The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Protein glycosylation: Structural and functional aspects
Abstract
During the last decade, there have been enormous advances in our knowledge of glycoproteins and the stage has been set for the biotechnological production of many of them for therapeutic use. These advances are reviewed, with special emphasis on the structure and function of the glycoproteins (excluding the proteoglycans). Current methods for structural analysis of glycoproteins are surveyed, as are novel carbohydrate–peptide linking groups, and mono‐ and oligo‐saccharide constituents found in these macromolecules. The possible roles of the carbohydrate units in modulating the physicochemical and biological properties of the parent proteins are discussed, and evidence is presented on their roles as recognition determinants between molecules and cells, or cell and cells. Finally, examples are given of changes that occur in the carbohydrates of soluble and cell‐surface glycoproteins during differentiation, growth and malignancy, which further highlight the important role of these substances in health and disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
Carbohydrate-Specific Receptors of the Liver
Ashwell, G., & Harford, J. (1982) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.51.070182.002531 · Cited by 1,914
Molecular genetic basis of the histo-blood group ABO system
Yamamoto, F.-I., Clausen, H., White, T., Marken, J., & Hakomori, S.-I. (1990) · Nature · doi:10.1038/345229a0 · Cited by 1,181
GLYCOSYLATION IN THE NUCLEUS AND CYTOPLASM
Hart, G. W., Haltiwanger, R. S., Holt, G. D., & Kelly, W. G. (1989) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.58.070189.004205 · Cited by 386
Developmental abnormalities in transgenic mice expressing a sialic acid-specific 9-O-acetylesterase
Varki, A., Hooshmand, F., Diaz, S., Varki, N. M., & Hedrick, S. M. (1991) · Cell · doi:10.1016/0092-8674(91)90408-q · Cited by 134
Cited by
Varki, A. (2017) · Glycobiology · doi:10.1093/glycob/cww086 · Cited by 2,635
Physiology of the prion protein
Linden, R., Martins, V. R., Prado, M. A. M., Cammarota, M., Izquierdo, I., & Brentani, R. R. (2008) · Physiological Reviews · doi:10.1152/physrev.00007.2007 · Cited by 617
Evolutionary considerations in relating oligosaccharide diversity to biological function
Gagneux, P., & Varki, A. (1999) · Glycobiology · doi:10.1093/glycob/9.8.747 · Cited by 495
The repertoire of glycan determinants in the human glycome
Cummings, R. D. (2009) · Molecular BioSystems · doi:10.1039/b907931a · Cited by 487
Impact of Product-Related Factors on Immunogenicity of Biotherapeutics
Singh, S. K. (2011) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22276 · Cited by 350
Runkel, L., Meier, W., Pepinsky, R. B., Karpusas, M., Whitty, A., Kimball, K., Brickelmaier, M., Muldowney, C., Jones, W., & Goelz, S. E. (1998) · Pharmaceutical Research · doi:10.1023/a:1011974512425 · Cited by 304
Wandall, H. H., Hassan, H., Mirgorodskaya, E., Kristensen, A. K., Roepstorff, P., Bennett, E. P., Nielsen, P. A., Hollingsworth, M. A., Burchell, J., Taylor-Papadimitriou, J., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.23503 · Cited by 303
N-linked oligosaccharides as outfitters for glycoprotein folding, form and function
Mitra, N., Sinha, S., Ramya, T. N. C., & Surolia, A. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.01.003 · Cited by 302
Developments and Challenges for mAb-Based Therapeutics
Goswami, S., Wang, W., Arakawa, T., & Ohtake, S. (2013) · Antibodies · doi:10.3390/antib2030452 · Cited by 144
N- and O-linked oligosaccharides of allergenic glycoproteins
Fötisch, K., & Vieths*, S. (2001) · Glycoconjugate Journal · doi:10.1023/a:1014860030380 · Cited by 118
Glycosylation shapes the efficacy and safety of diverse protein, gene and cell therapies
Rocamora, F., Peralta, A. G., Shin, S., Sorrentino, J., Wu, M. Y. M., Toth, E. A., Fuerst, T. R., & Lewis, N. E. (2023) · Biotechnology Advances · doi:10.1016/j.biotechadv.2023.108206 · Cited by 67
Amann, T., Schmieder, V., Faustrup Kildegaard, H., Borth, N., & Andersen, M. R. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.27101 · Cited by 46
De Palma, S., Capitanio, D., Vasso, M., Braghetta, P., Scotton, C., Bonaldo, P., Lochmüller, H., Muntoni, F., Ferlini, A., & Gelfi, C. (2014) · Journal of Proteome Research · doi:10.1021/pr500675e · Cited by 40
Metadata
- Authors
- LIS, H., & SHARON, N.
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 1993-11
- Volume
- 218
- Issue
- 1
- Pages
- 1-27
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W1969438932
- Cited by
- 833
- References
- 5
- FWCI
- 11.37
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
