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Cited by 259Bipolar Disorder and TreatmentSchizophrenia research and treatmentBlood Pressure and Hypertension Studies

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Cardiovascular disease and hypertension among adults with bipolar I disorder in the United States

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Goldstein, Benjamin I, Fagiolini, Andrea, Houck, Patricia, Kupfer, David J·2009·Bipolar Disorders
DOI 10.1111/j.1399-5618.2009.00735.xPMC PMC3401900
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Abstract

OBJECTIVE: Despite ample evidence of excess cardiovascular mortality in bipolar disorder (BD), few studies have demonstrated increased prevalence of cardiovascular disease (CVD) and/or hypertension (HTN) in BD. We therefore examined this topic in a representative epidemiologic sample. METHOD: The 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions was used to determine whether prevalence of physician-diagnosed CVD and HTN is elevated among subjects with lifetime bipolar I disorder (BD-I), and whether CVD and HTN are prevalent at earlier ages among subjects with BD-I. RESULTS: The age-, race-, and sex-adjusted prevalence of CVD was significantly greater among subjects with BD-I versus controls [odds ratio (OR) = 4.95, 95% confidence interval (CI): 4.27-5.75] and versus subjects with major depressive disorder [(MDD); OR =1.80, 95% CI: 1.52-2.14], as was the prevalence of HTN (OR = 2.38, 95% CI: 2.16-2.62 versus controls, OR = 1.44, 95% CI: 1.30-1.61 versus MDD; p < 0.0001 for all). Controlling additionally for marital status, education, income, obesity, smoking, anxiety disorders, and substance use disorders did not substantially alter these findings. The mean age of BD-I subjects with CVD and HTN was 14 and 13 years younger, respectively, than controls with CVD and HTN. CONCLUSIONS: Adults with BD-I are at increased risk of CVD and HTN, prevalent over a decade earlier than non-BD adults. Strategies are needed to prevent excessive and premature cardiovascular burden in BD-I.

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Metadata

Authors
Goldstein, B. I., Fagiolini, A., Houck, P., & Kupfer, D. J.
Affiliations
  • Sunnybrook Health Science Centre (CA)
  • University of Siena (IT)
  • University of Pittsburgh (US)
Corresponding author
Goldstein, Benjamin I
ORCID
Venue
Bipolar Disorders
Publisher
Wiley
Published
2009-08-10
Volume
11
Issue
6
Pages
657-662
ISSN
  • 1398-5647 (ISSN-L)
  • 1399-5618
DOI
10.1111/j.1399-5618.2009.00735.x
PMC
PMC3401900
OpenAlex
W1977370435
Cited by
259
References
35
Citations by year
2026: 6 · 2025: 6 · 2024: 8 · 2023: 8 · 2022: 13 · 2021: 13 · 2020: 22 · 2019: 10 · 2018: 19 · 2017: 17 · 2016: 24 · 2015: 30 · 2014: 20 · 2013: 20 · 2012: 17
FWCI
8.84
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Bipolar Disorders (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Use Siena air (University of Siena) (submittedVersion)
Funders
  • U.S. Department of Veterans Affairs
  • National Institute of Mental Health (R25MH060473)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
bipolar I disorder, cardiovascular disease, hypertension, prevalence, cardiovascular risk, major depressive disorder, comorbidities, NESARC
MeSH terms
Adult, Age Factors, Bipolar Disorder, Cardiovascular Diseases, Female, Humans, Hypertension, Male, Middle Aged, Psychiatric Status Rating Scales, Retrospective Studies, United States, Prevalence, Confidence Intervals, Odds Ratio

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