Endoderm development in vertebrates: fate mapping, induction and regional specification
Open accessAbstract
The formation of the vertebrate body plan begins with the differentiation of cells into three germ layers: ectoderm, mesoderm and endoderm. Cells in the endoderm give rise to the epithelial lining of the digestive tract, associated glands and respiratory system. One of the fundamental problems in developmental biology is to elucidate how these three primary germ layers are established from the homologous population of cells in the early blastomere. To address this question, ectoderm and mesoderm development have been extensively analyzed, but study of endoderm development has only begun relatively recently. In this review, we focus on the ‘where’, ‘when’ and ‘how’ of endoderm development in four vertebrate model organisms: the zebrafish, Xenopus, chick and mouse. We discuss the classical fate mapping of the endoderm and the more recent progress in characterizing its induction, segregation and regional specification.
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Many key genes involved in the initial formation of DE are evolutionarily conserved.
“Many of the key genes involved in the initial formation of DE are evolutionarily conserved.”
From A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE) (2007) · cites this paper as [7]
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“…homologue, CdxA and the HMG domain containing the Sox2 gene begin to be expressed in caudal and rostral endoderm at the 8– 10 somite stages (Duprey et al. 1988; Frumkin et al. 1993; Suh et al. 1994; Ishii et al. 1997; Freund et al. 1998; Ishii et al. 1998; Wood & Episkopou 1999; Beck et al. 2003).”
Background<i>Mixl1</i>is required for axial mesendoderm morphogenesis and patterning in the murine embryo
Hart, A. H., Hartley, L., Sourris, K., Stadler, E. S., Li, R., Stanley, E. G., Tam, P. P. L., Elefanty, A. G., & Robb, L. (2002) · Development · doi:10.1242/dev.129.15.3597 · Cited by 229 · see citing works
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Hou, J., Charters, A. M., Lee, S. C., Zhao, Y., Wu, M. K., Jones, S. J., Marra, M. A., & Hoodless, P. A. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-92 · Cited by 56 · see citing works
“They include Nodal and components of its signaling pathway, transcription factors of the mix-like paired homeodomain class, Forkhead domain factors, and Sox17 HMG domain proteins [7-11].”
Background
- Authors
- Fukuda, K., & Kikuchi, Y.
- Affiliations
- Tokyo Metropolitan University (JP)
- Nagoya University (JP)
- Corresponding author
- Kikuchi, Yutaka
- ORCID
- Kikuchi, Yutaka
- Venue
- Development, Growth & Differentiation
- Publisher
- Wiley
- Published
- 2005-08
- Volume
- 47
- Issue
- 6
- Pages
- 343-355
- ISSN
- 0012-1592 (ISSN-L)
- 1440-169X
- OpenAlex
- W1973617993
- Cited by
- 82
- References
- 3
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 14 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Development Growth & Differentiation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Mitsubishi Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- endoderm development, germ layer induction, fate mapping, regional specification, digestive tract epithelium, respiratory epithelium, zebrafish, Xenopus, chick embryo, mouse embryo
- MeSH terms
- Animals, Cell Differentiation, Chick Embryo, Ectoderm, Embryonic Induction, Endoderm, Mesoderm, Vertebrates, Xenopus, Zebrafish, Mice
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