HL‐A Antigens and Diseases. I. Multiple Sclerosis
Abstract
A total of 135 patients with a definite diagnosis of Multiple Sclerosis (MS) has been HL–A typed. Increased frequencies of HL–A3 and 7 were found. Combining our material with other data revealed significant increases in HL–A3, HL–A7 and W18 and significant decreases in HL–A2 and HL–A12. The relative incidence ratios of Woolf (1955) were used in these comparisons and depicted graphically. Titres of anti‐measles virus antibody were determined in sera of 132 of the patients. Increased titres were significantly more frequent in patients carrying HL–A3, 7 and/or W18 as compared to patients lacking these antigens. This finding may be interpreted as possibly reflecting the existence of an immune recognition locus (Ir) linked to the HL–A loci.
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The first genetic risk factors discovered for multiple sclerosis were three serological alleles of the human leucocyte antigens encoded in the major histocompatibility complex.
“three serological alleles of the human leucocyte antigens (HLA), encoded in the major histocompatibility complex8, 9, 10, 11 (MHC, chromosome 6p21).”
From Genome‐wide association studies of multiple sclerosis (2018) · cites this paper as [10]
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- Authors
- Jersild, C., Svejgaard, A., Fog, T., & Ammitzbøll, T.
- Affiliations
- Rigshospitalet (DK)
- Corresponding author
- Jersild, C.
- Venue
- Tissue Antigens
- Publisher
- Wiley
- Published
- 1973-09
- Volume
- 3
- Issue
- 5
- Pages
- 243-250
- ISSN
- 0001-2815 (ISSN-L)
- 1399-0039
- OpenAlex
- W2060890537
- Cited by
- 78
- References
- 15
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2019: 1 · 2018: 1 · 2012: 1
- FWCI
- 19.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Tissue Antigens (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Keywords
- HLA antigens, multiple sclerosis, HLA and disease association
- MeSH terms
- Antibodies, Cytotoxicity Tests, Immunologic, Hemagglutination Inhibition Tests, Histocompatibility Antigens, Histocompatibility Testing, Humans, Lymphocytes, Measles virus, Multiple Sclerosis
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