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Cited by 14Cardiovascular and exercise physiologyPhysiological and biochemical adaptationsThermoregulation and physiological responses

Haemodynamic and metabolic responses of laboratory rabbits to near-maximal treadmill exercise

Jover, Bernard, McGrath, Barry P., Ludbrook, John·1987·Clinical and Experimental Pharmacology and Physiology
DOI 10.1111/j.1440-1681.1987.tb02418.x
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Abstract

SUMMARY: 1. The haemodynamic and metabolic responses of four laboratory rabbits to horizontal treadmill exercise at 8, 12, 16 and 20 m/min were studied. The primary haemodynamic variables measured were heart rate, cardiac output and arterial pressure. The metabolic variables measured were arteriovenous oxygen difference, whole‐body oxygen consumption and central venous plasma lactate concentration. 2. Only at 8 m/min did the haemodynamic and metabolic variables reach an approximate steady state. This was the greatest speed at whichaerobic exercise could be sustained for 4 min in all rabbits. 3. As the speed of the treadmill was increased the rabbits showed signs of exhaustion after progressively shorter periods of exercise. Exhaustion was associated with steep rises in central venous plasma lactate concentration. Exhaustion was also usually associated with secondary rises in systemic vascular resistance and arterial pressure, especially at 20 m/min. 4. The asymptotic (maximal) values for heart rate, cardiac index and O 2 consumption were 386 beats/min, 263 ml/kg per min and 21.7 ml/kg per min, respectively. heart do not permit it to run continuously at other than a slow rate. Exhaustion is associated with increasing oxygen debt and, especially at near‐maximal rates of exercise, with intense vasoconstriction in as yet unidentified vascular beds.

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Crossref · 10.1111/j.1440-1681.1987.tb02418.x

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26 of 26 references verified0 citation errors · 0 not checkable

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  • Rabbit in vivo heart rate range is 155-360 bpm, higher than humans but closer to humans than mouse and rat heart rates.

    “Rabbits have an in vivo heart rate range of 155–360 bpm (Gaustad, Rolim, & Wisloff, 2010; Jover, McGrath, & Ludbrook, 1987) which is still higher than humans (Flamm, et al., 1990; Stratton, et al., 1994) but significantly closer than mouse and rats”

    From Small and large animal models in cardiac contraction research: advantages and disadvantages (2014) · cites this paper as Jover, et al., 1987

  • During peak exercise, rabbits can increase heart rate from 155-211 bpm to 328-360 bpm, a 71-112% increase.

    “Exercise studies suggest that rabbits can increase their heart rates from 155–211 bpm to 328–360 bpm (71–112% increase) during peak exercise (Gaustad, et al., 2010; Jover, et al., 1987).”

    From Small and large animal models in cardiac contraction research: advantages and disadvantages (2014) · cites this paper as Jover, et al., 1987

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Authors
Jover, B., McGrath, B. P., & Ludbrook, J.
Affiliations
  • Baker Heart and Diabetes Institute (AU)
  • Monash University (AU)
Corresponding author
Ludbrook, John
ORCID
Jover, Bernard
Venue
Clinical and Experimental Pharmacology and Physiology
Publisher
Wiley
Published
1987-12
Volume
14
Issue
11-12
Pages
811-823
ISSN
  • 0305-1870 (ISSN-L)
  • 1440-1681
DOI
10.1111/j.1440-1681.1987.tb02418.x
OpenAlex
W2047109872
Cited by
14
References
26
Citations by year
2024: 1 · 2022: 1 · 2020: 2 · 2013: 1
FWCI
2.93
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7149 d)
Locations
  • Clinical and Experimental Pharmacology and Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
Keywords
treadmill exercise, exercise exhaustion, hemodynamic response, metabolic response, heart rate, cardiac output, arterial pressure, systemic vascular resistance, arteriovenous oxygen difference, oxygen consumption, aerobic exercise capacity, oxygen debt, vasoconstriction, rabbits
MeSH terms
Animals, Cardiac Output, Physical Exertion, Heart Rate, Hemodynamics, Metabolism, Oxygen, Oxygen Consumption, Rabbits, Vascular Resistance

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