Short communication: Comparison of the OptiMAL rapid test and microscopy for detection of malaria in pregnant women in Nigeria
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Summary: Malaria during pregnancy causes anaemia in pregnant women and low birthweight in infants. The purpose of this study was to evaluate the OptiMAL rapid malaria test in comparison with standard microscopy for malaria diagnosis in 268 pregnant women attending antenatal clinics at the Jos University Teaching Hospital and the Federal Medical Centre‐Gombe in Nigeria. Positive results by either method were confirmed using a polymerase chain reaction assay for malaria. Although the OptiMAL assay did not detect malaria in the blood of pregnant women with low levels of parasitaemia, it may be useful for the detection of placental malaria which predisposes to low birthweight infants.
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The sensitivity of the OptiMAL test increases with parasite density.
“The sensitivity of the OptiMAL test increases with parasite density.”
From Diagnosing malaria in pregnancy: An update (2012) · cites this paper as [11]
In one study, all samples with parasite density below 100/μl were missed by OptiMAL.
“In one study, all samples with parasite density of <100/μl were missed [11].”
From Diagnosing malaria in pregnancy: An update (2012) · cites this paper as [11]
The OptiMAL test, based on pLDH detection, gave varying results between studies when compared with peripheral blood smears, with sensitivity ranging from 15 to 96.6% and specificity from 90.8 to 98%.
“The OptiMAL test, based on the detection of pLDH, gave varying results between studies when compared with peripheral BS. The sensitivity ranged from 15 to 96.6% and specificity from 90.8 to 98% [10–12].”
From Diagnosing malaria in pregnancy: An update (2012) · cites this paper as [11]
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- I. O. A. Ujah, Department of Obstetrics and Gynaecology, Jos University Teaching Hospital, PMB 2076, Jos, Nigeria. E-mail: iujah@uniceg.org Tropical Medicine and International Health volume 10 no 1 pp 39-41 january 2005
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- Authors
- VanderJagt, T. A., Ikeh, E. I., Ujah, I. O. A., Belmonte, J., Glew, R. H., & VanderJagt, D. J.
- Affiliations
- University of New Mexico (US)
- University of Jos (NG)
- Corresponding author
- VanderJagt, T. A.
- Ikeh, E. I.
- Ujah, I. O. A.
- Belmonte, J.
- Glew, R. H.
- VanderJagt, D. J.
- ORCID
- Glew, R. H.
- Venue
- Tropical Medicine & International Health
- Publisher
- Wiley
- Published
- 2005-01
- Volume
- 10
- Issue
- 1
- Pages
- 39-41
- ISSN
- 1360-2276 (ISSN-L)
- 1365-3156
- OpenAlex
- W2080948536
- Cited by
- 31
- References
- 5
- Citations by year
- 2021: 1 · 2018: 1 · 2017: 2 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 4
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Tropical Medicine & International Health (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Fogarty International Center
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
- Keywords
- malaria in pregnancy, rapid diagnostic tests, microscopy, placental malaria, low birth weight, parasitemia, prenatal care, Nigeria
- MeSH terms
- Adult, Animals, Antigens, Protozoan, Developing Countries, Female, Humans, Immunoassay, L-Lactate Dehydrogenase, Malaria, Microscopy, Nigeria, Plasmodium, Pregnancy, Reagent Strips, Pregnancy Complications, Parasitic, Polymerase Chain Reaction, Parasitemia
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