The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
AtHMA1 contributes to the detoxification of excess Zn(II) in Arabidopsis
Open accessAbstract
Summary: AtHMA1 is a member of the heavy metal‐transporting ATPase family. It exhibits amino acid sequence similarity to two other Zn(II) transporters, AtHMA2 and AtHMA4, and contains poly‐His motifs that are commonly found in Zn(II)‐binding proteins, but lacks some amino acids that are typical for this class of transporters. AtHMA1 localizes to the chloroplast envelope. In comparison with wild‐type plants, we observed a more pronounced sensitivity in the presence of high Zn(II) concentrations, and increased accumulation of Zn in the chloroplast of T‐DNA insertional mutants in AtHMA1 . The Zn(II)‐sensitive phenotype of AtHMA1 knock‐out plants was complemented by the expression of AtHMA1 under the control of its own promoter. The Zn(II)‐transporting activity of AtHMA1 was confirmed in a heterologous expression system, Saccharomyces cerevisiae . The sensitivity of yeast to high concentrations of Zn(II) was altered by the expression of AtHMA1 lacking its N‐terminal chloroplast‐targeting signal. Taken together, these results suggest that under conditions of excess Zn(II), AtHMA1 contributes to Zn(II) detoxification by reducing the Zn content of Arabidopsis thaliana plastids.
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Cites
Evolution of metal hyperaccumulation required cis-regulatory changes and triplication of HMA4
Hanikenne, M., Talke, I. N., Haydon, M. J., Lanz, C., Nolte, A., Motte, P., Kroymann, J., Weigel, D., & Krämer, U. (2008) · Nature · doi:10.1038/nature06877 · Cited by 812
The zntA gene of Escherichia coli encodes a Zn(II)-translocating P-type ATPase
Rensing, C., Mitra, B., & Rosen, B. P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14326 · Cited by 419
Desbrosses-Fonrouge, A.-G., Voigt, K., Schröder, A., Arrivault, S., Thomine, S., & Krämer, U. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.06.046 · Cited by 305
Cited by
The zinc homeostasis network of land plants
Sinclair, S. A., & Krämer, U. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.05.016 · Cited by 502
Heavy metal transporters: Functional mechanisms, regulation, and application in phytoremediation
Yang, Z., Yang, F., Liu, J.-L., Wu, H.-T., Yang, H., Shi, Y., Liu, J., Zhang, Y.-F., Luo, Y.-R., & Chen, K.-M. (2022) · Science of The Total Environment · doi:10.1016/j.scitotenv.2021.151099 · Cited by 308
Zinc hyperaccumulation in plants: A review
Balafrej, H., Bogusz, D., Triqui, Z.-E. A., Guedira, A., Bendaou, N., Smouni, A., & Fahr, M. (2020) · Plants · doi:10.3390/plants9050562 · Cited by 275
Ueno, D., Milner, M. J., Yamaji, N., Yokosho, K., Koyama, E., Clemencia Zambrano, M., Kaskie, M., Ebbs, S., Kochian, L. V., & Ma, J. F. (2011) · The Plant Journal · doi:10.1111/j.1365-313x.2011.04548.x · Cited by 243
Zhao, H., Wang, L., Zhao, F., Wu, L., Liu, A., & Xu, W. (2019) · Plant, Cell & Environment · doi:10.1111/pce.13456 · Cited by 112
Metadata
- Authors
- Kim, Y., Choi, H., Segami, S., Cho, H., Martinoia, E., Maeshima, M., & Lee, Y.
- Venue
- The Plant Journal
- Publisher
- Wiley
- Published
- 2009-05-26
- Volume
- 58
- Issue
- 5
- Pages
- 737-753
- ISSN
- 0960-7412 (ISSN-L)
- 1365-313X
- OpenAlex
- W2146857662
- Cited by
- 197
- References
- 3
- FWCI
- 13.60
- Type
- journal article
- Language
- en
- Open access
- green
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- Kim, Y., Choi, H., Segami, S., Cho, H., Martinoia, E., Maeshima, M., & Lee, Y. (2009). AtHMA1 contributes to the detoxification of excess Zn(II) in Arabidopsis. The Plant Journal. https://doi.org/10.1111/j.1365-313x.2009.03818.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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