The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Elevated levels of serum advanced glycation end products in patients with non‐alcoholic steatohepatitis
Abstract
Background and Aim: Advanced glycation end products (AGE), senescent macroprotein derivatives formed at an accelerated rate in diabetes, play important roles in the pathogenesis of diabetic vascular complications. Recently, AGE have also been found to be involved in insulin resistance. Although non‐alcoholic steatohepatitis (NASH) is generally considered a hepatic manifestation of insulin resistance, there are no reports showing the link of AGE to NASH. The aim of this study was to evaluate the clinical significance of AGE in patients with NASH. Methods: Glyceraldehyde‐derived AGE levels were assayed from serum obtained from 106 patients: 66 with NASH, 10 with simple steatosis, and 30 controls. Results: Serum glyceraldehyde‐derived AGE levels (U/mL) were significantly elevated in NASH patients (9.78 ± 3.73) compared with simple steatosis (7.17 ± 2.28, P = 0.018) or healthy controls (6.96 ± 2.36, P = 0.003). Moreover, these were inversely correlated with adiponectin, an adipocytokine with insulin‐sensitizing and anti‐inflammatory properties. In addition, immunohistochemistry of glyceraldehyde‐derived AGE showed intense staining in the livers of NASH patients. Conclusion: The present data suggest that the sustained increase of glyceraldehyde‐derived AGE could at least in part contribute to the pathogenesis of NASH. The serum glyceraldehyde‐derived AGE level may be a useful biomarker for discriminating NASH from simple steatosis.
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Nonalcoholic Fatty Liver Disease
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Non‐alcoholic steatohepatitis: another disease of affluence
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Romero-Gómez, M., Zelber-Sagi, S., & Trenell, M. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.05.016 · Cited by 1,347
Zelber-Sagi, S., Ivancovsky-Wajcman, D., Fliss Isakov, N., Webb, M., Orenstein, D., Shibolet, O., & Kariv, R. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.01.015 · Cited by 297
Zelber‐Sagi, S., Salomone, F., & Mlynarsky, L. (2017) · Liver International · doi:10.1111/liv.13435 · Cited by 273
Fernando, D. H., Forbes, J. M., Angus, P. W., & Herath, C. B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205037 · Cited by 184
Tahara, N., Yamagishi, S., Matsui, T., Takeuchi, M., Nitta, Y., Kodama, N., Mizoguchi, M., & Imaizumi, T. (2012) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2010.00177.x · Cited by 116
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Metadata
- Authors
- Hyogo, H., Yamagishi, S., Iwamoto, K., Arihiro, K., Takeuchi, M., Sato, T., Ochi, H., Nonaka, M., Nabeshima, Y., Inoue, M., Ishitobi, T., Chayama, K., & Tazuma, S.
- Venue
- Journal of Gastroenterology and Hepatology
- Publisher
- Wiley
- Published
- 2007-06-07
- Volume
- 22
- Issue
- 7
- Pages
- 1112-1119
- ISSN
- 0815-9319 (ISSN-L)
- 1440-1746
- OpenAlex
- W2094939617
- Cited by
- 187
- References
- 6
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hyogo, H., Yamagishi, S., Iwamoto, K., Arihiro, K., Takeuchi, M., Sato, T., Ochi, H., Nonaka, M., Nabeshima, Y., Inoue, M., Ishitobi, T., Chayama, K., & Tazuma, S. (2007). Elevated levels of serum advanced glycation end products in patients with non‐alcoholic steatohepatitis. Journal of Gastroenterology and Hepatology. https://doi.org/10.1111/j.1440-1746.2007.04943.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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