Rapamycin attenuates the expression of cocaine‐induced place preference and behavioral sensitization

TOR signaling in growth and metabolism

Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787 · see citing works

Upstream and downstream of mTOR

Hay, N., & Sonenberg, N. (2004) · Genes & Development · doi:10.1101/gad.1212704 · Cited by 4,181 · see citing works

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881 · see citing works

NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory

Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647 · see citing works

Growing roles for the mTOR pathway

Sarbassov, D. D., Ali, S. M., & Sabatini, D. M. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.09.009 · Cited by 1,556 · see citing works

Is there a common molecular pathway for addiction?

Nestler, E. J. (2005) · Nature Neuroscience · doi:10.1038/nn1578 · Cited by 1,388 · see citing works

Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies

Vanderschuren, L. J. M. J., & Kalivas, P. W. (2000) · Psychopharmacology · doi:10.1007/s002130000493 · Cited by 1,337 · see citing works

REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

Tzschentke, T. M. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00070.x · Cited by 1,336 · see citing works

NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders

Lau, C. G., & Zukin, R. S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2153 · Cited by 1,159 · cited 1× · see citing works

Drugs of Abuse and Stress Trigger a Common Synaptic Adaptation in Dopamine Neurons

Saal, D., Dong, Y., Bonci, A., & Malenka, R. C. (2003) · Neuron · doi:10.1016/s0896-6273(03)00021-7 · Cited by 1,147 · see citing works

A translational profiling approach for the molecular characterization of CNS cell types

Heiman, M., Schaefer, A., Gong, S., Peterson, J. D., Day, M., Ramsey, K. E., Suárez-Fariñas, M., Schwarz, C., Stephan, D. A., Surmeier, D. J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.028 · Cited by 1,134 · see citing works

Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons

Ungless, M. A., Whistler, J. L., Malenka, R. C., & Bonci, A. (2001) · Nature · doi:10.1038/35079077 · Cited by 1,106 · see citing works

Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving

Conrad, K. L., Tseng, K. Y., Uejima, J. L., Reimers, J. M., Heng, L.-J., Shaham, Y., Marinelli, M., & Wolf, M. E. (2008) · Nature · doi:10.1038/nature06995 · Cited by 790 · see citing works

A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus

Tang, S. J., Reis, G., Kang, H., Gingras, A.-C., Sonenberg, N., & Schuman, E. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012605299 · Cited by 734 · see citing works

Time-Dependent Increases in Brain-Derived Neurotrophic Factor Protein Levels within the Mesolimbic Dopamine System after Withdrawal from Cocaine: Implications for Incubation of Cocaine Craving

Grimm, J. W., Lü, L., Hayashi, T., Hope, B. T., Su, T., & Shaham, Y. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00742.2003 · Cited by 551 · see citing works

Behavioral Sensitization to Cocaine Is Associated with Increased AMPA Receptor Surface Expression in the Nucleus Accumbens

Boudreau, A. C., & Wolf, M. E. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2252-05.2005 · Cited by 481 · see citing works

BDNF Regulates the Translation of a Select Group of mRNAs by a Mammalian Target of Rapamycin-Phosphatidylinositol 3-Kinase-Dependent Pathway during Neuronal Development

Schratt, G., Nigh, E., Chen, W. G., Hu, L. S., & Greenberg, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1739-04.2004 · Cited by 425 · see citing works

Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse

Graham, D. L., Edwards, S., Bachtell, R. K., Dileone, R., Rios, M., & Self, D. W. (2007) · Nature Neuroscience · doi:10.1038/nn1929 · Cited by 401 · see citing works

A Single Infusion of Brain-Derived Neurotrophic Factor into the Ventral Tegmental Area Induces Long-Lasting Potentiation of Cocaine Seeking after Withdrawal

Lü, L., Dempsey, J., Liu, S. Y., Bossert, J. M., & Shaham, Y. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5124-03.2004 · Cited by 282 · see citing works

Rapid Synthesis and Synaptic Insertion of GluR2 for mGluR-LTD in the Ventral Tegmental Area

Mameli, M., Balland, B., Luján, R., & Lüscher, C. (2007) · Science · doi:10.1126/science.1142365 · Cited by 265 · see citing works

BDNF activates mTOR to regulate GluR1 expression required for memory formation

Slipczuk, L., Bekinschtein, P., Katche, C., Cammarota, M., Izquierdo, I., & Medina, J. H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006007 · Cited by 246 · see citing works

Effects of dopaminergic and glutamatergic receptor antagonists on the acquisition and expression of cocaine conditioning place preference

Cervo, L., & SAMANIN, R. (1995) · Brain Research · doi:10.1016/0006-8993(94)01420-m · Cited by 239 · see citing works

Binge Drinking Upregulates Accumbens mGluR5-Homer2-PI3K Signaling: Functional Implications for Alcoholism

Cozzoli, D. K., Goulding, S. P., Zhang, P. W., Xiao, B., Hu, J. H., Ary, A. W., Obara, I., Rahn, A., Abou-Ziab, H., Tyrrel, B., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5900-08.2009 · Cited by 149 · see citing works

Glutamatergic Regulation of the p70S6 Kinase in Primary Mouse Neurons*

Lenz, G., & Avruch, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500363200 · Cited by 140 · see citing works

Role for mammalian target of rapamycin complex 1 signaling in neuroadaptations underlying alcohol-related disorders

Neasta, J., Hamida, S. B., Yowell, Q. V., Carnicella, S., & Dorit Ron, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005554107 · Cited by 136 · see citing works

Antidepressive-like effects of rapamycin in animal models: Implications for mTOR inhibition as a new target for treatment of affective disorders

Cleary, C., Linde, J. A. S., Hiscock, K. M., Hadas, I., Belmaker, R. H., Agam, G., Flaisher-Grinberg, S., & Einat, H. (2008) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2008.03.005 · Cited by 130 · see citing works

Role of accumbens BDNF and TrkB in cocaine-induced psychomotor sensitization, conditioned-place preference, and reinstatement in rats

Bahí, A., Boyer, F., & Dreyer, J. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1164-1 · Cited by 128 · see citing works

Extinction Training Regulates Neuroadaptive Responses to Withdrawal from Chronic Cocaine Self-AdministrationPreprint

Self, D. W., Choi, K.-H., Simmons, D. L., Walker, J. R., & Smagula, C. S. (2004) · Learning & Memory · doi:10.1101/lm.81404 · Cited by 125 · see citing works

Homer 2 tunes G protein–coupled receptors stimulus intensity by regulating RGS proteins and PLCβ GAP activities

Shin, D. M., Dehoff, M. H., Luo, X., Kang, S. H., Tu, J., Nayak, S. K., Ross, E. M., Worley, P. F., & Muallem, S. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200210109 · Cited by 89 · see citing works

Nucleus Accumbens Core Mammalian Target of Rapamycin Signaling Pathway Is Critical for Cue-Induced Reinstatement of Cocaine Seeking in Rats

Wang, X., Luo, Y.-X., He, Y.-Y., Li, F.-Q., Shi, H.-S., Xue, L.-F., Xue, Y.-X., & Lu, L. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1264-10.2010 · Cited by 88 · see citing works

A role for the mTOR pathway in surface expression of AMPA receptors

Wang, Y., Barbaro, M. F., & Baraban, S. C. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.03.011 · Cited by 79 · see citing works

Regional differences in the effects of withdrawal from repeated cocaine upon Homer and glutamate receptor expression: A two-species comparison

Ary, A. W., & Szumlinski, K. K. (2007) · Brain Research · doi:10.1016/j.brainres.2007.09.035 · Cited by 64 · see citing works

Gene Expression Profiling in the Brains of Human Cocaine Abusers

Bannon, M. J., Kapatos, G., & Albertson, D. N. (2004) · Addiction Biology · doi:10.1080/13556210412331308921 · Cited by 60 · see citing works

Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization

Izzo, E., Martin‐Fardon, R., Koob, G. F., Weiss, F., & Sanna, P. P. (2002) · Nature Neuroscience · doi:10.1038/nn977 · Cited by 59 · see citing works

Gene expression induced by drugs of abuse

Rhodes, J. S., & Crabbe, J. C. (2004) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.12.001 · Cited by 58 · see citing works

Accumbens Homer2-mediated signaling: a factor contributing to mouse strain differences in alcohol drinking?

Goulding, S. P., Obara, I., Lominac, K. D., Gould, A. T., Miller, B. W., Klugmann, M., & Szumlinski, K. K. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00647.x · Cited by 45 · see citing works

Unconditioned and conditioned factors contribute to the ‘reinstatement’ of cocaine place conditioning following extinction in C57BL/6 mice

Szumlinski, K. K., Price, K. L., Frys, K. A., & Middaugh, L. D. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00102-x · Cited by 42 · see citing works

PI3 kinase is involved in cocaine behavioral sensitization and its reversal with brain area specificity

Zhang, X., Mi, J., Wetsel, W. C., Davidson, C., Xiong, X., Chen, Q., Ellinwood, E. H., & Lee, T. H. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.12.114 · Cited by 41 · see citing works

Prenatal stress alters limbo‐corticostriatal homer protein expression

Ary, A. W., Aguilar, V. R., Szumlinski, K. K., & Kippin, T. E. (2007) · Synapse · doi:10.1002/syn.20439 · Cited by 32 · see citing works

Assessment of genome and proteome profiles in cocaine abuse

Hemby, S. E. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)58009-4 · Cited by 31 · see citing works

Effect of rapamycin on cue-induced drug craving in abstinent heroin addicts

Shi, J., Jun, W., Zhao, L.-Y., Xue, Y.-X., Zhang, X.-Y., Kosten, T. R., & Lu, L. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.05.011 · Cited by 31 · see citing works

Involvement of mitogen-stimulated p70-S6 kinase in the development of sensitization to the methamphetamine-induced rewarding effect in rats

Narita, M., Akai, H., Kita, T., Nagumo, Y., Narita, M., Sunagawa, N., Hara, C., Hasebe, K., Nagase, H., & Suzuki, T. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.12.050 · Cited by 31 · see citing works

Chronic alcohol consumption alters mammalian target of rapamycin (mTOR), reduces ribosomal p70s6 kinase and p4E-BP1 levels in mouse cerebral cortex

Li, Q., & Ren, J. T. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.01.005 · Cited by 30 · see citing works

Identification of a Deubiquitinating Enzyme as a Novel AGS3-Interacting Protein

Xu, Z., Xia, B., Gong, Q., Bailey, J., Groves, B., Radeke, M. J., Wood, S. A., Szumlinski, K. K., & Ma, D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009725 · Cited by 19 · see citing works

PRECLINICAL STUDY: Protracted ‘anti‐addictive’ effects of adolescent phenylpropanolamine exposure in C57BL/6J mice

Penzner, J. H., Thompson, D. L., Arth, C., Fowler, J. K., Ary, A. W., & Szumlinski, K. K. (2008) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00101.x · Cited by 14 · see citing works

Protracted ‘Pro-Addictive’ Phenotype Produced in Mice by Pre-Adolescent Phenylpropanolamine

Szumlinski, K. K., Liu, A., Penzner, J. H., & Lominac, K. D. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301306 · Cited by 11 · see citing works

mTOR in Brain Physiology and Pathologies

Bockaert, J., & Marin, P. (2015) · Physiological Reviews · doi:10.1152/physrev.00038.2014 · Cited by 360 · see citing works

Ribosomal Protein S6 Phosphorylation in the Nervous System: From Regulation to Function

Biever, A., Valjent, E., & Puighermanal, E. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00075 · Cited by 214 · see citing works

Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse

Barak, S., Liu, F., Hamida, S. B., Yowell, Q. V., Neasta, J., Kharazia, V., Janak, P. H., & Ron, D. (2013) · Nature Neuroscience · doi:10.1038/nn.3439 · Cited by 172 · see citing works

mTOR complex 1: a key player in neuroadaptations induced by drugs of abuse

Neasta, J., Barak, S., Hamida, S. B., & Ron, D. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12725 · Cited by 114 · see citing works

Phosphoproteomic approach for agonist-specific signaling in mouse brains: mTOR pathway is involved in κ opioid aversion

Liu, J. J., Chiu, Y.-T., DiMattio, K. M., Chen, C., Huang, P., Gentile, T. A., Muschamp, J. W., Cowan, A., Mann, M., & Liu‐Chen, L. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0155-0 · Cited by 96 · see citing works

Cannabidiol, a Cannabis sativa constituent, inhibits cocaine-induced seizures in mice: Possible role of the mTOR pathway and reduction in glutamate release

Gobira, P. H., Vilela, L. R., Gonçalves, B. D. C., Santos, R. P. M., de Oliveira, A. C., Vieira, L. B., Aguiar, D. C., Crippa, J. A., & Moreira, F. A. (2015) · NeuroToxicology · doi:10.1016/j.neuro.2015.08.007 · Cited by 89 · see citing works

Reactivation of cocaine reward memory engages the Akt/GSK3/mTOR signaling pathway and can be disrupted by GSK3 inhibition

Shi, X., Miller, J. S., Harper, L. J., Poole, R. L., Gould, T. J., & Unterwald, E. M. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3491-8 · Cited by 79 · see citing works

Interactions of neuroimmune signaling and glutamate plasticity in addiction

Gipson, C. D., Rawls, S. M., Scofield, M. D., Siemsen, B. M., Bondy, E. O., & Maher, E. E. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02072-8 · Cited by 67 · see citing works

Rapamycin prevents drug seeking via disrupting reconsolidation of reward memory in rats

Lin, J., Liu, L., Wen, Q., Zheng, C., Gao, Y., Peng, S., Tan, Y., & Li, Y. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713001156 · Cited by 60 · see citing works

Protein Translation and Psychiatric Disorders

Laguesse, S., & Dorit Ron, A. (2019) · The Neuroscientist · doi:10.1177/1073858419853236 · Cited by 59 · see citing works

Metabotropic Glutamate Receptor I (mGluR1) Antagonism Impairs Cocaine-Induced Conditioned Place Preference via Inhibition of Protein Synthesis

Yu, F., Zhong, P., Liu, X., Sun, D., Gao, H., & Liu, Q.-S. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.29 · Cited by 52 · see citing works

Cannabinoid exposure in rat adolescence reprograms the initial behavioral, molecular, and epigenetic response to cocaine

Scherma, M., Qvist, J. S., Asok, A., Huang, S. C., Masia, P., Deidda, M. L., Wei, Y. B., Soni, R. K., Fratta, W., Fadda, P., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1920866117 · Cited by 47 · see citing works

Protein Translation in the Nucleus Accumbens Is Dysregulated during Cocaine Withdrawal and Required for Expression of Incubation of Cocaine Craving

Werner, C. T., Stefanik, M. T., Milovanovic, M., Caccamise, A. J., & Wolf, M. E. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2412-17.2018 · Cited by 45 · see citing works

Pharmacological modulation of protein kinases as a new approach to treat addiction to cocaine and opiates

García-Pardo, M. P., Roger-Sánchez, C., Rodríguez‐Arias, M., Miñarro, J., & Aguilar, M. A. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.03.065 · Cited by 39 · see citing works

An Emerging Role for the Mammalian Target of Rapamycin in “Pathological” Protein Translation: Relevance to Cocaine Addiction

Dayas, C. V., Smith, D. W., & Dunkley, P. R. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00013 · Cited by 38 · see citing works

Essential role of D1R in the regulation of mTOR complex1 signaling induced by cocaine

Sutton, L. P., & Caron, M. G. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.08.024 · Cited by 36 · see citing works

mTOR signaling in the nucleus accumbens mediates behavioral sensitization to methamphetamine

Huang, S., Wu, W.-R., Lee, L., Huang, P., & Chen, J. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.03.017 · Cited by 33 · see citing works

Rapamycin reduces motivated responding for cocaine and alters GluA1 expression in the ventral but not dorsal striatum

James, M. H., Quinn, R. K., Ong, L. K., Levi, E. M., Smith, D. W., Dickson, P. W., & Dayas, C. V. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.05.013 · Cited by 32 · see citing works

FDA-Approved Kinase Inhibitors in Preclinical and Clinical Trials for Neurological Disorders

Lui, A., Vanleuven, J., Perekopskiy, D., Liu, D., Xu, D., Alzayat, O., Elgokhy, T., Do, T., Gann, M., Martin, R. M., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15121546 · Cited by 35 · see citing works

mTORC1 Inhibition in the Nucleus Accumbens ‘Protects’ Against the Expression of Drug Seeking and ‘Relapse’ and Is Associated with Reductions in GluA1 AMPAR and CAMKIIα Levels

James, M. H., Quinn, R. K., Ong, L. K., Levi, E. M., Charnley, J. L., Smith, D. W., Dickson, P. W., & Dayas, C. V. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.16 · Cited by 32 · see citing works

VTA mTOR Signaling Regulates Dopamine Dynamics, Cocaine-Induced Synaptic Alterations, and Reward

Liu, X., Li, Y., Yu, L., Vickstrom, C. R., & Liu, Q.-S. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.247 · Cited by 32 · see citing works

Brain regions and molecular pathways responding to food reward type and value in honey bees

McNeill, M., Kapheim, K. M., Brockmann, A., McGill, T. A. W., & Robinson, G. E. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12275 · Cited by 27 · see citing works

Response of the Ubiquitin-Proteasome System to Memory Retrieval After Extended-Access Cocaine or Saline Self-Administration

Werner, C. T., Milovanovic, M., Christian, D., Loweth, J. A., & Wolf, M. E. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.156 · Cited by 28 · see citing works

Withdrawal From Cocaine Self-administration Alters the Regulation of Protein Translation in the Nucleus Accumbens

Stefanik, M. T., Milovanovic, M., Werner, C. T., Spainhour, J. C. G., & Wolf, M. E. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.02.012 · Cited by 26 · see citing works

PI3K activation within ventromedial prefrontal cortex regulates the expression of drug‐seeking in two rodent species

Szumlinski, K. K., Ary, A. W., Shin, C., Wroten, M. G., Courson, J. A., Miller, B. W., Ruppert‐Majer, M. A., Hiller, J. W., Shahin, J. R., Ben‐Shahar, O., et al. (2018) · Addiction Biology · doi:10.1111/adb.12696 · Cited by 25 · see citing works

Neuronal scaffolding protein spinophilin is integral for cocaine-induced behavioral sensitization and ERK1/2 activation

Areal, L. B., Hamilton, A., Martins-Silva, C., Pires, R. G. W., & Ferguson, S. S. G. (2019) · Molecular Brain · doi:10.1186/s13041-019-0434-7 · Cited by 25 · see citing works

Multinuclear NMR and MRI Reveal an Early Metabolic Response to mTOR Inhibition in Sarcoma

Gialleonardo, V. D., Aldeborgh, H. N., Miloushev, V. Z., Folkers, K. M., Granlund, K. L., Tap, W. D., Lewis, J. S., Weber, W., & Keshari, K. R. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-3310 · Cited by 19 · see citing works

The role of the mTOR pathway in models of drug-induced reward and the behavioural constituents of addiction

Ucha, M., Roura‐Martínez, D., Ambrosio, E., & Higuera‐Matas, A. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120944159 · Cited by 18 · see citing works

The mammalian target of rapamycin pathway in the basolateral amygdala is critical for nicotine-induced behavioural sensitization.

Gao, Y., Peng, S., Wen, Q., Zheng, C., Lin, J., Tan, Y., Ma, Y., Luo, Y., Xue, Y.-X., Wu, P., et al. (2014) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000650 · Cited by 18 · see citing works

Preclinical evidence to support repurposing everolimus for craving reduction during protracted drug withdrawal

Chiu, A. S., Kang, M. C., Sanchez, L. L. H., Fabella, A. M., Holder, K. N., Barger, B. D., Elias, K. N., Shin, C., Chavez, C. L. J., Kippin, T. E., et al. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01064-9 · Cited by 15 · see citing works

Naltrexone and nalmefene attenuate cocaine place preference in male mice

Windisch, K. A., Reed, B., & Kreek, M. J. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.07.025 · Cited by 14 · see citing works

Morphine self-administration alters the expression of translational machinery genes in the amygdala of male Lewis rats

Ucha, M., Coria, S. M., Núñez, A. E., Santos‐Toscano, R., Roura‐Martínez, D., Fernández‐Ruíz, J., Higuera‐Matas, A., & Ambrosio, E. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119836206 · Cited by 14 · see citing works

Energy sensors in drug addiction: A potential therapeutic target

López-Gambero, A. J., de Fonseca, F. R., & Suárez, J. (2020) · Addiction Biology · doi:10.1111/adb.12936 · Cited by 14 · see citing works

Ethanol-Induced Changes in PKCε: From Cell to Behavior

Mohamed, R. M. P., Mokhtar, M. H., Yap, E., Hanim, A., Wahab, N. A., Jaffar, F. H. F., & Kumar, J. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00244 · Cited by 13 · see citing works

Rottlerin impairs the formation and maintenance of psychostimulant-supported memory

Liao, T. Y., Tzeng, W.-Y., Wu, H.-H., Cherng, C. G., Wang, C.-Y., Hu, S. S., & Yu, L. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4251-8 · Cited by 13 · see citing works

Activation of AMPK‐dependent autophagy in the nucleus accumbens opposes cocaine‐induced behaviors of mice

Lu, H., Xiao, W., Deng, S., Cheng, X., Zheng, H., Chen, J., & Wang, F. (2019) · Addiction Biology · doi:10.1111/adb.12736 · Cited by 11 · see citing works

Mammalian Target of Rapamycin-RhoA Signaling Impairments in Direct Striatal Projection Neurons Induce Altered Behaviors and Striatal Physiology in Mice

Rial, D., Puighermanal, E., Chazalon, M., Valjent, E., Schiffmann, S. N., & d’Exaerde, A. D. K. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.05.029 · Cited by 11 · see citing works

Quantitative Systems Pharmacological Analysis of Drugs of Abuse Reveals the Pleiotropy of Their Targets and the Effector Role of mTORC1

Pei, F., Li, H., Liu, B., & Bahar, İ. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00191 · Cited by 10 · see citing works

Conditioned Place Preference as a Preclinical Model for Screening Pharmacotherapies for Drug Abuse

Bardo, M. T., Horton, D. B., & Yates, J. R. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420172-9.00007-2 · Cited by 9 · see citing works

Granulocyte-Colony-Stimulating Factor Alters the Proteomic Landscape of the Ventral Tegmental Area

Mervosh, N. L., Wilson, R. S., Rauniyar, N., Hofford, R. S., Kutlu, M. G., Calipari, E. S., Lam, T. T., & Kiraly, D. D. (2018) · Proteomes · doi:10.3390/proteomes6040035 · Cited by 9 · see citing works

mTOR Involvement in the Mechanisms of Memory

Giovannini, M., & Lana, D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802733-2.00018-9 · Cited by 6 · see citing works

Impairment of synaptic plasticity in the primary somatosensory cortex in a model of diabetic mice

García‐Magro, N., Mesa-Lombardo, A., Barros-Zulaica, N., & Núñez, Á. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1444395 · Cited by 5 · see citing works

The PI3-Kinase p110β Isoform Controls Severity of Cocaine-Induced Sequelae and Alters the Striatal Transcriptome

Shapiro, L. P., Pitts, E. G., Li, D. C., Barbee, B. R., Hinton, E. A., Bassell, G. J., Groß, C., & Gourley, S. L. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.01.008 · Cited by 5 · see citing works

Functional Genomic Analysis of Amphetamine Sensitivity in Drosophila

Karam, C. S., Williams, B. L., Morozova, I., Yuan, Q., Panarsky, R., Zhang, Y., Hodgkinson, C. A., Goldman, D. A., Kalachikov, S. M., & Javitch, J. A. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.831597 · Cited by 5 · see citing works

Autophagy pathways in drug abusers after forensic autopsy: LC3B, ph-mTOR and p70S6K analysis

Chindemi, C., Cirielli, V., Cima, L., Danzi, O. P., Raniero, D., Tagliaro, F., Turrina, S., Eccher, A., Ghimenton, C., Bortolotti, F., et al. (2019) · Medicine Science and the Law · doi:10.1177/0025802419828910 · Cited by 5 · see citing works

Experimental and clinical tests of FDA-approved kinase inhibitors for the treatment of neurological disorders (update 2024)

Aliashrafzadeh, H., Liu, D., Alba, S. D., Akbar, I., Lui, A., Vanleuven, J., Martin, R. M., Wang, Z., & Liu, D. (2025) · Exploration of Drug Science · doi:10.37349/eds.2025.1008116 · Cited by 5 · see citing works

Translin deletion impairs cocaine-induced locomotor sensitization and RGS8 expression in the nucleus accumbens

Fu, X., Wu, R., Shah, A. P., Ladenheim, B., Alt, J., Cadet, J. L., Rais, R., Chandra, R., Cen, X., & Baraban, J. M. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01565-z · Cited by 4 · see citing works

Recency memory is altered in cocaine-withdrawn adolescent rats: Implication of cortical mTOR signaling

Díaz, F. C., Mottarlini, F., Targa, G., Rizzi, B., Fumagalli, F., & Caffino, L. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110822 · Cited by 4 · see citing works

mTOR and the Regulation of Translational Capacity in Late Forms of Synaptic Plasticity

Tsokas, P., & Blitzer, R. D. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1761-7_7 · Cited by 3 · see citing works

Translational Control Through the EIF4E Binding Proteins in the Brain

Aguilar‐Valles, A., Matta‐Camacho, E., & Sonenberg, N. (2018) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190686307.013.5 · Cited by 3 · see citing works

Autophagy: A double-edged sword in drug addiction

Sun, C., Yin, X., Zheng, Y., Tian, Y., Li, H. Z., Su, L., & Liu, Q. (2025) · The Innovation Life · doi:10.59717/j.xinn-life.2025.100163 · Cited by 1 · see citing works

Interactions between estradiol and ERK, but not mTOR, signaling is necessary for enhanced cocaine-induced conditioned place preference in female rats

Kokane, S. S., Butler, B. D., Antonio, J. H., Armant, R. J., Hoch, A. C., Coelho, C. S., Brady, B., Chamseddine, H. H., & Perrotti, L. I. (2023) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2023.173653 · Cited by 1 · see citing works

Contribution of Spinal Cord mTORC1 to Chronic Opioid Tolerance and Hyperalgesia

Sun, L., Lutz, B. M., & Tao, Y. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800634-4.00048-2 · Cited by 1 · see citing works

mTOR and Drugs of Abuse

Beckley, J. T., & Dorit Ron, A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802733-2.00005-0

Modulation of the mTOR pathway in male Lewis rats after morphine self-administration and subsequent extinction trainingPreprint

Ucha, M., Coria, S. M., Núñez, A. E., Santos‐Toscano, R., Roura‐Martínez, D., Fernández‐Ruíz, J., Higuera‐Matas, A., & Ambrosio, E. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/276121

Neuronal mRNA Translation in Addiction

Puighermanal, E., & Valjent, E. (2018) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190686307.013.19

Preclinical evidence to support repurposing Everolimus for craving reduction during protracted drug withdrawalPreprint

Chiu, A. S., Kang, M. C., Sanchez, L. L. H., Fabella, A. M., Holder, K. N., Barger, B. D., Elias, K. N., Shin, C., Chavez, C. L. J., Kippin, T. E., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-147118/v1

Faculty Opinions recommendation of Metabotropic glutamate receptor I (mGluR1) antagonism impairs cocaine-induced conditioned place preference via inhibition of protein synthesis.

Napier, C., & Herrold, A. A. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718009250.793476390

Neurochemical and Neurocircuitry Perspectives on the Science of Addiction

Othman, O., & Mokhtar, Y. (2025) · Journal of Health and Biology · doi:10.71428/jhb.2025.0103

Treatment with rapamycin prevents induction and expression of locomotor sensitization to synthetic cathinone 3,4-methylenedioxypyrovalerone (MDPV) in mice

Wojcieszak, J., Kuczyńska, K., & Zawilska, J. B. (2025) · Forensic Toxicology · doi:10.1007/s11419-025-00749-w

The effect of neuroimmune signalling on drug addiction

Chen, Q., Chi, H., Liu, S. J., & Zhou, Y. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1830998

Inhibition of the mTOR pathway by rapamycin blocks cocaine-induced locomotor sensitization

Wu, J.-F., McCallum, S. E., Glick, S., & Huang, Y.-F. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.10.041 · Cited by 52 · see citing works

mTOR regulates cocaine-induced behavioural sensitization through the SynDIG1–GluA2 interaction in the nucleus accumbens

Li, H.-C., Zhang, J., Xu, R., Wang, Y., Xu, W., Chen, R., Wan, X., Zhang, H., Wang, L., Wang, X., et al. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00760-y · Cited by 11 · see citing works

mTORC1 Inhibition in the Nucleus Accumbens ‘Protects’ Against the Expression of Drug Seeking and ‘Relapse’ and Is Associated with Reductions in GluA1 AMPAR and CAMKIIα Levels

James, M. H., Quinn, R. K., Ong, L. K., Levi, E. M., Charnley, J. L., Smith, D. W., Dickson, P. W., & Dayas, C. V. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.16 · Cited by 32 · see citing works

P.1.039 Lateral habenula stimulation restores glutamate receptor subunits levels in the ventral tegmental area and inhibits cocaine seeking behaviour

Lax, E., Friedman, A., Dikshtein, Y., Abraham, L., Flaumenhaft, Y., Sudai, E., Ben‐Tzion, M., Ami-Ad, L., Yaka, R., & Yadid, G. (2011) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(11)70038-4 · Cited by 1 · see citing works

Treatment with rapamycin prevents induction and expression of locomotor sensitization to synthetic cathinone 3,4-methylenedioxypyrovalerone (MDPV) in mice

Wojcieszak, J., Kuczyńska, K., & Zawilska, J. B. (2025) · Forensic Toxicology · doi:10.1007/s11419-025-00749-w