Intense vasoconstriction and bradycardia evoked by stimulation of neurones within the midbrain ventral tegmentum of the rabbit
Abstract
Electrical stimulation of sites in the midbrain ventral tegmental area (VTA) and the lateral hypothalamic area of the anaesthetized rabbit elicited intense vasoconstriction and profound bradycardia. The same effects were elicited by microinjections of glutamate ions into the VTA but not the lateral hypothalamic area. Following baroreceptor denervation, the bradycardic component of the response was greatly reduced, but the vasoconstrictor component was unaffected. It is concluded that the cardiovascular response is generated by excitation of a cell group within the VTA, but within the hypothalamus the response arises from excitation of axons of passage.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Electrical brain stimulation at the medial forebrain bundle/VTA increases blood pressure, an effect that is blocked by pretreatment with dopamine antagonists or 6-OHDA, suggesting dopamine mediation.
“Such electrical brain stimulation also increases blood pressure, an effect that is blocked by pretreatment with dopamine antagonists or 6-OHDA (Spring and Winkelmuller, 1975; Tan et al., 1983; Burgess et al., 1993; Cornish and van den Buuse, 1994), suggesting dopamine mediation.”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Tan et al., 1983
Cites
Goodchild, A. K., Dampney, R. A. L., & Bandler, R. J. (1982) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(82)90036-x · Cited by 397 · see citing works
Self-citationDampney, R. A. L., Goodchild, A. K., Robertson, L. G., & Montgomery, W. S. (1982) · Brain Research · doi:10.1016/0006-8993(82)90056-7 · Cited by 319 · see citing works
Self-citationElectrophysiological studies of neurons in the ventral tegmental area of tsai
Yim, C. Y., & Mogenson, G. J. (1980) · Brain Research · doi:10.1016/0006-8993(80)90614-9 · Cited by 184 · see citing works
Distribution of catecholamine‐containing cell bodies in the rabbit central nervous system
Blessing, W. W., Chalmers, J. P., & Howe, P. R. C. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901790210 · Cited by 144 · see citing works
Locomotor activity initiated by microinfusions of picrotoxin into the ventral tegmental area
Mogenson, G. J., Wu, M., & Machanda, S. K. (1979) · Brain Research · doi:10.1016/0006-8993(79)90072-6 · Cited by 86 · see citing works
Gellman, M. D., Schneiderman, N., Wallach, J. H., & LeBlanc, W. G. (1981) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(81)90034-5 · Cited by 42 · see citing works
Potentiation of a cardioinhibitory reflex by hypothalamic stimulation in the rabbit
Evans, M. H. (1978) · Brain Research · doi:10.1016/0006-8993(78)90704-7 · Cited by 28 · see citing works
White, S. W. (1975) · Brain Research · doi:10.1016/0006-8993(75)90413-8 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477 · see citing works
Brain reward circuitry beyond the mesolimbic dopamine system: a neurobiological theory
Ikemoto, S. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.02.001 · Cited by 454 · see citing works
- Authors
- Tan, E., Goodchild, A. K., & Dampney, R. A. L.
- Affiliations
- The University of Sydney (AU)
- Venue
- Clinical and Experimental Pharmacology and Physiology
- Publisher
- Wiley
- Published
- 1983-06
- Volume
- 10
- Issue
- 3
- Pages
- 305-309
- ISSN
- 0305-1870 (ISSN-L)
- 1440-1681
- OpenAlex
- W2007856200
- Cited by
- 19
- References
- 8
- Citations by year
- 2015: 1
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical and Experimental Pharmacology and Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council
- National Medical Research Council
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- ventral tegmental area, lateral hypothalamus, vasoconstriction, bradycardia, glutamate, electrical stimulation, baroreceptor denervation, cardiovascular reflexes, rabbits
- MeSH terms
- Animals, Bradycardia, Electric Stimulation, Hypothalamus, Neurons, Pressoreceptors, Rabbits, Sodium Glutamate, Tegmentum Mesencephali, Vasoconstriction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
