MicroRNA-146a and Human Disease
Abstract
MicroRNAs (MiRNAs) belong to a class of small non-coding regulatory RNAs that act through repression of protein expression at post-transcriptional level and emerge to play important roles in many physiological and pathophysiological processes. MiR-146a is a miRNA supposed to regulate innate immune, inflammatory response and antiviral pathway negatively. In this review, we focus on the recent progress in functional role of miR-146a in innate immune, inflammatory response, virus infection and human diseases. Together, these findings indicate that manipulation of miR-146a expression may represent a potential new therapy for several human diseases. Potential use of miR-146a as a biomarker for disease diagnosis, prevention and treatment is also discussed.
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miRNAs play a critical role in post-transcriptional gene regulation in several biological processes of the central nervous system and in the pathogenesis of different disorders.
“An increasing body of literature supports the critical role of miRNAs in post-transcriptional gene regulation in several biological processes of the central nervous system (CNS), as well as in the pathogenesis of different disorders (including developmental, neurodegenerative, vascular and neuroinflammatory disorders), and in oncogenesis [10]–[12].”
From MicroRNA-146a: A Key Regulator of Astrocyte-Mediated Inflammatory Response (2012) · cites this paper as [11]
Cites
Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317 · see citing works
MicroRNAs: novel regulators in skin inflammation
Sonkoly, E., Ståhle, M., & Pivarcsi, A. (2008) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.2008.02804.x · Cited by 194 · see citing works
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MicroRNA-146a: A Key Regulator of Astrocyte-Mediated Inflammatory Response
Iyer, A., Zurolo, E., Prabowo, A., Fluiter, K., Spliet, W. G. M., van Rijen, P. C., Gorter, J. A., & Aronica, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044789 · Cited by 330 · see citing works
Aberrant microRNA expression in patients with painful peripheral neuropathies
Leinders, M., Üçeyler, N., Thomann, A., & Sommer, C. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.07.041 · Cited by 57 · see citing works
- Authors
- Li, L., Chen, X.-P., & Li, Y.-J.
- Venue
- Scandinavian Journal of Immunology
- Publisher
- Wiley
- Published
- 2010-04
- Volume
- 71
- Issue
- 4
- Pages
- 227-231
- ISSN
- 0300-9475
- 1365-3083
- Cited by
- 193
- References
- 2
- Language
- en
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