Likelihood of transmitting Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in families with periodontitis
Abstract
This study examined the frequency of spouse‐to‐spouse and parent‐child transmission of the periodontal pathogens Actinobacillus actinomycetemcomitans (124 subjects in 47 families) and Porphyromonas gingivalis (78 subjects in 31 families). The two test organisms were recovered from subgingival and tongue surface specimens using established microbiological techniques. Arbitrarily primed polymerase chain reaction (AP‐PCR) was used to genetically characterize isolates of the test species. The probability of isolating identical AP‐PCR types of A. actinomycetemcomitans and P. gingivalis in family members by chance was estimated from the AP‐PCR genotype distribution of the two species among unrelated individuals. A probability of 5% or less for occurrence by chance alone suggests intra‐familial transmission. With a bacterium‐positive spouse, A. actinomycetemcomitans revealed inter‐spousal transmission in 4/11 (36%) married couples and P. gingivalis in 2/10 (20%) married couples. Parent‐child transmission of A. actinomycetemcomitans took place in 6/19 (32%) families. P. gingivalis was not transmitted from parent to child in any of the study families. The intra‐familial transmission of A. actinomycetemcomitans and P. gingivalis may in part explain a familial pattern of periodontitis and may have important prophylactic and treatment implications.
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Oral bacteria are transferred vertically from primary caregiver(s) in early childhood and horizontally between family members later in life.
“In addition, oral bacteria are transferred vertically from the primary caregiver(s) in early childhood18 and horizontally between family members later in life18,19, making archaeological dental calculus a potentially unique means of tracing population structure, movement and admixture between ancient cultures, as well as the spread of diseases.”
From Sequencing ancient calcified dental plaque shows changes in oral microbiota with dietary shifts of the Neolithic and Industrial revolutions (2013) · cites this paper as [18]
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- Authors
- Asikainen, S., Chen, C., & Slots, J.
- Affiliations
- University of Southern California (US)
- Corresponding author
- Asikainen, S.
- Venue
- Oral Microbiology and Immunology
- Publisher
- Wiley
- Published
- 1996-12
- Volume
- 11
- Issue
- 6
- Pages
- 387-394
- ISSN
- 0902-0055 (ISSN-L)
- 1399-302X
- OpenAlex
- W2067454035
- Cited by
- 114
- References
- 25
- Citations by year
- 2024: 2 · 2023: 2 · 2021: 1 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 6
- FWCI
- 7.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oral Microbiology and Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
- Health Sciences › Health Professions › Pharmacy › Oral and gingival health research
- Keywords
- Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, periodontitis, parent-child transmission, subgingival bacteria, bacterial transmission
- MeSH terms
- Adolescent, Adult, Child, Family Health, Female, Genotype, Humans, Male, Middle Aged, Periodontitis, Polymerase Chain Reaction, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Infectious Disease Transmission, Vertical, Disease Transmission, Infectious, Genetic Heterogeneity
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