The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Vacuolar membrane transporters OsVIT1 and OsVIT2 modulate iron translocation between flag leaves and seeds in rice
Abstract
Summary: The plant vacuole is an important organelle for storing excess iron (Fe), though its contribution to increasing the Fe content in staple foods remains largely unexplored. In this study we report the isolation and functional characterization of two rice genes OsVIT1 and OsVIT2, orthologs of the Arabidopsis VIT1. Transient expression of OsVIT1:EGFP and OsVIT2:EGFP protein fusions revealed that OsVIT1 and OsVIT2 are localized to the vacuolar membrane. Ectopic expression of OsVIT1 and OsVIT2 partially rescued the Fe 2+‐ and Zn 2+‐sensitive phenotypes in yeast mutant Δccc1 and Δzrc1, and further increased vacuolar Fe 2+, Zn 2+ and Mn 2+ accumulation. These data together suggest that OsVIT1 and OsVIT2 function to transport Fe 2+, Zn 2+ and Mn 2+ across the tonoplast into vacuoles in yeast. In rice, OsVIT1 and OsVIT2 are highly expressed in flag leaf blade and sheath, respectively, and in contrast to OsVIT1, OsVIT2 is highly responsive to Fe treatments. Interestingly, functional disruption of OsVIT1 and OsVIT2 leads to increased Fe/Zn accumulation in rice seeds and a corresponding decrease in the source organ flag leaves, indicating an enhanced Fe/Zn translocation between source and sink organs, which might represent a novel strategy to biofortify Fe/Zn in staple foods.
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Cites
IRT1, an Arabidopsis Transporter Essential for Iron Uptake from the Soil and for Plant Growth
Vert, G., Grotz, N., Dédaldéchamp, F., Gaymard, F., Guerinot, M. L., Briat, J.-F., & Curie, C. (2002) · The Plant Cell · doi:10.1105/tpc.001388 · Cited by 1,679
Cited by
ROLE OF IRON IN PLANT GROWTH AND METABOLISM
Rout, G. R., & Sahoo, S. (2015) · Reviews in Agricultural Science · doi:10.7831/ras.3.1 · Cited by 958
Manganese in Plants: From Acquisition to Subcellular Allocation
Alejandro, S., Höller, S., Meier, B., & Peiter, E. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.00300 · Cited by 859
Using membrane transporters to improve crops for sustainable food production
Schroeder, J. I., Delhaize, E., Frommer, W. B., Guerinot, M. L., Harrison, M. J., Herrera-Estrella, L., Horie, T., Kochian, L. V., Munns, R., Nishizawa, N. K., et al. (2013) · Nature · doi:10.1038/nature11909 · Cited by 512
Iron homeostasis in plants – a brief overview
Connorton, J. M., Balk, J., & Rodríguez-Celma, J. (2017) · Metallomics · doi:10.1039/c7mt00136c · Cited by 425
Heavy metal transporters: Functional mechanisms, regulation, and application in phytoremediation
Yang, Z., Yang, F., Liu, J.-L., Wu, H.-T., Yang, H., Shi, Y., Liu, J., Zhang, Y.-F., Luo, Y.-R., & Chen, K.-M. (2022) · Science of The Total Environment · doi:10.1016/j.scitotenv.2021.151099 · Cited by 308
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Metadata
- Authors
- Zhang, Y., Xu, Y., Yi, H., & Gong, J.
- Venue
- The Plant Journal
- Publisher
- Wiley
- Published
- 2012-08-03
- Volume
- 72
- Issue
- 3
- Pages
- 400-410
- ISSN
- 0960-7412 (ISSN-L)
- 1365-313X
- OpenAlex
- W1570621366
- Cited by
- 413
- References
- 1
- FWCI
- 12.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhang, Y., Xu, Y., Yi, H., & Gong, J. (2012). Vacuolar membrane transporters OsVIT1 and OsVIT2 modulate iron translocation between flag leaves and seeds in rice. The Plant Journal. https://doi.org/10.1111/j.1365-313x.2012.05088.x
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