The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Roles of Hes genes in neural development
Abstract
Hes genes are mammalian homologues of Drosophila hairy and Enhancer of split, which encode basic helix‐loop‐helix (bHLH) transcriptional repressors. In the developing central nervous system, Hes1, Hes3 and Hes5 are highly expressed by neural stem cells. Inactivation of these Hes genes leads to upregulation of proneural genes, acceleration of neurogenesis and premature depletion of neural stem cells. Conversely, overexpression of Hes genes leads to inhibition of neurogenesis and maintenance of neural stem cells. At later stages of development, Hes genes promote gliogenesis. Furthermore, Hes genes regulate maintenance of boundaries, which partition the nervous system into many compartments and endow the neighboring compartments with regional identities by secreting morphogens. Boundary cells usually proliferate slowly and do not give rise to neurons, unlike neural stem cells in compartments. Interestingly, these different characteristics between boundary cells and compartmental neural stem cells are regulated by different modes of Hes1 expression, which is variable in neural stem cells in compartments and persistent and high in boundary cells. Thus, Hes genes play an essential role in neural development by regulating proliferation, differentiation and specification of neural stem cells.
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Cites
STATs: transcriptional control and biological impact
Levy, D. E., & Darnell, J. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm909 · Cited by 3,201
The STATs of cancer — new molecular targets come of age
Yu, H., & Jove, R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1275 · Cited by 2,278
The cell biology of neurogenesis
Götz, M., & Huttner, W. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1739 · Cited by 2,130
Cited by
miR-9: a versatile regulator of neurogenesis
Coolen, M., Katz, S., & Bally-Cuif, L. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00220 · Cited by 306
The Evolution of Early Neurogenesis
Hartenstein, V., & Stollewerk, A. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.02.004 · Cited by 161
Spatial Regionalization and Heterochrony in the Formation of Adult Pallial Neural Stem Cells
Dirian, L., Galant, S., Coolen, M., Chen, W., Bedu, S., Houart, C., Bally-Cuif, L., & Foucher, I. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.05.012 · Cited by 109
let-7 miRNAs Can Act through Notch to Regulate Human Gliogenesis
Patterson, M., Gaeta, X., Loo, K., Edwards, M., Smale, S., Cinkornpumin, J., Xie, Y., Listgarten, J., Azghadi, S., Douglass, S. M., et al. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.08.015 · Cited by 103
Bai, G., Cheung, I., Shulha, H. P., Coelho, J. E., Li, P., Dong, X., Jakovcevski, M., Wang, Y., Grigorenko, A., Jiang, Y., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddu561 · Cited by 77
Metadata
- Authors
- Kageyama, R., Ohtsuka, T., & Kobayashi, T.
- Venue
- Development, Growth & Differentiation
- Publisher
- Wiley
- Published
- 2008-04-22
- Volume
- 50
- Issue
- s1
- Pages
- S97-103
- ISSN
- 0012-1592 (ISSN-L)
- 1440-169X
- OpenAlex
- W1551331657
- Cited by
- 283
- References
- 3
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- closed
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