The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Identification of an Intracellular Trafficking and Assembly Pathway for HIV‐1 Gag
Abstract
Retroviral Gag proteins are membrane‐bound polyproteins that are necessary and sufficient for virus‐like particle (VLP) formation. It is not known how Gag traffics through the cell or how the site of particle production is determined. Here we use two techniques, biarsenical/tetracysteine (TC) labeling and release from a cycloheximide block, to follow the trafficking of newly synthesized HIV‐1 Gag. Gag first appears diffusely distributed in the cytosol, accumulates in perinuclear clusters, passes transiently through a multivesicular body (MVB)‐like compartment, and then travels to the plasma membrane (PM). Sequential passage of Gag through these temporal intermediates was confirmed by live cell imaging. Induction of a transient rise in cytoplasmic calcium increased the amounts of Gag, Gag assembly intermediates and VLPs in MVBs, and resulted in a dramatic increase in VLP release. These results define an intracellular trafficking pathway for HIV‐1 Gag that uses perinuclear compartments and the MVB as trafficking intermediates. We propose that the regulation of Gag association with MVB‐like compartments regulates the site of HIV‐1 budding and particle formation.
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Cites
Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding
Garrus, J. E., von Schwedler, U. K., Pornillos, O. W., Morham, S. G., Zavitz, K. H., Wang, H. E., Wettstein, D. A., Stray, K. M., Côté, M., Rich, R. L., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00506-2 · Cited by 1,369
HIV-1 Gag proteins: diverse functions in the virus life cycle
Freed, E. O. (1998) · Virology · doi:10.1006/viro.1998.9398 · Cited by 717
Martin-Serrano, J., Zang, T., & Bieniasz, P. D. (2001) · Nature Medicine · doi:10.1038/nm1201-1313 · Cited by 710
Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55 Gag
VerPlank, L., Bouamr, F., LaGrassa, T. J., Agresta, B., Kikonyogo, A., Leis, J., & Carter, C. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131059198 · Cited by 584
Pryor, P. R., Mullock, B. M., Bright, N. A., Gray, S. R., & Luzio, J. P. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.5.1053 · Cited by 347
Ubiquitin is part of the retrovirus budding machinery
Patnaik, A., Chau, V., & Wills, J. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.24.13069 · Cited by 292
Burniston, M. T., Cimarelli, A., Colgan, J., Curtis, S. P., & Luban, J. (1999) · Journal of Virology · doi:10.1128/jvi.73.10.8527-8540.1999 · Cited by 190
Cited by
Plasma Membrane Is the Site of Productive HIV-1 Particle Assembly
Jouvenet, N., Neil, S. J. D., Bess, C., Johnson, M. C., Virgen, C. A., Simon, S. M., & Bieniasz, P. D. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040435 · Cited by 357
Deneka, M., Pelchen-Matthews, A., Byland, R., Ruiz-Mateos, E., & Marsh, M. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200609050 · Cited by 339
The Interferon Response Inhibits HIV Particle Production by Induction of TRIM22
Barr, S. D., Smiley, J. R., & Bushman, F. D. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000007 · Cited by 276
Host factors exploited by retroviruses
Goff, S. P. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1541 · Cited by 247
Jolly, C., Mitar, I., & Sattentau, Q. J. (2007) · Journal of Virology · doi:10.1128/jvi.01469-06 · Cited by 211
Metadata
- Authors
- Perlman, M., & Resh, M. D.
- Venue
- Traffic
- Publisher
- Wiley
- Published
- 2006-05-08
- Volume
- 7
- Issue
- 6
- Pages
- 731-745
- ISSN
- 1398-9219 (ISSN-L)
- 1600-0854
- OpenAlex
- W2107627347
- Cited by
- 162
- References
- 7
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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