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Cited by 39Oral microbiology and periodontitis researchOral and gingival health researchPeriodontal Regeneration and Treatments

Deficiency of iNOS contributes to Porphyromonas gingivalis‐induced tissue damage

Alayan, J., Ivanovski, S., Gemmell, E., Ford, P., Hamlet, S., Farah, C. S.·2006·Oral Microbiology and Immunology
DOI 10.1111/j.1399-302x.2006.00304.x
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Abstract

Periodontitis is a chronic inflammatory disease that results in extensive soft and hard tissue destruction of the periodontium. Porphyromonas gingivalis possesses an array of virulence factors and has been shown to induce expression of inducible nitric oxide synthase (iNOS) in inflammatory cells. The aim of this study was to investigate the effect of eliminating iNOS in a murine model of P. gingivalis infection. This was achieved by utilizing a P. gingivalis-induced skin abscess model, and an alveolar bone loss model employing an oral infection of P. gingivalis in iNOS knockout mice. The results indicated that iNOS knockout mice exhibit more extensive soft tissue damage and alveolar bone loss in response to P. gingivalis infection compared to wild-type mice. The local immune response to P. gingivalis in iNOS knockout mice was characterized by increased numbers of polymorphonuclear monocytes, while the systemic immune response was characterized by high levels of interleukin-12. The iNOS is required for an appropriate response to P. gingivalis infection.

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Crossref · 10.1111/j.1399-302x.2006.00304.x

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  • Cytotoxic products of P. gingivalis (e.g., lipopolysaccharide) can induce host cells release of inflammatory cytokines such as TNF-α, IL-1β, and IL-6, which in turn increase NO production leading to lung epithelial cell damage.

    “Cytotoxic products of P. gingivalis (e.g., lipopolysaccharide) can induce host cells release of inflammatory cytokines such as TNF-α, IL-1β, and IL-6 (Ke et al., 2016), which in turn increase NO production leading to lung epithelial cell damage (Alayan et al., 2006; Wu et al., 2016; Ahamed et al., 2017).”

    From Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection (2020) · cites this paper as Alayan et al., 2006

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Authors
Alayan, J., Ivanovski, S., Gemmell, E., Ford, P., Hamlet, S., & Farah, C. S.
Affiliations
The University of Queensland (AU)
Corresponding author
Farah, C. S.
ORCID
Venue
Oral Microbiology and Immunology
Publisher
Wiley
Published
2006-10-24
Volume
21
Issue
6
Pages
360-365
ISSN
  • 0902-0055 (ISSN-L)
  • 1399-302X
DOI
10.1111/j.1399-302x.2006.00304.x
OpenAlex
W1999928791
Cited by
39
References
34
Citations by year
2021: 4 · 2020: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 5 · 2012: 2
FWCI
3.97
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Oral Microbiology and Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Griffith Research Online (submittedVersion)
Funders
Australian Dental Research Foundation
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Health Professions › Pharmacy › Oral and gingival health research
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
Keywords
inducible nitric oxide synthase, Porphyromonas gingivalis, periodontitis, alveolar bone loss, iNOS knockout mice, IL-12, bacterial virulence factors, host immune response
MeSH terms
Abscess, Animals, Female, Mice, Inbred C57BL, Neutrophils, Periodontitis, Alveolar Bone Loss, Porphyromonas gingivalis, Mice, Knockout, Interleukin-12, Virulence Factors, Mice, Nitric Oxide Synthase Type II

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