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Chronic rhinosinusitis in Europe - an underestimated disease. A GA2LEN study

Hastan, D., Fokkens, W. J., Bachert, C., Newson, R. B., Bislimovska, J., Bockelbrink, A., Bousquet, P. J., Brozek, G., Bruno, A., Dahlén, S. E., Forsberg, B., Gunnbjörnsdóttir, M., Kasper, L., Krämer, U., Kowalski, M. L., Lange, B., Lundbäck, B., Salagean, E., Todo-Bom, A., Tomassen, P., Toskala, E., van Drunen, C. M., Bousquet, J., Zuberbier, T., Jarvis, D., Burney, P.·2011·Allergy

Abstract

To cite this article: Hastan D, Fokkens WJ, Bachert C, Newson RB, Bislimovska J, Bockelbrink A, Bousquet PJ, Brozek G, Bruno A, Dahlén SE, Forsberg B, Gunnbjörnsdóttir M, Kasper L, Krämer U, Kowalski ML, Lange B, Lundbäck B, Salagean E, Todo-Bom A, Tomassen P, Toskala E, van Drunen CM, Bousquet J, Zuberbier T, Jarvis D, Burney P. Chronic rhinosinusitis in Europe – an underestimated disease. A GA2LEN study. Allergy 2011; 66: 1216–1223. Abstract Background: Chronic rhinosinusitis (CRS) is a common health problem, with significant medical costs and impact on general health. Even so, prevalence figures for Europe are unavailable. In this study, conducted by the GA2LEN network of excellence, the European Position Paper on Rhinosinusitis and nasal Polyps (EP3OS) diagnostic criteria are applied to estimate variation in the prevalence of Chronic rhinosinusitis (CRS) for Europe. Method: A postal questionnaire was sent to a random sample of adults aged 15–75 years in 19 centres in Europe. Participants reported symptoms of CRS, and doctor diagnosed CRS, allergic rhinitis, age, gender and smoking history. Definition of CRS was based on the EP3OS diagnostic criteria: the presence of more than two of the symptoms: (i) nasal blockage, (ii) nasal discharge, (iii) facial pain/pressure or (iv) reduction in sense of smell, for >12 weeks in the past year – with at least one symptom being nasal blockage or discharge. Results: Information was obtained from 57 128 responders living in 19 centres in 12 countries. The overall prevalence of CRS by EP3OS criteria was 10.9% (range 6.9–27.1). CRS was more common in smokers than in nonsmokers (OR 1.7: 95% CI 1.6–1.9). The prevalence of self-reported physician-diagnosed CRS within centres was highly correlated with the prevalence of EP3OS-diagnosed CRS. Conclusion: This is the first European international multicentre prevalence study of CRS. In this multicentre survey of adults in Europe, about one in ten participants had CRS with marked geographical variation. Smoking was associated with having CRS in all parts of Europe.

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Crossref · 10.1111/j.1398-9995.2011.02646.x

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Metadata

Authors
Hastan, D., Fokkens, W. J., Bachert, C., Newson, R. B., Bislimovska, J., Bockelbrink, A., Bousquet, P. J., Brozek, G., Bruno, A., Dahlén, S. E., Forsberg, B., Gunnbjörnsdóttir, M., Kasper, L., Krämer, U., Kowalski, M. L., Lange, B., Lundbäck, B., Salagean, E., Todo-Bom, A., Tomassen, P., Toskala, E., van Drunen, C. M., Bousquet, J., Zuberbier, T., Jarvis, D., & Burney, P.
Venue
Allergy
Publisher
Wiley
Published
2011-05-24
Volume
66
Issue
9
Pages
1216-1223
ISSN
0105-4538 (ISSN-L)
OpenAlex
W2165726810
Cited by
1,112
References
1
FWCI
29.88
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Chronic rhinosinusitis in Europe - an underestimated disease. A GA2LEN study. https://app.cochat.ai/papers/10.1111/j.1398-9995.2011.02646.x
The paper
Hastan, D., Fokkens, W. J., Bachert, C., Newson, R. B., Bislimovska, J., Bockelbrink, A., Bousquet, P. J., Brozek, G., Bruno, A., Dahlén, S. E., Forsberg, B., Gunnbjörnsdóttir, M., Kasper, L., Krämer, U., Kowalski, M. L., Lange, B., Lundbäck, B., Salagean, E., Todo-Bom, A., . . . Burney, P. (2011). Chronic rhinosinusitis in Europe - an underestimated disease. A GA2LEN study. Allergy. https://doi.org/10.1111/j.1398-9995.2011.02646.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.