The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
ARGINASE: A CRITICAL REGULATOR OF NITRIC OXIDE SYNTHESIS AND VASCULAR FUNCTION
Open accessAbstract
SUMMARY: Arginase is the focal enzyme of the urea cycle hydrolysing l‐arginine to urea and l‐ornithine. Emerging studies have identified arginase in the vasculature and have implicated this enzyme in the regulation of nitric oxide (NO) synthesis and the development of vascular disease. Arginase inhibits the production of NO via several potential mechanisms, including competition with NO synthase (NOS) for the substrate l‐arginine, uncoupling of NOS resulting in the generation of the NO scavenger, superoxide and peroxynitrite, repression of the translation and stability of inducible NOS protein, inhibition of inducible NOS activity via the generation of urea and by sensitization of NOS to its endogenous inhibitor asymmetric dimethyl‐l‐arginine. Upregulation of arginase inhibits endothelial NOS‐mediated NO synthesis and may contribute to endothelial dysfunction in hypertension, ageing, ischaemia–reperfusion and diabetes. Arginase also redirects the metabolism of l‐arginine to l‐ornithine and the formation of polyamines and l‐proline, which are essential for smooth muscle cell growth and collagen synthesis. Therefore, the induction of arginase may also promote aberrant vessel wall remodelling and neointima formation. Arginase represents a promising novel therapeutic target that may reverse endothelial and smooth muscle cell dysfunction and prevent vascular disease.
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“Finally, it must be noted that arginases play an important role in the regulation of l-arginine levels (144, 259, 734, 804).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [259]
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Cites
Vascular endothelial cells synthesize nitric oxide from L-arginine
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Research works printed but not linked: 1
- Durante W, 2005, Arginase induces endothelial dysfunction and hypertension in obese Zucker rats, Diabetes, 54, A51
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Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms
Rőszer, T. (2015) · Mediators of Inflammation · doi:10.1155/2015/816460 · Cited by 1,762
“Similarly, CD206 expressing human decidual macrophages produce IL-10 and CCL18 with a possible role in the maternal immunological tolerance of the fetus [79].”
BackgroundArginine metabolism and nutrition in growth, health and disease
Wu, G., Bazer, F. W., Davis, T. A., Kim, S. W., Li, P., Marc Rhoads, J., Carey Satterfield, M., Smith, S. B., Spencer, T. E., & Yin, Y. (2009) · Amino Acids · doi:10.1007/s00726-008-0210-y · Cited by 1,362
“Therefore, relative changes in their enzymatic activities serve as major determinants of NO and polyamine production in many cell types (Durante et al. 2007; Li et al. 2001; Wei et al. 2001).”
BackgroundKolluru, G. K., Bir, S. C., & Kevil, C. G. (2012) · International Journal of Vascular Medicine · doi:10.1155/2012/918267 · Cited by 752
“many of the vascular complications observed during diabetes [183].”
BackgroundTakeda, N., O'Dea, E. L., Doedens, A. L., Kim, J., Weidemann, A., Stockmann, C., Asagiri, M., Simon, M. C., Hoffmann, A., & Johnson, R. S. (2010) · Genes & Development · doi:10.1101/gad.1881410 · Cited by 646
Self-citationAmino acid metabolism in health and disease
Ling, Z., Jiang, Y.-F., Ru, J.-N., Lu, J.-H., Ding, B., & Wu, J. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01569-3 · Cited by 590
“171,205,206 Fig.”
Metadata
- Authors
- Durante, W., Johnson, F. K., & Johnson, R. A.
- Affiliations
- University of Missouri (US)
- Tulane University (US)
- Corresponding author
- Durante, William
- Venue
- Clinical and Experimental Pharmacology and Physiology
- Publisher
- Wiley
- Published
- 2007-04-26
- Volume
- 34
- Issue
- 9
- Pages
- 906-911
- ISSN
- 0305-1870 (ISSN-L)
- 1440-1681
- PMC
- PMC1955221
- OpenAlex
- W2125031388
- Cited by
- 577
- References
- 75
- Citations by year
- 2026: 25 · 2025: 29 · 2024: 21 · 2023: 27 · 2022: 32 · 2021: 45 · 2020: 33 · 2019: 21 · 2018: 25 · 2017: 23 · 2016: 33 · 2015: 25 · 2014: 45 · 2013: 40 · 2012: 29
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical and Experimental Pharmacology and Physiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL074966, R01HL076187, R01HL059976)
- National Center for Research Resources (P20RR017659)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Keywords
- arginase, nitric oxide production, nitric oxide synthase, arginine metabolism, urea cycle, endothelial dysfunction, vascular disease, asymmetric dimethylarginine, inducible nitric oxide synthase, superoxide, peroxynitrite, polyamines, proline, smooth muscle cell proliferation, neointima formation, hypertension, ischaemia-reperfusion, diabetes mellitus, aging
- MeSH terms
- Animals, Arginase, Arginine, Cardiovascular Diseases, Collagen, Endothelium, Vascular, Homeostasis, Humans, Muscle, Smooth, Vascular, Nitric Oxide, Urea, Reactive Oxygen Species, Cell Proliferation, Nitric Oxide Synthase Type III
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