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Cited by 347

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Identification of a distinct human high‐density lipoprotein subspecies defined by a lipoprotein‐associated protein, K‐45: Identity of K‐45 with paraoxonase

BLATTER, Marie‐Claude, JAMES, Richard W., MESSMER, Sylvia, BARJA, Francisco, POMETTA, Daniel·1993·European Journal of Biochemistry
DOI 10.1111/j.1432-1033.1993.tb17620.x
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Abstract

In an attempt to provide immunological tools for subfractionation of high‐density lipoproteins (HDL), monoclonal antibodies were raised against HDL complexes. Two clones identified a peptide, provisionally named K‐45 (pI 4.5–4.9; molecular mass 45 kDa, range 42–48 kDa), whose plasma distribution and lipoprotein association were fully characterised. Gel filtration localised the peptide to the HDL region of human plasma where it co‐eluted with apolipoprotein (apo) A‐I, the structural protein of HDL. Complementary studies employing immunoabsorption with anti‐(apo A‐I) antibodies removed 90% of K‐45 from plasma: conversely, anti‐(apo A‐II) antibodies eliminated only 10% of K‐45. Immunoaffinity chromatography on an anti‐(K‐45) column revealed that the peptide was present in a distinct. HDL subspecies containing three major proteins: K‐45, apo A‐I and clusterin or apo J. The lipoprotein nature of the bound fraction was indicated by electron microscopy (diameter 9.6 ± 3.3 nm) and quantification of lipids, the latter showing an unusually high triacyglycerol concentration. Plasma concentrations of K‐45 were positively correlated with apo A‐I and HDL‐cholesterol and negatively correlated with apo B and total cholesterol. Thus, the peptide appears to be linked, directly or indirectly, to processes which give rise to an anti‐atherogenic lipid profile. After completion of the present studies, an N‐terminal sequence identical to that of K‐45 was reported in recently isolated cDNA clones. These clones encode paraxonasc.

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Metadata

Authors
BLATTER, M., JAMES, R. W., MESSMER, S., BARJA, F., & POMETTA, D.
Venue
European Journal of Biochemistry
Publisher
Wiley
Published
1993-02
Volume
211
Issue
3
Pages
871-879
ISSN
  • 0014-2956 (ISSN-L)
  • 1432-1033
DOI
10.1111/j.1432-1033.1993.tb17620.x
OpenAlex
W2049698305
Cited by
347
References
49
FWCI
8.14
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Identification of a distinct human high‐density lipoprotein subspecies defined by a lipoprotein‐associated protein, K‐45: Identity of K‐45 with paraoxonase. https://app.cochat.ai/papers/10.1111/j.1432-1033.1993.tb17620.x
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BLATTER, M., JAMES, R. W., MESSMER, S., BARJA, F., & POMETTA, D. (1993). Identification of a distinct human high‐density lipoprotein subspecies defined by a lipoprotein‐associated protein, K‐45: Identity of K‐45 with paraoxonase. European Journal of Biochemistry. https://doi.org/10.1111/j.1432-1033.1993.tb17620.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.