Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms
Open accessAbstract
The alternatively activated or M2 macrophages are immune cells with high phenotypic heterogeneity and are governing functions at the interface of immunity, tissue homeostasis, metabolism, and endocrine signaling. Today the M2 macrophages are identified based on the expression pattern of a set of M2 markers. These markers are transmembrane glycoproteins, scavenger receptors, enzymes, growth factors, hormones, cytokines, and cytokine receptors with diverse and often yet unexplored functions. This review discusses whether these M2 markers can be reliably used to identify M2 macrophages and define their functional subdivisions. Also, it provides an update on the novel signals of the tissue environment and the neuroendocrine system which shape the M2 activation. The possible evolutionary roots of the M2 macrophage functions are also discussed.
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The appearance of anti-inflammatory cytokines, such as IL-10, IL-4 or IL-13, promotes the M2 phenotype, which is coordinated by the STAT-6 transcription factor.
“In turn, the appearance of anti-inflammatory cytokines, such as IL-10, IL-4 or IL-13, promotes the M2 phenotype, which is coordinated by the STAT-6 transcription factor [192,193,194].”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [193]
Section 2 identifies IL-4 and IL-13 as M2a-inducing stimuli and includes IL-10 in an M2 activation classification. Section 5 refers to an IL-4 receptor/STAT6 pathway, but also says other signals can promote M2 activation independently of it. The source therefore does not support STAT6 as coordinating the M2 phenotype induced by all three listed cytokines. (LLM, conf=0.88)
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Cites
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481 · see citing works
Macrophage activation and polarization: nomenclature and experimental guidelines
Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337 · see citing works
Macrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335 · see citing works
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528 · see citing works
The M1 and M2 paradigm of macrophage activation: Time for reassessment
Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689 · see citing works
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578 · see citing works
What we talk about when we talk about fat
Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373 · see citing works
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339 · cited 1× · see citing works
“However, it is shown that the resident tissue macrophages have heterogeneous progeny [187, 188].”
BackgroundThe cellular and signaling networks linking the immune system and metabolism in disease
Osborn, O., & Olefsky, J. M. (2012) · Nature Medicine · doi:10.1038/nm.2627 · Cited by 1,551 · see citing works
Epelman, S., Lavine, K. J., Beaudin, A. E., Sojka, D. K., Carrero, J. A., Calderon, B., Brija, T., Gautier, E. L., Ivanov, S., Satpathy, A. T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.11.019 · Cited by 1,494 · see citing works
Sica, A., Schioppa, T., Mantovani, A., & Allavena, P. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.01.003 · Cited by 1,451 · see citing works
Macrophage Polarization in Bacterial Infections
Benoit, M. E., Desnues, B., & Mège, J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.3733 · Cited by 1,317 · see citing works
Bain, C. C., Bravo-Blas, A., Scott, C. L., Gomez Perdiguero, E., Geissmann, F., Henri, S., Malissen, B., Osborne, L. C., Artis, D., & Mowat, A. M. (2014) · Nature Immunology · doi:10.1038/ni.2967 · Cited by 1,178 · see citing works
Trophic macrophages in development and disease
Pollard, J. W. (2009) · Nature Reviews Immunology · doi:10.1038/nri2528 · Cited by 1,178 · see citing works
Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
Nguyen, K. D., Qiu, Y., Cui, X., Goh, Y. P. S., Mwangi, J., David, T., Mukundan, L., Brombacher, F., Locksley, R. M., & Chawla, A. (2011) · Nature · doi:10.1038/nature10653 · Cited by 1,038 · see citing works
Inflammation and Lipid Signaling in the Etiology of Insulin Resistance
Glass, C. K., & Olefsky, J. M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.001 · Cited by 942 · see citing works
Qiu, Y., Nguyen, K. D., Odegaard, J. I., Cui, X., Tian, X., Locksley, R. M., Palmiter, R. D., & Chawla, A. (2014) · Cell · doi:10.1016/j.cell.2014.03.066 · Cited by 869 · see citing works
Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo
Jetten, N., Verbruggen, S. E. L., Gijbels, M. J., Post, M. J., de Winther, M. P. J., & Donners, M. M. P. C. (2013) · Angiogenesis · doi:10.1007/s10456-013-9381-6 · Cited by 841 · see citing works
Macrophage activation switching: an asset for the resolution of inflammation
Porcheray, F., Viaud, S., Rimaniol, A.-C., Léone, C., Samah, B., Dereuddre-Bosquet, N., Dormont, D., & Gras, G. (2005) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2005.02934.x · Cited by 840 · see citing works
Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance
Odegaard, J. I., Ricardo-González, R. R., Eagle, A. R., Vats, D., Morel, C. R., Goforth, M. H., Subramanian, V., Mukundan, L., Ferrante, A. W., & Chawla, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.04.003 · Cited by 840 · see citing works
Possible involvement of the M2 anti‐inflammatory macrophage phenotype in growth of human gliomas
Komohara, Y., Ohnishi, K., Kuratsu, J., & Takeya, M. (2008) · The Journal of Pathology · doi:10.1002/path.2370 · Cited by 738 · see citing works
Arginase: an emerging key player in the mammalian immune system
Munder, M. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00291.x · Cited by 701 · see citing works
A-González, N., Bensinger, S. J., Hong, C., Beceiro, S., Bradley, M. N., Zelcer, N., Deniz, J. M., Ramírez, C. M., Díaz, M., Gallardo, G., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.018 · Cited by 674 · see citing works
Macrophage phenotypes during tissue repair
Novak, M. L., & Koh, T. J. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.1012512 · Cited by 658 · cited 2× · see citing works
“In response to the stimulus they sense, macrophages are being activated, which allows them to combat the pathogens, exert an immunomodulatory role, and maintain tissue integrity [4, 8, 9].”
BackgroundHolcomb, I. N., Kabakoff, R. C., Chan, B., Baker, T. W., Gurney, A. L., Henzel, W. J., Nelson, C., Lowman, H. B., Wright, B. D., Skelton, N. J., et al. (2000) · The EMBO Journal · doi:10.1093/emboj/19.15.4046 · Cited by 658 · see citing works
Macrophage phenotypes in atherosclerosis
Colin, S., Chinetti‐Gbaguidi, G., & Staels, B. (2014) · Immunological Reviews · doi:10.1111/imr.12218 · Cited by 657 · see citing works
Zizzo, G., Hilliard, B. A., Monestier, M., & Cohen, P. L. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200662 · Cited by 650 · see citing works
Godson, C., Mitchell, S., Harvey, K., Petasis, N. A., Hogg, N., & Brady, H. R. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.4.1663 · Cited by 638 · see citing works
Preparing the ground for tissue regeneration: from mechanism to therapy
Forbes, S. J., & Rosenthal, N. A. (2014) · Nature Medicine · doi:10.1038/nm.3653 · Cited by 585 · see citing works
Regulation of Macrophage Polarization and Wound Healing
Ferrante, C., & Leibovich, S. (2012) · Advances in wound care · doi:10.1089/wound.2011.0307 · Cited by 578 · see citing works
ARGINASE: A CRITICAL REGULATOR OF NITRIC OXIDE SYNTHESIS AND VASCULAR FUNCTION
Durante, W., Johnson, F. K., & Johnson, R. A. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04638.x · Cited by 577 · cited 1× · see citing works
“Similarly, CD206 expressing human decidual macrophages produce IL-10 and CCL18 with a possible role in the maternal immunological tolerance of the fetus [79].”
BackgroundTh1/Th2-Regulated Expression of Arginase Isoforms in Murine Macrophages and Dendritic Cells
Munder, M., Eichmann, K., Morán, J. M., Centeno, F., Soler, G., & Modolell, M. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.7.3771 · Cited by 561 · see citing works
Wan, J., Benkdane, M., Teixeira-Clerc, F., Bonnafous, S., Louvet, A., Lafdil, F., Pecker, F., Tran, A., Gual, P., Mallat, A., et al. (2014) · Hepatology · doi:10.1002/hep.26607 · Cited by 558 · see citing works
Dalli, J., & Serhan, C. N. (2012) · Blood · doi:10.1182/blood-2012-04-423525 · Cited by 556 · see citing works
Macrophage Polarisation: an Immunohistochemical Approach for Identifying M1 and M2 Macrophages
Barros, M. H., Hauck, F., Dreyer, J., Kempkes, B., & Niedobitek, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080908 · Cited by 556 · see citing works
Zeyda, M., Farmer, D., Todoric, J., Aszmann, O. C., Speiser, M., Györi, G., Zlabinger, G. J., & Stulnig, T. M. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803632 · Cited by 553 · see citing works
Rivollier, A., He, J., Kole, A., Valatas, V., & Kelsall, B. L. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20101387 · Cited by 548 · see citing works
Regulation of Alternative Macrophage Activation by Galectin-3
MacKinnon, A. C., Farnworth, S. L., Hodkinson, P. S., Henderson, N. C., Atkinson, K. M., Leffler, H., Nilsson, U. J., Haslett, C., Forbes, S. J., & Sethi, T. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2650 · Cited by 543 · see citing works
Progressive replacement of embryo-derived cardiac macrophages with age
Molawi, K., Wolf, Y., Kandalla, P. K., Favret, J., Hagemeyer, N., Frenzel, K., Pinto, A. R., Klapproth, K., Henri, S., MALISSEN, B., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20140639 · Cited by 504 · see citing works
Mannose Receptor-Mediated Regulation of Serum Glycoprotein Homeostasis
Lee, S. J., Evers, S., Röder, D., Parlow, A. F., Risteli, J., Risteli, L., Lee, Y. C., Feizi, T., Langen, H., & Nussenzweig, M. C. (2002) · Science · doi:10.1126/science.1069540 · Cited by 484 · see citing works
C-type lectins in immunity: recent developments
Dambuza, I. M., & Brown, G. D. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.12.002 · Cited by 482 · see citing works
Comparison of polarization properties of human adult microglia and blood‐derived macrophages
Durafourt, B. A., Moore, C. S., Zammit, D., Johnson, T., Zaguia, F., Guiot, M., Bar‐Or, A., & Antel, J. P. (2012) · Glia · doi:10.1002/glia.22298 · Cited by 470 · see citing works
Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages
Raes, G., BAETSELIER, P. D., Noël, W., Beschin, A., Brombacher, F., & Gh., G. H. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.597 · Cited by 443 · see citing works
Suppression of T-cell functions by human granulocyte arginase
Munder, M. (2006) · Blood · doi:10.1182/blood-2006-11-010389 · Cited by 417 · see citing works
Titos, E., Rius, B., González-Périz, A., López-Vicario, C., Morán-Salvador, E., Martínez-Clemente, M., Arroyo, V., & Clària, J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100225 · Cited by 412 · see citing works
Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD.
(2006) · Journal of Neuroinflammation · doi:10.1186/1742-2094-3-27 · Cited by 393 · see citing works
Aron‐Wisnewsky, J., Tordjman, J., Poitou, C., Darakhshan, F., Hugol, D., Basdevant, A., Aissat, A., Guerre-Millo, M., & Clément, K. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0925 · Cited by 379 · see citing works
Adenosine promotes alternative macrophage activation via A2A and A2B receptors
Csóka, B., Selmeczy, Z., Koscsó, B., Németh, Z. H., Pacher, P., Murray, P. J., Kepka‐Lenhart, D., Morris, S. M., Gause, W. C., Leibovich, S. J., et al. (2011) · The FASEB Journal · doi:10.1096/fj.11-190934 · Cited by 378 · see citing works
Ferrante, C. J., Pinhal-Enfield, G., Elson, G., Cronstein, B. N., Hasko, G., Outram, S., & Leibovich, S. J. (2013) · Inflammation · doi:10.1007/s10753-013-9621-3 · Cited by 375 · see citing works
Svensson‐Arvelund, J., Jenmalm, M. C., Matussek, A., Geffers, R., Berg, G. E., & Ernerudh, J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100130 · Cited by 372 · see citing works
Shaul, M. E., Bennett, G., Strissel, K. J., Greenberg, A. S., & Obin, M. S. (2010) · Diabetes · doi:10.2337/db09-1402 · Cited by 370 · see citing works
Solinas, G., Schiarea, S., Liguori, M., Fabbri, M., Pesce, S., Zammataro, L. A., Pasqualini, F., Nebuloni, M., Chiabrando, C., Mantovani, A., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000413 · Cited by 369 · see citing works
Regulation of macrophage activation
Ma, J., Chen, T., Mandelin, J., Čeponis, A., Miller, N. E., Hukkanen, M., Ma, G. F., & Konttinen, Y. T. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3020-0 · Cited by 367 · see citing works
Rőszer, T. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1985-7 · Cited by 338 · see citing works
Self-citationCrain, J. M., Nikodémová, M., & Watters, J. J. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23242 · Cited by 335 · see citing works
Caesar, R., Reigstad, C. S., Bäckhed, H. K., Reinhardt, C., Ketonen, M., Östergren‐Lundén, G., Cani, P. D., & Bäckhed, F. (2012) · Gut · doi:10.1136/gutjnl-2011-301689 · Cited by 330 · see citing works
Svensson‐Arvelund, J., Mehta, R. B., Lindau, R. H., Mirrasekhian, E., Rodríguez‐Martínez, H., Berg, G. E., Lash, G. E., Jenmalm, M. C., & Ernerudh, J. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401536 · Cited by 319 · see citing works
Muraille, É., Léo, O., & Moser, M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00603 · Cited by 313 · see citing works
Hellmann, J. L., Tang, Y., Kosuri, M., Bhatnagar, A., & Spite, M. R. (2011) · The FASEB Journal · doi:10.1096/fj.10-178657 · Cited by 306 · see citing works
Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells
Raes, G., Van den Bergh, R., De Baetselier, P., & Ghassabeh, G. H. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.6561 · Cited by 302 · see citing works
Relloso, M., Puig‐Kröger, A., Pello, Ó. M., Rodríguez‐Fernández, J. L., de la Rosa, G., Longo, N., Navarro, J., Muñoz‐Fernández, M. Á., Sánchez‐Mateos, P., & Corbí, A. L. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.6.2634 · Cited by 301 · see citing works
Arginase modulates nitric oxide production in activated macrophages
Chang, C., Liao, J. C., & Kuo, L. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.274.1.h342 · Cited by 300 · see citing works
Complement, C1q, and C1q-Related Molecules Regulate Macrophage Polarization
Bohlson, S. S., Oâ€TMConner, S. D., Hulsebus, H. J., Ho, M.-M., & Fraser, D. A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00402 · Cited by 299 · see citing works
Kämmerer, U., Eggert, A. O., Kapp, M., McLellan, A. D., Geijtenbeek, T. B. H., Dietl, J., van Kooyk, Y., & Kämpgen, E. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63884-9 · Cited by 296 · see citing works
HUMAN MONOCYTES EXPRESS CD163, WHICH IS UPREGULATED BY IL-10 AND IDENTICAL TO p155
Sulahian, T. H., Högger, P., Wahner, A. E., Wardwell, K., Goulding, N. J., Sorg, C., Droste, A., Stehling, M., Wallace, P. K., Morganelli, P. M., et al. (2000) · Cytokine · doi:10.1006/cyto.2000.0720 · Cited by 281 · see citing works
A Macrophage Protein, Ym1, Transiently Expressed during Inflammation Is a Novel Mammalian Lectin*
Chang, N., Hung, S.-I., Hwa, K., Kato, I., Chen, J.-E., Liu, C.-H., & Chang, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010417200 · Cited by 276 · see citing works
Human recombinant interleukin 4 induces Fc epsilon R2/CD23 on normal human monocytes.
Vercelli, D., Jabara, H. H., Lee, B. W., Woodland, N., Geha, R. S., & Leung, D. Y. M. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.4.1406 · Cited by 274 · see citing works
Müller, U., Stenzel, W., Köhler, G., Werner, C., Polte, T., Hansen, G., Schütze, N., Straubinger, R. K., Blessing, M., McKenzie, A. N. J., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5367 · Cited by 272 · see citing works
Nair, M. G., Du, Y., Perrigoue, J., Zaph, C., Taylor, J. J., Goldschmidt, M. H., Swain, G. P., Yancopoulos, G. D., Valenzuela, D. M., Murphy, A. J., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082048 · Cited by 272 · see citing works
Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation
Osborne, L. C., Monticelli, L. A., Nice, T. J., Sutherland, T. E., Siracusa, M. C., Hepworth, M. R., Tomov, V. T., Kobuley, D. E., Tran, S. V., Bittinger, K. L., et al. (2014) · Science · doi:10.1126/science.1256942 · Cited by 271 · see citing works
Pelegrı́n, P., & Surprenant, A. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.163 · Cited by 265 · see citing works
Adipose tissue macrophages: phenotypic plasticity and diversity in lean and obese states
Morris, D. L., Singer, K., & Lumeng, C. N.-K. (2011) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328347970b · Cited by 260 · see citing works
Molecular Mechanism for Adiponectin-dependent M2 Macrophage Polarization
Mandal, P., Pratt, B. T., Barnes, M. A., McMullen, M. R., & Nagy, L. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.204644 · Cited by 256 · see citing works
Raes, G., Brys, L., Dahal, B. K., Brandt, J., Grooten, J., Brombacher, F., Vanham, G., Noël, W., Bogaert, P., Boonefaes, T., et al. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0304212 · Cited by 246 · see citing works
Local proliferation of macrophages in adipose tissue during obesity-induced inflammation
Haase, J., Weyer, U., Immig, K., Klöting, N., Blüher, M., Eilers, J., Bechmann, I., & Gericke, M. T. (2013) · Diabetologia · doi:10.1007/s00125-013-3139-y · Cited by 237 · see citing works
Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes.
Nassar, G. M., Morrow, J. D., Roberts, L. J., Lakkis, F. G., & Badr, K. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47031-7 · Cited by 234 · see citing works
Welch, J. S., Escoubet‐Lozach, L., Sykes, D. B., Liddiard, K., Greaves, D. R., & Glass, C. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205873200 · Cited by 233 · see citing works
Ling, H., & Recklies, A. D. (2004) · Biochemical Journal · doi:10.1042/bj20040099 · Cited by 225 · see citing works
M1/M2 Macrophage Polarity in Normal and Complicated Pregnancy
Brown, M. B., von Chamier, M., Allam, A. B., & Reyes, L. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00606 · Cited by 224 · see citing works
Regulation of CD163 on human macrophages: cross-linking of CD163 induces signaling and activation
van den Heuvel, M. M., Tensen, C. P., van As, J., van den Berg, T. K., Fluitsma, D. M., Dijkstra, C. D., Döpp, E. A., Droste, A., van Gaalen, F. A., Sorg, C., et al. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.66.5.858 · Cited by 222 · see citing works
Advanced Age Impairs Macrophage Polarization
Mahbub, S., Deburghgraeve, C. R., & Kovacs, E. J. (2012) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2011.0058 · Cited by 222 · see citing works
Wang, Q., Ni, H., Lan, L., Wei, X., Xiang, R., & Wang, Y. (2010) · Cell Research · doi:10.1038/cr.2010.52 · Cited by 219 · see citing works
Sutherland, T. E., Logan, N., Rückerl, D., Humbles, A. A., Allan, S. M., Papayannopoulos, V., Stockinger, B., Maizels, R. M., & Allen, J. E. (2014) · Nature Immunology · doi:10.1038/ni.3023 · Cited by 217 · see citing works
Retnla (Relmα/Fizz1) Suppresses Helminth-Induced Th2-Type Immunity
Pesce, J. T., Ramalingam, T. R., Wilson, M. S., Mentink-Kane, M. M., Thompson, R. W., Cheever, A. W., Urban, J. F., & Wynn, T. A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000393 · Cited by 213 · see citing works
Macrophage Plasticity in Skeletal Muscle Repair
Rigamonti, E., Zordan, P., Sciorati, C., Rovere-Querini, P., & Brunelli, S. (2014) · BioMed Research International · doi:10.1155/2014/560629 · Cited by 196 · see citing works
Skin Wound Healing Is Accelerated and Scarless in the Absence of Commensal Microbiota
Canesso, M. C. C., Vieira, A. T., Castro, T. B. R., Schirmer, B. G. D. A., Cisalpino, D., Martins, F. S., Rachid, M. A., Nicoli, J. R., Teixeira, M. M., & Barcelos, L. S. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400625 · Cited by 182 · see citing works
Greenlee, K. J., Corry, D. B., Engler, D. A., Matsunami, R. K., Tessier, P. A., Cook, R. G., Werb, Z., & Kheradmand, F. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.7312 · Cited by 182 · see citing works
NCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids
Li, P., Spann, N. J., Kaikkonen, M. U., Lu, M. M., Oh, D. Y., Fox, J. N., Bandyopadhyay, G. K., Talukdar, S., Xu, J., Lagakos, W., et al. (2013) · Cell · doi:10.1016/j.cell.2013.08.054 · Cited by 177 · see citing works
Rőszer, T., Menéndez-Gutierrez, M. P., Lefterova, M. I., Alameda, D., Núñez, V., Lazar, M. A., Fischer, T., & Ricote, M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002230 · Cited by 176 · see citing works
Self-citationAllavena, P., Chieppa, M., Bianchi, G., Solinas, G., Fabbri, M., Laškarin, G., & Mantovani, A. (2010) · Journal of Immunology Research · doi:10.1155/2010/547179 · Cited by 170 · see citing works
Liu, T., Jin, H., Ullenbruch, M. R., Hu, B., Hashimoto, N., Moore, B. B., McKenzie, A. N. J., Lukacs, N. W., & Phan, S. H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.5.3425 · Cited by 167 · see citing works
Microparticles from apoptotic platelets promote resident macrophage differentiation
Vasina, E. M., Cauwenberghs, S., Feijge, M. A. H., Heemskerk, J. W. M., Weber, C., & Koenen, R. R. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.94 · Cited by 166 · see citing works
Caescu, C. I., Guo, X., Tesfa, L., Bhagat, T. D., Verma, A. K., Zheng, D., & Stanley, E. R. (2015) · Blood · doi:10.1182/blood-2014-10-608000 · Cited by 151 · see citing works
Ji, Y., Sun, S., Xia, S., Yang, L., Li, X., & Qi, L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.371807 · Cited by 150 · see citing works
Biochemical Characterization of Endogenously Formed Eosinophilic Crystals in the Lungs of Mice*
Guo, L., Johnson, R. S., & Schuh, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.8032 · Cited by 149 · see citing works
Sun, J. T., Ramnath, R. D., Liang, Z., Tamizhselvi, R., & Bhatia, M. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00129.2008 · Cited by 146 · see citing works
Arora, S., Hernández, Y., Erb‐Downward, J. R., McDonald, R. A., Toews, G. B., & Huffnagle, G. B. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.6346 · Cited by 144 · see citing works
Bunt, S. M., Hooley, C., Hu, N., Scahill, C. M., Weavers, H., & Skaer, H. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.07.019 · Cited by 139 · see citing works
Ueda, Y., Kayama, H., Jeon, S. G., Kusu, T., Isaka, Y., Rakugi, H., Yamamoto, M., & Takeda, K. (2010) · International Immunology · doi:10.1093/intimm/dxq449 · Cited by 138 · see citing works
Retinoid X receptors in macrophage biology
Rőszer, T., Menéndez-Gutiérrez, M. P., Cedenilla, M., & Ricote, M. (2013) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.04.004 · Cited by 137 · see citing works
Self-citationInterleukin-33 contributes to both M1 and M2 chemokine marker expression in human macrophages
Joshi, A., Oak, S. R., Hartigan, A. J., Finn, W. G., Kunkel, S. L., Duffy, K. E., Das, A., & Hogaboam, C. M. (2010) · BMC Immunology · doi:10.1186/1471-2172-11-52 · Cited by 135 · see citing works
Tsuchida, Y., Hatao, F., Fujisawa, M., Murata, T., Kaminishi, M., Seto, Y., Hori, M., & Ozaki, H. (2010) · Gut · doi:10.1136/gut.2010.227546 · Cited by 135 · see citing works
Zhou, T., Chen, Y., Li, H., & Zhang, Y. (2006) · PubMed · Cited by 134 · see citing works
Novel Effector Molecules in Type 2 Inflammation: Lessons Drawn from Helminth Infection and Allergy
Nair, M. G., Guild, K. J., & Artis, D. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1393 · Cited by 130 · see citing works
Ward, J. M., Yoon, M., Anver, M. R., Haines, D. C., Kudo, G., Gonzalez, F. J., & Kimura, S. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63972-7 · Cited by 130 · see citing works
Stütz, A. M., Pickart, L. A., Trifilieff, A., Baumruker, T., Prieschl, E. E., & Woisetschläger, M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.4.1789 · Cited by 129 · see citing works
Reid, D. M., Montoya, M., Taylor, P. R., Borrow, P., Gordon, S., Brown, G. D., & Wong, S. Y. C. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0104031 · Cited by 128 · see citing works
Phenotypic characterization of lung macrophages in asthmatic patients: Overexpression of CCL17
Staples, K. J., Hinks, T., Ward, J., Gunn, V., Smith, C. G., & Djukanović, R. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.07.023 · Cited by 126 · see citing works
Expression of the Inhibitory CD200 Receptor Is Associated with Alternative Macrophage Activation
Koning, N., van Eijk, M., Pouwels, W., Brouwer, M. S. M., Voehringer, D., Huitinga, I., Hoek, R. M., Raes, G., & Hamann, J. (2009) · Journal of Innate Immunity · doi:10.1159/000252803 · Cited by 122 · see citing works
Adiponectin Promotes Monocyte-to-Fibroblast Transition in Renal Fibrosis
Yang, J., Lin, S.-C., Chen, G., He, L., Hu, Z., Chan, L., Trial, J., Entman, M. L., & Wang, Y. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013030217 · Cited by 122 · see citing works
Luan, B., Goodarzi, M. O., Phillips, N., Guo, X., Chen, Y. I., Yao, J., Allison, M., Rotter, J. I., Shaw, R. J., & Montminy, M. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.024 · Cited by 120 · see citing works
Fuentes, L., Rőszer, T., & Ricote, M. (2010) · Mediators of Inflammation · doi:10.1155/2010/219583 · Cited by 119 · see citing works
Self-citationChartouni, C. E., Schwarzfischer, L., & Rehli, M. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.05.031 · Cited by 119 · see citing works
Evolutionary Roots of Arginase Expression and Regulation
Dzik, J. M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00544 · Cited by 119 · see citing works
Substance P induces M2-type macrophages after spinal cord injury
Jiang, M., Chung, E., Chi, G. F., Ahn, W., Lim, J. E., Hong, H. S., Kim, D., Choi, H., Kim, J., & Son, Y. (2012) · Neuroreport · doi:10.1097/wnr.0b013e3283572206 · Cited by 119 · see citing works
Lipoxin A 4 attenuates adipose inflammation
Börgeson, E., McGillicuddy, F. C., Harford, K. A., Corrigan, N., Higgins, D. F., MADERNA, P., Roche, H. M., & Godson, C. (2012) · The FASEB Journal · doi:10.1096/fj.12-208249 · Cited by 114 · see citing works
Alternative activation of macrophages in human peritoneum: implications for peritoneal fibrosis
Bellón, T., Martínez, V., Lucendo, B., del Peso, G., Castro, M. J., Aroeira, L. S., Rodríguez-Sanz, A., Ossorio, M., Sánchez-Villanueva, R., Selgas, R., et al. (2011) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfq771 · Cited by 114 · see citing works
van Stijn, C. M. W., Kim, J., Lusis, A. J., Barish, G. D., & Tangirala, R. K. (2014) · The FASEB Journal · doi:10.1096/fj.14-253831 · Cited by 113 · see citing works
Arora, M., Chen, L., Paglia, M., Gallagher, I. J., Allen, J. E., Vyas, Y. M., Ray, A., & Ray, P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508492103 · Cited by 112 · see citing works
M2 macrophage polarisation is associated with alveolar formation during postnatal lung development
Jones, C. V., Williams, T. M., Walker, K. A., Dickinson, H., Sakkal, S., Rumballe, B. A., Little, M. H., Jenkin, G., & Ricardo, S. D. (2013) · Respiratory Research · doi:10.1186/1465-9921-14-41 · Cited by 111 · see citing works
Fujisaka, S., Usui, I., Kanatani, Y., Ikutani, M., Takasaki, I., Tsuneyama, K., Tabuchi, Y., Bukhari, A., Yamazaki, Y., Suzuki, H., et al. (2011) · Endocrinology · doi:10.1210/en.2010-1312 · Cited by 105 · see citing works
Qi, G., Jia, L., Li, Y., Li, H., & Du, J. (2014) · Endocrinology · doi:10.1210/en.2013-2011 · Cited by 105 · see citing works
Ranganathan, P. V., Jayakumar, C., & Ramesh, G. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00580.2012 · Cited by 102 · see citing works
Neuropeptide Y Is Produced by Adipose Tissue Macrophages and Regulates Obesity-Induced Inflammation
Singer, K., Morris, D. L., Oatmen, K. E., Wang, T., DelProposto, J. L., Mergian, T. A., Cho, K. W., & Lumeng, C. N.-K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057929 · Cited by 100 · see citing works
Exocytosis and proteomic analysis of the vesicle content of granular hemocytes from a crayfish
Sricharoen, S., Kim, J. J., Tunkijjanukij, S., & Söderhäll, I. (2005) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2005.03.010 · Cited by 92 · see citing works
Ym1 Is a Neutrophil Granule Protein That Crystallizes in p47 -deficient Mice
Harbord, M., Novelli, M. R., Cañas, B., Power, D., Davis, C., Godovac‐Zimmermann, J., Roes, J., & Segal, A. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110635200 · Cited by 91 · see citing works
Lefèvre, L., Galès, A., Olagnier, D. P., Bernad, J., Perez, L., Burcelin, R., Valentin, A., Auwerx, J. H., Pipy, B., & Coste, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012828 · Cited by 91 · see citing works
Endogenous transforming growth factor‐beta promotes quiescence of primary microglia in vitro
Spittau, B., Wullkopf, L., Zhou, X., Rilka, J., Pfeifer, D., & KRIEGLSTEIN, K. G. (2012) · Glia · doi:10.1002/glia.22435 · Cited by 91 · see citing works
Loures, F. V., de Araújo, E. F., Feriotti, C., Bazan, S. B., da Costa, T. A., Brown, G. D., & Calich, V. L. G. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu136 · Cited by 89 · see citing works
Chung, W., Chang, A. C., Kato, I., & Chang, N.-C. A. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.72.1.72 · Cited by 88 · see citing works
Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines
Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.07.009 · Cited by 88 · see citing works
Kirkpatrick, R. B., Matico, R., McNulty, D. E., Strickler, J. E., & Rosenberg, M. J. (1995) · Gene · doi:10.1016/0378-1119(94)00756-i · Cited by 88 · see citing works
Stempin, C. C., Dulgerian, L. R., Garrido, V. V., & Cerbán, F. M. (2009) · BioMed Research International · doi:10.1155/2010/683485 · Cited by 86 · see citing works
Gordts, P. L. S. M., Foley, E. M., Lawrence, R., Sinha, R., Lameda-Diaz, C., Deng, L., Nock, R., Glass, C. K., Erbilgin, A., Lusis, A. J., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.09.016 · Cited by 86 · see citing works
Arginase and autoimmune inflammation in the central nervous system
Xu, L., Hilliard, B. A., Carmody, R. J., Tsabary, G., Shin, H., Christianson, D. W., & Chen, Y. H. (2003) · Immunology · doi:10.1046/j.1365-2567.2003.01713.x · Cited by 85 · see citing works
Pettitt, T. R., Rowley, A. F., Barrow, S. E., Mallet, A. I., & Secombes, C. J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31505-9 · Cited by 84 · see citing works
In Vivo Depletion of CD206+ M2 Macrophages Exaggerates Lung Injury in Endotoxemic Mice
Kambara, K., Ohashi, W., Tomita, K., Takashina, M., Fujisaka, S., Hayashi, R., Mori, H., Tobe, K., & Hattori, Y. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.09.005 · Cited by 84 · see citing works
Yamaji-Kegan, K., Su, Q., Angelini, D. J., Myers, A. C., Cheadle, C., & Johns, R. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904021 · Cited by 82 · see citing works
van Kooyk, Y., Ilarregui, J. M., & van Vliet, S. J. (2014) · Immunobiology · doi:10.1016/j.imbio.2014.10.002 · Cited by 81 · see citing works
Macrophage Polarization in Pancreatic Carcinoma: Role of Heparanase Enzyme
Hermano, E., Meirovitz, A., Meir, K. S., Nussbaum, G., Appelbaum, L., Peretz, T., & Elkin, M. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju332 · Cited by 81 · see citing works
Heterogeneous induction of microglia M2a phenotype by central administration of interleukin-4
Pepe, G., Calderazzi, G., Maglie, M. D., Villa, A. M., & Vegeto, E. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0211-6 · Cited by 77 · see citing works
Gosset, P., Tillie‐Leblond, I., Oudin, S., Parmentier, O., Wallaert, B., Joseph, M., & Tonnel, A. (1999) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(99)70504-x · Cited by 77 · see citing works
The Scavenger Receptor CD163: Regulation, Promoter Structure and Genomic Organization
Ritter, M., Buechler, C., Langmann, T., Orsó, E., Klucken, J., & Schmitz, G. (1999) · Pathobiology · doi:10.1159/000028105 · Cited by 76 · see citing works
Repair of molluscan tissue injury: role of PDGF and TGF-β
Franchini, A., & Ottaviani, E. (2000) · Tissue and Cell · doi:10.1054/tice.2000.0118 · Cited by 73 · see citing works
Ahn, M., Yang, W., Kim, H., Jin, J., Moon, C., & Shin, T. (2012) · Brain Research · doi:10.1016/j.brainres.2012.03.023 · Cited by 73 · see citing works
Arginase and Arginine Dysregulation in Asthma
Benson, R. C., Hardy, K. A., & Morris, C. R. (2011) · Journal of Allergy · doi:10.1155/2011/736319 · Cited by 72 · see citing works
Critical Role of Regulator G-Protein Signaling 10 (RGS10) in Modulating Macrophage M1/M2 Activation
Lee, J., Chung, J., Kannarkat, G. T., & Tansey, M. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081785 · Cited by 71 · see citing works
Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling
Menéndez-Gutierrez, M. P., Rőszer, T., Fuentes, L., Núñez, V., Escolano, A., Redondo, J. M., Clerck, N. D., METZGER, D., Valledor, A. F., & Ricote, M. (2015) · Journal of Clinical Investigation · doi:10.1172/jci77186 · Cited by 71 · see citing works
Self-citationArginase Activity Mediates Retinal Inflammation in Endotoxin-Induced Uveitis
Zhang, W., Baban, B., Rojas, M., Tofigh, S., Virmani, S. K., Patel, C., Behzadian, M. A., Romero, M. J., Caldwell, R. W., & Caldwell, R. B. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.081115 · Cited by 67 · see citing works
A Lipidomic Perspective on Inflammatory Macrophage Eicosanoid Signaling
Norris, P. C., & Dennis, E. (2013) · Advances in Biological Regulation · doi:10.1016/j.jbior.2013.09.009 · Cited by 66 · see citing works
Nio‐Kobayashi, J., Fujimoto, W., Konno, A., Kon, Y., Owhashi, M., & Iwanaga, T. (2004) · Histochemistry and Cell Biology · doi:10.1007/s00418-004-0654-4 · Cited by 66 · see citing works
Yamaji-Kegan, K., Takimoto, E., Zhang, A., Weiner, N. C., Meuchel, L. W., Berger, A. E., Cheadle, C., & Johns, R. A. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00279.2013 · Cited by 66 · see citing works
Aki, K., Shimizu, A., Masuda, Y., Kuwahara, N., Arai, T., Ishikawa, A., Fujita, E., Mii, A., Natori, Y., Fukunaga, Y., et al. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00374.2009 · Cited by 65 · see citing works
Buechler, C., Eisinger, K., & Krautbauer, S. (2013) · Inflammation & Allergy - Drug Targets · doi:10.2174/18715281113126660060 · Cited by 65 · see citing works
Macrophages control innate inflammation
Akira, S., Misawa, T., Satoh, T., & Saitoh, T. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12151 · Cited by 62 · see citing works
Dupasquier, M., Stoitzner, P., Wan, H., Cerqueira, D. I., van Oudenaren, A., Voerman, J. S. A., Denda‐Nagai, K., Irimura, T., Raes, G., Romani, N., et al. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1005564 · Cited by 62 · see citing works
Hong, H. S., & Son, Y. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.09.090 · Cited by 61 · see citing works
The occurrence of chitin in the hemocytes of invertebrates
Heath-Heckman, E., & McFall‐Ngai, M. (2011) · Zoology · doi:10.1016/j.zool.2011.02.002 · Cited by 60 · see citing works
Tatano, Y., Shimizu, T., & Tomioka, H. (2014) · Scientific Reports · doi:10.1038/srep04146 · Cited by 60 · see citing works
Glucocorticoids Enhance CD163 Expression in Placental Hofbauer Cells
Tang, Z., Niven‐Fairchild, T., Tadesse, S., Norwitz, E. R., Buhimschi, C. S., Buhimschi, I. A., & Guller, S. M. (2012) · Endocrinology · doi:10.1210/en.2012-1575 · Cited by 57 · see citing works
Bhatt, S., Qin, J., Bennett, C. D., Qian, S., Fung, J. J., Hamilton, T. A., & Lü, L. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303073 · Cited by 57 · see citing works
Differing association of macrophage subsets with atherosclerotic plaque stability.
Medbury, H. J., James, J., Ngo, J., Hitos, K., Wang, Y., Dc, H., & Jp, F. (2013) · PubMed · Cited by 57 · see citing works
The immune inhibitory complex CD200/CD200R is developmentally regulated in the mouse brain
Shrivastava, K., González, P., & Acarín, L. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23062 · Cited by 56 · see citing works
Activated Hepatic Stellate Cells Mediate the Differentiation of Macrophages
Chang, J., Hisamatsu, T., Shimamura, K., Yoneno, K., Adachi, M., Naruse, H., Igarashi, T., Higuchi, H., Matsuoka, K., Kitazume, M. T., et al. (2013) · Hepatology Research · doi:10.1111/j.1872-034x.2012.01111.x · Cited by 56 · see citing works
Dissociation of Endotoxin Tolerance and Differentiation of Alternatively Activated Macrophages
Rajaiah, R., Perkins, D. J., Polumuri, S. K., Zhao, A., Keegan, A. D., & Vogel, S. N. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202407 · Cited by 55 · see citing works
Increased Level of Arginase Activity Correlates with Disease Severity in HIV‐Seropositive Patients
Cloke, T., Garvey, L. J., Choi, B., Abebe, T., Hailu, A., Hancock, M., Kadolsky, U. D., Bangham, C. R. M., Munder, M., Müller, I., et al. (2010) · The Journal of Infectious Diseases · doi:10.1086/653736 · Cited by 55 · see citing works
Beta adrenoceptor regulation of macrophage arginase activity☆☆☆
Bernard, A. C., Fitzpatrick, E. A., Maley, M. E., Gellin, G. L., Tsuei, B. J., Arden, W. A., Boulanger, B. R., Kearney, P. A., & Ochoa, J. B. (2000) · Surgery · doi:10.1067/msy.2000.104115 · Cited by 55 · see citing works
Preza, G. C., Tanner, K., Elliott, J. E., Yang, O. O., Anton, P. A., & Ochoa, M. T. (2013) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2013.0145 · Cited by 51 · see citing works
Localized retinal neuropeptide regulation of macrophage and microglial cell functionality
Kawanaka, N., & Taylor, A. W. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.09.025 · Cited by 50 · see citing works
Chang, Z. L. (2009) · Biology of the Cell · doi:10.1042/bc20080227 · Cited by 49 · see citing works
Karniychuk, U. U., & Nauwynck, H. (2009) · Placenta · doi:10.1016/j.placenta.2009.03.016 · Cited by 49 · see citing works
Chen, W., Liu, J., Meng, J., Lu, C., Li, X., Wang, E., & Shan, F. (2012) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-012-1240-6 · Cited by 48 · see citing works
Hegyi, B., Környei, Z., Ferenczi, S., Fekete, R., Kudlik, G., Kovács, K., Madarász, E., & Uher, F. (2014) · Stem Cells and Development · doi:10.1089/scd.2014.0088 · Cited by 48 · see citing works
Sakaguchi, S., Shono, J., Suzuki, T., Sawano, S., Anderson, J. E., Do, M. Q., Ohtsubo, H., Mizunoya, W., Sato, Y., Nakamura, M., et al. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.05.032 · Cited by 44 · see citing works
LPS converts Gr-1+CD115+ myeloid-derived suppressor cells from M2 to M1 via P38 MAPK
Yang, Y., Zhang, R., Xia, F., Zou, T., Huang, A., Xiong, S., & Zhang, J. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.05.007 · Cited by 41 · see citing works
Müller, U., Stenzel, W., Piehler, D., Grahnert, A., Protschka, M., Köhler, G., Frey, O., Held, J., Richter, T., Eschke, M., et al. (2013) · International Immunology · doi:10.1093/intimm/dxt003 · Cited by 40 · see citing works
Moreno, C., Prieto, P., Macías, Á., Pimentel-Santillana, M., de la Cruz, A., Través, P. G., Boscá, L., & Valenzuela, C. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300235 · Cited by 40 · see citing works
Badariotti, F., Lelong, C., Dubos, M., & Favrel, P. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05898.x · Cited by 40 · see citing works
Nadella, V., Wang, Z., Johnson, T. S., Griffin, M., & Devitt, A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.09.020 · Cited by 40 · see citing works
Macia, L., Yulyaningsih, E., Pangon, L., Nguyen, A., Lin, S., Shi, Y. C., Zhang, L., Bijker, M. S., Grey, S. T., Mackay, F., et al. (2012) · Diabetes · doi:10.2337/db12-0156 · Cited by 40 · see citing works
Boomershine, C. S., Lafuse, W. P., & Zwilling, B. S. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00134-4 · Cited by 39 · see citing works
la Fuente, M. D., Delgado, M., Rio, M. D., Martínez, C., Hernánz, Á., & Gomariz, R. P. (1993) · Regulatory Peptides · doi:10.1016/0167-0115(93)90163-3 · Cited by 39 · see citing works
VIP and PACAP Induce Shift to a Th2 Response by Upregulating B7.2 Expression
Delgado, M., Leceta, J., Sun, W. C., Gomariz, R. P., & Ganea, D. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06952.x · Cited by 38 · see citing works
Pongsomboon, S., Tang, S., Boonda, S., Aoki, T., Hırono, I., Yasuike, M., & Tassanakajon, A. (2008) · BMB Reports · doi:10.5483/bmbrep.2008.41.9.670 · Cited by 38 · see citing works
Blum, A. M., Setiawan, T., Hang, L., Stoyanoff, K. M., & Weinstock, J. V. (2008) · Infection and Immunity · doi:10.1128/iai.00358-08 · Cited by 37 · see citing works
Némethova, A., Michel, K., Gomez‐Pinilla, P. J., Boeckxstaens, G. E., & Schemann, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079264 · Cited by 35 · see citing works
Tuluc, F., Meshki, J., Spitsin, S. V., & Douglas, S. D. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.4ab0813-434rr · Cited by 35 · see citing works
Zhao, J., Lv, Z., Wang, F., Wei, J., Zhang, Q., Li, S., Yang, F., Zeng, X., Wu, X., & Wu, Z. (2013) · Parasitology Research · doi:10.1007/s00436-013-3436-x · Cited by 34 · see citing works
Molecular cloning and characterization of markers and cytokines for equid myeloid cells
Steinbach, F., Stark, R., Ibrahim, S. M., El-Gawad, E., Ludwig, H., Walter, J. H., Commandeur, U., & Mauel, S. (2005) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2005.07.015 · Cited by 34 · see citing works
Nuclear Receptors and Clearance of Apoptotic Cells: Stimulating the Macrophage’s Appetite
A-González, N., & Hidalgo, A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00211 · Cited by 34 · see citing works
Arginase inhibition promotes wound healing in mice
Kavalukas, S. L., Uzgare, A. R., Bivalacqua, T. J., & Barbul, A. (2011) · Surgery · doi:10.1016/j.surg.2011.07.012 · Cited by 33 · see citing works
The anti-inflammatory potential of neuropeptide FF in vitro and in vivo
Sun, Y., Zhang, X., Sun, T., He, N., Li, J., Zhuang, Y., Zeng, Q., Yu, J., Fang, Q., & Wang, R. (2013) · Peptides · doi:10.1016/j.peptides.2013.07.003 · Cited by 29 · see citing works
Sarang, Z., Garabuczi, É., Joós, G., Kiss, B., Tóth, K., Rühl, R., & Szondy, Z. (2013) · Immunobiology · doi:10.1016/j.imbio.2013.06.009 · Cited by 28 · see citing works
Golbar, H. M., Izawa, T., Murai, F., Kuwamura, M., & Yamate, J. (2010) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2010.05.011 · Cited by 28 · see citing works
Formation of lipoxins by alveolar macrophages
Kim, S. J. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(88)90473-1 · Cited by 27 · see citing works
Goren, I., Pfeilschifter, J., & Frank, S. (2014) · American Journal of Pathology · doi:10.1016/j.ajpath.2014.08.011 · Cited by 24 · see citing works
Jackson, K. A., Stott, J. L., Horohov, D. W., & Watson, J. L. (2004) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2004.05.001 · Cited by 23 · see citing works
Lipoxin A4 Inhibits NF-κB Activation and Cell Cycle Progression in RAW264.7 Cells
Huang, Y., Wang, H., Cai, Z., Xu, F., & Zhou, X. (2014) · Inflammation · doi:10.1007/s10753-014-9832-2 · Cited by 22 · see citing works
Waern, I., Jia, J., Pejler, G., Zcharia, E., Vlodavsky, I., Li, J., & Wernersson, S. (2010) · Molecular Immunology · doi:10.1016/j.molimm.2010.02.004 · Cited by 21 · see citing works
Li, F., Xu, L., Gai, X., Zhou, Z., Wang, L., Zhang, H., Gai, Y., Song, L., Yu, J., & Liang, C. (2013) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2013.07.042 · Cited by 19 · see citing works
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The Tumor Microenvironment Innately Modulates Cancer Progression
Hinshaw, D. C., & Shevde, L. A. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3962 · Cited by 3,270 · see citing works
Orecchioni, M., Ghosheh, Y., Pramod, A. B., & Ley, K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01084 · Cited by 2,063 · see citing works
The metabolic signature of macrophage responses
Viola, A., Munari, F., Sánchez-Rodríguez, R., Scolaro, T., & Castegna, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01462 · Cited by 2,021 · see citing works
Macrophage Polarization States in the Tumor Microenvironment
Boutilier, A. J., & Elsawa, S. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136995 · Cited by 1,631 · see citing works
Krzyszczyk, P., Schloss, R. S., Palmer, A. F., & Francois Berthiaume, B. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00419 · Cited by 1,562 · see citing works
Moncada, R., Barkley, D., Wagner, F., Chiodin, M., Devlin, J. C., Baron, M., Hajdu, C. H., Simeone, D. M., & Yanai, I. (2020) · Nature Biotechnology · doi:10.1038/s41587-019-0392-8 · Cited by 1,045 · see citing works
Implications of macrophage polarization in autoimmunity
Funes, S. C., Rios, M., Escobar‐Vera, J., & Kalergis, A. M. (2018) · Immunology · doi:10.1111/imm.12910 · Cited by 1,005 · see citing works
Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD
Na, Y. R., Stakenborg, M., Seok, S. H., & Matteoli, G. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0172-4 · Cited by 900 · see citing works
Zhang, S., Chuah, S. J., Lai, R. C., Hui, J. H. P., Lim, S. K., & Toh, W. S. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2017.11.028 · Cited by 919 · see citing works
Macrophage Phenotypes Regulate Scar Formation and Chronic Wound Healing
Hesketh, M., Sahin, K. B., West, Z. E., & Murray, R. Z. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071545 · Cited by 852 · see citing works
M2b macrophage polarization and its roles in diseases
Wang, L., Zhang, S.-X., Wu, H., Rong, X., & Guo, J. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ru1018-378rr · Cited by 889 · see citing works
A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling
Qian, J., Olbrecht, S., Boeckx, B., Vos, H., Laoui, D., Etlioglu, E., Wauters, E., Pomella, V., Verbandt, S., Busschaert, P., et al. (2020) · Cell Research · doi:10.1038/s41422-020-0355-0 · Cited by 818 · see citing works
The liver cancer immune microenvironment: Therapeutic implications for hepatocellular carcinoma
Donné, R., & Lujambio, A. (2022) · Hepatology · doi:10.1002/hep.32740 · Cited by 651 · see citing works
Jayasingam, S., Citartan, M., Thang, T. H., Zin, A. A. M., Kai, C.-E.-A., & Ch'ng, E. S. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2019.01512 · Cited by 554 · see citing works
M1/M2 macrophages and their overlaps – myth or reality?
Strizova, Z. O., Benešová, I., Bartolini, R., Novysedlák, R., Cecrdlova, E., Foley, L. K., & Střı́ž, I. (2023) · Clinical Science · doi:10.1042/cs20220531 · Cited by 655 · see citing works
Myc Cooperates with Ras by Programming Inflammation and Immune Suppression
Kortlever, R. M., Sodir, N. M., Wilson, C. H., Burkhart, D. L., Pellegrinet, L., Brown Swigart, L., Littlewood, T. D., & Evan, G. I. (2017) · Cell · doi:10.1016/j.cell.2017.11.013 · Cited by 553 · see citing works
Exosome‐Guided Phenotypic Switch of M1 to M2 Macrophages for Cutaneous Wound Healing
Kim, H., Wang, S. Y., Kwak, G., Yang, Y., Kwon, I. C., & Kim, S. H. (2019) · Advanced Science · doi:10.1002/advs.201900513 · Cited by 542 · see citing works
Myeloid immunosuppression and immune checkpoints in the tumor microenvironment
Nakamura, K., & Smyth, M. J. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0306-1 · Cited by 521 · see citing works
Metabolism, metabolites, and macrophages in cancer
Li, M., Yang, Y., Xiong, L., Jiang, P., Wang, J., & Li, C. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01478-6 · Cited by 518 · see citing works
Macrophages and the maintenance of homeostasis
Mosser, D. M., Hamidzadeh, K., & Gonçalves, R. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00541-3 · Cited by 509 · see citing works
Macrophage polarization: an important role in inflammatory diseases
Luo, M., Zhao, F., Cheng, H., Su, M., & Wang, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1352946 · Cited by 515 · see citing works
Tumor‐associated macrophages in liver cancer: From mechanisms to therapy
Cheng, K., Cai, N., Zhu, J.-H., Yang, X., Liang, H.-F., & Zhang, W.-G. (2022) · Cancer Communications · doi:10.1002/cac2.12345 · Cited by 447 · see citing works
Material stiffness influences the polarization state, function and migration mode of macrophages
Sridharan, R., Cavanagh, B., Cameron, A. R., Kelly, D. J., & O'Brien, F. J. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.02.048 · Cited by 450 · see citing works
Macrophages: The Good, the Bad, and the Gluttony
Ross, E. A., Devitt, A., & Johnson, J. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.708186 · Cited by 436 · see citing works
Hall, B. M., Balan, V., Gleiberman, A. S., Strom, E., Krasnov, P., Virtuoso, L. P., Rydkina, E., Vujcic, S., Balan, K., Gitlin, I. I., et al. (2017) · Aging · doi:10.18632/aging.101268 · Cited by 407 · see citing works
Immune Cells in the BBB Disruption After Acute Ischemic Stroke: Targets for Immune Therapy?
Qiu, Y., Zhang, C., Chen, A., Wang, H.-L., Zhou, Y., Li, Y., & Hu, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.678744 · Cited by 405 · see citing works
Macrophage Polarization and Osteoporosis: A Review
Muñoz, J., Akhavan, N. S., Mullins, A. P., & Arjmandi, B. H. (2020) · Nutrients · doi:10.3390/nu12102999 · Cited by 389 · see citing works
Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer
Li, C., Xu, X., Wei, S., Jiang, P., Xue, L., & Wang, J. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001341 · Cited by 360 · see citing works
Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets
Guan, F., Wang, R., Yi, Z., Luo, P., Liu, W., Xie, Y., Liu, Z., Xia, Z., Zhang, H., & Cheng, Q. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02124-y · Cited by 371 · see citing works
Macrophage biology in the peripheral nervous system after injury
Zigmond, R. E., & Echevarría, F. D. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.12.001 · Cited by 369 · see citing works
Regulating IRFs in IFN Driven Disease
Jefferies, C. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00325 · Cited by 364 · see citing works
Macrophages: An Inflammatory Link Between Angiogenesis and Lymphangiogenesis
Corliss, B. A., Azimi, M. S., Munson, J. M., Peirce, S. M., & Murfee, W. L. (2016) · Microcirculation · doi:10.1111/micc.12259 · Cited by 356 · see citing works
Dual roles and therapeutic targeting of tumor-associated macrophages in tumor microenvironments
Xu, J., Ding, L., Mei, J., Hu, Y., Kong, X., Dai, S., Bu, T., Xiao, Q., & Ding, K. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02325-5 · Cited by 356 · see citing works
Wang, J., Li, D., Cang, H., & Guo, B. (2019) · Cancer Medicine · doi:10.1002/cam4.2327 · Cited by 353 · see citing works
Lund, M. E., To, J., O’Brien, B. A., & Donnelly, S. (2016) · Journal of Immunological Methods · doi:10.1016/j.jim.2016.01.012 · Cited by 345 · see citing works
Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging
Ma, S., Sun, S., Geng, L., Song, M., Wang, W., Ye, Y., Ji, Q., Zou, Z., Wang, S., He, X., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.008 · Cited by 349 · see citing works
Major pathways involved in macrophage polarization in cancer
Kerneur, C., Cano, C. E., & Olive, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1026954 · Cited by 348 · see citing works
Tumor-associated macrophages: an effective player of the tumor microenvironment
Basak, U., Sarkar, T., Mukherjee, S., Chakraborty, S., Dutta, A., Dutta, S., Nayak, D., Kaushik, S., Das, T., & Sa, G. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1295257 · Cited by 346 · see citing works
Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages
Runtsch, M. C., Angiari, S., Hooftman, A., Wadhwa, R., Zhang, Y., Zheng, Y., Spina, J. S., Ruzek, M. C., Argiriadi, M. A., McGettrick, A. F., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.02.002 · Cited by 331 · see citing works
Tumors induce de novo steroid biosynthesis in T cells to evade immunity
Mahata, B., Pramanik, J., van der Weyden, L., Polański, K., Kar, G., Riedel, A., Chen, X. X., Fonseca, N. A., Kundu, K., Campos, L. S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17339-6 · Cited by 329 · see citing works
Xu, Z., Chen, Y., Ma, L., Chen, Y., Liu, J., Guo, Y., Yu, T., Zhang, L., Zhu, L., & Shu, Y. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.01.046 · Cited by 325 · see citing works
Park, J. E., Dutta, B., Tse, S. W., Gupta, N., Tan, C. F., Low, J. K., Yeoh, K. W., Kon, O. L., Tam, J. P., & Sze, S. K. (2019) · Oncogene · doi:10.1038/s41388-019-0782-x · Cited by 317 · see citing works
Resolution of inflammation in bone regeneration: From understandings to therapeutic applications
Newman, H., Shih, Y.-R. V., & Varghese, S. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121114 · Cited by 318 · see citing works
Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes
Gusev, E., & Sarapultsev, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097910 · Cited by 336 · see citing works
Mapping macrophage polarization over the myocardial infarction time continuum
Mouton, A. J., DeLeon‐Pennell, K. Y., Gonzalez, O. J. R., Flynn, E. R., Freeman, T. C., Saucerman, J. J., Garrett, M. R., Ma, Y., Harmancey, R., & Lindsey, M. L. (2018) · Basic Research in Cardiology · doi:10.1007/s00395-018-0686-x · Cited by 307 · see citing works
Galectin-3 Activation and Inhibition in Heart Failure and Cardiovascular Disease: An Update
Suthahar, N., Meijers, W. C., Silljé, H. H. W., Ho, J. E., Liu, F., & de Boer, R. A. (2017) · Theranostics · doi:10.7150/thno.22196 · Cited by 309 · see citing works
Macrophage spatial heterogeneity in gastric cancer defined by multiplex immunohistochemistry
Huang, Y., Wang, M., Yu, S. Y., Costanzo, N. D., Mitchell, C., Achuthan, A. A., Hamilton, J. A., Busuttil, R. A., & Boussioutas, A. (2019) · Nature Communications · doi:10.1038/s41467-019-11788-4 · Cited by 301 · see citing works
Macrophage reaction against biomaterials in the mouse model–phenotypes, functions and markers
Klopfleisch, R. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.07.003 · Cited by 298 · see citing works
When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma
Roesch, S., Rapp, C., Dettling, S., & Herold‐Mende, C. C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020436 · Cited by 293 · see citing works
Diverse macrophages polarization in tumor microenvironment
Rhee, I. (2016) · Archives of Pharmacal Research · doi:10.1007/s12272-016-0820-y · Cited by 291 · see citing works
Macrophage Related Chronic Inflammation in Non-Healing Wounds
Li, M.-R., Hou, Q., Zhong, L.-Z., Zhao, Y.-L., & Fu, X.-B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.681710 · Cited by 289 · see citing works
Alternatively activated macrophages; a double-edged sword in allergic asthma
Abdelaziz, M. H., Abdelwahab, S. F., Wan, J., Cai, W., Wang, H., Cheng, J., Kesavan, D. K., Vasudevan, A., Sadek, A., Su, Z., et al. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02251-w · Cited by 283 · see citing works
Advances in the role of STAT3 in macrophage polarization
Xia, T., Zhang, M., Lei, W., Yang, R., Fu, S.-P., Fan, Z., Yang, Y., & Zhang, T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1160719 · Cited by 289 · see citing works
Macrophages, Inflammation, and Lung Cancer
Conway, E. M., Pikor, L. A., Kung, S. H. Y., Hamilton, M. J., Lam, S. C., Lam, W. L., & Bennewith, K. L. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201508-1545ci · Cited by 285 · see citing works
Single tumor-initiating cells evade immune clearance by recruiting type II macrophagesPreprint
Guo, X., Zhao, Y., Yan, H., Yang, Y., Shen, S., Dai, X., Ji, X., Ji, F., Gong, X., Li, L., et al. (2017) · Genes & Development · doi:10.1101/gad.294348.116 · Cited by 283 · see citing works
Hirz, T., Mei, S., Sarkar, H., Kfoury, Y. S., Wu, S., Verhoeven, B. M., Subtelny, A. O., Zlatev, D. V., Wszolek, M. W., Salari, K., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36325-2 · Cited by 281 · see citing works
Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression
Gurevich, D., Severn, C. E., Twomey, C., Greenhough, A., Cash, J. L., Toye, A., Mellor, H., & Martin, P. (2018) · EMBO Journal · doi:10.15252/embj.201797786 · Cited by 252 · see citing works
Regulation of TNF-Induced Osteoclast Differentiation
Yao, Z., Getting, S. J., & Locke, I. C. (2021) · Cells · doi:10.3390/cells11010132 · Cited by 280 · see citing works
Russo, S. L. M. L., Kwiatkowski, M., Govorukhina, N. I., Bischoff, R., & Melgert, B. N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.746151 · Cited by 280 · see citing works
Role of Macrophages in Acute Lung Injury and Chronic Fibrosis Induced by Pulmonary Toxicants
Laskin, D. L., Malaviya, R., & Laskin, J. D. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy309 · Cited by 263 · see citing works
Targeting of CD163+ Macrophages in Inflammatory and Malignant Diseases
Skytthe, M. K., Graversen, J. H., & Moestrup, S. K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155497 · Cited by 264 · see citing works
Acute Inflammation in Tissue Healing
Soliman, A. M., & Barreda, D. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010641 · Cited by 283 · see citing works
Han, J., Kim, Y. S., Lim, M.-Y., Kim, H. Y., Kong, S., Kang, M., Choo, Y. W., Jun, J. H., Ryu, S., Jeong, H.-Y., et al. (2018) · ACS Nano · doi:10.1021/acsnano.7b09107 · Cited by 261 · see citing works
Takahashi, H., Sakakura, K., Kudo, T., Toyoda, M., Kaira, K., Oyama, T., & Chikamatsu, K. (2016) · Oncotarget · doi:10.18632/oncotarget.14374 · Cited by 260 · see citing works
Bain, C. C., & MacDonald, A. S. (2022) · Mucosal Immunology · doi:10.1038/s41385-021-00480-w · Cited by 253 · see citing works
The many facets of macrophages in rheumatoid arthritis
Siouti, E., & Andreakos, E. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.03.029 · Cited by 249 · see citing works
The Role of Mitophagy in Innate Immunity
Gkikas, I., Palikaras, K., & Tavernarakis, N. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01283 · Cited by 244 · see citing works
Jain, N., Moeller, J., & Vogel, V. (2019) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-062117-121224 · Cited by 237 · see citing works
Melanoma exosomes promote mixed M1 and M2 macrophage polarization
Bardi, G. T., Smith, M. A. L., & Hood, J. L. (2018) · Cytokine · doi:10.1016/j.cyto.2018.02.002 · Cited by 235 · see citing works
Toledo, B., Chen, L. Z., Paniagua-Sancho, M., Marchal, J. A., Perán, M., & Giovannetti, E. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01559-0 · Cited by 242 · see citing works
Therapeutic Targeting of Hepatic Macrophages for the Treatment of Liver Diseases
van der Heide, D., Weiskirchen, R., & Bansal, R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02852 · Cited by 234 · see citing works
Kim, W., Lee, E. J., Bae, I., Myoung, K., Kim, S. T., Park, P. J., Lee, K., Pham, A. V. Q., Ko, J., Oh, S. H., et al. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2020.1793514 · Cited by 232 · see citing works
Martin, C. J., Datta, A., Littlefield, C., Kalra, A., Chapron, C., Wawersik, S., Dagbay, K. B., Brueckner, C. T., Nikiforov, A., Danehy, F. T., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay8456 · Cited by 224 · see citing works
Kovács, B., Vajda, E., & Nagy, E. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184653 · Cited by 224 · see citing works
Kim, K.-H., Kim, Y. H., Son, J. E., Lee, J. H., Kim, S., Choe, M. S., Moon, J. H., Zhong, J., Fu, K., Lenglin, F., et al. (2017) · Cell Research · doi:10.1038/cr.2017.126 · Cited by 217 · see citing works
Progesterone-Related Immune Modulation of Pregnancy and Labor
Shah, N. M., Lai, P. F., Imami, N., & Johnson, M. R. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00198 · Cited by 218 · see citing works
The Current State of Nanoparticle-Induced Macrophage Polarization and Reprogramming Research
Miao, X.-Y., Leng, X.-F., & Zhang, Q. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020336 · Cited by 196 · see citing works
Targeting of M2-like tumor-associated macrophages with a melittin-based pro-apoptotic peptide
Lee, C., Jeong, H., Bae, Y., Shin, K., Kang, S., Kim, H., Oh, J., & Bae, H. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0610-4 · Cited by 211 · see citing works
Blame the signaling: Role of cAMP for the resolution of inflammation
Tavares, L. P., Negreiros-Lima, G. L., Lima, K. M., Silva, P., Pinho, V., Teixeira, M. M., & Sousa, L. P. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105030 · Cited by 205 · see citing works
TNF signaling and macrophages govern fin regeneration in zebrafish larvae
Nguyen-Chi, M., Laplace-Builhé, B., Travnickova, J., Luz-Crawford, P., Tejedor, G., Lutfalla, G., Kissa, K., Jorgensen, C., & Djouad, F. (2017) · Cell Death & Disease · doi:10.1038/cddis.2017.374 · Cited by 190 · see citing works
Macrophage p38α promotes nutritional steatohepatitis through M1 polarization
Zhang, X., Fan, L., Wu, J., Xu, H., Leung, W. Y., Fu, K., Wu, J., Liu, K., Man, K., Yang, X., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.03.014 · Cited by 205 · see citing works
Xu, Y., Romero, R. J., Miller, D., Kadam, L., Mial, T. N., Plazyo, O., Garcia‐Flores, V., Hassan, S. S., Xu, Z., Tarca, A. L., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502055 · Cited by 201 · see citing works
Hofbauer Cells: Their Role in Healthy and Complicated Pregnancy
Reyes, L., & Golos, T. G. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02628 · Cited by 200 · see citing works
Lieberman, N. A. P., DeGolier, K., Kovar, H. M., Davis, A. D., Hoglund, V. J., Stevens, J., Winter, C., Deutsch, G. H., Furlan, S. N., Vitanza, N. A., et al. (2018) · Neuro-Oncology · doi:10.1093/neuonc/noy145 · Cited by 194 · see citing works
Neutrophils in Post-myocardial Infarction Inflammation: Damage vs. Resolution?
Puhl, S., & Steffens, S. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00025 · Cited by 197 · see citing works
Control of innate immune response by biomaterial surface topography, energy, and stiffness
Abaricia, J. O., Farzad, N., Heath, T. J., Simmons, J., Morandini, L., & Olivares-Navarrete, R. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.04.021 · Cited by 199 · see citing works
Emerging Function and Clinical Values of Exosomal MicroRNAs in Cancer
Wang, M., Yu, F., Ding, H., Wang, Y., Li, P., & Wang, K. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.04.027 · Cited by 196 · see citing works
Xin, L., Lin, X.-N., Zhou, F., Li, C., Wang, X., Yu, H.-Y., Pan, Y., Fei, H., Ma, L., & Zhang, S.-Y. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.06.029 · Cited by 173 · see citing works
Ruella, M., Klichinsky, M., Kenderian, S. S., Shestova, O. E., Ziober, A. F., Kraft, D. O., Feldman, M. D., Wasik, M. A., June, C. H., & Gill, S. I. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0850 · Cited by 194 · see citing works
Regulatory cells and the effect of cancer immunotherapy
Iglesias-Escudero, M., Arias-González, N., & Martínez-Cáceres, E. M. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01714-0 · Cited by 195 · see citing works
Molecular Mechanisms Modulating the Phenotype of Macrophages and Microglia
Amici, S. A., Dong, J., & Guerau‐de‐Arellano, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01520 · Cited by 192 · see citing works
Ramesh, A., Kumar, S., Nandi, D., & Kulkarni, A. A. (2019) · Advanced Materials · doi:10.1002/adma.201904364 · Cited by 191 · see citing works
Kozłowska, U., Krawczenko, A., Futoma, K., Jurek, T., Rorat, M., Patrzałek, D., & Klimczak, A. (2019) · World Journal of Stem Cells · doi:10.4252/wjsc.v11.i6.347 · Cited by 188 · see citing works
Benner, B. N., Scarberry, L., Suarez‐Kelly, L. P., Duggan, M. C., Campbell, A. R., Smith, E., Lapurga, G., Jiang, K., Butchar, J. P., Tridandapani, S., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0622-0 · Cited by 185 · see citing works
Macrophage Polarization in Cardiac Tissue Repair Following Myocardial Infarction
Kim, Y., Nurakhayev, S., Nurkesh, A., Zharkinbekov, Z., & Saparov, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052715 · Cited by 185 · see citing works
Extracellular Vesicles in Fatty Liver Promote a Metastatic Tumor Microenvironment
Wang, Z.-J., Kim, S. Y., Tu, W., Kim, J., Xu, A. M., Yang, Y. M., Matsuda, M., Reolizo, L., Tsuchiya, T., Billet, S., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.04.013 · Cited by 181 · see citing works
Eapen, M. S., Hansbro, P. M., McAlinden, K. D., Kim, R., Ward, C., Hackett, T., Walters, E. H., & Sohal, S. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-13888-x · Cited by 180 · see citing works
Gomez‐Brouchet, A., Illac, C., Gilhodes, J., Bouvier, C., Aubert, S., Guinebretière, J., Marie, B., Larousserie, F., Entz‐Werlé, N., Pinieux, G. D. B. D., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1331193 · Cited by 179 · see citing works
Tumor immune microenvironment in head and neck cancers
Chen, S. M. Y., Krinsky, A. L., Woolaver, R. A., Wang, X., Chen, Z., & Wang, J. H. (2020) · Molecular Carcinogenesis · doi:10.1002/mc.23162 · Cited by 179 · see citing works
- Authors
- Rőszer, T.
- Affiliations
- Universität Ulm (DE)
- Corresponding author
- Rőszer, Tamás
- ORCID
- Rőszer, Tamás
- Venue
- Mediators of Inflammation
- Publisher
- Wiley
- Published
- 2015-01
- Volume
- 2015
- Issue
- 1
- Pages
- 816460-816460
- ISSN
- 0962-9351 (ISSN-L)
- 1466-1861
- PMC
- PMC4452191
- OpenAlex
- W1518095394
- Cited by
- 1,762
- References
- 209
- Citations by year
- 2026: 105 · 2025: 169 · 2024: 198 · 2023: 189 · 2022: 214 · 2021: 215 · 2020: 203 · 2019: 150 · 2018: 143 · 2017: 109 · 2016: 58 · 2015: 9
- FWCI
- 10.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Mediators of Inflammation (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Universität Ulm
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- M2 macrophages, scavenger receptors, tissue microenvironment, tissue homeostasis, hormone signaling
- MeSH terms
- Humans, Macrophage Activation, Macrophages, Neurosecretory Systems
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