The DOI matches its Crossref record; 100 of the 102 references it cites were found in a registry or an index.
Cannabis and psychiatric disorders: it is not only addiction
Abstract
Since the discovery of the endocannabinoid system, a growing body of psychiatric research has emerged focusing on the role of this system in major psychiatric disorders like schizophrenia (SCZ), bipolar disorder (BD), major depression and anxiety disorder. Continuing in the line of earlier epidemiological studies, recent replication studies indicate that frequent cannabis use doubles the risk for psychotic symptoms and SCZ. Further points of clinical research interest are alterations of endocannabinoids and their relation to symptoms as well as postmortem analyses of cannabinoid CB 1 receptor densities in SCZ. A possible neurobiological mechanism for the deleterious influence of cannabis use in SCZ has been suggested, involving the disruption of endogenous cannabinoid signaling and functioning. Even though the number of studies is still limited for affective and anxiety disorders, previous results suggest these diseases to be exciting objectives of cannabinoid‐associated research. Therefore, it became apparent that cannabis use is not only frequent in patients suffering from BD, but that it also induces manic symptoms in this group. In addition, prior antipsychotic treatment decreased the numerical density of CB 1 immunoreactive glial cells in bipolar patients. Although the data on the influence of cannabis use on the development of major depression is controversial, cannabinoid compounds could display a new class of medication, as suggested by the antidepressive effects of the fatty acid amino hydrolase inhibitor URB597 in animal models. With numerous open questions and controversial results, further research is required to specify and extend the findings in this area, which provides a promising target for novel pharmacotherapeutic interventions.
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“as direct activation of CB1 receptors with plant-derived cannabinoids over an extended period of time leads to down-regulation of CB1 receptors52, 53”
From Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: A positron emission tomography study (2013) · cites this paper as [53]
Citations
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Cited by
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Neumeister, A., Normandin, M. D., Pietrzak, R. H., Piomelli, D., Zheng, M. Q., Gujarro-Anton, A., Potenza, M. N., Bailey, C. R., Lin, S. F., Najafzadeh, S., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.61 · Cited by 361
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Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions
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Metadata
- Authors
- Leweke, F. M., & Koethe, D.
- Affiliations
- University of Cologne (DE)
- Corresponding author
- Leweke, F. Markus
- Venue
- Addiction Biology
- Publisher
- Wiley
- Published
- 2008-06
- Volume
- 13
- Issue
- 2
- Pages
- 264-275
- ISSN
- 1355-6215 (ISSN-L)
- 1369-1600
- OpenAlex
- W2113864940
- Cited by
- 213
- References
- 102
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 6 · 2022: 12 · 2021: 13 · 2020: 7 · 2019: 11 · 2018: 8 · 2017: 13 · 2016: 20 · 2015: 14 · 2014: 13 · 2013: 9 · 2012: 18
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Addiction Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Keywords
- cannabis use, endocannabinoid system, schizophrenia, bipolar disorder, major depressive disorder, anxiety disorders, psychotic symptoms, CB1 receptor, endocannabinoids, manic symptoms, glial cells, URB597
- MeSH terms
- Affect, Animals, Anxiety Disorders, Bipolar Disorder, Brain, Cannabinoids, Marijuana Abuse, Cognition Disorders, Depressive Disorder, Major, Major Depressive Disorder, Drug Interactions, Humans, Psychoses, Substance-Induced, Risk Factors, Schizophrenia, Dronabinol, Antipsychotic Agents, Signal Transduction, Mood Disorders, Receptor, Cannabinoid, CB1, Cannabinoid Receptor Modulators
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