The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Human Peroxisome‐Proliferator‐Activated Receptor‐γ is Activated by Inducers of Adipogenesis, Including Thiazolidinedione Drugs
Open accessAbstract
We have cloned a human cognate of the mouse peroxisome‐proliferator‐activated receptor‐γ (hPPARγ) from a human placenta cDNA library. Sequence analysis reveals a high degree of similarity with the mouse receptor and, like other PPAR, hPPARγ forms heterodimers with the retinoid X receptor α(RXRα) and binds in vitro to DNA elements containing direct repeats of the sequence TGACCT. In common with mouse PPARγ, hPPARγ is expressed strongly in adipose tissue, but significant levels also are detectable in placenta, lung and ovary. In vitro trans ‐activation data suggest hPPARγ is only poorly activated by xenobiotic peroxisome proliferators, although certain fatty acids and eicosanoids are potent activators of this receptor. Both mouse and human PPARγ are capable of being activated by thiazolidinedione drugs, although the two receptors appear to differ in their sensitivity to these compounds. Taken together, these data suggest a high degree of structural and functional similarity between mouse and human PPARγ, and provide evidence for variation in human receptor structure which may result in differential sensitivity to activators.
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Cites
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519
Tugwood, J. D., Issemann, I., Anderson, R. G., Bundell, K. R., McPheat, W. L., & Green, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05072.x · Cited by 895
Self-citation
Cited by
The PPARs: From Orphan Receptors to Drug Discovery
Willson, T. M., Brown, P. J., Sternbach, D. D., & Henke, B. R. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm990554g · Cited by 1,816
The Insulin-Related Ovarian Regulatory System in Health and Disease
Poretsky, L., Cataldo, N. A., Rosenwaks, Z., & Giudice, L. C. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.4.0374 · Cited by 818
Miyazaki, Y., Mahankali, A., Matsuda, M., Mahankali, S., Hardies, J., Cusi, K., Mandarino, L. J., & DeFronzo, R. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.6.8567 · Cited by 726
Polyunsaturated Fatty Acids: Biochemical, Nutritional and Epigenetic Properties
Benatti, P., Peluso, G., Nicolai, R., & Calvani, M. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719371 · Cited by 444
Bajaj, M., Suraamornkul, S., Piper, P., Hardies, L. J., Glass, L., Cersosimo, E., Pratipanawatr, T., Miyazaki, Y., & DeFronzo, R. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031315 · Cited by 358
Metadata
- Authors
- Lambe, K. G., & Tugwood, J. D.
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 1996-07
- Volume
- 239
- Issue
- 1
- Pages
- 1-7
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W2027269951
- Cited by
- 198
- References
- 2
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: A Human Peroxisome‐Proliferator‐Activated Receptor‐γ is Activated by Inducers of Adipogenesis, Including Thiazolidinedione Drugs. https://app.cochat.ai/papers/10.1111/j.1432-1033.1996.0001u.x
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- Lambe, K. G., & Tugwood, J. D. (1996). A Human Peroxisome‐Proliferator‐Activated Receptor‐γ is Activated by Inducers of Adipogenesis, Including Thiazolidinedione Drugs. European Journal of Biochemistry. https://doi.org/10.1111/j.1432-1033.1996.0001u.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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