Excretion of Steroid Hormones in Adults: Steroids in Faeces from Adults
Abstract
The steroids in faeces from three healthy persons, one woman and two men, were analyzed by gas‐liquid chromatography and gas chromatography‐mass spectrometry. Both C19O2, C19O3, C21O2 and C21O3 steroids were found in the free steroid and in the steroid monosulphate fractions. Incubation of various precursor steroids with intestinal contents recovered from the ileostoma of a colectomized patient demonstrated the presence of intestinal bacterial 16α‐ and 21‐dehydroxylating enzymes. Furthermore, it was shown that a Δ16‐C21 steroid was converted to a 17α‐pregnane derivative and that the side chain of 11β,21‐dihydroxy‐4‐pregnene‐3,20‐dione could be removed by the intestinal bacteria.
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Biliary excretion is increased during pregnancy.
“Biliary excretion is increased during pregnancy [201,203,204]”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [203]
Cites
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- Authors
- Eriksson, H., & Gustafsson, J.
- Affiliations
- Karolinska Institutet (SE)
- ORCID
- Eriksson, Håkan
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 1971-01
- Volume
- 18
- Issue
- 1
- Pages
- 146-150
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W2036728864
- Cited by
- 59
- References
- 18
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2016: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- steroid excretion, bile acid deconjugation, 21-hydroxylase, pregnane synthesis, ileostomy, colectomy, bile acid metabolism
- MeSH terms
- Adult, Androstanes, Carbon Isotopes, Chromatography, Gas, Colectomy, Feces, Female, Humans, Ileostomy, Male, Pregnanediol, Pregnanetriol, Spectrum Analysis
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