Cited by 193Bariatric Surgery and OutcomesLiver Disease Diagnosis and TreatmentOrgan Transplantation Techniques and Outcomes

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Effects of bariatric surgery on nonalcoholic fatty liver disease: Preliminary findings after 2 years

Furuya, Carlos K, De Oliveira, Claudia P M S, De Mello, Evandro S, Faintuch, Joel, Raskovski, Alessandra, Matsuda, Mitsunori, Vezozzo, Denise C P, Halpern, Alfredo, Garrido, Arthur B, Alves, Venâncio A F, Carrilho, Flair J·2007·Journal of Gastroenterology and Hepatology

DOI 10.1111/j.1440-1746.2007.04833.x

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Abstract

Background and Aim: Although nonalcoholic fatty liver disease (NAFLD) is very common among morbidly obese patients, the effect of weight loss after bariatric surgery on inflammation and fibrosis related to NAFLD is still a matter of debate. The aim of this study was to evaluate the impact of Roux‐en‐Y gastric bypass (RYGB) surgery on NAFLD with a follow up of 2 years. Methods: Eighteen consecutive NAFLD patients with body mass index >40 kg/m 2 undergoing gastroplasty with RYGB were enrolled, and wedge liver biopsy was obtained at the operation. After 2 years, these patients underwent percutaneous liver biopsy. Results: At baseline, 67% of patients had nonalcoholic steatohepatitis (NASH) and 33% had steatosis, according to the NASH Clinical Research Network Scoring System (NAS) for biopsy. Cirrhosis was present in 5.5% of the patients with NASH. After a mean excess weight loss of 60%, steatosis disappeared in 84% and fibrosis disappeared in 75% of the patients. Hepatocellular ballooning disappeared in 50%. A slight lobular inflammatory infiltrate remained in 81%, apparently unrelated to fatty degeneration. As liver biochemical variables had been found within normal limits in 92.3% of patients at initial biopsy, no difference was found 2 years later. Lipid profile and blood sugar plasma concentration were closer to normal in all patients after 2 years (P < 0.05). Conclusions: Aspects of NAFLD including steatohepatitis improved significantly with massive weight loss at 2 years after RYGB surgery. No patient in this series had progression of hepatic fibrosis.

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“La primera opción de tratamiento para el hígado graso por enfermedad no alcohólica es la pérdida de peso, sea con cambios en el estilo de vida, apoyo de fármacos como orlistat (7, 8) o cirugía bariátrica, que parece ser la forma más eficaz de reducir la esteatosis hepática (9).”
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Authors: Furuya, C. K., De Oliveira, C. P. M. S., De Mello, E. S., Faintuch, J., Raskovski, A., Matsuda, M., Vezozzo, D. C. P., Halpern, A., Garrido, A. B., Alves, V. A. F., & Carrilho, F. J.
Affiliations: Universidade de São Paulo (BR)
Corresponding author: De Oliveira, Claudia P M S
ORCID: De Oliveira, Claudia P M S
De Mello, Evandro S
Alves, Venâncio A F
Carrilho, Flair J
Venue: Journal of Gastroenterology and Hepatology
Publisher: Wiley
Published: 2007-03-20
Volume: 22
Issue: 4
Pages: 510-514
ISSN: 0815-9319 (ISSN-L)
1440-1746
DOI: 10.1111/j.1440-1746.2007.04833.x
OpenAlex: W2067021370
Cited by: 193
References: 26
Citations by year: 2026: 1 · 2025: 1 · 2024: 4 · 2023: 8 · 2022: 5 · 2021: 7 · 2020: 8 · 2019: 11 · 2018: 13 · 2017: 13 · 2016: 14 · 2015: 18 · 2014: 10 · 2013: 10 · 2012: 11
FWCI: 15.94
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Gastroenterology and Hepatology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
Keywords: non-alcoholic fatty liver disease, Roux-en-Y gastric bypass, bariatric surgery, morbid obesity, weight loss, nonalcoholic steatohepatitis, hepatic steatosis, liver fibrosis, liver biopsy, hepatocyte ballooning, liver cirrhosis, lipid profile, blood glucose
MeSH terms: Adult, Biopsy, Fatty Liver, Female, Follow-Up Studies, gamma-Glutamyltransferase, Humans, Lipids, Liver, Liver Cirrhosis, Male, Middle Aged, Obesity, Morbid, Comorbidity, Body Mass Index, Bariatric Surgery

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Effects of bariatric surgery on nonalcoholic fatty liver disease: Preliminary findings after 2 years

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