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Cardiovascular disease and hypertension among adults with bipolar I disorder in the United States
Open accessAbstract
OBJECTIVE: Despite ample evidence of excess cardiovascular mortality in bipolar disorder (BD), few studies have demonstrated increased prevalence of cardiovascular disease (CVD) and/or hypertension (HTN) in BD. We therefore examined this topic in a representative epidemiologic sample. METHOD: The 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions was used to determine whether prevalence of physician-diagnosed CVD and HTN is elevated among subjects with lifetime bipolar I disorder (BD-I), and whether CVD and HTN are prevalent at earlier ages among subjects with BD-I. RESULTS: The age-, race-, and sex-adjusted prevalence of CVD was significantly greater among subjects with BD-I versus controls [odds ratio (OR) = 4.95, 95% confidence interval (CI): 4.27-5.75] and versus subjects with major depressive disorder [(MDD); OR =1.80, 95% CI: 1.52-2.14], as was the prevalence of HTN (OR = 2.38, 95% CI: 2.16-2.62 versus controls, OR = 1.44, 95% CI: 1.30-1.61 versus MDD; p < 0.0001 for all). Controlling additionally for marital status, education, income, obesity, smoking, anxiety disorders, and substance use disorders did not substantially alter these findings. The mean age of BD-I subjects with CVD and HTN was 14 and 13 years younger, respectively, than controls with CVD and HTN. CONCLUSIONS: Adults with BD-I are at increased risk of CVD and HTN, prevalent over a decade earlier than non-BD adults. Strategies are needed to prevent excessive and premature cardiovascular burden in BD-I.
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“CVD develops more than a decade earlier in patients with bipolar disorders than in controls.443”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [443]
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Grant, B. F., Stinson, F. S., Dawson, D. A., Chou, S. P., Dufour, M. C., Compton, W., Pickering, R. P., & Kaplan, K. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.8.807 · Cited by 2,889
Smoking and Mental Illness: A Population-Based Prevalence Study
Lasser, K., Boyd, J. W., Woolhandler, S., Himmelstein, D. U., McCormick, D., & Bor, D. H. (2000) · JAMA · doi:10.1001/jama.284.20.2606 · Cited by 2,508
Manic-Depressive Insanity and Paranoia.
(1921) · JAMA · doi:10.1001/jama.1921.02630330070026 · Cited by 1,612
Manic Depressive Insanity and Paranoia
Kraepelin, E. (1921) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-192104000-00057 · Cited by 1,319
Excess Mortality in Bipolar and Unipolar Disorder in Sweden
Ösby, U., Brandt, L., Correia, N., Ekbom, A., & Sparén, P. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.9.844 · Cited by 1,120
Grant, B. F., Dawson, D. A., Stinson, F. S., Chou, P. S., Kay, W., & Pickering, R. (2003) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(03)00070-x · Cited by 1,110
Mental Disorders and Use of Cardiovascular Procedures After Myocardial Infarction
Druss, B. G. (2000) · JAMA · doi:10.1001/jama.283.4.506 · Cited by 541
Grant, B. F., Stinson, F. S., Hasin, D. S., Dawson, D. A., Chou, S. P., Ruan, W. J., & Huang, B. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n1001 · Cited by 479 · cited 1×
“The AUDADIS-IV diagnoses of SUD and of mood and anxiety disorders have demonstrated adequate reliability and validity (17, 26, 27).”
MethodBurden of general medical conditions among individuals with bipolar disorder
Kilbourne, A. M., Cornelius, J. R., Han, X., Pincus, H. A., Shad, M. U., Salloum, I. M., Conigliaro, J. C., & Haas, G. L. (2004) · Bipolar Disorders · doi:10.1111/j.1399-5618.2004.00138.x · Cited by 423
Antipsychotic medications: metabolic and cardiovascular risk.
Newcomer, J. W. (2007) · PubMed · Cited by 416
Research works printed but not linked: 1
- 10.1176/appi.ps.58.8.1073 · DOI
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Özerdem, A. (2015) · Dusunen Adam The Journal of Psychiatry and Neurological Sciences · doi:10.5350/dajpn20152803001 · Cited by 2
Integrating Primary Care and Behavioral Health: A Nurse Practitioner’s
Thai, L., & Saw, A. (2014) · AAPI Nexus Policy Practice and Community · doi:10.17953/appc.12.1-2.l77724297684g720 · Cited by 2
Bipolar disorders, obesity, and metabolic disturbances: Mechanisms and implications
Murru, A., Anmella, G., Giménez, A., & Vieta, E. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819182-8.00022-3 · Cited by 2
Fountoulakis, K. N. (2014) · Springer eBooks · doi:10.1007/978-3-642-37216-2_2 · Cited by 2
Hudak, R., & Gannon, J. M. (2022) · Current clinical practice · doi:10.1007/978-3-030-98709-1_3 · Cited by 2
Chen, P., Hsu, J., Chung, K., Huang, S., Huang, Y., & Tsai, S. (2021) · The European Journal of Psychiatry · doi:10.1016/j.ejpsy.2021.03.006 · Cited by 2
Liu, Z., Wang, H., Yang, Z., Yu, L., Wang, J., & Zou, C. (2023) · medRxiv · doi:10.1101/2023.08.29.23294761 · Cited by 2
Chen, P., Chang, C.-K., Lin, Y., Chiang, S.-J., & Trang, N. N. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-06105-3 · Cited by 3
Ercis, M., Solares‐Bravo, M., Pazdernik, V., González-Campos, T., Sánchez-Ruiz, J. A., Ceylan, D., Larson, N. L., Ruddy, K. J., Couch, F. J., Olson, J. E., et al. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2025.116598 · Cited by 1
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Scola, G., & Andreazza, A. C. (2014) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4939-0440-2_3 · Cited by 1
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Ralat, S. I., & Barrios, R. I. (2020) · Revista Puertorriqueña de Psicología · Cited by 1
Neuroimmune pathways in bipolar disorder
Barbosa, I. G., Bauer, M. E., & Teixeira, A. L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821398-8.00003-5 · Cited by 1
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Tong, S. Y. C. (2012) · TSpace (University of Toronto) · Cited by 1
Intra-individual reaction time variability in sustained attention
Moss, R. A. (2018) · Cited by 1
Attar, R., Valentin, J. B., Andell, P., Nielsen, R. E., & Jensen, S. E. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3948431 · Cited by 1
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Gomes, F. A. (2012) · Americanae (AECID Library)
Immunology, Inflammation, Mental Disorders, and Cardiovascular Risk
Baune, B. T. (2015) · Springer eBooks · doi:10.1007/978-981-4560-53-5_39-1
Depression-Avoidance Defences in Bipolar-Euthymia
Granger, S. (2015) · Victoria University Research Repository (Victoria University)
Preventing Sensitization and Kindling‐like Progression in the Recurrent Mood Disorders
Post, R. M. (2016) · Wiley eBooks · doi:10.1002/9781119125556.devpsy419
Lenaerts, F., Herdt, A. D., Probst, M., & Vancampfort, D. (2014) · Lirias
Metabolic syndrome in acute psychiatric inpatients: Clinical correlates
Solia, F., Rosso, G., & Maina, G. (2015) · Institutional Research Information System University of Turin (University of Turin) · Cited by 5
The Role of Glutathione Metabolism in the Neuroprotective Effect of Mood Stabilizers
Pasiliao, C. C. (2011) · TSpace (University of Toronto)
Ou, X. (2015) · TSpace (University of Toronto)
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Kim, H. K. (2015) · TSpace (University of Toronto)
Huzayyin, A. A. S. (2013) · TSpace (University of Toronto)
Oliveira, V. R., de Almeida, K. M., & Lafer, B. (2016) · Debates em Psiquiatria · doi:10.25118/2236-918x-6-5-6
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Relojo, D. (2018) · PSIHOLOGÌÂ Ì SUSPÌLʹSTVO · doi:10.35774/pis2018.01.143
de Paula, D. C. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.22.2018.tde-29052018-155934
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Pan, A. (2017) · TSpace (University of Toronto)
Allostatic load: Implications for the pathophysiology, evolution, and treatment of bipolar disorder
DuBow, A., Melun, J.-P., & Juster, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819182-8.00021-1 · Cited by 1
Bipolar disorder and cardiovascular dysfunction: Mechanisms and implications
Mio, M., & Goldstein, B. I. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819182-8.00019-3
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Toma, S. (2019) · TSpace (University of Toronto)
Urback, A. L. (2017) · TSpace (University of Toronto)
Oliveira, V. R., de Almeida, K. M., & Lafer, B. (2016) · Debates em Psiquiatria · doi:10.25118/2763-9037.2016.v6.121
Ralat, S. I., Alicea-Cuprill, G., Arroyo, Y., & Otero, W. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10245890
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Baune, B. T. (2016) · Springer eBooks · doi:10.1007/978-981-287-206-7_39
Ahlman, C. (2019) · doi:10.1093/oso/9780190886578.003.0006
Cognition and Bipolar Disorder in Older Adults (Including Question of ‘Neuroprogression’)
Strejilevich, S., & Martino, D. J. (2016) · Mental health and illness worldwide · doi:10.1007/978-981-10-0370-7_12-1
Siddiqui, J. A., Qureshi, S. F., Alotaibi, H. M., Saudi board Psychiatry, S. A., Alkhammash, W. M., & Saudi Board Psychiatry, S. A. (2024) · Journal of Psychiatry Psychology and Behavioral Research · doi:10.21776/ub.jppbr.2024.005.01.1
Sipos, B., Vecsey-Nagy, M., Vattay, B., Boussoussou, M., Jokkel, Z., Borzsák, S., Jermendy, Á. L., Panajotu, A., Gonda, X., Rihmer, Z., et al. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.07.092
General medical comorbidities in psychotic disorders in the Finnish SUPER study
Ahti, J., Kieseppä, T., Haaki, W., Suvisaari, J., Niemelä, S., Suokas, K., Torniainen‐Holm, M., Wegelius, A., Kampman, O., Lähteenvuo, M., et al. (2024) · Schizophrenia · doi:10.1038/s41537-024-00546-1 · Cited by 1
Hou, L., Li, Y., Xiong, X., Tanigawa, Y., Park, Y., Lenz, S. W., Grayson, A., Lee, J., Ryu, E., Olson, J. E., et al. (2025) · medRxiv · doi:10.1101/2025.03.17.25324124
Kulkarni, N. P., Zai, C. C. H., Dimick, M. K., Sultan, A. A., Young, L. T., & Goldstein, B. I. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120926
McGowan, N. M., Nichols, M., Bilderbeck, A. C., Goodwin, G. M., & Saunders, K. (2021) · Figshare · doi:10.6084/m9.figshare.13671105
Levin, J. B., Moore, D. J., Depp, C. A., Montoya, J. L., Briggs, F., Rahman, M., Stange, K. C., Einstadter, D., Weise, C., Conroy, C. M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20193408
Levin, J. B., Moore, D. J., Depp, C. A., Montoya, J. L., Briggs, F., Rahman, M., Stange, K. C., Einstadter, D., Weise, C., Conroy, C. M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20193414
Metabolic shifts, a consequence of hyperosmolarity, are a hallmark of mental disorders
Schwartz, L. H., Bakkar, A., Bouillaud, F., Attal, R., & Leboyer, M. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2026.01.047
Kulkarni, N. P., Zai, C. C. H., Kennedy, K. G., Mio, M., Young, L. T., MacIntosh, B. J., & Goldstein, B. I. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107347
Diversité Génétique des Molécules de Réponse Immunitaire Innée dans les Troubles Bipolaires
Oliveira, J. (2015) · theses.fr (ABES) · doi:10.70675/b5f62909z8b9az49b8zb797zc725c6e8f7ef
Hou, L., Li, Y., Xiong, X., Tanigawa, Y., Park, Y., Lenz, S. W., Grayson, A., Lee, J., Ryu, E., Olson, J. E., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-72543-0 · Cited by 1
Mil-Homens, I., Barreira, J., Neto, A., Freitas, A., & Gonçalves‐Pinho, M. (2026) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2026.112985
Metadata
- Authors
- Goldstein, B. I., Fagiolini, A., Houck, P., & Kupfer, D. J.
- Affiliations
- Sunnybrook Health Science Centre (CA)
- University of Siena (IT)
- University of Pittsburgh (US)
- Corresponding author
- Goldstein, Benjamin I
- Venue
- Bipolar Disorders
- Publisher
- Wiley
- Published
- 2009-08-10
- Volume
- 11
- Issue
- 6
- Pages
- 657-662
- ISSN
- 1398-5647 (ISSN-L)
- 1399-5618
- PMC
- PMC3401900
- OpenAlex
- W1977370435
- Cited by
- 259
- References
- 35
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 8 · 2023: 8 · 2022: 13 · 2021: 13 · 2020: 22 · 2019: 10 · 2018: 19 · 2017: 17 · 2016: 24 · 2015: 30 · 2014: 20 · 2013: 20 · 2012: 17
- FWCI
- 8.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Bipolar Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Use Siena air (University of Siena) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institute of Mental Health (R25MH060473)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- bipolar I disorder, cardiovascular disease, hypertension, prevalence, cardiovascular risk, major depressive disorder, comorbidities, NESARC
- MeSH terms
- Adult, Age Factors, Bipolar Disorder, Cardiovascular Diseases, Female, Humans, Hypertension, Male, Middle Aged, Psychiatric Status Rating Scales, Retrospective Studies, United States, Prevalence, Confidence Intervals, Odds Ratio
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