MicroRNAs: novel regulators in skin inflammation
Abstract
Compelling evidence indicates that microRNAs (miRNAs), short, non-protein coding RNAs, are critical for the development and survival of multicellular organisms. Recently, miRNAs were implicated in the pathogenesis of psoriasis and atopic eczema (AE), the two most common chronic inflammatory disorders in skin. In particular, miR-203, the first skin-specific miRNA, showing an intriguing expression profile being confined to skin epithelium, is specifically overexpressed in psoriasis. MiR-146a, another miRNA showing specific upregulation in psoriasis, is involved in the regulation of innate immune responses and the tumour necrosis factor (TNF)-alpha pathway. Interestingly, miR-125b, another miRNA involved in the TNF-alpha pathway, is also deregulated in psoriasis and AE. As skin inflammation may serve as a model for chronic inflammatory disorders, it is likely that miRNAs involved in skin inflammation will eventually emerge in other inflammatory or autoimmune disorders, and some of these may become disease markers and therapeutic targets. In this review we present an overview of what is currently known about the roles of miRNAs in chronic inflammatory skin disorders.
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miR-203 is increased in psoriasis and its targets include p63, suppressor of cytokine signaling 3 (SOCS3), and IL-8.
“miR-203 is also increased in psoriasis and its targets include p63, suppressor of cytokine signaling 3 (SOCS3), and IL-8,89”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [89]
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Retracted
- Authors
- Sonkoly, E., Ståhle, M., & Pivarcsi, A.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Pivarcsi, A.
- Venue
- Clinical and Experimental Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-05
- Volume
- 33
- Issue
- 3
- Pages
- 312-315
- ISSN
- 0307-6938 (ISSN-L)
- 1365-2230
- OpenAlex
- W2138201174
- Semantic Scholar
- 4f0a9c7636f8905753e42022dc0507190c837a15
- Cited by
- 194
- References
- 34
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 11 · 2020: 9 · 2019: 11 · 2018: 12 · 2017: 12 · 2016: 14 · 2015: 15 · 2014: 19 · 2013: 15 · 2012: 10
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical and Experimental Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Psoriasis Foundation
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- microRNA, skin inflammation, psoriasis, atopic dermatitis, miR-203, miR-146a, miR-125b, TNF signaling, innate immune regulation, skin epithelium, disease biomarkers, therapeutic target
- MeSH terms
- Dermatitis, Gene Expression Regulation, Humans, Psoriasis, Skin, Keratinocytes, Up-Regulation, Cytokines, MicroRNAs
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