The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Diversity of TH cytokine profiles in patients with chronic rhinosinusitis: A multicenter study in Europe, Asia, and Oceania
Open accessAbstract
Background To date, no study has evaluated the diversity of T H cell cytokine patterns of patients with chronic rhinosinusitis (CRS) among centers in different continents using identical methods. Objective We sought to assess T H cytokine profiles in patients with CRS from Europe, Asia, and Australia. Methods Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP; n = 435) and control subjects (n = 138) were recruited from centers in Adelaide, Benelux, Berlin, Beijing, Chengdu, and Tochigi. Nasal mucosal concentrations of T H 2, T H 17, and T H 1 cytokines; eosinophilic cationic protein (ECP); myeloperoxidase (MPO); IL-8; and tissue total and Staphylococcus aureus enterotoxin (SE)–specific IgE were measured by using identical tools. Results Combinations of T H 1/T H 2/T H 17 cytokine profiles in patients with CRSwNP varied considerably between regions. CRSwNP tissues from patients from Benelux, Berlin, Adelaide, and Tochigi were T H 2 biased, whereas those from Beijing mainly demonstrated T H 2/T H 1/T H 17 mixed patterns, and patients from Chengdu showed an even lower T H 2 expression. Concentrations of IL-8 and tissue total IgE in patients with CRSwNP were significantly higher than those in control subjects in all regions. More than 50% of patients with CRSwNP in Benelux, Berlin, Adelaide, and Tochigi showed a predominantly eosinophilic endotype compared with less than 30% of patients in Beijing and Chengdu. SE-specific IgE was found in significantly greater numbers in patients with CRSwNP from Benelux, Adelaide, and Tochigi and significantly lower numbers in patients from Beijing and Chengdu. Moreover, the T H 1/T H 2/T H 17 cytokine profiles in patients with CRSsNP showed diversity among the 6 regions. Conclusion T H cytokine levels, eosinophilic/neutrophilic patterns, and SE-specific IgE expressions show extreme diversity among patients with CRS from Europe, Asia, and Oceania.
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European Position Paper on Rhinosinusitis and Nasal Polyps 2020
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Self-citationInflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers
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Self-citationHas the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System?
Lee, Y. K., & Mazmanian, S. K. (2010) · Science · doi:10.1126/science.1195568 · Cited by 1,121
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Self-citationRhinosinusitis: Establishing definitions for clinical research and patient care
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Self-citationDifferent types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease
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Self-citationNasal IL-5 levels determine the response to anti–IL-5 treatment in patients with nasal polyps
Gevaert, P., Lang-Loidolt, D., Lackner, A., Stammberger, H., Staudinger, H., Van Zele, T., Holtappels, G., Tavernier, J., van Cauwenberge, P., & Bachert, C. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.05.031 · Cited by 442
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Cited by
Cross-talk between TH2 and TH17 pathways in patients with chronic rhinosinusitis with nasal polyps
Wang, M., Zhang, N., Zheng, M., Li, Y., Meng, L., Ruan, Y., Han, J., Zhao, N., Wang, X., Zhang, L., et al. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.06.023 · Cited by 61
Self-citationUnderstanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases
Jiménez‐Saiz, R., Iborra, S., Blanco, C., González‐Pérez, R., Nuñez‐Borque, E., Zeyneloglu, C., Babayev, H., Göksel, O., Göksel, T., Khaitov, M., et al. (2026) · Allergy · doi:10.1111/all.70512 · Cited by 2
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Metadata
- Authors
- Wang, X., Zhang, N., Bo, M., Holtappels, G., Zheng, M., Lou, H., Wang, H., Zhang, L., & Bachert, C.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 138
- Issue
- 5
- Pages
- 1344-1353
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2507811495
- Cited by
- 616
- References
- 26
- FWCI
- 38.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
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