In vitro evaluation of voriconazole against clinical isolates of yeasts, moulds and dermatophytes in comparison with itraconazole, ketoconazole, amphotericin B and griseofulvin: In vitro Bewertung von Voriconazol gegenüber klinischen Isolaten von Hefen, Schimmelpilzen und Dermatophyten im Vergleich mit Itraconazol, Ketoconazol, Amphotericin B und Griseofulvin
Abstract
Summary. The in vitro activity of voriconazole (UK‐109, 496), a new antifungal triazole derivative, against 650 clinical isolates of yeasts, moulds and dermatophytes was compared with that of itraconazole, ketoconazole, amphotericin B and griseofulvin. The geometric means of the minimum inhibitory concentrations (MICs) of voriconazole were 0.05 μg ml‐1 against yeasts (n= 187), 0.58 μg ml‐1 against moulds (n= 260) and 0.08 μg ml‐1 against dermatophytes (n= 203). The overall activity of voriconazole against yeasts and moulds was good, being similar to that of itraconazole, ketoconazole and amphotericin B. Voriconazole was highly effective against Aspergillus fumigatus (mean MIC 0.23 μg ml‐1) and other Aspergillus species and showed noteworthy activity (mean MICs 0.08‐0.78 μg ml‐1) against emerging and less common clinical isolates of opportunistic moulds, such as Altenaria spp., Cladosporium spp., Acremonium spp., Chrysosporium spp. and Fusarium spp. On the other hand, voriconazole was less active in vitro than the comparative agents studied against various species of zygomycetes, such as Mucor spp., Rhizopus spp. and Absidia spp. Voriconazole and the other two azoles, itraconazole and ketoconazole, were more active than griseofulvin in vitro against most dermatophytes tested. Zusammenfassung. Die In‐vitro‐Aktivität von Voriconazol (UK‐109,496), einem neuen antimy‐kotischen Triazol‐Derivat, wurde gegen 650 klinische Isolate von Hefen, Schimmelpilzen und Dermatophyten mit Itraconazol, Ketoconazol, Amphotericin B und Griseofulvin verglichen. Die mittieren MHK‐Werte (minimalen Hemmkonzentrationen) betrugen gegenüber Hefen 0.05 μg ml‐1 (n= 187), Schimmelpilzen 0.58 μg ml‐1 (n= 260) und Dermatophyten 0.08 μg ml‐1 (n= 203). Insgesamt war die Aktivität von Voriconazol gegen Hefen und Schimmelpilze gut und vergleichbar mit Itraconazol, Ketoconazol und Amphotericin B. Voriconazol war sehr wirksam gegen Aspergillus fumigatus (mittlere MHK 0.23 μg ml‐1) und andere Aspergillus‐Spezies und zeigte ein bemerkenswerte Aktivität (mittlere MHK 0.08‐0.78 μg ml‐1) gegen aufkommende und bisher weniger häufige klinische Isolate opportunistischer Schimmelpilze wie Alternaria spp., Cladosporium spp., Acremonium spp., Chrysosporium spp. und Fusarium spp., Andererseits war Voriconazol in vitro gegen verschiedene Spezies von Zygomyceten wie Mucor spp., Rhizopus spp. und Absidia spp. weniger wirksam als die untersuchten Vergleichssubstanzen. Voriconazol und die anderen beiden Azole, Itraconazol und Ketoconazol, waren in vitro gegen die meisten geprüften Dermatophyten wirksamer als Griseofulvin.
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Azole treatment for fungal infections has limitations such as poor aqueous solubility, limited bioavailability, and common adverse effects from high or prolonged dosing.
“the administration of azoles for treating fungal infections has encountered certain limitations, such as their low water solubility, low bioavailability, and frequent side effects consequent on the requirement of high doses and/or long-term administration.21,42”
Cites
Rex, J. H., Bennett, J. E., Sugar, A. M., Pappas, P. G., van der Horst, C. M., Edwards, J. E., Washburn, R. G., Scheld, W. M., Karchmer, A. W., Dine, A. P., et al. (1994) · New England Journal of Medicine · doi:10.1056/nejm199411173312001 · Cited by 1,039 · see citing works
Therapeutic Outcome in Invasive Aspergillosis
Denning, D. W. (1996) · Clinical Infectious Diseases · doi:10.1093/clinids/23.3.608 · Cited by 694 · see citing works
Oral Azole Drugs as Systemic Antifungal Therapy
Wood, A. J. J., Como, J. A., & Dismukes, W. E. (1994) · New England Journal of Medicine · doi:10.1056/nejm199401273300407 · Cited by 595 · see citing works
Fungal infections in cancer patients: An international autopsy survey
Bodey, G. P., Bueltmann, B., Duguid, W. P., Gibbs, D. L., Hanak, H., Hotchi, M., Mall, G., Martino, P., Meunier, F., Milliken, S., et al. (1992) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf01967060 · Cited by 546 · see citing works
NIAID mycoses study group multicenter trial of oral itraconazole therapy for invasive aspergillosis
Denning, D. W., Lee, J. Y., Hostetler, J. S., Pappas, P. G., Kauffman, C. A., Dewsnup, D. H., Galgiani, J. N., Graybill, J. R., Sugar, A. M., Catanzaro, A., et al. (1994) · The American Journal of Medicine · doi:10.1016/0002-9343(94)90023-x · Cited by 448 · see citing works
Powderly, W. G., Saag, M. S., Cloud, G. A., Robinson, P. A., Meyer, R. D., Jacobson, J. M., Graybill, J. R., Sugar, A. M., McAuliffe, V. J., Follansbee, S., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199203193261203 · Cited by 351 · see citing works
Non-Candida fungal infections after bone marrow transplantation: Risk factors and outcome
Morrison, V. A., Haake, R. J., & Weisdorf, D. J. (1994) · The American Journal of Medicine · doi:10.1016/0002-9343(94)90088-4 · Cited by 214 · see citing works
Radford, S. A., Johnson, E. M., & Warnock, D. W. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.4.841 · Cited by 188 · see citing works
In vitro evaluation of voriconazole against some clinically important fungi
McGinnis, M. R., Pasarell, L., Sutton, D. A., Fothergill, A. W., Cooper, C. R., & Rinaldi, M. G. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.8.1832 · Cited by 132 · see citing works
Antifungal Agents in the 1990s
Kauffman, C. A., & Carver, P. L. (1997) · Drugs · doi:10.2165/00003495-199753040-00001 · Cited by 128 · see citing works
Barry, A. L., & Brown, S. D. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.8.1948 · Cited by 125 · see citing works
Disseminated Infection with Fusarium in Recipients of Bone Marrow Transplants
Gamis, A. S., Guðnason, Þ., Giebink, G. S., & Ramsay, N. K. C. (1991) · Clinical Infectious Diseases · doi:10.1093/clinids/13.6.1077 · Cited by 100 · see citing works
The pharmacokinetics of oral itraconazole in AIDS patients
Smith, D., de Velde, V. V., Woestenborghs, R. J. H., & Gazzard, B. (1992) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1992.tb05478.x · Cited by 77 · see citing works
Fluconazole in the treatment of oropharyngeal candidosis in HIV‐positive patients
Just‐Nübling, G., Gentschew, G., Döhle, M., Böttinger, C., Helm, E.-B., & Stille, W. (1990) · Mycoses · doi:10.1111/myc.1990.33.9-10.435 · Cited by 30 · see citing works
Pharmacology and Pharmacokinetics of Traditional Systemic Antifungal Agents
Barriere, S. L. (1990) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/j.1875-9114.1990.tb02598.x · Cited by 24 · see citing works
The in vitro activity of fluconazole against fungi involved in dermal infections
Wildfeuer, A., & Seidl, H. (1994) · Mycoses · doi:10.1111/j.1439-0507.1994.tb00398.x · Cited by 22 · see citing works
Self-citationWildfeuer, A., Seidl, H. P., Paule, I., & Haberreiter, A. (1997) · PubMed · Cited by 19 · see citing works
Self-citationKintzel, P. E., Rollins, C. J., Yee, W. J., & List, A. F. (1995) · Annals of Pharmacotherapy · doi:10.1177/106002809502900208 · Cited by 18 · see citing works
Kotoğyan, A., Harmanyeri, Y., Güneş, A. T., Erboz, S., Palali, Z., Sabuncu, İ., Kot, S., Baransü, O., Karaman, A., Yazar, Ş., et al. (1996) · Clinical Drug Investigation · doi:10.2165/00044011-199612020-00001 · Cited by 9 · see citing works
DICKINSON, R. P., Bell, A., Hitchcock, C. A., Narayanaswami, S., Ray, S. J., Richardson, K., & Troke, P. F. (1996) · ChemInform · doi:10.1002/chin.199652173 · Cited by 1 · see citing works
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Sorted by citations
Arendrup, M. C., Boekhout, T., Akova, M., Meis, J. F. G. M., Cornely, O. A., & Lortholary, O. (2013) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12360 · Cited by 533 · see citing works
Dignani, M. C., & Anaissie, E. J. (2004) · Clinical Microbiology and Infection · doi:10.1111/j.1470-9465.2004.00845.x · Cited by 351 · see citing works
In vitro susceptibilities of zygomycetes to conventional and new antifungals
Dannaoui, É. (2002) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg020 · Cited by 313 · see citing works
Antifungal drug resistance to azoles and polyenes
Canuto, M. M., & Rodero, F. G. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(02)00371-7 · Cited by 310 · see citing works
Espinel‐Ingroff, A., Boyle, K., & Sheehan, D. J. (2001) · Mycopathologia · doi:10.1023/a:1010954803886 · Cited by 251 · see citing works
Population Pharmacokinetic Analysis of Voriconazole Plasma Concentration Data from Pediatric Studies
Karlsson, M. O., Lutsar, I., & Milligan, P. A. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00751-08 · Cited by 228 · see citing works
Weschta, M., Rimek, D., Formanek, M., Polzehl, D., Podbielski, A., & Riechelmann, H. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.03.038 · Cited by 216 · see citing works
Amphotericin B nasal lavages: Not a solution for patients with chronic rhinosinusitis
Ebbens, F. A., Scadding, G. K., Badia, L., Hellings, P. W., Jorissen, M., Mullol, J., Cardesín, A., Bachert, C., Zele, T. V., Dijkgraaf, M. G. W., et al. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.07.058 · Cited by 212 · see citing works
In Vitro Activities of 10 Antifungal Drugs against 508 Dermatophyte Strains
Fernández-Torres, B., Carrillo, A., Martin, E., del Palacio, A., Moore, M. K., Valverde, A., Serrano, M. C. L., & Guarro, J. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.9.2524-2528.2001 · Cited by 164 · see citing works
Novel triazole antifungal agents
Hoffman, H. L., Ernst, E. J., & Klepser, M. E. (2000) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.9.3.593 · Cited by 133 · see citing works
Collaborative Evaluation of Optimal Antifungal Susceptibility Testing Conditions for Dermatophytes
Fernández-Torres, B., Cabañes, F. J., Carrillo‐Muñoz, A. J., Esteban, A., Inza, I., Abarca, M. L., & Guarro, J. (2002) · Journal of Clinical Microbiology · doi:10.1128/jcm.40.11.3999-4003.2002 · Cited by 126 · see citing works
New Drugs and Novel Targets for Treatment of Invasive Fungal Infections in Patients with Cancer
Chiou, C. C., Groll, A. H., & Walsh, T. J. (2000) · The Oncologist · doi:10.1634/theoncologist.5-2-120 · Cited by 123 · see citing works
Voriconazole—a new therapeutic agent with an extended spectrum of antifungal activity
Donnelly, J. P., & Pauw, B. E. D. (2004) · Clinical Microbiology and Infection · doi:10.1111/j.1470-9465.2004.00838.x · Cited by 111 · see citing works
Review of the safety and efficacy of voriconazole
Rathbun, R. C., & Hoffman, H. L. (2002) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.11.3.409 · Cited by 110 · see citing works
Gupta, A. K., & Tomas, E. T. (2003) · Dermatologic Clinics · doi:10.1016/s0733-8635(03)00024-x · Cited by 107 · see citing works
Scopulariopsis brevicaulis, a Fungal Pathogen Resistant to Broad-Spectrum Antifungal Agents
Cuenca‐Estrella, M., Gómez‐López, A., Mellado, E., Buitrago, M. J., Monzón, A., & Rodrı́guez-Tudela, J. L. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.7.2339-2341.2003 · Cited by 99 · see citing works
Inhibition of human pathogenic fungi by ethnobotanically selected plant extracts
Ficker, C., Arnason, J. T., Vindas, P. S., Álvarez, L. P., Akpagana, K., Gbéassor, M., de Souza, C., & Smith, M. L. (2003) · Mycoses · doi:10.1046/j.1439-0507.2003.00838.x · Cited by 97 · see citing works
Favre, B., Hofbauer, B., Hildering, K.-S., & Ryder, N. S. (2003) · Journal of Clinical Microbiology · doi:10.1128/jcm.41.10.4817-4819.2003 · Cited by 97 · see citing works
DiDomenico, B. (1999) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(99)00009-0 · Cited by 91 · see citing works
Perea, S. H., Fothergill, A. W., Sutton, D. A., & Rinaldi, M. G. (2001) · Journal of Clinical Microbiology · doi:10.1128/jcm.39.1.385-388.2001 · Cited by 91 · see citing works
In vitro activity of antifungals against Zygomycetes
Alastruey‐Izquierdo, A., Castelli, M. V., Cuesta, I., Zaragoza, Ó., Monzón, A., Mellado, E., & Rodríguez-Tudela, J. L. (2009) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2009.02984.x · Cited by 83 · see citing works
Trichosporon beigelii: a life-threatening pathogen in immunocompromised hosts
Erer, B., GALIMBERTI, M., Lucarelli, G. T., Giardini, C., Polchi, P., BARONCIANI, D., Gaziev, J., Angelucci, E., & Izzi, G. C. (2000) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1702231 · Cited by 82 · see citing works
Ebbens, F. A., Georgalas, C., Luiten, S., van Drunen, C. M., Badia, L., Scadding, G. K., Hellings, P. W., Jorissen, M., Mullol, J., Cardesín, A., et al. (2009) · The Laryngoscope · doi:10.1002/lary.20064 · Cited by 78 · see citing works
Ruhnke, M., Cornely, O. A., Schmidt‐Hieber, M., Alakel, N., Boell, B., Buchheidt, D., Christopeit, M., Hasenkamp, J., Heinz, W., Hentrich, M., et al. (2020) · Mycoses · doi:10.1111/myc.13082 · Cited by 76 · see citing works
Zhou, L., Glickman, R. D., Chen, N., Sponsel, W. E., Graybill, J. R., & Lam, K. (2002) · Journal of Chromatography B · doi:10.1016/s1570-0232(02)00344-6 · Cited by 73 · see citing works
The Exciting Future of Antifungal Therapy
Neely, M. N., & Ghannoum, M. A. (2000) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s100960000395 · Cited by 71 · see citing works
Hector, R. F. (2005) · Clinical Techniques in Small Animal Practice · doi:10.1053/j.ctsap.2005.07.005 · Cited by 70 · see citing works
Jenks, J. D., Seidel, D., Cornely, O. A., Chen, W., van Hal, S. J., Kauffman, C. A., Miceli, M. H., Heinemann, M., Christner, M., Jover-Sáenz, A., et al. (2020) · Mycoses · doi:10.1111/myc.13067 · Cited by 63 · see citing works
Omolo, J. J., Johnson, M. M., van Vuuren, S. F., & de Koning, C. B. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.09.088 · Cited by 59 · see citing works
Synthesis and Antifungal Activities of Novel 2-Aminotetralin Derivatives
Bin, Y., Ji, H., Cao, Y., Zhou, Y., Zhu, J., Lü, J., Li, Y., Chen, J., Zheng, C., Jiang, Y., et al. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm0701167 · Cited by 59 · see citing works
Chen, A. L., & Sobel, J. D. (2005) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.10.1.21 · Cited by 60 · see citing works
Cabral, M. E., Figueroa, L. I. C., & Fariña, J. I. (2013) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2012.09.006 · Cited by 54 · see citing works
Phaeohyphomycosis due to Alternaria species in transplant recipients
Boyce, R., Deziel, P. J., Otley, C. C., Wilhelm, M. P., Eid, A. J., Wengenack, N. L., & Razonable, R. R. (2009) · Transplant Infectious Disease · doi:10.1111/j.1399-3062.2009.00482.x · Cited by 57 · see citing works
Carrillo‐Muñoz, A. J., Giusiano, G., Guarro, J., Quindós, G., Guardia, C., del Valle, O., Rodríguez, V., Estivill, D., & Cárdenes, C. D. (2007) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2007.04.004 · Cited by 54 · see citing works
Costa, C. R., Lemos, J. A., Passos, X. S., de Araújo, C. R., Cohen, A. J., Souza, L. K. H. E., & Silva, M. D. R. R. (2006) · Mycopathologia · doi:10.1007/s11046-006-0032-y · Cited by 52 · see citing works
Gerlinger, I., Fittler, A., Fonai, F., Patzkó, Á., Mayer, A., & Botz, L. (2008) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-008-0836-0 · Cited by 51 · see citing works
Imidazole Analogues of Fluoxetine, a Novel Class of Anti-CandidaAgents
Silvestri, R., Artico, M., Regina, G. L., Pasquali, A. D., Martino, G. D., D’Auria, F. D., Nencioni, L., & Palamara, A. T. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm049856v · Cited by 50 · see citing works
Trinh, J. V., Steinbach, W. J., Schell, W. A., Kurtzberg, J., Giles, S. S., & Perfect, J. R. (2003) · Medical Mycology · doi:10.1080/369378031000137369 · Cited by 49 · see citing works
Mattner, F., Weißbrodt, H., & Strueber, M. (2004) · Scandinavian Journal of Infectious Diseases · doi:10.1080/00365540410019408 · Cited by 49 · see citing works
Martin, C. A., Roberts, S., & Greenberg, R. N. (2002) · Clinical Infectious Diseases · doi:10.1086/342302 · Cited by 48 · see citing works
Henrich, T. J., Marty, F. M., Milner, D. A., & Thorner, A. R. (2009) · Transplant Infectious Disease · doi:10.1111/j.1399-3062.2009.00418.x · Cited by 47 · see citing works
Gupta, A. K., Ahmad, I., & Summerbell, R. C. (2002) · Medical Mycology · doi:10.1080/mmy.40.2.201.208 · Cited by 47 · see citing works
Antifungal Pharmacodynamics: Review of the Literature and Clinical Applications
Dodds, E. S., Drew, R. H., & Perfect, J. R. (2000) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.20.17.1335.34901 · Cited by 46 · see citing works
In Vitro Antifungal Susceptibilities of Uncommon Basidiomycetous Yeasts
Serena, C., Pastor, F. J., Ortoneda, M., Capilla, J., NOLARD, N., & Guarro, J. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.7.2724-2726.2004 · Cited by 45 · see citing works
Arıkan, S., & Hasçelik, G. (2002) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(02)00376-0 · Cited by 44 · see citing works
Effect of Nasal Antifungal Therapy on Nasal Cell Activation Markers in Chronic Rhinosinusitis
Weschta, M., Rimek, D., Formanek, M., Podbielski, A., & Riechelmann, H. (2006) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.132.7.743 · Cited by 44 · see citing works
Nardoni, S., Mugnaini, L., Papini, R. A., Fiaschi, M., & Mancianti, F. (2013) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2013.05.005 · Cited by 43 · see citing works
Measurement of voriconazole in serum and plasma
Langman, L. J., & Boakye‐Agyeman, F. (2007) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2007.07.024 · Cited by 43 · see citing works
Onychomycosis caused by Alternaria spp. in Tuscany, Italy from 1985 to 1999
Romano, C., Paccagnini, E., & Difonzo, E. M. (2001) · Mycoses · doi:10.1046/j.1439-0507.2001.00622.x · Cited by 41 · see citing works
Gómez‐López, A. (2001) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/48.6.919 · Cited by 40 · see citing works
Schinabeck, M. K., & Ghannoum, M. A. (2003) · Journal of Chemotherapy · doi:10.1179/joc.2003.15.supplement-2.5 · Cited by 38 · see citing works
Pelegrín, I., Ayats, J., Xiol, X., Cuenca‐Estrella, M., Jucglá, A., Boluda, S., Sabé, N., Rafecas, A., Gudiol, F., & Cabellos, C. (2011) · Transplant Infectious Disease · doi:10.1111/j.1399-3062.2011.00611.x · Cited by 37 · see citing works
Hubka, V., Lysková, P., Frisvad, J. C., Peterson, S. W., Skořepová, M., & Kolařík, M. (2014) · Medical Mycology · doi:10.1093/mmy/myu022 · Cited by 37 · see citing works
Effects of disinfectants on inactivation of mold spores relevant to the food industry: a review
Visconti, V., Coton, E., Rigalma, K., & Dantigny, P. (2021) · Fungal Biology Reviews · doi:10.1016/j.fbr.2021.09.004 · Cited by 34 · see citing works
Simitsopoulou, M., Roilides, E., Maloukou, A., Gil‐Lamaignere, C., & Walsh, T. J. (2007) · Mycoses · doi:10.1111/j.1439-0507.2007.01457.x · Cited by 34 · see citing works
Regina, G. L., D’Auria, F. D., Tafi, A., Piscitelli, F., Olla, S., Caporuscio, F., Nencioni, L., Cirilli, R., Torre, F. L., de Melo, N. R., et al. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm800009r · Cited by 33 · see citing works
Serena, C. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki131 · Cited by 33 · see citing works
van de Sande, W. W. J., & Fahal, A. H. (2024) · Clinical Microbiology Reviews · doi:10.1128/cmr.00034-23 · Cited by 31 · see citing works
Species of Aspergillus section Aspergillus from clinical samples in the United States
Siqueira, J. P. Z., Sutton, D. A., Gené, J., García, D., Wiederhold, N. P., & Guarro, J. (2017) · Medical Mycology · doi:10.1093/mmy/myx085 · Cited by 31 · see citing works
New and Investigational Triazole Agents for the Treatment of Invasive Fungal Infections
Sarro, A. D., Camera, E. L., & Fera, M. T. (2008) · Journal of Chemotherapy · doi:10.1179/joc.2008.20.6.661 · Cited by 31 · see citing works
Eisen, D. P., & Robson, J. (2004) · Mycoses · doi:10.1111/j.1439-0507.2004.00959.x · Cited by 31 · see citing works
Antifúngicos disponibles para el tratamiento de las micosis ungueales
Carrillo‐Muñoz, A. J., Tur‐Tur, C., Hernández-Molina, J. M., Santos, P., Cárdenes, D., & Giusiano, G. (2010) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2010.01.007 · Cited by 30 · see citing works
New developments in chemotherapy for non-invasive fungal infections
Hossain, M. A., & Ghannoum, M. A. (2001) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.10.8.1501 · Cited by 30 · see citing works
Yu, S., Xu, K., Huang, L., Xu, Z. Q., Wang, Y., Bai, G.-J., Wu, Q., Wang, X., & Jiang, Y. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s74989 · Cited by 29 · see citing works
Triazole derivatives with improved in vitro antifungal activity over azole drugs
Yu, S., Chai, X., Wang, Y., Cao, Y., Zhang, J., Wu, Q., Zhang, D., Jiang, Y., Yan, T., & Sun, Q. (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s58680 · Cited by 29 · see citing works
New agents for the treatment of systemic fungal infections – current status
Rex, J. H., & Arıkan, S. (2002) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.7.1.3 · Cited by 29 · see citing works
Aboul-Enein, M. N., El‐Azzouny, A. A., Attia, M. I., Saleh, O. A., & Kansoh, A. L. (2011) · Archiv der Pharmazie · doi:10.1002/ardp.201000224 · Cited by 28 · see citing works
Paecilomyces variotii fungemia in a patient with multiple myeloma: case report and literature review
Salle, V., Lecuyer, E., Chouaki, T., Lescure, F.-X., Smaïl, A., Vaidie, A., Dayen, C., Schmit, J., Ducroix, J. P., & Douadi, Y. (2004) · Journal of Infection · doi:10.1016/j.jinf.2004.09.006 · Cited by 28 · see citing works
Synthesis of some Mannich base derivatives and their antimicrobial activity study
Idhayadhulla, A., Surendrakumar, R., Nasser, A. J. A., Selvin, J., & Manilal, A. (2010) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2010.12.025 · Cited by 28 · see citing works
Zygomycosis:Two Case Reports and Review of Reported Cases in the Literature in Japan
Mori, T., Egashira, M., Kawamata, N., Oshimi, K., Nakamura, K., Oguri, T., Aida, H., Hiruma, A., & 一戸, 正. (2003) · Nippon Ishinkin Gakkai Zasshi · doi:10.3314/jjmm.44.163 · Cited by 28 · see citing works
Hubka, V., Nováková, A., Jurjević, Ž., Sklenář, F., Frisvad, J. C., Houbraken, J. A. M. P., Arendrup, M. C., Jørgensen, K. M., Siqueira, J. P. Z., Gené, J., et al. (2018) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijsem.0.002583 · Cited by 27 · see citing works
New agents for treatment of systemic fungal infections
Arıkan, S., & Rex, J. H. (2000) · Emerging Drugs · doi:10.1517/14728214.5.2.135 · Cited by 26 · see citing works
Newer antifungal therapy for emerging fungal pathogens
Steinbach, W. J., & Perfect, J. R. (2003) · International Journal of Infectious Diseases · doi:10.1016/s1201-9712(03)90037-3 · Cited by 27 · see citing works
Saeed, S., Rashid, N., Jones, P. G., & Tahir, A. (2010) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.510 · Cited by 25 · see citing works
Meerpoel, L., Backx, L. J. J., der Veken, L. J. E. V., Heeres, J., Corens, D., Groot, A. D., Odds, F. C., Gerven, F. V., Woestenborghs, F., Breda, A. V., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm0494772 · Cited by 25 · see citing works
García-Martos, P., García-Agudo, L., Jl, G. C., Ruiz-Aragón, J., Saldarreaga, A., & Marín, P. (2005) · Enfermedades Infecciosas y Microbiología Clínica · doi:10.1157/13070403 · Cited by 24 · see citing works
Weinstein, W. L., Moore, P. A., Sánchez, S., Dietrich, U. M., Wooley, R. E., & Ritchie, B. W. (2006) · American Journal of Veterinary Research · doi:10.2460/ajvr.67.4.562 · Cited by 24 · see citing works
Siqueira, J. P. Z., Sutton, D. A., Gené, J., García, D., Wiederhold, N. P., Peterson, S. W., & Guarro, J. (2017) · Journal of Clinical Microbiology · doi:10.1128/jcm.02012-16 · Cited by 23 · see citing works
Successful treatment of resistant onychomycosis with voriconazole in a liver transplant patient
Nofal, A., Fawzy, M. M., & El‐Hawary, E. E. (2020) · Dermatologic Therapy · doi:10.1111/dth.14014 · Cited by 23 · see citing works
Antifungal susceptibility profile of clinical Alternaria spp. identified by molecular methods
Alastruey‐Izquierdo, A., Cuesta, I., Ros, L., Mellado, E., & Rodríguez-Tudela, J. L. (2011) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkr365 · Cited by 22 · see citing works
Trends in the treatment of dermatophytosis.
del Palacio, A., Garau, M. V., González-Escalada, A., Calvo, M. T., Kushwaha, R. K. S., & Guarro, J. (2000) · Cited by 22 · see citing works
Carrillo‐Muñoz, A. J., Cárdenes, C. D., Carrillo-Orive, B., Rodríguez, V., del Valle, O., Casals, J. B., Ezkurra, P. A., & Quindós, G. (2005) · Revista Iberoamericana de Micología · doi:10.1016/s1130-1406(05)70019-x · Cited by 22 · see citing works
Unusual dermatomycoses caused by Nannizzia nana: the geophilic origin of human infections
Gnat, S., Łagowski, D., Nowakiewicz, A., & Dyląg, M. (2020) · Infection · doi:10.1007/s15010-020-01416-5 · Cited by 21 · see citing works
Central nervous system infection due to Penicillium chrysogenum
Kantarcıoğlu, A. S., Apaydın, H., Yücel, A., de Hoog, S., Samson, R. A., Vural, M., & Özekmekçi, S. (2004) · Mycoses · doi:10.1111/j.1439-0507.2004.00974.x · Cited by 20 · see citing works
Carrillo‐Muñoz, A. J., Fernández-Torres, B., Cárdenes, D., & Guarro, J. (2003) · Chemotherapy · doi:10.1159/000072449 · Cited by 20 · see citing works
Hocquette, A., Grondin, M., Bertout, S., & Mallié, M. (2005) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2005.06.002 · Cited by 18 · see citing works
Saeed, S., Rashid, N., Jones, P. G., & Yunas, U. (2010) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.439 · Cited by 18 · see citing works
Topical 5% Natamycin With Oral Ketoconazole in Filamentous Fungal Keratitis
Rajaraman, R., Bhat, P., Vaidee, V., Maskibail, S., Raghavan, A., Sivasubramaniam, S., & Prajna, N. V. (2014) · Asia-Pacific Journal of Ophthalmology · doi:10.1097/apo.0000000000000035 · Cited by 17 · see citing works
Lal, N., Jangir, S., Bala, V., Mandalapu, D., Sarswat, A., Kumar, L., Jain, A., Kumar, L., Kushwaha, B., Pandey, A. K., et al. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.03.012 · Cited by 17 · see citing works
New options for the treatment of invasive fungal infections
Rubin, Z., & Somani, J. (2004) · Seminars in Oncology · doi:10.1053/j.seminoncol.2004.02.020 · Cited by 14 · see citing works
Dermatophytosis caused by Nannizzia nana in two siblings
Bonifáz, A., Córdoba-García, B., Simancas-Llanos, T., Hernández, M. A. L., Martínez-Herrera, E. O., & Tirado‐Sánchez, A. (2019) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2018.02.003 · Cited by 14 · see citing works
A case of peritonitis caused by Rhizopus microsporus
Monecke, S., Hochauf-Stange, K., Gottschlich, B., & Ehricht, R. (2006) · Mycoses · doi:10.1111/j.1439-0507.2006.01190.x · Cited by 14 · see citing works
Wang, R., Liu, W., Liu, X., Wan, Z., de Hoog, S., Li, R., & Song, Y. (2023) · Emerging Microbes & Infections · doi:10.1080/22221751.2023.2219346 · Cited by 13 · see citing works
Determination of Voriconazole Concentrations in Serum by GC‐MS
Smith, A., & Leung‐Pineda, V. (2015) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.21871 · Cited by 13 · see citing works
New imidazole derivatives of 2(3H)‐benzazolones as potential antifungal agents
Petrov, O., Gerova, M. S., Petrova, K. V., & Ivanova, Y. (2009) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.11 · Cited by 13 · see citing works
Leahy, T. R., Punnett, A., Richardson, S. E., Gharabaghi, F., & Wadhwa, A. (2009) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2009.09.019 · Cited by 12 · see citing works
Ouf, S. A., Gomha, S. M., Farag, B., Zaki, M. E. A., Ewies, M. M., Sharawy, I. A. A., Khalil, F. O., & Mahmoud, H. K. (2024) · Results in Chemistry · doi:10.1016/j.rechem.2024.101406 · Cited by 11 · see citing works
Actividad in vitro de voriconazol y otros tres antifúngicos frente a dermatofitos
Serrano, M. D. C., Chávez-Caballero, M., Valverde, A., Claro, R. M., Pemán, J., & Martín‐Mazuelos, E. (2003) · Enfermedades Infecciosas y Microbiología Clínica · doi:10.1016/s0213-005x(03)72992-9 · Cited by 11 · see citing works
Systemic Infection due to Acremonium after Allogeneic Peripheral Blood Stem Cell Transplantation
Yamazaki, R., Mori, T., Aisa, Y., Nakazato, T., Mihara, A., Ikeda, Y., & Okamoto, S. (2006) · Internal Medicine · doi:10.2169/internalmedicine.45.1827 · Cited by 10 · see citing works
Soft-tissue infection withAbsidia corymbiferaand kidney complications in an AIDS patient
Righi, E., Giacomazzi, C., Bassetti, M., Bisio, F., Soro, O., McDermott, J. L., Varnier, O. E., Ratto, S., & Viscoli, C. (2007) · Medical Mycology · doi:10.1080/13693780701435358 · Cited by 10 · see citing works
- Authors
- Wildfeuer, A., Seidl, H. P., Paule, I., & Haberreiter, A.
- Affiliations
- Pfizer (United States) (US)
- Technical University of Munich (DE)
- Corresponding author
- Wildfeuer, A.
- Venue
- Mycoses
- Publisher
- Wiley
- Published
- 1998-09
- Volume
- 41
- Issue
- 7-8
- Pages
- 309-319
- ISSN
- 0027-5557 (ISSN-L)
- 0933-7407
- 1439-0507
- OpenAlex
- W1992535097
- Cited by
- 140
- References
- 20
- Citations by year
- 2024: 5 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 7 · 2014: 5 · 2013: 3 · 2012: 2
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mycoses (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Health Sciences › Medicine › Epidemiology › Nail Diseases and Treatments
- Keywords
- voriconazole, antifungal activity, yeast, molds, dermatophytes, itraconazole, ketoconazole, amphotericin B, griseofulvin, minimum inhibitory concentration, Aspergillus fumigatus, Zygomycetes, triazole antifungals, clinical isolates
- MeSH terms
- Amphotericin B, Antifungal Agents, Fungi, Griseofulvin, Humans, Ketoconazole, Microbial Sensitivity Tests, Mycoses, Pyrimidines, Triazoles, Itraconazole, Voriconazole
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