994-02
- Volume
- 16
- Issue
- 2
- Pages
- 63-67
- ISSN
- 0141-9838 (ISSN-L)
- 1365-3024
- OpenAlex
- W1965543649
- Cited by
- 175
- References
- 0
- FWCI
- 17.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Immunization against malaria with a recombinant protein. https://app.cochat.ai/papers/10.1111/j.1365-3024.1994.tb00324.x
- The paper
- LING, I. T., OGUN, S. A., & HOLDER, A. A. (1994). Immunization against malaria with a recombinant protein. Parasite Immunology. https://doi.org/10.1111/j.1365-3024.1994.tb00324.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
