Groundworks for an evolutionary biochemistry: The iron-sulphur world
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The catalysis was provided by the transition metals and transition metal sulfides themselves of the hydrothermal mound.
“The catalysis was provided by the transition metals and transition metal sulfides themselves of the hydrothermal mound.”
From Early bioenergetic evolution (2013) · cites this paper as [49]
There is a consistent and robust line of biochemical evolutionary reasoning that FeS clusters, chemolithoautotrophy and anaerobes tend to reflect antiquity.
“There is a consistent and robust line of biochemical evolutionary reasoning that FeS clusters, chemolithoautotrophy and anaerobes tend to reflect antiquity [44,49,160,161].”
From Early bioenergetic evolution (2013) · cites this paper as [49]
Cites
Woese, C. R. (1987) · Microbiological Reviews · doi:10.1128/mr.51.2.221-271.1987 · Cited by 5,042 · see citing works
Energy conservation in chemotrophic anaerobic bacteria
Thauer, R. K., Jungermann, K., & Decker, K. (1977) · Bacteriological Reviews · doi:10.1128/br.41.1.100-180.1977 · Cited by 4,146 · see citing works
Selforganization of matter and the evolution of biological macromolecules
Eigen, M. (1971) · Die Naturwissenschaften · doi:10.1007/bf00623322 · Cited by 3,788 · see citing works
Westheimer, F. H. (1987) · Science · doi:10.1126/science.2434996 · Cited by 1,711 · see citing works
Before enzymes and templates: theory of surface metabolism
Wächtershäuser, G. (1988) · Microbiological Reviews · doi:10.1128/mmbr.52.4.452-484.1988 · Cited by 1,242 · see citing works
Self-citationOn the evolution of the genetic code.
Woese, C. R. (1965) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.54.6.1546 · Cited by 487 · see citing works
Chiral selection in poly(C)-directed synthesis of oligo(G)
Joyce, G. F., Visser, G. M., van Boeckel, C. A. A., van Boom, J. H., Orgel, L. E., & van Westrenen, J. (1984) · Nature · doi:10.1038/310602a0 · Cited by 398 · see citing works
Pyrite Formation, the First Energy Source for Life: a Hypothesis
Wächtershäuser, G. (1988) · Systematic and Applied Microbiology · doi:10.1016/s0723-2020(88)80001-8 · Cited by 374 · see citing works
Self-citationVolcanic production of polyphosphates and its relevance to prebiotic evolution
Yamagata, Y., Watanabe, H., Saitoh, M., & Namba, T. (1991) · Nature · doi:10.1038/352516a0 · Cited by 371 · see citing works
Stadtman, T. C. (1990) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.59.070190.000551 · Cited by 364 · see citing works
Submarine hot springs and the origin of life
Miller, S. L., & Bada, J. L. (1988) · Nature · doi:10.1038/334609a0 · Cited by 338 · see citing works
Prebiotic Ribose Synthesis: A Critical Analysis
Shapiro, R. (1988) · Origins of life and evolution of the biosphere · doi:10.1007/bf01808782 · Cited by 276 · see citing works
Lundberg, R. D., & Doty, P. (1957) · Journal of the American Chemical Society · doi:10.1021/ja01572a004 · Cited by 202 · see citing works
Beale, S. I., Gough, S. P., & Granick, S. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.7.2719 · Cited by 200 · see citing works
Submarine hot springs and the origin of life
RUSSELL, M. J., HALL, A. J., CAIRNS-SMITH, A. G., & BRATERMAN, P. S. (1988) · Nature · doi:10.1038/336117a0 · Cited by 161 · see citing works
The evolutionary transition from RNA to DNA in early cells
Lazcano, A., Guerrero, R., Margulis, L., & Oró, J. (1988) · Journal of Molecular Evolution · doi:10.1007/bf02101189 · Cited by 119 · see citing works
Prebiotic co-evolution of self-replication and translation or RNA world?
Lahav, N. (1991) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(05)80368-6 · Cited by 28 · see citing works
Did template-directed nucleation precede molecular replication
Orgel, L. E. (1986) · Origins of life and evolution of the biosphere · doi:10.1007/bf01809810 · Cited by 21 · see citing works
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The major evolutionary transitions
Szathmáry, E., & Smith, J. M. (1995) · Nature · doi:10.1038/374227a0 · Cited by 1,095 · see citing works
Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism
Patel, B. H., Percivalle, C., Ritson, D. J., Duffy, C. D., & Sutherland, J. D. (2015) · Nature Chemistry · doi:10.1038/nchem.2202 · Cited by 949 · see citing works
The emergence of life from iron monosulphide bubbles at a submarine hydrothermal redox and pH front
RUSSELL, M. J., & HALL, A. J. (1997) · Journal of the Geological Society · doi:10.1144/gsjgs.154.3.0377 · Cited by 822 · see citing works
On the origin of biochemistry at an alkaline hydrothermal vent
Martin, W., & Russell, M. J. (2007) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1881 · Cited by 771 · see citing works
Activated Acetic Acid by Carbon Fixation on (Fe,Ni)S Under Primordial Conditions
Huber, C., & Wächtershäuser, G. (1997) · Science · doi:10.1126/science.276.5310.245 · Cited by 714 · see citing works
Hazen, R. M., Papineau, D., Bleeker, W., Downs, R. T., Ferry, J. M., McCoy, T. J., Sverjensky, D. A., & Yang, H. (2008) · American Mineralogist · doi:10.2138/am.2008.2955 · Cited by 701 · see citing works
Universality in intermediary metabolism
Smith, E., & Morowitz, H. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404922101 · Cited by 408 · see citing works
Energy conservation via electron-transferring flavoprotein in anaerobic bacteria
Herrmann, G., Jayamani, E., Mai, G., & Buckel, W. (2008) · Journal of Bacteriology · doi:10.1128/jb.01422-07 · Cited by 407 · see citing works
The Origin of Life—Out of the Blue
Sutherland, J. D. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201506585 · Cited by 401 · see citing works
Vasas, V., Fernando, C., Santos, M., Kauffman, S., & Szathmáry, E. (2012) · Biology Direct · doi:10.1186/1745-6150-7-1 · Cited by 369 · see citing works
Mineral surfaces, geochemical complexities, and the origins of life
Hazen, R. M., & Sverjensky, D. A. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002162 · Cited by 344 · see citing works
Nonenzymatic Metabolic Reactions and Life’s Origins
Muchowska, K. B., Varma, S. J., & Moran, J. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00191 · Cited by 317 · see citing works
Zahnle, K., Schaefer, L., & Fegley, B. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004895 · Cited by 298 · see citing works
Sousa, F. L., Thiergart, T., Landan, G., Nelson-Sathi, S., Pereira, I. A. C., Allen, J. F., Lane, N., & Martin, W. F. (2013) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0088 · Cited by 286 · see citing works
“There is a consistent and robust line of biochemical evolutionary reasoning that FeS clusters, chemolithoautotrophy and anaerobes tend to reflect antiquity [44,49,160,161].”
BackgroundIron–sulfur proteins with nonredox functions
Flint, D. H., & Allen, R. M. (1996) · Chemical Reviews · doi:10.1021/cr950041r · Cited by 280 · see citing works
Synthesis of Carbohydrates in Mineral-Guided Prebiotic Cycles
Kim, H.-J., Ricardo, A., Illangkoon, H. I., Kim, M. J., Carrigan, M. A., Frye, F., & Benner, S. A. (2011) · Journal of the American Chemical Society · doi:10.1021/ja201769f · Cited by 268 · see citing works
Glansdorff, N., Xu, Y., & Labedan, B. (2008) · Biology Direct · doi:10.1186/1745-6150-3-29 · Cited by 264 · see citing works
Some like it hot, but not the first biomolecules
Bada, J. L., & Lazcano, A. (2002) · Science · doi:10.1126/science.1069487 · Cited by 222 · see citing works
Vasas, V., Szathmáry, E., & Santos, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912628107 · Cited by 196 · see citing works
The algorithmic origins of life
Walker, S. I., & Davies, P. C. W. (2013) · Journal of The Royal Society Interface · doi:10.1098/rsif.2012.0869 · Cited by 196 · see citing works
From pre‐cells to Eukarya – a tale of two lipids
Wächtershäuser, G. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03267.x · Cited by 176 · see citing works
Self-citationPrebiotic cytosine synthesis: A critical analysis and implications for the origin of life
Shapiro, R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4396 · Cited by 172 · see citing works
Small Molecule Interactions Were Central to the Origin of Life
Shapiro, R. (2006) · The Quarterly Review of Biology · doi:10.1086/506024 · Cited by 180 · see citing works
Schönheit, P., Buckel, W., & Martin, W. F. (2016) · Trends in Microbiology · doi:10.1016/j.tim.2015.10.003 · Cited by 156 · see citing works
Older than genes: the acetyl CoA pathway and origins
Martin, W. F. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00817 · Cited by 132 · see citing works
Early Microbial Evolution: The Age of Anaerobes
Martin, W. F., & Sousa, F. L. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018127 · Cited by 129 · see citing works
Causation and the Origin of Life. Metabolism or Replication First?
Pross, A. (2004) · Origins of life and evolution of the biosphere · doi:10.1023/b:orig.0000016446.51012.bc · Cited by 122 · see citing works
Eschenmoser, A. (2007) · Chemistry & Biodiversity · doi:10.1002/cbdv.200790050 · Cited by 115 · see citing works
Martin, W. F. (2012) · FEBS Letters · doi:10.1016/j.febslet.2011.09.031 · Cited by 108 · see citing works
Serpentinization: connecting geochemistry, ancient metabolism and industrial hydrogenation
Preiner, M., Xavier, J. C., Sousa, F. L., Zimorski, V., Neubeck, A., Lang, S. Q., Greenwell, H. C., Kleinermanns, K., Tüysüz, H., McCollom, T. M., et al. (2018) · Life · doi:10.3390/life8040041 · Cited by 97 · see citing works
On the emergence of life via catalytic iron‐sulphide membranes
Russell, M. J., Daniel, R. M., & Hall, A. J. (1993) · Terra Nova · doi:10.1111/j.1365-3121.1993.tb00267.x · Cited by 92 · see citing works
Quantum Computing for Molecular Biology**
Baiardi, A., Christandl, M., & Reiher, M. (2023) · ChemBioChem · doi:10.1002/cbic.202300120 · Cited by 93 · see citing works
Hydrothermal conditions and the origin of cellular life
Deamer, D. W., & Georgiou, C. D. (2015) · Astrobiology · doi:10.1089/ast.2015.1338 · Cited by 81 · see citing works
Prebiotic Chemistry: What We Know, What We Don’t
Cleaves, H. J. (2012) · Evolution: Education and Outreach · doi:10.1007/s12052-012-0443-9 · Cited by 75 · see citing works
The emergence of life on Earth
Lahav, N., Nir, S., & Elitzur, A. C. (2001) · Progress in Biophysics and Molecular Biology · doi:10.1016/s0079-6107(01)00003-7 · Cited by 73 · see citing works
Walker, S. I., Grover, M. A., & Hud, N. V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034166 · Cited by 70 · see citing works
“It also remains challenging to determine the environmental context from which the first informational polymers emerged, as illustrated by the wide variety of proposed sites for the origin of life, including (but not limited to): tidal shores [19,20], deserts [21], hydrothermal vents [22], mineral surfaces [23–25], the…”
BackgroundSaladino, R., Barontini, M., Cossetti, C., Di Mauro, E., & Crestini, C. (2011) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-011-9236-3 · Cited by 54 · see citing works
Elucidation of an iterative process of carbon-carbon bond formation of prebiotic significance
Loison, A., Dubant, S., Adam, P., & Albrecht, P. (2010) · Astrobiology · doi:10.1089/ast.2009.0441 · Cited by 26 · see citing works
Wächtershäuser, G. (2016) · Journal of Molecular Evolution · doi:10.1007/s00239-015-9727-3 · Cited by 21 · see citing works
Self-citationChemoautotrophic Origin of Life: The Iron–Sulfur World Hypothesis
Wächtershäuser, G. (2010) · Geomicrobiology: Molecular and Environmental Perspective · doi:10.1007/978-90-481-9204-5_1 · Cited by 13 · see citing works
Self-citation
- Authors
- Wächtershäuser, G.
- Corresponding author
- Wächtershäuser, Günter
- Venue
- Progress in Biophysics and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 1992
- Volume
- 58
- Issue
- 2
- Pages
- 85-201
- ISSN
- 0079-6107 (ISSN-L)
- OpenAlex
- W2026255826
- Cited by
- 677
- References
- 18
- Citations by year
- 2026: 19 · 2025: 13 · 2024: 29 · 2023: 36 · 2022: 25 · 2021: 27 · 2020: 24 · 2019: 32 · 2018: 15 · 2017: 22 · 2016: 21 · 2015: 33 · 2014: 10 · 2013: 17 · 2012: 29
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Progress in Biophysics and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Metalloenzymes and iron-sulfur proteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- origin of life, coenzymes, vitamin B12, coenzyme A, adenine biosynthesis, amino acid biosynthesis, purine biosynthesis, pyrimidine synthesis
- MeSH terms
- Origin of Life, Biochemical Phenomena, Biochemistry, Biophysics, Biological Evolution, Iron, Molecular Biology, Sulfur, Biophysical Phenomena
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