The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
White matter abnormalities in bipolar disorder and schizophrenia detected using diffusion tensor magnetic resonance imaging
Abstract
Objectives: Strong qualitative and quantitative evidence exists of white matter abnormalities in both schizophrenia and bipolar disorder (BD). Diffusion tensor imaging (DTI) studies suggest altered connectivity in both disorders. We aim to address the diagnostic specificity of white matter abnormalities in these disorders. Methods: DTI was used to assess white matter integrity in clinically stable patients with familial BD (n = 42) and familial schizophrenia (n = 28), and in controls (n = 38). Differences in fractional anisotropy (FA) were measured using voxel‐based morphometry and automated region of interest analysis. Results: Reduced FA was found in the anterior limb of the internal capsule (ALIC), anterior thalamic radiation (ATR), and in the region of the uncinate fasciculus in patients with BD and those with schizophrenia compared with controls. A direct comparison between patient groups found no significant differences in these regions. None of the findings were associated with psychotropic medication. Conclusions: Reduced integrity of the ALIC, uncinate fasciculus, and ATR regions is common to both schizophrenia and BD. These results imply an overlap in white matter pathology, possibly relating to risk factors common to both disorders.
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Dissecting the uncinate fasciculus: disorders, controversies and a hypothesis.
Von Der Heide, R. J., Skipper, L. M., Klobusicky, E., & Olson, I. R. (2013) · Brain · doi:10.1093/brain/awt094 · Cited by 829
Dysconnectivity in schizophrenia: where are we now?
Pettersson-Yeo, W., Allen, P., Benetti, S., McGuire, P., & Mechelli, A. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.11.004 · Cited by 712
A review of multivariate methods for multimodal fusion of brain imaging data
Sui, J., Adali, T., Yu, Q., Chen, J., & Calhoun, V. D. (2012) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2011.10.031 · Cited by 401
The structure of creative cognition in the human brain
Jung, R. E. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00330 · Cited by 391
Effects of medication on neuroimaging findings in bipolar disorder: an updated review
Hafeman, D. M., Chang, K. D., Garrett, A. S., Sanders, E. M., & Phillips, M. L. (2012) · Bipolar Disorders · doi:10.1111/j.1399-5618.2012.01023.x · Cited by 379
Metadata
- Authors
- Sussmann, J. E., Lymer, G. K. S., McKirdy, J., Moorhead, T. W. J., Maniega, S. M., Job, D., Hall, J., Bastin, M. E., Johnstone, E. C., Lawrie, S. M., & McIntosh, A. M.
- Venue
- Bipolar Disorders
- Publisher
- Wiley
- Published
- 2009-01-09
- Volume
- 11
- Issue
- 1
- Pages
- 11-18
- ISSN
- 1398-5647 (ISSN-L)
- 1399-5618
- OpenAlex
- W1998504213
- Cited by
- 273
- References
- 54
- FWCI
- 18.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sussmann, J. E., Lymer, G. K. S., McKirdy, J., Moorhead, T. W. J., Maniega, S. M., Job, D., Hall, J., Bastin, M. E., Johnstone, E. C., Lawrie, S. M., & McIntosh, A. M. (2009). White matter abnormalities in bipolar disorder and schizophrenia detected using diffusion tensor magnetic resonance imaging. Bipolar Disorders. https://doi.org/10.1111/j.1399-5618.2008.00646.x
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