The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The pancreatic ductal epithelium serves as a potential pool of progenitor cells
Open accessAbstract
With the increasing success of islet transplantation, beta-cell replacement therapy has had renewed interest. To make such a therapy available to more than a few of the thousands of patients with diabetes, new sources of insulin-producing cells must become readily available. The most promising sources are stem cells, whether embryonic or adult stem cells. Clearly identifiable adult pancreatic stem cells have yet to be characterized. Although considerable evidence suggests their possibility, recent lineage-tracing experiments challenge their existence. Even in light of these lineage-tracing experiments, we suggest that evidence for neogenesis or new islet formation after birth remains strong. Our work has suggested that the pancreatic duct epithelium itself serves as a pool for progenitors for both islet and acinar tissues after birth and into adulthood and, thus, that the duct epithelium can be considered 'facultative stem cells'. We will develop our case for this hypothesis in this perspective.
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Cites
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Dor, Y., Brown, J., Martinez, O. I., & Melton, D. A. (2004) · Nature · doi:10.1038/nature02520 · Cited by 2,219
Wang, T. C., Bonner-Weir, S., Oates, P. S., Chulak, M., Simon, B., Merlino, G. T., Schmidt, E. V., & Brand, S. J. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116708 · Cited by 270
Self-citationMontanya, E., Nacher, V, Biarnés, M., & Soler, J. (2000) · Diabetes · doi:10.2337/diabetes.49.8.1341 · Cited by 220
Parsons, J. A., Bartke, A., & Sorenson, R. L. (1995) · Endocrinology · doi:10.1210/en.136.5.2013 · Cited by 152
Cited by
Very Slow Turnover of β-Cells in Aged Adult Mice
Teta, M., Long, S. Y., Wartschow, L. M., Rankin, M. M., & Kushner, J. A. (2005) · Diabetes · doi:10.2337/diabetes.54.9.2557 · Cited by 465
Inada, A., Nienaber, C., Katsuta, H., Fujitani, Y., Levine, J., Morita, R., Sharma, A., & Bonner-Weir, S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805803105 · Cited by 448
Self-citationCardinale, V., Wang, Y., Carpino, G., Cui, C.-B., Gatto, M., Rossi, M., Berloco, P. B., Cantafora, A., Wauthier, E., Furth, M. E., et al. (2010) · Hepatology · doi:10.1002/hep.24590 · Cited by 337
Cyclins D2 and D1 Are Essential for Postnatal Pancreatic β-Cell Growth
Kushner, J. A., Ciemerych, M. A., Sicinska, E., Wartschow, L. M., Teta, M., Long, S. Y., Sicinski, P., & White, M. F. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.9.3752-3762.2005 · Cited by 334
All β Cells Contribute Equally to Islet Growth and Maintenance
Brennand, K., Huangfu, D., & Melton, D. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050163 · Cited by 210
Metadata
- Authors
- Bonner-Weir, S., Toschi, E., Inada, A., Reitz, P., Fonseca, S. Y., Aye, T., & Sharma, A.
- Venue
- Pediatric Diabetes
- Publisher
- Hindawi Limited
- Published
- 2004-12
- Volume
- 5
- Issue
- s2
- Pages
- 16-22
- ISSN
- 1399-543X (ISSN-L)
- 1399-5448
- OpenAlex
- W2107471483
- Cited by
- 311
- References
- 4
- FWCI
- 17.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bonner-Weir, S., Toschi, E., Inada, A., Reitz, P., Fonseca, S. Y., Aye, T., & Sharma, A. (2004). The pancreatic ductal epithelium serves as a potential pool of progenitor cells. Pediatric Diabetes. https://doi.org/10.1111/j.1399-543x.2004.00075.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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