The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Untangling asthma phenotypes and endotypes
Open accessAbstract
Asthma phenotypes have been developed to address the complexities of the disease. However, owing to a lack of longitudinal studies, little is known about the onset as well as the stability of phenotypes. Distinguishing phenotypes with regard to the severity or duration of the disease is essential. A phenotype covers the clinically relevant properties of the disease, but does not show the direct relationship to disease etiology and pathophysiology. Different pathogenetic mechanisms might cause similar asthma symptoms and might be operant in a certain phenotype. These putative mechanisms are addressed by the term ‘endotype’. Classification of asthma based on endotypes provides advantages for epidemiological, genetic, and drug‐related studies. A successful definition of endotypes should link key pathogenic mechanisms with the asthma phenotype. Thus, the identification of corresponding molecular biomarkers for individual pathogenic mechanism underlying phenotypes or subgroups within a phenotype is important. Whether newly defined asthma endotypes predict the individual course of asthma has to be validated in longitudinal studies. The accurate endotyping reflects natural history of asthma and should help to predict treatment response. Thus, understanding asthma endotypes might be useful in clinical practice.
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Cites
Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma
Haldar, P., Brightling, C. E., Hargadon, B., Gupta, S., Monteiro, W., Sousa, A., Marshall, R. P., Bradding, P., Green, R. H., Wardlaw, A. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808991 · Cited by 1,871
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Lebrikizumab Treatment in Adults with Asthma
Corren, J., Lemanske, R. F., Hanania, N. A., Korenblat, P. E., Parsey, M. V., Arron, J. R., Harris, J. M., Scheerens, H., Wu, L. C., Su, Z., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1106469 · Cited by 1,514
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Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome
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Self-citationEndotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease
Anderson, G. P. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61452-x · Cited by 999
Inflammatory subtypes in asthma: Assessment and identification using induced sputum
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Self-citationHow much asthma is really attributable to atopy?
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Cited by
International consensus statement on allergy and rhinology: rhinosinusitis 2021
Orlandi, R. R., Kingdom, T. T., Smith, T. L., Bleier, B., DeConde, A., Luong, A. U., Poetker, D. M., Soler, Z., Welch, K. C., Wise, S. K., et al. (2021) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22741 · Cited by 959
The 3 major types of innate and adaptive cell-mediated effector immunity
Annunziato, F., Romagnani, C., & Romagnani, S. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.11.001 · Cited by 818
Atopic dermatitis endotypes and implications for targeted therapeutics
Czarnowicki, T., He, H., Krueger, J. G., & Guttman-Yassky, E. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.10.032 · Cited by 631
Wang, X., Zhang, N., Bo, M., Holtappels, G., Zheng, M., Lou, H., Wang, H., Zhang, L., & Bachert, C. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.05.041 · Cited by 616
Akdis, C. A., Bachert, C., Cingi, C., Dykewicz, M. S., Hellings, P. W., Naclerio, R. M., Schleimer, R. P., & Ledford, D. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.02.036 · Cited by 538
Metadata
- Authors
- Agache, I., Akdis, C., Jutel, M., & Virchow, J. C.
- Venue
- Allergy
- Publisher
- Wiley
- Published
- 2012-05-17
- Volume
- 67
- Issue
- 7
- Pages
- 835-846
- ISSN
- 0105-4538 (ISSN-L)
- 1398-9995
- OpenAlex
- W1972288125
- Cited by
- 345
- References
- 72
- FWCI
- 19.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Agache, I., Akdis, C., Jutel, M., & Virchow, J. C. (2012). Untangling asthma phenotypes and endotypes. Allergy. https://doi.org/10.1111/j.1398-9995.2012.02832.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
