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Formation of Malonaldehyde from Phospholipid Arachidonate during Microsomal Lipid Peroxidation
Open accessAbstract
The thiobarbituric acid reacting material produced during enzymatic microsomal lipid peroxidation has been identified as malonaldehyde. The malonaldehyde was condensed with urea to form 2‐hydroxy‐pyrimidine, which was identified by its ultraviolet spectrum, chromato‐graphic properties, and mass spectrum. Incubations with phosphatidyl choline labelled with tritiated arachidonate yielded 2‐hydroxy‐pyrimidine with a specific activity nearly equal to that of the phospholipid arachidonate. Incubations with tritiated arachidonic acid yielded 2‐hydroxy‐pyrimidine with a specific activity nearly 2 orders of magnitude less than that of free arachidonic acid. Therefore, phospholipid arachidonate has been established as the major source of the malonaldehyde produced during microsomal lipid peroxidation.
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Citations
Cited by
Pryor, W. A., Stanley, J. P., & Blair, E. (1976) · Lipids · doi:10.1007/bf02532843 · Cited by 503
Lipid Peroxidation and Mechanisms of Toxicity
Horton, A. A., Fairhurst, S., & Bus, J. S. (1987) · CRC Critical Reviews in Toxicology · doi:10.3109/10408448709089856 · Cited by 339
Yogalakshmi, B., Viswanathan, P., & Anuradha, C. V. (2010) · Toxicology · doi:10.1016/j.tox.2009.12.018 · Cited by 296
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Rocha-Pereira, P., Santos-Silva, A., Rebelo, I., Figueiredo, A., Quintanilha, A., & Teixeira, F. (2004) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2004.05984.x · Cited by 258
Zhao, Z., Wang, W., Guo, H., & Zhou, D. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.06.030 · Cited by 187
Metadata
- Authors
- Niehaus, W. G., & Samuelsson, B.
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 1968-10
- Volume
- 6
- Issue
- 1
- Pages
- 126-130
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W1995382021
- Cited by
- 1,406
- References
- 0
- FWCI
- 6.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Formation of Malonaldehyde from Phospholipid Arachidonate during Microsomal Lipid Peroxidation. https://app.cochat.ai/papers/10.1111/j.1432-1033.1968.tb00428.x
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- Niehaus, W. G., & Samuelsson, B. (1968). Formation of Malonaldehyde from Phospholipid Arachidonate during Microsomal Lipid Peroxidation. European Journal of Biochemistry. https://doi.org/10.1111/j.1432-1033.1968.tb00428.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
