Effect of Roux-en-y Gastric Bypass on Nonalcoholic Fatty Liver Disease Evaluated Through NAFLD Fibrosis Score: a Prospective Study

Cazzo, Everton; Jimenez, Laísa Simakawa; Pareja, José Carlos; Chaim, Elinton Adami

doi:10.1007/s11695-014-1489-2

Cited by 72Bariatric Surgery and OutcomesLiver Disease Diagnosis and TreatmentLiver Disease and Transplantation

Effect of Roux-en-y Gastric Bypass on Nonalcoholic Fatty Liver Disease Evaluated Through NAFLD Fibrosis Score: a Prospective Study

Cazzo, Everton, Jimenez, Laísa Simakawa, Pareja, José Carlos, Chaim, Elinton Adami·2015·Obesity Surgery

DOI 10.1007/s11695-014-1489-2

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Abstract

Background Nonalcoholic fatty liver disease (NAFLD) is common among subjects who undergo bariatric surgery and its postsurgical improvement has been reported. This study aimed to determine the evolution of liver disease evaluated through NAFLD fibrosis score 12 months after surgery. Methods It is a prospective cohort study which evaluated patients immediately before and 12 months following Roux-en-Y gastric bypass (RYGB). Results Mean score decreased from 1.142 to 0.066; surgery led to a resolution rate of advanced fibrosis of 55 %. Resolution was statistically associated with female gender, percentage of excess weight loss, postsurgical body mass index, postsurgical platelet count, and diabetes resolution. Conclusions As previously reported by studies in which postsurgical biopsies were performed, RYGB leads to a great resolution rate of liver fibrosis. Since postsurgical biopsy is not widely available and has a significant risk, calculation of NAFLD fibrosis score is a simple tool to evaluate this evolution through a noninvasive approach.

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Cazzo et al. demonstrated a significant reduction in NAFLD fibrosis scores within 12 months post-RYGB.
“Cazzo et al. demonstrated a significant reduction in NAFLD fibrosis scores within 12 months post-surgery, emphasizing the procedure’s capacity to reverse early liver damage associated with obesity [30].”
From Impact of Bariatric Surgery and Endoscopic Therapies on Liver Health in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Review (2025) · cites this paper as [30]
Long-term follow-up data show reduced incidence of progression to advanced liver disease such as fibrosis in individuals undergoing RYGB compared with nonsurgical treatments.
“Additionally, long-term follow-up data have demonstrated reduced incidence of progression to advanced liver disease such as fibrosis in individuals undergoing RYGB compared to nonsurgical treatments, reinforcing its critical therapeutic role in managing NAFLD [30].”
From Impact of Bariatric Surgery and Endoscopic Therapies on Liver Health in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Review (2025) · cites this paper as [30]

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Authors: Cazzo, E., Jimenez, L. S., Pareja, J. C., & Chaim, E. A.
Affiliations: Universidade Estadual de Campinas (UNICAMP) (BR)
Corresponding author: Cazzo, Everton
ORCID: Cazzo, Everton
Jimenez, Laísa Simakawa
Venue: Obesity Surgery
Publisher: Springer Science and Business Media LLC
Published: 2014-11-08
Volume: 25
Issue: 6
Pages: 982-985
ISSN: 0960-8923 (ISSN-L)
1708-0428
DOI: 10.1007/s11695-014-1489-2
OpenAlex: W2020496879
Cited by: 72
References: 30
Citations by year: 2026: 2 · 2025: 4 · 2024: 1 · 2023: 6 · 2022: 11 · 2021: 10 · 2020: 4 · 2019: 9 · 2018: 5 · 2017: 8 · 2016: 5 · 2015: 7
FWCI: 6.61
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Obesity Surgery (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Keywords: Roux-en-Y gastric bypass, non-alcoholic fatty liver disease
MeSH terms: Adolescent, Adult, Aged, Biopsy, Female, Humans, Liver Cirrhosis, Male, Middle Aged, Obesity, Morbid, Prospective Studies, Gastric Bypass, Body Mass Index, Young Adult, Non-alcoholic Fatty Liver Disease

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Effect of Roux-en-y Gastric Bypass on Nonalcoholic Fatty Liver Disease Evaluated Through NAFLD Fibrosis Score: a Prospective Study

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