The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Nonribosomal biosynthesis of peptide antibiotics
Abstract
Peptide antibiotics are known to contain non‐protein amino acids, D‐amino acids, hydroxy acids, and other unusual constituents. In addition they may be modified by N‐methylation and cyclization reactions. Their biosynthetic origin has been connected in many cases to an enzymatic system referred to as the ‘thiotemplate multienzymic mechanism’. This mechanism includes the activation of the constituent residues as adenylates on the enzymic template, the acylation of specific template thiol groups, epimerization or N‐methylation at this thioester stage, and polymerization in the sequence directed by the multienzymic structure with the aid of 4′‐phosphopantetheine as a cofactor, including possible cyclization or terminal modification reactions. The reaction sequences leading to gramicidin S, tyrocidine, cyclosporine, bacitracin, polymyxin, actinomycin, enniatin, beauvericin, δ‐(L‐α‐aminoadipyl)‐L‐cysteinyl‐D‐valine and linear gramicidin are discussed. The structures of the multienzymes, their genetic organization, the biological functions of these peptides and results on related systems are discussed.
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Cites
Schimmel, P. (1987) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.56.070187.001013 · Cited by 544
Lechevalier, H. A., & Lechevalier, M. P. (1967) · Annual Review of Microbiology · doi:10.1146/annurev.mi.21.100167.000443 · Cited by 471
Biotechnology of industrial antibiotics
Hermann, J. (1985) · Enzyme and Microbial Technology · doi:10.1016/0141-0229(85)90157-7 · Cited by 368
Martin, J. F., & Liras, P. (1989) · Annual Review of Microbiology · doi:10.1146/annurev.mi.43.100189.001133 · Cited by 327
The transition state transcription regulator abrB of Bacillus subtilis is a DNA binding protein.
Strauch, M. A., Spiegelman, G. B., Perego, M., Johnson, W. C., Burbulys, D., & Hoch, J. A. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03546.x · Cited by 271
Krätzschmar, J., Krause, M., & Marahiel, M. A. (1989) · Journal of Bacteriology · doi:10.1128/jb.171.10.5422-5429.1989 · Cited by 244
Biotechnology of industrial antibiotics
Vandamme, E. J. M. C. (1984) · Medical Entomology and Zoology · Cited by 205
Phenoxazinone synthase: mechanism for the formation of the phenoxazinone chromophore of actinomycin
Barry, C. E., Nayar, P. G., & Begley, T. P. (1989) · Biochemistry · doi:10.1021/bi00441a026 · Cited by 196
Biosynthesis of Peptide Antibiotics
Kleinkauf, H., & Von Dohren, H. (1987) · Annual Review of Microbiology · doi:10.1146/annurev.mi.41.100187.001355 · Cited by 172
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Cited by
Genetics and Assembly Line Enzymology of Siderophore Biosynthesis in Bacteria
Crosa, J. H., & Walsh, C. T. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.2.223-249.2002 · Cited by 797
Groundworks for an evolutionary biochemistry: The iron-sulphur world
Wächtershäuser, G. (1992) · Progress in Biophysics and Molecular Biology · doi:10.1016/0079-6107(92)90022-x · Cited by 677
Meyer, J.-M. (2000) · Archives of Microbiology · doi:10.1007/s002030000188 · Cited by 437
Emerging knowledge of regulatory roles of d-amino acids in bacteria
Cava, F., Lam, H., de Pedro, M. A., & Waldor, M. K. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0571-8 · Cited by 400
Mootz, H. D., & Marahiel, M. A. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.21.6843-6850.1997 · Cited by 300
Metadata
- Authors
- KLEINKAUF, H., & von DÖHREN, H.
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 1990-08
- Volume
- 192
- Issue
- 1
- Pages
- 1-15
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W1996610802
- Cited by
- 314
- References
- 25
- FWCI
- 16.91
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
