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Distinct regulation of IgE, IgG4 and IgA by T regulatory cells and toll‐like receptors
Open accessAbstract
Background: Allergic diseases are characterized by the activation of the immune system and formation of immunoglobulin (Ig)E antibodies against normally innocuous environmental antigens, whereas IgG4 and IgA represent noninflammatory and blocking antibody isotypes. The T helper 2 (Th2) cells induce and T regulatory (Treg) cells suppress several features of allergic inflammation. Our aim was to investigate the role of allergen‐specific T regulatory type 1 (Tr1) cells and CD4 + CD25 + Treg cells and toll‐like receptors (TLRs) on IgE, IgG4 and IgA production. Methods: Germline or productive Ig‐transcripts are determined by real‐time reverse transcriptase‐polymerase chain reaction, secreted Igs are measured by enzyme‐linked immunosorbent assay and the frequency of Ig‐producing plasma cells is investigated by enzyme‐linked immunosorbent spot. Circulating CD4 + CD25 + Treg cells and allergen‐specific Tr1 cells are used. Results: Both allergen‐specific, interleukin‐10‐secreting Tr1 cells and CD4 + CD25 + Treg cells from healthy individuals induced IgG4 and suppressed IgE production in peripheral blood mononuclear cells and purified B‐cell cultures. In contrast, induction of IgA production is independent of T‐cell help and the role of Tr1 or Treg cells is very limited, whereas it was highly induced by direct B‐cell activation via TLR7 and 9. Conclusions: These data suggest that T regulatory cells may contribute to the suppression of allergic diseases by suppression of IgE and induction of IgG4, whereas IgA production is enhanced by B‐cell activation via TLR7 and TLR9.
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Cites
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745
Ono, M., Shimizu, J., Miyachi, Y., & Sakaguchi, S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.8.4748 · Cited by 162 · cited 1×
“If the mechanism by which regulatory T cells act on B cells consists of physical cell-to-cell contact via intercellular adhesion molecule 1 (ICAM-1), TGF-b (46), cytotoxic T cell-associated antigen-4 (CTLA-4) (47), glucocorticoid-induced tumor necrosis factor receptor (48), programmed death-1 (PD-1) (49) and OX40 (CD1…”
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Cited by
T cell subsets and their signature cytokines in autoimmune and inflammatory diseases
Raphael, I., Nalawade, S., Eagar, T. N., & Forsthuber, T. G. (2015) · Cytokine · doi:10.1016/j.cyto.2014.09.011 · Cited by 1,160
Immunoglobulin G4: an odd antibody
Aalberse, R. C., Stapel, S. O., Schuurman, J., & Rispens, T. (2009) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2009.03207.x · Cited by 818
Mechanisms of allergen-specific immunotherapy
Akdis, C. A., & Akdis, M. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.11.030 · Cited by 803
Self-citationFood allergy: immune mechanisms, diagnosis and immunotherapy
Yu, W., Freeland, D. M. H., & Nadeau, K. C. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.111 · Cited by 659
Suárez-Fariñas, M., Dhingra, N., Gittler, J., Shemer, A., Cardinale, I., de Guzman Strong, C., Krueger, J. G., & Guttman-Yassky, E. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.04.046 · Cited by 483
Metadata
- Authors
- Meiler, F., Klunker, S., Zimmermann, M., Akdis, C. A., & Akdis, M.
- Venue
- Allergy
- Publisher
- Wiley
- Published
- 2008-10-10
- Volume
- 63
- Issue
- 11
- Pages
- 1455-1463
- ISSN
- 0105-4538 (ISSN-L)
- 1398-9995
- OpenAlex
- W2041302559
- Cited by
- 302
- References
- 2
- FWCI
- 9.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Meiler, F., Klunker, S., Zimmermann, M., Akdis, C. A., & Akdis, M. (2008). Distinct regulation of IgE, IgG4 and IgA by T regulatory cells and toll‐like receptors. Allergy. https://doi.org/10.1111/j.1398-9995.2008.01774.x
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