High Levels of Spontaneous and Parasite Antigen-Driven Interieukin-10 Production Are Associated with Antigen-Specific Hyporesponsiveness in Human Lymphatic Filariasis
Abstract
To determine whether counterregulation by interleukin (IL)-10 plays a role in the generation or maintenance of the antigen-specific hyporesponsiveness seen in asymptomatic microfilaremic (MF) patients, parasite antigen (PAg)- and nonparasite antigen (NPAg)-driven IL-10 production by peripheral blood mononuclear cells (PBMC) was studied in 10 MF patients and in ll patients with chronic lymphatic pathology (CP). PBMC from MF patients spontaneously secreted 10-fold more IL-10 than did PBMC from patients with CP. PAg also induced significantly more IL-10 production by PBMC from CP patients. There was a negative correlation between PAg driven IL-10 production by PBMC and PAg-specific T cell proliferation in the MF group. IL-10 secretion by plastic adherent cells from MF persons was higher in response to PAg than NPAg, whereas IL-6 and tumor necrosis factor-alpha secretion were equivalent for PAg and NPAg, suggesting that PAg preferentially induces IL-10 secretion in these cells. Thus, PAg-induced IL-10 likely plays an important role in down-regulating antigen-specific proliferative responses in MF patients.
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IL-10 expression is related to hyporesponsiveness in lymphatic filariasis.
“IL-10 expression is related to hyporesponsiveness in lymphatic filariasis (248,316,350)”
From Human and animal dirofilariasis: The emergence of a zoonotic mosaic (2012) · cites this paper as [248]
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- Authors
- Mahanty, S., Mollis, S. N., Ravichandran, M., Abrams, J. S., Kumaraswami, V., Jayaraman, K., Ottesen, E. A., & Nutman, T. B.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Mahanty, S.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-03-01
- Volume
- 173
- Issue
- 3
- Pages
- 769-772
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2099221469
- Cited by
- 165
- References
- 21
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 8 · 2014: 8 · 2013: 3 · 2012: 6
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Keywords
- lymphatic filariasis, IL-10, parasite antigens, microfilaremia, peripheral blood mononuclear cells, T cell proliferation, interleukin-6, TNF-α, counterregulation
- MeSH terms
- Adolescent, Adult, Animals, Antibodies, Helminth, Antigens, Helminth, Child, Elephantiasis, Filarial, Female, Humans, Immune Tolerance, Lymphocyte Activation, Male, Middle Aged, Monocytes, T-Lymphocytes, Tumor Necrosis Factor-alpha, Wuchereria bancrofti, Down-Regulation, Interleukin-6, Interleukin-10, In Vitro Techniques
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