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Cited by 191Neurological Complications and SyndromesTransplantation: Methods and OutcomesRenal Transplantation Outcomes and Treatments

Neurologic complications after solid organ transplantation.

Marco, Senzolo, Cecilia, Ferronato, Patrizia, Burra·2009·Transplant International
DOI 10.1111/j.1432-2277.2008.00780.x
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Abstract

Neurologic complications are common after solid organ transplantation and are associated with significant morbidity. Approximately one-third of transplant recipients experiences neurologic alterations with incidence ranging from 10% to 59%. The complications can be divided into such of those common to all types of transplant and others of those specific to transplanted organ. The most common complication seen with all types of transplanted organ is neurotoxicity attributable to immunosuppressive drugs, followed by seizures, opportunistic central nervous system (CNS) infections, cardiovascular events, encephalopathy and de novo CNS neoplasms. Amongst immunosuppressants, calcineurin inhibitors are the main drugs involved in neurotoxicity, leading to complications which ranges from mild symptoms, such as tremors and paresthesia to severe symptoms, such as disabling pain syndrome and leukoencephalopathy. Neurologic complications of liver transplantation are more common than that of other solid organ transplants (13-47%); encephalopathy is the most common CNS complication, followed by seizures; however, central pontine myelinolysis can appear in 1-8% of the patients leading to permanent disabilities or death. In kidney transplanted patients, stroke is the most common neurologic complication, whereas cerebral infarction and bleeding are more typical after heart transplantation. Metabolic, electrolyte and infectious anomalies represent common risk factors; however, identification of specific causes and early diagnosis are still difficult, because of patient's poor clinical status and concomitant systemic and metabolic disorders, which may obscure symptoms.

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Authors
Marco, S., Cecilia, F., & Patrizia, B.
Affiliations
Azienda Ospedale - Università Padova (IT)
Venue
Transplant International
Publisher
Frontiers Media SA
Published
2009-03
Volume
22
Issue
3
Pages
269-278
ISSN
  • 0934-0874 (ISSN-L)
  • 1432-2277
DOI
10.1111/j.1432-2277.2008.00780.x
OpenAlex
W2063663826
Cited by
191
References
95
Citations by year
2026: 9 · 2025: 5 · 2024: 6 · 2023: 6 · 2022: 12 · 2021: 9 · 2020: 7 · 2019: 11 · 2018: 14 · 2017: 14 · 2016: 12 · 2015: 16 · 2014: 14 · 2013: 18 · 2012: 15
FWCI
0.98
Type
journal article
Language
en
Open access
closed
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 2375 d)
Locations
  • Transplant International (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
  • Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
  • Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
Keywords
neurological complications, solid organ transplantation, calcineurin inhibitors, seizures, opportunistic CNS infection, encephalopathy, central pontine myelinolysis, stroke, leukoencephalopathy, liver transplantation, kidney transplantation, heart transplantation, central nervous system tumors, risk factors
MeSH terms
Central Nervous System Diseases, Humans, Immunosuppression Therapy, Postoperative Complications, Risk Factors, Incidence, Transplants

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