Cited by 213Cannabis and Cannabinoid ResearchSchizophrenia research and treatmentPsychedelics and Drug Studies

The DOI matches its Crossref record; 100 of the 102 references it cites were found in a registry or an index.

Cannabis and psychiatric disorders: it is not only addiction

Leweke, F. Markus, Koethe, Dagmar·2008·Addiction Biology

DOI 10.1111/j.1369-1600.2008.00106.x

Open this paper in CoChat — free account

Abstract

Since the discovery of the endocannabinoid system, a growing body of psychiatric research has emerged focusing on the role of this system in major psychiatric disorders like schizophrenia (SCZ), bipolar disorder (BD), major depression and anxiety disorder. Continuing in the line of earlier epidemiological studies, recent replication studies indicate that frequent cannabis use doubles the risk for psychotic symptoms and SCZ. Further points of clinical research interest are alterations of endocannabinoids and their relation to symptoms as well as postmortem analyses of cannabinoid CB 1 receptor densities in SCZ. A possible neurobiological mechanism for the deleterious influence of cannabis use in SCZ has been suggested, involving the disruption of endogenous cannabinoid signaling and functioning. Even though the number of studies is still limited for affective and anxiety disorders, previous results suggest these diseases to be exciting objectives of cannabinoid‐associated research. Therefore, it became apparent that cannabis use is not only frequent in patients suffering from BD, but that it also induces manic symptoms in this group. In addition, prior antipsychotic treatment decreased the numerical density of CB 1 immunoreactive glial cells in bipolar patients. Although the data on the influence of cannabis use on the development of major depression is controversial, cannabinoid compounds could display a new class of medication, as suggested by the antidepressive effects of the fatty acid amino hydrolase inhibitor URB597 in animal models. With numerous open questions and controversial results, further research is required to specify and extend the findings in this area, which provides a promising target for novel pharmacotherapeutic interventions.

Integrity signals

Registry

Crossref · 10.1111/j.1369-1600.2008.00106.x

Cites

100 of 100 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Comorbidity of Mental Disorders With Alcohol and Other Drug Abuse: Results From the Epidemiologic Catchment Area (ECA) Study
Regier, D. A. (1990) · JAMA · doi:10.1001/jama.1990.03450190043026 · Cited by 3,962
Cannabinoid receptor localization in brain.
Herkenham, M., Lynn, A. B., Little, M. D., Johnson, M. R., Melvin, L. S., de Costa, B. R., & Rice, K. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1932 · Cited by 2,321
The endogenous cannabinoid system controls extinction of aversive memories
Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G., Hermann, H., Tang, J., Hofmann, C., Zieglgänsberger, W., et al. (2002) · Nature · doi:10.1038/nature00839 · Cited by 1,728
Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: Longitudinal evidence of a gene X environment interaction
Caspi, A., Moffitt, T. E., Cannon, M., McClay, J., Murray, R., Harrington, H., Taylor, A., Arseneault, L., Williams, B., Braithwaite, A., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.026 · Cited by 1,409
Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study.
Arseneault, L., Cannon, M., Poulton, R., Murray, R., Caspi, A., & Moffitt, T. E. (2002) · BMJ · doi:10.1136/bmj.325.7374.1212 · Cited by 1,399
Modulation of anxiety through blockade of anandamide hydrolysis
Kathuria, S., Gaetani, S., Fegley, D., Valiño, F., Duranti, A., Tontini, A., Mor, M., Tarzia, G., Rana, G. L., Calignano, A., et al. (2003) · Nature Medicine · doi:10.1038/nm803 · Cited by 1,293
Endocannabinoid Signaling in the Brain
Wilson, R. I., & Nicoll, R. A. (2002) · Science · doi:10.1126/science.1063545 · Cited by 1,280
Cannabis and schizophrenia. A longitudinal study of Swedish conscripts
Andréasson, S., Engström, A., Allebeck, P., & Rydberg, U. (1987) · The Lancet · doi:10.1016/s0140-6736(87)92620-1 · Cited by 1,166
Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain
Glass, M., Faull, R. L. M., & Dragunow, M. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00428-9 · Cited by 1,052
The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: Implications for psychosis
D'Souza, D. C., Perry, E., MacDougall, L., Ammerman, Y., Cooper, T., Wu, Y.-T., Braley, G., Gueorguieva, R., & Krystal, J. H. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300496 · Cited by 1,024
Cannabis use and mental health in young people: cohort study.
Patton, G. C., Coffey, C., Carlin, J. B., Degenhardt, L., Lynskey, M., & Hall, W. (2002) · BMJ · doi:10.1136/bmj.325.7374.1195 · Cited by 997
Cannabis use and psychosis: A longitudinal population-based study
van Os, J. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf043 · Cited by 928
Causal association between cannabis and psychosis: examination of the evidence
Arseneault, L., Cannon, M. D., Witton, J., & Murray, R. M. (2004) · The British Journal of Psychiatry · doi:10.1192/bjp.184.2.110 · Cited by 924
Self reported cannabis use as a risk factor for schizophrenia in Swedish conscripts of 1969: Historical cohort study
Zammit, S., Allebeck, P., Andreasson, S., Lundberg, I., & Lewis, G. (2002) · BMJ · doi:10.1136/bmj.325.7374.1199 · Cited by 871
Dopamine activation of endogenous cannabinoid signaling in dorsal striatum
Giuffrida, A., Parsons, L. H., Kerr, T. M., de Fonseca, F. R., Navarro, M. A., & Piomelli, D. (1999) · Nature Neuroscience · doi:10.1038/7268 · Cited by 782
Prospective cohort study of cannabis use, predisposition for psychosis, and psychotic symptoms in young people
Henquet, C., Krabbendam, L., Spauwen, J., Kaplan, C., Lieb, R., Wittchen, H.-U., & van Os, J. (2005) · BMJ · doi:10.1136/bmj.38267.664086.63 · Cited by 765
Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis
Gobbi, G., Bambico, F. R., Mangieri, R. A., Bortolato, M., Campolongo, P., Solinas, M., Cassano, T., Morgese, M. G., Debonnel, G., Duranti, A., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509591102 · Cited by 692
Cannabis Abuse and the Course of Recent-Onset Schizophrenic Disorders
LINSZEN, D. H. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950040017002 · Cited by 665
Delta-9-tetrahydrocannabinol effects in schizophrenia: Implications for cognition, psychosis, and addiction
D’Souza, D. C., Abi-Saab, W. M., Madonick, S., Forselius-Bielen, K., Doersch, A., Braley, G., Gueorguieva, R., Cooper, T. B., & Krystal, J. H. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.12.006 · Cited by 617
Action of cannabidiol on the anxiety and other effects produced by ?9-THC in normal subjects
Zuardi, A. W., Shirakawa, I., Finkelfarb, E., & Karniol, I. G. (1982) · Psychopharmacology · doi:10.1007/bf00432554 · Cited by 608
Exploring the association between cannabis use and depression.
Degenhardt, L., Hall, W., & Lynskey, M. (2003) · Addiction · doi:10.1046/j.1360-0443.2003.00437.x · Cited by 587
Presynaptic Inhibition Caused by Retrograde Signal from Metabotropic Glutamate to Cannabinoid Receptors
Maejima, T., Hashimoto, K., Yoshida, T., Aiba, A., & Kano, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00375-0 · Cited by 575
Cannabis use and psychosocial adjustment in adolescence and young adulthood
Fergusson, D. M., Horwood, L. J., & Swain‐Campbell, N. (2002) · Addiction · doi:10.1046/j.1360-0443.2002.00103.x · Cited by 563
Cannabidiol: An Overview of Some Pharmacological Aspects
Mechoulam, R., Parker, L. A., & Gallily, R. (2002) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.2002.tb05998.x · Cited by 530
Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects
Jiang, W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25509 · Cited by 527
Specificity of social anxiety disorder as a risk factor for alcohol and cannabis dependence
Buckner, J. D., Schmidt, N. B., Lang, A. R., Small, J. W., Schlauch, R. C., & Lewinsohn, P. M. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2007.01.002 · Cited by 506
Health aspects of cannabis
Hollister, L. E. (1987) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(87)90030-4 · Cited by 500
Endocannabinoid system and stress and anxiety responses
VIVEROS, M., MARCO, E., & FILE, S. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.01.029 · Cited by 485
The Consequences in Young Adulthood of Adolescent Drug Involvement
Kandel, D. B. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800080032005 · Cited by 484
Cerebrospinal Anandamide Levels are Elevated in Acute Schizophrenia and are Inversely Correlated with Psychotic Symptoms
Giuffrida, A., Leweke, F. M., Gerth, C. W., Schreiber, D., Koethe, D., Faulhaber, J., Klosterkötter, J., & Piomelli, D. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300558 · Cited by 481
Self-citation
Cannabis Abuse as a Risk Factor for Depressive Symptoms
BOVASSO, G. B. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.12.2033 · Cited by 455
Elevated endogenous cannabinoids in schizophrenia
Leweke, F. M., Giuffrida, A., Wurster, U., Emrich, H. M., & Piomelli, D. (1999) · Neuroreport · doi:10.1097/00001756-199906030-00008 · Cited by 431
Self-citation
Chronic Pubertal, but not Adult Chronic Cannabinoid Treatment Impairs Sensorimotor Gating, Recognition Memory, and the Performance in a Progressive Ratio Task in Adult Rats
Schneider, M., & Koch, M. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300225 · Cited by 425
Metabotropic Glutamate Receptors Drive the Endocannabinoid System in Hippocampus
Varma, N., Carlson, G. C., Ledent, C. A., & Alger, B. E. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-24-j0003.2001 · Cited by 414
Evidence for novel cannabinoid receptors
Begg, M., Pacher, P., Bátkai, S., Osei‐Hyiaman, D., Offertáler, L., Mo, F.-M., LIU, J., & Kunos, G. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.11.005 · Cited by 396
Studies on [3H]CP-55940 binding in the human central nervous system: regional specific changes in density of cannabinoid-1 receptors associated with schizophrenia and cannabis use
Dean, B., Sundram, S., Bradbury, R., Scarr, E., & Copolov, D. (2001) · Neuroscience · doi:10.1016/s0306-4522(00)00552-2 · Cited by 381
Effects of ipsapirone and cannabidiol on human experimental anxiety
Zuardi, A. W., Cosme, R. A., Graeff, F. G., & Guimarães, F. S. (1993) · Journal of Psychopharmacology · doi:10.1177/026988119300700112 · Cited by 364
The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety
Haller, J., Bakos, N., Szirmay, M., Ledent, C., & Freund, T. F. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02192.x · Cited by 354
In silico patent searching reveals a new cannabinoid receptor
Baker, D., Pryce, G., Davies, W. I. L., & Hiley, C. R. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.11.003 · Cited by 347
Antidepressant-like Activity of the Fatty Acid Amide Hydrolase Inhibitor URB597 in a Rat Model of Chronic Mild Stress
Bortolato, M., Mangieri, R. A., Fu, J., Kim, J. H., Arguello, O., Duranti, A., Tontini, A., Mor, M., Tarzia, G., & Piomelli, D. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.12.001 · Cited by 347
The endocannabinoid system drives neural progenitor proliferation
Aguado, T., Monory, K., Palazuelos, J., Stella, N., Cravatt, B. F., Lutz, B., Marsicano, G., Kokaia, Z., Guzmán, M., & Galve‐Roperh, I. (2005) · The FASEB Journal · doi:10.1096/fj.05-3995fje · Cited by 335
Placebo-Controlled Evaluation of Four Novel Compounds for the Treatment of Schizophrenia and Schizoaffective Disorder
Meltzer, H. Y., Arvanitis, L. A., Bauer, D., Rein, W., & Meta-Trial Study Group (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.6.975 · Cited by 330
Impact of complex genetic variation in COMT on human brain function
Meyer‐Lindenberg, A., Nichols, T. E., Callicott, J. H., Ding, J., Kolachana, B. S., Buckholtz, J. W., Mattay, V. S., Egan, M. F., & Weinberger, D. R. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001860 · Cited by 326
Cannabis use and cannabis use disorders and their relationship to mental disorders: a 10-year prospective-longitudinal community study in adolescents
Wittchen, H.-U., Fröhlich, C., Behrendt, S., Günther, A., Rehm, J., Zimmermann, P., Lieb, R., & Perkonigg, A. (2007) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2006.12.013 · Cited by 311 · cited 1×
“…psychopathological conditions including depressive, bipolar and anxiety disorders, as well as the degree of their comorbidity, are significantly associated with cannabis use and the progression to cannabis use disorder (CUD) even when controlling for externalizing disorders (Wittchen et al. 2007).”
Background
Longitudinal study of co-occurring psychiatric disorders and substance use.
BROOK, J. S., COHEN, P., & BROOK, D. W. (1998) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199803000-00018 · Cited by 308
Acute administration of the CB1 cannabinoid receptor antagonist SR 141716A induces anxiety-like responses in the rat
Navarro, M., Hernández, E., Muñoz, R. M., del Arco, I., Villanúa, M. Á., Carrera, M. R. A., & de Fonseca, F. R. (1997) · Neuroreport · doi:10.1097/00001756-199701200-00023 · Cited by 306
A longitudinal study of cannabis use and mental health from adolescence to early adulthood
McGee, R. O., Williams, S., Poulton, R., & Moffitt, T. E. (2000) · Addiction · doi:10.1046/j.1360-0443.2000.9544912.x · Cited by 298
Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor
Berghuis, P., Dobszay, M. B., Wang, X., Spano, S., Ledda, F., Sousa, K. M., Schulte, G., Ernfors, P., Mackie, K., Paratcha, G., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509494102 · Cited by 291
Selective antagonist [3H]SR141716A binding to cannabinoid CB1 receptors is increased in the anterior cingulate cortex in schizophrenia
Zavitsanou, K., Garrick, T. M., & Huang, X. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.11.005 · Cited by 270
The Endocannabinoid System Promotes Astroglial Differentiation by Acting on Neural Progenitor Cells
Aguado, T., Palazuelos, J., Monory, K., Stella, N., Cravatt, B. F., Lutz, B., Marsicano, G., Kokaia, Z., Guzmán, M., & Galve‐Roperh, I. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3101-05.2006 · Cited by 269
Cannabis and Anxiety and Depression in Young Adults
Hayatbakhsh, M. R., Najman, J. M., Jamrozik, K. D., Mamun, A. A., Alati, R., & Bor, W. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31802dc54d · Cited by 266
Cannabis Use and Age at Onset of Schizophrenia
Veen, N. D., Selten, J., van der Tweel, I., Feller, W., Hoek, H. W., & Kahn, R. S. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.3.501 · Cited by 266
Reasons for increased substance use in psychosis
Gregg, L., Barrowclough, C., & Haddock, G. (2007) · Clinical Psychology Review · doi:10.1016/j.cpr.2006.09.004 · Cited by 249
CB1 cannabinoid receptors mediate anxiolytic effects: convergent genetic and pharmacological evidence with CB1-specific agents
Haller, J., Varga, B., Ledent, C., & Freund, T. F. (2004) · Behavioural Pharmacology · doi:10.1097/01.fbp.0000135704.56422.40 · Cited by 241 · cited 1×
“The importance of endocannabinoids is further indicated by the confounding effect of stress on anxiogenic behaviors and their modulations (Haller et al. 2004; Patel, Cravatt & Hillard 2005).”
Background
The impact of substance abuse on the course of bipolar disorder
Strakowski, S. M., DelBello, M. P., Fleck, D. E., & Arndt, S. V. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00900-8 · Cited by 240
Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients: Impact of cannabis use
Leweke, F. M., Giuffrida, A., Koethe, D., Schreiber, D., Nolden, B. M., Kranaster, L., Neatby, M. A., Schneider, M., Gerth, C. W., Hellmich, M., et al. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.04.025 · Cited by 240
Self-citation
Diagnostic and demographic correlates of substance abuse in schizophrenia and major affective disorder
Mueser, K. T., Yarnold, P. R., & Bellack, A. S. (1992) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1992.tb01441.x · Cited by 229
Towards a cannabinoid hypothesis of schizophrenia: cognitive impairments due to dysregulation of the endogenous cannabinoid system
Emrich, H. M., Leweke, F. M., & Schneider, U. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00426-1 · Cited by 226
Self-citation
Substance Abuse and Bipolar Affective Disorder
SONNE, S. C., BRADY, K. T., & MORTON, W. A. (1994) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199406000-00007 · Cited by 211
Major Depressive Disorder, Suicidal Ideation, and Suicide Attempt inTwins Discordant for Cannabis Dependence and Early-Onset Cannabis Use
Lynskey, M. T., Glowinski, A. L., Todorov, A. A., Bucholz, K. K., Madden, P. A. F., Nelson, E. C., Statham, D. J., Martin, N. G., & Heath, A. C. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.10.1026 · Cited by 205
Effects of cannabidiol in animal models predictive of antipsychotic activity
Zuardi, A. W., Antunes Rodrigues, J., & Cunha, J. M. (1991) · Psychopharmacology · doi:10.1007/bf02244189 · Cited by 191
Expression of CB1 cannabinoid receptor in the anterior cingulate cortex in schizophrenia, bipolar disorder, and major depression
Koethe, D., Llenos, I. C., Dulay, J. R., Hoyer, C., Torrey, Ε. F., Leweke, F. M., & Weis, S. (2007) · Journal of Neural Transmission · doi:10.1007/s00702-007-0660-5 · Cited by 187
Self-citation
Trends in the Development of New Antidepressants. Is there a Light at the End of the Tunnel?
Pacher, P., & Kecskeméti, V. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043455594 · Cited by 182
Increased cannabinoid receptor density in the posterior cingulate cortex in schizophrenia
Newell, K. A., Deng, C., & Huang, X. (2006) · Experimental Brain Research · doi:10.1007/s00221-006-0503-x · Cited by 179
Substance Use Disorder and the Early Course of Illness in Schizophrenia and Affective Psychosis
Kovasznay, B. M., Fleischer, J., Tanenberg‐Karant, M., Jandorf, L., Miller, A. D., & Bromet, E. J. (1997) · Schizophrenia Bulletin · doi:10.1093/schbul/23.2.195 · Cited by 177
Cannabis use and expression of mania in the general population
Henquet, C., A, L. K. M., de Graaf, R., ten Have, M., & van Os, J. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.05.002 · Cited by 176
Cannabinoid effects on anxiety-related behaviours and hypothalamic neurotransmitters
Arévalo, C., de Miguel, R., & Hernández‐Tristán, R. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00578-0 · Cited by 175
Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors
Bilkei‐Gorzó, A., Rácz, I., Valverde, O., Otto, M., Michel, K., Sarstre, M., & Zimmer, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504640102 · Cited by 166
Effects of Co-occurring Cannabis Use Disorders on the Course of Bipolar Disorder After a First Hospitalization for Mania
Strakowski, S. M., DelBello, M. P., Fleck, D. E., Adler, C. M., Anthenelli, R. M., Keck, P. E., Arnold, L. M., & Amicone, J. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.1.57 · Cited by 165
Synergistic interactions between cannabinoids and environmental stress in the activation of the central amygdala
Patel, S., Cravatt, B. F., & Hillard, C. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300535 · Cited by 164
Deficient Social and Play Behavior in Juvenile and Adult Rats after Neonatal Cortical Lesion: Effects of Chronic Pubertal Cannabinoid Treatment
Schneider, M., & Koch, M. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300634 · Cited by 160
Comorbidity of Mood Disorders: A Longitudinal Prospective Study
Angst, J. (1996) · The British Journal of Psychiatry · doi:10.1192/s0007125000298383 · Cited by 160
Schizophrenia in users and nonusers of cannabis
Andréasson, S., Allebeck, P., & Rydberg, U. S. (1989) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1989.tb10296.x · Cited by 157
The short-term consequences of early onset cannabis use
Fergusson, D. M., Lynskey, M. T., & Horwood, L. J. (1996) · Research on Child and Adolescent Psychopathology · doi:10.1007/bf01441571 · Cited by 157
Effects of Co-occurring Alcohol Abuse on the Course of Bipolar Disorder Following a First Hospitalization for Mania
Strakowski, S. M., DelBello, M. P., Fleck, D. E., Adler, C. M., Anthenelli, R. M., Keck, P. E., Arnold, L. M., & Amicone, J. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.8.851 · Cited by 150
Different Effects of Nabilone and Cannabidiol on Binocular Depth Inversion in Man
Leweke, F. M., Schneider, U., Radwan, M., Schmidt, E., & Emrich, H. M. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00201-x · Cited by 150
Self-citation
Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential
Ashton, C. H., Moore, P. B., Gallagher, P., & Young, A. H. (2005) · Journal of Psychopharmacology · doi:10.1177/0269881105051541 · Cited by 135
Effect of cannabis and certain of its constituents on pentobarbitone sleeping time and phenazone metabolism
Paton, W. D. M., & Pertwee, R. G. (1972) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1972.tb07261.x · Cited by 134
Cannabis use and psychiatric and cogitive disorders: the chicken or the egg?
di Forti, M., Morrison, P., Butt, A., & Murray, R. (2007) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3280fa838e · Cited by 120
Involvement of the Endocannabinoid System in the Ability of Long-Term Tricyclic Antidepressant Treatment to Suppress Stress-Induced Activation of the Hypothalamic–Pituitary–Adrenal Axis
Hill, M. N., Ho, W. ‐. V., Sinopoli, K. J., Viau, V., Hillard, C. J., & Gorzalka, B. B. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301092 · Cited by 118
Substance Abuse in First-Episode Bipolar I Disorder: Indications for Early Intervention
Baethge, C., Baldessarini, R. J., Khalsa, H.-M. K., Hennen, J. A., Salvatore, P., & Tohen, M. F. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.5.1008 · Cited by 112
Effects of synthetic Δ 9 -tetrahydrocannabinol on binocular depth inversion of natural and artificial objects in man
Leweke, F. M., Schneider, U., Thies, M., Münte, T. F., & Emrich, H. M. (1999) · Psychopharmacology · doi:10.1007/s002130050884 · Cited by 102
Self-citation
Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells
Allister, S. D. M., Chan, C. C., Taft, R. J., Luu, T., Abood, M. E., Moore, D. H., Aldape, K., & Yount, G. L. (2005) · Journal of Neuro-Oncology · doi:10.1007/s11060-004-5950-2 · Cited by 102
Anxiogenic profile of AM-251, a selective cannabinoid CB1 receptor antagonist, in plus-maze-na??ve and plus-maze-experienced mice
Rodgers, R. J., Evans, P., & Murphy, A. (2005) · Behavioural Pharmacology · doi:10.1097/00008877-200509000-00013 · Cited by 101
Disturbances of visual information processing in early states of psychosis and experimental delta-9-tetrahydrocannabinol altered states of consciousness
Koethe, D., Gerth, C. W., Neatby, M. A., Haensel, A., Thies, M., Schneider, U., Emrich, H. M., Klosterkötter, J., Schultze-Lutter, F., & Leweke, F. M. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.07.023 · Cited by 93
Self-citation
Cannabinoid modulation of rat pup ultrasonic vocalizations
McGregor, I. S., Dastur, F. N., McLellan, R. A., & Brown, R. E. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00511-0 · Cited by 88
The development of suicide ideation and attempts: an epidemiologic study of first graders followed into young adulthood.
Wilcox, H. C., & Anthony, J. C. (2004) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2004.08.007 · Cited by 88
The Involvement of Glutamate in the Pathophysiology of Depression
Pałucha-Poniewiera, A., & Pilc, A. (2005) · Drug News & Perspectives · doi:10.1358/dnp.2005.18.4.908661 · Cited by 86
Cannabis and neurodevelopment: implications for psychiatric disorders
Sundram, S. (2006) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.762 · Cited by 86
Persistent and anatomically selective reduction in prefrontal cortical dopamine metabolism after repeated, intermittent cannabinoid administration to rats
Verrico, C. D., Jentsch, J. D., & Roth, R. H. (2003) · Synapse · doi:10.1002/syn.10215 · Cited by 85
Behavioral effects in adult rats of chronic prepubertal treatment with the cannabinoid receptor agonist WIN 55,212-2
Schneider, M., Drews, E., & Koch, M. (2005) · Behavioural Pharmacology · doi:10.1097/00008877-200509000-00018 · Cited by 72
Blockade of cannabinoid (CB1) receptors by SR 141716 selectively antagonizes drug-induced reinstatement of exploratory behaviour in gerbils
Poncelet, M., Barnouin, M. C., Brelière, J.-C., Fur, G. L., & Soubrié, P. (1999) · Psychopharmacology · doi:10.1007/s002130050987 · Cited by 66
Effects of cannabinoids on the anxiety-like response in mice.
Rutkowska, M., Jamontt, J., & Gliniak, H. (2006) · PubMed · Cited by 66
Anger and Depressive States Among Treatment‐Seeking Drug Abusers: Testing the Psychopharmacological Specificity Hypothesis
Aharonovich, E., Nguyen, H. T., & Nunes, E. V. (2001) · American Journal on Addictions · doi:10.1111/j.1521-0391.2001.tb00522.x · Cited by 63
Rimonabant: A novel selective cannabinoid-1 receptor antagonist for treatment of obesity
Patel, P. N., & Pathak, R. (2007) · American Journal of Health-System Pharmacy · doi:10.2146/060258 · Cited by 63
The Effects of Tetrahydrocannabinol on the Recognition of Emotionally Charged Words: An Analysis Using Event-Related Brain Potentials
Leweke, F. M., Kampmann, C., Radwan, M., Dietrich, D. E., Johannes, S., Emrich, H. M., & Münte, T. F. (1998) · Neuropsychobiology · doi:10.1159/000026487 · Cited by 44
Self-citation
The seed and the soil: effect of dosage, personality and starting state on the response to delta 9 tetrahydrocannabinol in man.
Ashton, H., Golding, J. B., Marsh, V. R., Millman, J. E., & Thompson, J. (1981) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1981.tb01294.x · Cited by 42
Modulation of Δ9-THC-induced increase of cortical and hippocampal acetylcholine release by μ opioid and D1 dopamine receptors
Pisanu, A., Acquas, E., Fenu, S., & Chiara, G. D. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.11.023 · Cited by 38
Neurobiological aspects of depressive disorder and antidepressant treatment: role of glia
Páv, M., Kovárů, H., Fišerová, A., Havrdová, E., & Lisá, V. (2008) · Physiological Research · doi:10.33549/physiolres.930990 · Cited by 34
Problems With Odds Ratios
Epstein, D. H. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.1.190-a · Cited by 5

Research works printed but not linked: 4

Beringer K, 1932, Zur klinik des haschischrausches, Nervenarzt, 5, 337
10.1007/s00702-007-0660-5 · DOI
Leweke FM, 2007, Program No 118.3.2007
Moreau de Tours J‐J, 1845, Du Hachisch et de L'aliénation Mentale, Études Psychologiques

Sorted by citations

Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: A positron emission tomography study
Neumeister, A., Normandin, M. D., Pietrzak, R. H., Piomelli, D., Zheng, M. Q., Gujarro-Anton, A., Potenza, M. N., Bailey, C. R., Lin, S. F., Najafzadeh, S., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.61 · Cited by 361
Chemistry, metabolism, and toxicology of cannabis: clinical implications.
Sharma, P., Murthy, P., & Bharath, M. M. S. (2012) · Europe PMC (PubMed Central) · Cited by 338
Puberty as a highly vulnerable developmental period for the consequences of cannabis exposure
Schneider, M. (2008) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00110.x · Cited by 330
Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions
Lafourcade, M., Larrieu, T., Mato, S., Duffaud, A. M., Sepers, M. D., Matias, I., Smedt, V. D., Labrousse, V. F., Brétillon, L., Matute, C., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2736 · Cited by 344
A positive association between anxiety disorders and cannabis use or cannabis use disorders in the general population- a meta-analysis of 31 studies
Kedzior, K. K., & Laeber, L. T. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-136 · Cited by 309

See all 213

Authors: Leweke, F. M., & Koethe, D.
Affiliations: University of Cologne (DE)
Corresponding author: Leweke, F. Markus
ORCID: Leweke, F. Markus
Koethe, Dagmar
Venue: Addiction Biology
Publisher: Wiley
Published: 2008-06
Volume: 13
Issue: 2
Pages: 264-275
ISSN: 1355-6215 (ISSN-L)
1369-1600
DOI: 10.1111/j.1369-1600.2008.00106.x
OpenAlex: W2113864940
Cited by: 213
References: 102
Citations by year: 2026: 1 · 2025: 5 · 2024: 3 · 2023: 6 · 2022: 12 · 2021: 13 · 2020: 7 · 2019: 11 · 2018: 8 · 2017: 13 · 2016: 20 · 2015: 14 · 2014: 13 · 2013: 9 · 2012: 18
FWCI: 2.15
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 27 d)
Locations: Addiction Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
Keywords: cannabis use, endocannabinoid system, schizophrenia, bipolar disorder, major depressive disorder, anxiety disorders, psychotic symptoms, CB1 receptor, endocannabinoids, manic symptoms, glial cells, URB597
MeSH terms: Affect, Animals, Anxiety Disorders, Bipolar Disorder, Brain, Cannabinoids, Marijuana Abuse, Cognition Disorders, Depressive Disorder, Major, Major Depressive Disorder, Drug Interactions, Humans, Psychoses, Substance-Induced, Risk Factors, Schizophrenia, Dronabinol, Antipsychotic Agents, Signal Transduction, Mood Disorders, Receptor, Cannabinoid, CB1, Cannabinoid Receptor Modulators

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cannabis and psychiatric disorders: it is not only addiction

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks