Cited by 78Multiple Sclerosis Research StudiesGenetic Associations and EpidemiologySystemic Lupus Erythematosus Research

HL‐A Antigens and Diseases. I. Multiple Sclerosis

Jersild, C., Svejgaard, A., Fog, T., Ammitzbøll, T.·1973·Tissue Antigens

Abstract

A total of 135 patients with a definite diagnosis of Multiple Sclerosis (MS) has been HL–A typed. Increased frequencies of HL–A3 and 7 were found. Combining our material with other data revealed significant increases in HL–A3, HL–A7 and W18 and significant decreases in HL–A2 and HL–A12. The relative incidence ratios of Woolf (1955) were used in these comparisons and depicted graphically. Titres of anti‐measles virus antibody were determined in sera of 132 of the patients. Increased titres were significantly more frequent in patients carrying HL–A3, 7 and/or W18 as compared to patients lacking these antigens. This finding may be interpreted as possibly reflecting the existence of an immune recognition locus (Ir) linked to the HL–A loci.

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Crossref · 10.1111/j.1399-0039.1973.tb01002.x

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15 of 15 references verified0 citation errors · 0 not checkable

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  • The first genetic risk factors discovered for multiple sclerosis were three serological alleles of the human leucocyte antigens encoded in the major histocompatibility complex.

    “three serological alleles of the human leucocyte antigens (HLA), encoded in the major histocompatibility complex8, 9, 10, 11 (MHC, chromosome 6p21).”

    From Genome‐wide association studies of multiple sclerosis (2018) · cites this paper as [10]

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Authors
Jersild, C., Svejgaard, A., Fog, T., & Ammitzbøll, T.
Affiliations
Rigshospitalet (DK)
Corresponding author
Jersild, C.
Venue
Tissue Antigens
Publisher
Wiley
Published
1973-09
Volume
3
Issue
5
Pages
243-250
ISSN
  • 0001-2815 (ISSN-L)
  • 1399-0039
OpenAlex
W2060890537
Cited by
78
References
15
Citations by year
2024: 1 · 2023: 1 · 2022: 1 · 2019: 1 · 2018: 1 · 2012: 1
FWCI
19.72
Type
journal article
Language
en
Open access
closed
Locations
  • Tissue Antigens (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Keywords
HLA antigens, multiple sclerosis, HLA and disease association
MeSH terms
Antibodies, Cytotoxicity Tests, Immunologic, Hemagglutination Inhibition Tests, Histocompatibility Antigens, Histocompatibility Testing, Humans, Lymphocytes, Measles virus, Multiple Sclerosis

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