Cited by 166Alcohol Consumption and Health EffectsLiver physiology and pathologyLiver Disease Diagnosis and Treatment

The DOI matches its Crossref record; 216 of the 219 references it cites were found in a registry or an index.

Pathogenesis of alcohol‐induced liver disease: Classical concepts and recent advances

Open access

Seth, Devanshi, Haber, Paul S, Syn, Wing‐Kin, Diehl, Anna Mae, Day, Christopher P·2011·Journal of Gastroenterology and Hepatology

DOI 10.1111/j.1440-1746.2011.06756.x

Open this paper in CoChat — free account Open PDF

Abstract

Alcoholic liver disease (ALD) is a primary consequence of heavy and prolonged drinking. ALD contributes to the bulk of liver disease burden worldwide. Progression of ALD is a multifactorial and multistep process that includes many genetic and environmental risk factors. The molecular pathogenesis of ALD involves alcohol metabolism and secondary mechanisms such as oxidative stress, endotoxin, cytokines and immune regulators. The histopathological manifestation of ALD occurs as an outcome of complex but controlled interactions between hepatic cell types. Hepatic stellate cells (HSCs) are the key drivers of fibrogenesis, but transformation of hepatocytes to myofibroblastoids also implicate parenchymal cells as playing an active role in hepatic fibrogenesis. Recent discoveries indicate that lipogenesis during the early stages of ALD is a risk for advancement to cirrhosis. Other recently identified novel molecules and physiological/cell signaling pathways include fibrinolysis, osteopontin, transforming growth factor‐β‐SMAD and hedgehog signaling, and involvement of novel cytokines in hepatic fibrogenesis. The observation that ALD and non‐alcoholic steatohepatitis share common pathways and genetic polymorphisms suggests operation of parallel pathogenic mechanisms. Future research involving genomics, epigenomics, deep sequencing and non‐coding regulatory elements holds promise to identify novel diagnostic and therapeutic targets for ALD. There is also a need for adequate animal models to study pathogenic mechanisms at the molecular level and targeted therapy.

Integrity signals

Registry

Crossref · 10.1111/j.1440-1746.2011.06756.x

Cites

216 of 216 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

GLUTATHIONE TRANSFERASES
Hayes, J. D., Flanagan, J. U., & Jowsey, I. R. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.45.120403.095857 · Cited by 3,565
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
Romeo, S., Kozlitina, J., Xing, C., Pertsemlidis, A., Cox, D., Pennacchio, L. A., Boerwinkle, E., Cohen, J. C., & Hobbs, H. H. (2008) · Nature Genetics · doi:10.1038/ng.257 · Cited by 3,416
Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity.
MATTEONI, C., YOUNOSSI, Z., GRAMLICH, T., BOPARAI, N., LIU, Y., & MCCULLOUGH, A. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70506-8 · Cited by 3,345
Mechanisms of Hepatic Fibrogenesis
Friedman, S. L. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.003 · Cited by 2,687
Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C
Tanaka, Y., Nishida, N., Sugiyama, M., Kurosaki, M., Matsuura, K., Sakamoto, N., Nakagawa, M., Korenaga, M., Hino, K., Hige, S., et al. (2009) · Nature Genetics · doi:10.1038/ng.449 · Cited by 2,141
IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy
Study, F. T. H. C., Suppiah, V., Moldovan, M. V., Ahlenstiel, G., Berg, T., Weltman, M., Abate, M. L., Bassendine, M. F., Spengler, U., Dore, G. J., et al. (2009) · Nature Genetics · doi:10.1038/ng.447 · Cited by 1,829
Innate Immunity
Medzhitov, R. M., & Janeway, C. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008033430506 · Cited by 1,827
Eta-1 (Osteopontin): An Early Component of Type-1 (Cell-Mediated) Immunity
Ashkar, S., Weber, G. F., Panoutsakopoulou, V., Sanchirico, M. E., Jansson, M., Zawaideh, S., Rittling, S. R., Denhardt, D. T., Glimcher, M. J., & Cantor, H. (2000) · Science · doi:10.1126/science.287.5454.860 · Cited by 1,125
Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
Feldstein, A. E., Canbay, A., Angulo, P., Taniai, M., Burgart, L. J., Lindor, K. D., & Gores, G. J. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00907-7 · Cited by 1,085
A meta-analysis of alcohol consumption and the risk of 15 diseases
Corrao, G. (2004) · Preventive Medicine · doi:10.1016/j.ypmed.2003.11.027 · Cited by 1,077
Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors
Iredale, J. P., Benyon, R. C., Pickering, J., McCullen, M., Northrop, M., Pawley, S., Hovell, C., & Arthur, M. J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1018 · Cited by 1,075
Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival
Denhardt, D. T., Noda, M., O'Regan, A. W., Pavlin, D., & Berman, J. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12980 · Cited by 1,060
HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
study, F. T. D., Daly, A. K., Donaldson, P. T., Bhatnagar, P., Shen, Y., Pe’er, I., Floratos, A., Daly, M. J., Goldstein, D. B., John, S., et al. (2009) · Nature Genetics · doi:10.1038/ng.379 · Cited by 1,051
Self-citation
Cytochrome P-4502E1: its physiological and pathological role
Lieber, C. S. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.2.517 · Cited by 889
Fibroblasts Derive from Hepatocytes in Liver Fibrosis via Epithelial to Mesenchymal Transition
Zeisberg, M., Yang, C., Martino, M., Duncan, M. B., Rieder, F., Tanjore, H., & Kalluri, R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700194200 · Cited by 850
Prediction of risk of liver disease by alcohol intake, sex, and age: A prospective population study
Becker, U., Deis, A., Sørensen, T. I. A., Grønbæk, M., Borch‐Johnsen, K., Muller, C. F., Schnohr, P., & Jensen, G. B. (1996) · Hepatology · doi:10.1002/hep.510230513 · Cited by 847
A Polymorphism* in the 5′ Flanking Region of the CD14 Gene Is Associated with Circulating Soluble CD14 Levels and with Total Serum Immunoglobulin E
Baldini, M., Lohman, I. C., Halonen, M. J., Erickson, R. P., Holt, P. G., & Martínez, F. D. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.20.5.3494 · Cited by 834
Oxidative stress-related molecules and liver fibrosis
Parola, M., & Robino, G. (2001) · Journal of Hepatology · doi:10.1016/s0168-8278(01)00142-8 · Cited by 781
Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: A role for insulin resistance and diabetes
Fracanzani, A. L., Valenti, L. V. C., Bugianesi, E., Andreoletti, M., Colli, A., Vanni, E., Bertelli, C., Fatta, E., Bignamini, D., Marchesini, G., et al. (2008) · Hepatology · doi:10.1002/hep.22429 · Cited by 716
Essential role of tumor necrosis factor α in alcohol-induced liver injury in mice
Yin, M., Wheeler, M. D., Kono, H., Bradford, B. U., Gallucci, R. M., Luster, M. I., & Thurman, R. G. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70354-9 · Cited by 699
Antibiotics prevent liver injury in rats following long-term exposure to ethanol
Adachi, Y., Moore, L. E., Bradford, B. U., Gao, W., & Thurman, R. G. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90027-6 · Cited by 692
Genetic Polymorphisms in the 5′-Flanking Region Change Transcriptional Regulation of the Human Cytochrome P450IIE1 Gene1
Hayashi, S., Watanabe, J. A., & Kawajiri, K. (1991) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a123619 · Cited by 676
In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
Wieckowska, A., Zein, N. N., Yerian, L. M., López, R., McCullough, A. J., & Feldstein, A. E. (2006) · Hepatology · doi:10.1002/hep.21223 · Cited by 675
Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease
Parlesak, A., Schäfer, C., Schütz, T., Bode, J. C., & Bode, C. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80242-1 · Cited by 647
Drinking habits as cofactors of risk for alcohol induced liver damage
Bellentani, S., Saccoccio, G., Costa, G., Tiribelli, C., Manenti, F., Sodde, M., Croce’, L. S., Sasso, F., Pozzato, G., Cristianini, G., et al. (1997) · Gut · doi:10.1136/gut.41.6.845 · Cited by 630
Natural Killer Cells Ameliorate Liver Fibrosis by Killing Activated Stellate Cells in NKG2D-Dependent and Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Dependent Manners
Radaeva, S., Sun, R., Jaruga, B., Nguyen, V. T., Tian, Z., & Gao, B. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.10.055 · Cited by 610
Alcohol and Oxidative Liver Injury
Dey, A., & Cederbaum, A. I. (2006) · Hepatology · doi:10.1002/hep.20957 · Cited by 560
Ethanol Induces Fatty Acid Synthesis Pathways by Activation of Sterol Regulatory Element-binding Protein (SREBP)
You, M., Fischer, M., Deeg, M. A., & Crabb, D. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202411200 · Cited by 543
Experimental liver cirrhosis induced by alcohol and iron.
Tsukamoto, H., Horne, W., Kamimura, S., Niemelä, O. J., Parkkila, S., Ylä‐Herttuala, S., & Brittenham, G. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118077 · Cited by 512
FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization
Yuan, H., Chiou, J.-J., Tseng, W.-H., Liu, C.-H., Liu, C.-K., Lin, Y.-J., Wang, H.-H., Yao, A., Chen, Y., & Hsu, C. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl236 · Cited by 510
Signalling pathways in alcohol-induced liver inflammation
Mandrekar, P., & Szabó, G. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.03.007 · Cited by 500
Mechanisms of Disease Progression in Nonalcoholic Fatty Liver Disease
Jou, J. H., Choi, S. S., & Diehl, A. M. (2008) · Seminars in Liver Disease · doi:10.1055/s-0028-1091981 · Cited by 494
Self-citation
Toll–Like Receptor 4 Is Involved in the Mechanism of Early Alcohol–Induced Liver Injury in Mice
Uesugi, T., Froh, M., Arteel, G. E., Bradford, B. U., & Thurman, R. G. (2001) · Hepatology · doi:10.1053/jhep.2001.25350 · Cited by 488
Progressive Fibrosis in Nonalcoholic Steatohepatitis: Association With Altered Regeneration and a Ductular Reaction
Richardson, M. M., Jonsson, J. R., Powell, E. E., Brunt, E. M., Neuschwander–Tetri, B. A., Bhathal, P. S., Dixon, J. B., Weltman, M. D., Tilg, H., Moschen, A. R., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.05.012 · Cited by 482
Evidence of Genetic Predisposition to Alcoholic Cirrhosis and Psychosis: Twin Concordances for Alcoholism and Its Biological End Points by Zygosity among Male Veterans
Hrubec, Z., & Omenn, G. S. (1981) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1981.tb04890.x · Cited by 464
S-Adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial
Mato, J. M., Cámara, J., de Paz, J. F., Caballería, L., Coll, S., Caballero, A., Garcı́a-Buey, L., Beltrán, J., Benita, V., Caballería, J., et al. (1999) · Journal of Hepatology · doi:10.1016/s0168-8278(99)80263-3 · Cited by 462
Population-Based Genome-wide Association Studies Reveal Six Loci Influencing Plasma Levels of Liver Enzymes
Yuan, X., Waterworth, D. M., Perry, J. R. B., Lim, N., Song, K. S., Chambers, J. C., Zhang, W., Vollenweider, P., Stirnadel-Farrant, H. A., Johnson, T., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.09.012 · Cited by 457
Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer
Bellahcène, A., Castronovo, V., Ogbureke, K. U. E., Fisher, L. W., & Fedarko, N. S. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2345 · Cited by 454
Oxidative Stress and Oval Cell Accumulation in Mice and Humans with Alcoholic and Nonalcoholic Fatty Liver Disease
Roskams, T., Yang, S. Q., Koteish, A., Durnez, A., DeVos, R., Huang, X., Achten, R., Verslype, C., & Diehl, A. M. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63489-x · Cited by 447
Self-citation
Insulin Resistance in Nonalcoholic Fatty Liver Disease
Bugianesi, E., Moscatiello, S., Ciaravella, M. F., & Marchesini, G. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210791208875 · Cited by 446
CONSEQUENCES OF ALCOHOL CONSUMPTION ON HOST DEFENCE
Szabó, G. (1999) · Alcohol and Alcoholism · doi:10.1093/alcalc/34.6.830 · Cited by 439
Variant in PNPLA3 is associated with alcoholic liver disease
Tian, C., Stokowski, R. P., Kershenobich, D., Ballinger, D. G., & Hinds, D. A. (2009) · Nature Genetics · doi:10.1038/ng.488 · Cited by 435
The interleukin-17 pathway is involved in human alcoholic liver disease # †
Lemmers, A., Moreno, C., Gustot, T., Maréchal, R., Degré, D., Demetter, P., de Nadai, P., Geerts, A., Quertinmont, E., Vercruysse, V., et al. (2009) · Hepatology · doi:10.1002/hep.22680 · Cited by 394
Current concepts in the pathogenesis of alcoholic liver injury
Tsukamoto, H., & Lu, S. C.-L. (2001) · The FASEB Journal · doi:10.1096/fj.00-0650rev · Cited by 381
II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin
Thurman, R. G. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.4.g605 · Cited by 378
Steatosis: Co-factor in Other Liver Diseases *
Powell, E. E., Jonsson, J. R., & Clouston, A. D. (2005) · Hepatology · doi:10.1002/hep.20750 · Cited by 372
Interleukin-17–Producing Cd4+ T Cells Increase With Severity of Liver Damage in Patients With Chronic Hepatitis B
Zhang, J., Zhang, Z., Lin, F., Zou, Z., Xu, R., Jin, L., Fu, J., Shi, F., Shi, M., Wang, H., et al. (2009) · Hepatology · doi:10.1002/hep.23273 · Cited by 371
Genome-Wide Association Analysis in Primary Sclerosing Cholangitis
Karlsen, T. H., Franke, A., Melum, E., Kaser, A., Hov, J. R., Balschun, T. C., Lie, B. A., Bergquist, A. M., Schramm, C., Weismüller, T. J., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.11.046 · Cited by 365
I. TNF-induced liver injury
Bradham, C. A., Plümpe, J., Manns, M. P., Brenner, D. A., & Trautwein, C. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.3.g387 · Cited by 355
Transforming Growth Factor-β1 Induces an Epithelial-to-Mesenchymal Transition State in Mouse Hepatocytes in Vitro
Kaimori, A., Potter, J. J., Kaimori, J.-Y., Wang, C., Mezey, E., & Koteish, A. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700998200 · Cited by 354
Iron imports. IV. Hepcidin and regulation of body iron metabolism
Ganz, T., & Nemeth, E. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00412.2005 · Cited by 347
Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans
Omenetti, A., Porrello, A., Jung, Y., Yang, L., Popov, Y. V., Choi, S. S., Witek, R. P., Alpini, G. D., Venter, J., VanDongen, H. M. A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35875 · Cited by 346
Self-citation
The Australian Burden of Disease Study: measuring the loss of health from diseases, injuries and risk factors
Mathers, C. D., Stevenson, C., Vos, E. T., & Begg, S. J. (2000) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2000.tb124125.x · Cited by 339
Liver fibrogenesis and the role of hepatic stellate cells: New insights and prospects for therapy
Li, D., & Friedman, S. L. (1999) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.1999.01928.x · Cited by 337
The Cellular Pathogenesis of Portal Hypertension: Stellate Cell Contractility, Endothelin, and Nitric Oxide
Rockey, D. C. (1997) · Hepatology · doi:10.1002/hep.510250102 · Cited by 336
GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect
Fernández-Checa, J. C., Kaplowitz, N., García‐Ruiz, C., Colell, A., Miranda, M., Marı́, M., Ardite, E., & Morales, A. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.273.1.g7 · Cited by 332
Epithelial‐to‐mesenchymal transitions in the liver†
Choi, S. S., & Diehl, A. M. (2009) · Hepatology · doi:10.1002/hep.23196 · Cited by 314
Self-citation
Cross-Talk between Peroxisome Proliferator-Activated Receptor (PPAR) α and Liver X Receptor (LXR) in Nutritional Regulation of Fatty Acid Metabolism. I. PPARs Suppress Sterol Regulatory Element Binding Protein-1c Promoter through Inhibition of LXR Signaling
Yoshikawa, T., Ide, T., Shimano, H., Yahagi, N., Amemiya-Kudo, M., Matsuzaka, T., Yatoh, S., Kitamine, T., Okazaki, H., Tamura, Y., et al. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0190 · Cited by 306
Oxidative mechanisms in the pathogenesis of alcoholic liver disease
Albano, E. (2007) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2007.09.004 · Cited by 303
Role of Oxidative Stress and Antioxidant Therapy in Alcoholic and Nonalcoholic Liver Diseases
Lieber, C. S. (1996) · Advances in pharmacology · doi:10.1016/s1054-3589(08)61001-7 · Cited by 301
Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring
Mori, R., Shaw, T. J., & Martin, P. B. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071412 · Cited by 294
Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians
Stickel, F., Buch, S., Lau, K., zu Schwabedissen, H. E. M., Berg, T., Ridinger, M., Rietschel, M., Schafmayer, C., Braun, F., Hinrichsen, H. M., et al. (2010) · Hepatology · doi:10.1002/hep.24017 · Cited by 291
Increased expression of monocyte chemotactic protein-1 during active hepatic fibrogenesis: correlation with monocyte infiltration.
Marra, F., DeFranco, R., Grappone, C., Milani, S., Pastacaldi, S., Pinzani, M., Romanelli, R. G., Laffi, G., & Geñtilini, P. (1998) · Europe PMC (PubMed Central) · Cited by 289
Peroxisome Proliferator-activated Receptor α (PPARα) Agonist Treatment Reverses PPARα Dysfunction and Abnormalities in Hepatic Lipid Metabolism in Ethanol-fed Mice
Fischer, M., You, M., Matsumoto, M., & Crabb, D. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302140200 · Cited by 289
Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production
Pan, M., Cederbaum, A. I., Zhang, Y., Ginsberg, H. N., Williams, K. J., & Fisher, E. A. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19197 · Cited by 286
The Alcohol Hangover
Wiese, J. G., Shlipak, M. G., & Browner, W. S. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-132-11-200006060-00008 · Cited by 285
Hepatocyte-Specific Smad7 Expression Attenuates TGF-β–Mediated Fibrogenesis and Protects Against Liver Damage
Dooley, S., Hamzavi, J., Ciuclan, L. I., Godoy, P., Ilkavets, I., Ehnert, S., Ueberham, E., Gebhardt, R., Kanzler, S., Geier, A., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.038 · Cited by 284
Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease
Syn, W.-K., Oo, Y. H., Pereira, T. A., Karaca, G. F., Jung, Y., Omenetti, A., Witek, R. P., Choi, S. S., Guy, C. D., Fearing, C. M., et al. (2010) · Hepatology · doi:10.1002/hep.23599 · Cited by 283
Self-citation
Alcohol metabolism and cancer risk.
Seitz, H. K., & Becker, P. B. (2007) · PubMed · Cited by 281
Kupffer cell activation by lipopolysaccharide in rats: Role for lipopolysaccharide binding protein and toll‐like receptor 4
Su, G. L., Klein, R., Aminlari, A., Zhang, H. Y., Steinstraesser, L., Alarcon, W. H., Remick, D., & Wang, S. C. (2000) · Hepatology · doi:10.1053/he.2000.5634 · Cited by 280
Cytokines and Alcoholic Liver Disease
McClain, C. J., Hill, D. B., Schmidt, J., & Diehl, A. M. (1993) · Seminars in Liver Disease · doi:10.1055/s-2007-1007347 · Cited by 279
Self-citation
Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis
Syn, W.-K., Choi, S. S., Liaskou, E., Karaca, G. F., Agboola, K. M., Oo, Y. H., Mi, Z., Pereira, T. A., Zdanowicz, M., Malladi, P., et al. (2011) · Hepatology · doi:10.1002/hep.23998 · Cited by 275
Self-citation
Osteopontin Promotes Vascular Endothelial Growth Factor–Dependent Breast Tumor Growth and Angiogenesis via Autocrine and Paracrine Mechanisms
Chakraborty, G., Jain, S., & Kundu, G. C. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2126 · Cited by 268
Smad7 Antagonizes Transforming Growth Factor β Signaling in the Nucleus by Interfering with Functional Smad-DNA Complex Formation
Zhang, S., Fei, T., Zhang, L., Zhang, R., Chen, F., Ning, Y., Han, Y., Feng, X., Meng, A., & Chen, Y. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01636-06 · Cited by 265
Alcohol, host defence and society
Nelson, S., & Kolls, J. K. (2002) · Nature reviews. Immunology · doi:10.1038/nri744 · Cited by 263
Role of Adiponectin in the Protective Action of Dietary Saturated Fat Against Alcoholic Fatty Liver in Mice * #
You, M., Considine, R. V., Leone, T. C., Kelly, D. P., & Crabb, D. W. (2005) · Hepatology · doi:10.1002/hep.20821 · Cited by 259
Hedgehog-Mediated Epithelial-to-Mesenchymal Transition and Fibrogenic Repair in Nonalcoholic Fatty Liver Disease
Syn, W., Jung, Y., Omenetti, A., Abdelmalek, M. F., Guy, C. D., Yang, L., Wang, J., Witek, R. P., Fearing, C. M., Pereira, T. A., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.06.051 · Cited by 257
Self-citation
Genetic polymorphism of alcohol dehydrogenase in europeans: The ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1
Borràs, E., Coutelle, C., Rosell, A., Fernández-Muixí, F., Broch, M., Crosas, B., Hjelmqvist, L., Lorenzo, A., Gutiérrez, C., Mauro Santos, A., et al. (2000) · Hepatology · doi:10.1053/he.2000.5978 · Cited by 257
Recent Advances in Alcoholic Liver Disease IV. Dysregulated cytokine metabolism in alcoholic liver disease
McClain, C. J., Song, Z., Barve, S. S., Hill, D. B., & Deaciuc, I. V. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00171.2004 · Cited by 254
Adiponutrin, a Transmembrane Protein Corresponding to a Novel Dietary- and Obesity-linked mRNA Specifically Expressed in the Adipose Lineage
Baulande, S., Lasnier, F., Lucas, M., & Pairault, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105193200 · Cited by 252
Abrogation of the Antifibrotic Effects of Natural Killer Cells/Interferon-γ Contributes to Alcohol Acceleration of Liver Fibrosis
Jeong, W., Park, O., & Gao, B. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.09.034 · Cited by 250
Disease Progression in Chronic Hepatitis C: Modifiable and Nonmodifiable Factors
Missiha, S. B., Ostrowski, M., & Heathcote, E. J. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.02.069 · Cited by 227
Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases.
Diao, H., Kon, S., Iwabuchi, K., Kimura, C., Morimoto, J., Ito, D., Segawa, T., Maeda, M., Hamuro, J., Nakayama, T., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.012 · Cited by 226
Peroxisome proliferator-activated receptor ? protects against alcohol-induced liver damage
Nakajima, T., Kamijo, Y., Tanaka, N., Sugiyama, E., Tanaka, E., Kiyosawa, K., Fukushima, Y., Peters, J. M., Gonzalez, F. J., & Aoyama, T. (2004) · Hepatology · doi:10.1002/hep.1840400428 · Cited by 219
CD1d-restricted Human Natural Killer T Cells Are Highly Susceptible to Human Immunodeficiency Virus 1 Infection
Motsinger‐Reif, A. A., Haas, D. W., Stanic, A. K., Kaer, L. V., Joyce, S., & Unutmaz, D. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011712 · Cited by 218
Prognostic factors in alcoholic liver disease. VA Cooperative Study Group.
Chedid, A., Mendenhall, C. L., Gartside, P. S., French, S. W., Chen, T., & Rabin, L. (1991) · PubMed · Cited by 214
Peroxisome proliferator-activated receptor ? protects against alcohol-induced liver damage
Nakajima, T., Kamijo, Y., Tanaka, N., Sugiyama, E., Tanaka, E. I., Kiyosawa, K., Fukushima, Y., Peters, J. M., Gonzalez, F. J., & Aoyama, T. (2004) · Hepatology · doi:10.1002/hep.20399 · Cited by 214
Different Regulation and Expression of the Human CYP2E1 Gene Due to the Rsal Polymorphism in the 5'-Flanking Region1
Watanabe, J. A., Hayashi, S., & Kawajiri, K. (1994) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a124526 · Cited by 213
Hedgehog signaling maintains resident hepatic progenitors throughout life
Sicklick, J. K., Li, Y.-X., Melhem, A., Schmelzer, E., Zdanowicz, M., Huang, J., Caballero, M., Fair, J. H., Ludlow, J. W., McClelland, R., et al. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00456.2005 · Cited by 212
Self-citation
Alcohol and lipid metabolism
Sozio, M. S., & Crabb, D. W. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00011.2008 · Cited by 207
Metformin Prevents Alcohol-Induced Liver Injury in the Mouse: Critical Role of Plasminogen Activator Inhibitor-1
Bergheim, I., Guo, L., Davis, M. A., Lambert, J. C., Beier, J. I., Duveau, I., Luyendyk, J. P., Roth, R. A., & Arteel, G. E. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.03.020 · Cited by 204
Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease?
Zintzaras, E., Stefanidis, I., Mauro Santos, A., & Vidal, F. (2006) · Hepatology · doi:10.1002/hep.21023 · Cited by 201
Review article: alcoholic liver disease – pathophysiological aspects and risk factors
Gramenzi, A., Caputo, F., Biselli, M., KURIA, F., Loggi, E., Andreoné, P., & Bernardi, M. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03110.x · Cited by 195
Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling
Schattenberg, J. M., Wang, Y., Singh, R., Rigoli, R. M., & Czaja, M. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410310200 · Cited by 194
Acetaldehyde increases procollagen type I and fibronectin gene transcription in cultured rat fat-storing cells through a protein synthesis-dependent mechanism
Casini, A., Cunningham, M., Rojkind, M., & Lieber, C. S. (1991) · Hepatology · doi:10.1002/hep.1840130424 · Cited by 190
Growth inhibition by transforming growth factor beta (TGF-beta) type I is restored in TGF-beta-resistant hepatoma cells after expression of TGF-beta receptor type II cDNA.
Inagaki, M., Moustakas, A., Lin, H. Y.-F., Lodish, H. F., & Carr, B. I. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.11.5359 · Cited by 188
Essential role of the cryptic epitope SLAYGLR within osteopontin in a murine model of rheumatoid arthritis
Yamamoto, N., Sakai, F., Kon, S., Morimoto, J. O., Kimura, C., Yamazaki, H., Okazaki, I., Seki, N., Fujii, T., & Uede, T. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17778 · Cited by 187
Pattern recognition receptors: A contemporary view on liver diseases
Szabó, G., Dolganiuc, A., & Mandrekar, P. (2006) · Hepatology · doi:10.1002/hep.21308 · Cited by 182
Distribution of ethanol-induced protein adducts in vivo: relationship to tissue injury,
Niemelä, O. J. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00744-4 · Cited by 181
Upregulation of osteopontin expression is involved in the development of nonalcoholic steatohepatitis in a dietary murine model
Sahai, A., Malladi, P., Melin-Aldana, H., Green, R. M., & Whitington, P. F. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00002.2004 · Cited by 181
Cell Type–Dependent Pro- and Anti-Inflammatory Role of Signal Transducer and Activator of Transcription 3 in Alcoholic Liver Injury
Horiguchi, N., Wang, L., Mukhopadhyay, P., Park, O., Jeong, W. I., Lafdil, F., Osei‐Hyiaman, D., Moh, A., Fu, X. Y., Pacher, P., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.016 · Cited by 180
Leptin Promotes the Myofibroblastic Phenotype in Hepatic Stellate Cells by Activating the Hedgehog Pathway
Choi, S. S., Syn, W., Karaca, G., Omenetti, A., Moylan, C. A., Witek, R. P., Agboola, K. M., Jung, Y., Michelotti, G. A., & Diehl, A. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.168542 · Cited by 178
Self-citation
An osteopontin fragment is essential for tumor cell invasion in hepatocellular carcinoma
Takafuji, V., Forgues, M., Unsworth, E. J., Goldsmith, P. K., & Wang, X. W. (2007) · Oncogene · doi:10.1038/sj.onc.1210463 · Cited by 178
Genetic Predisposition to Organ‐Specific Endpoints of Alcoholism
Reed, T., Page, W. F., Viken, R. J., & Christian, J. C. (1996) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb01695.x · Cited by 171
Accumulation of Hedgehog-Responsive Progenitors Parallels Alcoholic Liver Disease Severity in Mice and Humans
Jung, Y., Brown, K. D., Witek, R. P., Omenetti, A., Yang, L., Vandongen, M., Milton, R. J., Hines, I. N., Rippe, R. A., Spahr, L., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.02.022 · Cited by 171
Self-citation
Acetate, the Key Modulator of Inflammatory Responses in Acute Alcoholic Hepatitis
Kendrick, S. F. W., O’Boyle, G., Mann, J., Zeybel, M., Palmer, J. M., Jones, D. E. J., & Day, C. (2010) · Hepatology · doi:10.1002/hep.23572 · Cited by 169
Self-citation
Interleukin 10 promoter region polymorphisms and susceptibility to advanced alcoholic liver disease
Grove, J., Daly, A. K., Bassendine, M. F., Gilvarry, E., & Day, C. P. (2000) · Gut · doi:10.1136/gut.46.4.540 · Cited by 166
Self-citation
Differential gene expression between chronic hepatitis B and C hepatic lesion
Honda, M., Kaneko, S., Kawai, H. F., Shirota, Y., & KOBAYASHI, K. P. (2001) · Gastroenterology · doi:10.1053/gast.2001.22468 · Cited by 161
Signals from dying hepatocytes trigger growth of liver progenitors
Jung, Y., Witek, R. P., Syn, W., Choi, S. S., Omenetti, A., Premont, R. T., Guy, C. D., & Diehl, A. M. (2010) · Gut · doi:10.1136/gut.2009.204354 · Cited by 161
Self-citation
Alcohol induced hepatic fibrosis: Role of acetaldehyde
Mello, T., Ceni, E., Surrenti, C., & Galli, A. (2008) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2007.10.001 · Cited by 160
Recent Advances in Alcoholic Liver Disease III. Role of the innate immune response in alcoholic hepatitis
Hines, I. N., & Wheeler, M. D. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00094.2004 · Cited by 158
[Cytokines in health and disease].
Fireman, L., & Qivity, S. (1996) · PubMed · Cited by 158
RNA Aptamer Blockade of Osteopontin Inhibits Growth and Metastasis of MDA-MB231 Breast Cancer Cells
Mi, Z., Guo, H., Russell, M. B., Liu, Y., Sullenger, B. A., & Kuo, P. C. (2008) · Molecular Therapy · doi:10.1038/mt.2008.235 · Cited by 157
Hepatic mitochondrial DNA deletion in alcoholics: Association with microvesicular steatosis
Fromenty, B., Grimbert, S., Mansouri, A., Beaugrand, M., Erlinger, S., Rötig, A., & Pessayre, D. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90024-1 · Cited by 151
Expression of Interleukin-10 by in Vitro and in Vivo Activated Hepatic Stellate Cells
Wang, S. C., Ohata, M., Schrum, L. W., Rippe, R. A., & Tsukamoto, H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.302 · Cited by 150
Promoter Polymorphism of the Cd14 Endotoxin Receptor Gene As A Risk Factor for Alcoholic Liver Disease
Järveläinen, H. A., Orpana, A., Perola, M., Savolainen, V. T., Karhunen, P. J., & Lindros, K. O. (2001) · Hepatology · doi:10.1053/jhep.2001.24236 · Cited by 149
Expression of Osteopontin in Kupffer Cells and Hepatic Macrophages and Stellate Cells in Rat Liver after Carbon Tetrachloride Intoxication: A Possible Factor for Macrophage Migration into Hepatic Necrotic Areas
Kawashima, R., Mochida, S., Matsui, A., YouLuTuZ, Y., Ishikawa, K., Toshima, K., Yamanobe, F., Inao, M., Ikeda, H., Ohno, A., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0372 · Cited by 148
Peroxisome proliferator‐activated receptor‐δ induces insulin‐induced gene‐1 and suppresses hepatic lipogenesis in obese diabetic mice†
Qin, X., Xie, X., Fan, Y., Tian, J., Guan, Y., Wang, X., Zhu, Y., & Wang, N. (2008) · Hepatology · doi:10.1002/hep.22334 · Cited by 147
MOLECULAR ASPECTS OF ALCOHOL METABOLISM: Transcription Factors Involved in Early Ethanol-Induced Liver Injury
Nagy, L. E. (2004) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132258 · Cited by 145
Adiponectin and alcoholic fatty liver disease
Rogers, C. Q., Ajmo, J. M., & You, M. (2008) · IUBMB Life · doi:10.1002/iub.124 · Cited by 139
ERK1/2 and Egr-1 contribute to increased TNF-α production in rat Kupffer cells after chronic ethanol feeding
Kishore, R., Hill, J. R., McMullen, M. R., Frenkel, J., & Nagy, L. E. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00328.2001 · Cited by 137
Prediction of Liver Fibrosis and Cirrhosis in Chronic Hepatitis B Infection by Serum Proteomic Fingerprinting: A Pilot Study
Poon, T. C. W., Hui, A., Chan, H. L., Ang, I. L., Chow, S. M., Wong, N., & Sung, J. J. �. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2004.041764 · Cited by 131
Bile ductules and stromal cells express hedgehog ligands and/or hedgehog target genes in primary biliary cirrhosis†
Jung, Y., McCall, S. J., Li, Y., & Diehl, A. M. (2007) · Hepatology · doi:10.1002/hep.21660 · Cited by 122
Self-citation
Identification of Transcriptional Networks during Liver Regeneration
White, P., Brestelli, J. E., Kaestner, K. H., & Greenbaum, L. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410844200 · Cited by 120
Homozygosity for alanine in the mitochondrial targeting sequence of superoxide dismutase and risk for severe alcoholic liver disease
Degoul, F., Sutton, A., Mansouri, A., Cepanec, C., Valla, D. C., Pessayre, D., Fromenty, B., Degott, C., & Beaugrand, M. (2001) · Gastroenterology · doi:10.1053/gast.2001.24051 · Cited by 117
Anti‐TGF‐β Strategies for the Treatment of Chronic Liver Disease
Breitkopf, K., Haas, S., Wiercinska, E., Singer, M. V., & Dooley, S. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000189284.98684.22 · Cited by 116
Early Growth Response-1 Transcription Factor Is Essential for Ethanol-Induced Fatty Liver Injury in Mice
McMullen, M. R., Pritchard, M. T., Wang, Q., Millward, C. A., Croniger, C. M., & Nagy, L. E. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.02.065 · Cited by 116
Evidence for epithelial-mesenchymal transitions in adult liver cells
Sicklick, J. K., Choi, S. S., Bustamante, M., McCall, S. J., Pérez, E. H., Huang, J., Li, Y., Rojkind, M., & Diehl, A. M. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00102.2006 · Cited by 115
Self-citation
THE ROLE OF GENETIC POLYMORPHISMS IN ALCOHOLIC LIVER DISEASE
Stickel, F., & Österreicher, C. (2006) · Alcohol and Alcoholism · doi:10.1093/alcalc/agl011 · Cited by 109
Alcoholic Liver Injury in the Rat Is Associated with Reduced Expression of Peroxisome Proliferator-α (PPARα)-Regulated Genes and Is Ameliorated by PPARα Activation
Nanji, A. A., Dannenberg, A. J., Jokelainen, K., & Bass, N. M. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.064717 · Cited by 107
The Adventures of Sonic Hedgehog in Development and Repair. II. Sonic hedgehog and liver development, inflammation, and cancer
Omenetti, A., & Diehl, A. M. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00543.2007 · Cited by 107
Self-citation
Structural Requirements for α9β1-Mediated Adhesion and Migration to Thrombin-Cleaved Osteopontin
Smith, L. L., & Giachelli, C. M. (1998) · Experimental Cell Research · doi:10.1006/excr.1998.4108 · Cited by 105
Hemochromatosis and alcoholic liver disease
Fletcher, L. M., & Powell, L. W. (2003) · Alcohol · doi:10.1016/s0741-8329(03)00128-9 · Cited by 103
AICAR, an AMPK Activator, Has Protective Effects on Alcohol‐Induced Fatty Liver in Rats
Tomita, K., Tamiya, G., Ando, S., Kitamura, N., Koizumi, H., Kato, S., Horie, Y., Kaneko, T., Azuma, T., Nagata, H., et al. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000191126.11479.69 · Cited by 102
Repair‐related activation of hedgehog signaling promotes cholangiocyte chemokine production†
Omenetti, A., Syn, W., Jung, Y., Francis, H., Porrello, A., Witek, R. P., Choi, S. S., Yang, L., Mayo, M. J., Gershwin, M. E., et al. (2009) · Hepatology · doi:10.1002/hep.23019 · Cited by 101
Self-citation
Role of osteopontin in hepatic neutrophil infiltration during alcoholic steatohepatitis
Apte, U. M., Banerjee, A., Mcree, R., Wellberg, E. A., & Ramaiah, S. K. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.12.018 · Cited by 101
Transforming growth factor‐β and hepatocyte transdifferentiation in liver fibrogenesis
Meindl‐Beinker, N. M., & Dooley, S. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05297.x · Cited by 100
Prevention of Ethanol-Induced Liver Injury in Rats by an Agonist of Peroxisome Proliferator-Activated Receptor-γ, Pioglitazone
Enomoto, N., Takei, Y., Hirose, M., Konno, A., Shibuya, T., Matsuyama, S., Suzuki, S., Ikejima, K., & Sato, N. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.047217 · Cited by 99
Interplay between oxidative stress and immunity in the progression of alcohol-mediated liver injury
Vidali, M., Stewart, S. F., & Albano, E. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.12.005 · Cited by 97
Quantifying the risk for alcohol‐use and alcohol‐attributable health disorders: Present findings and future research needs
Li, T. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05298.x · Cited by 95
Iron overload and cofactors with special reference to alcohol, hepatitis C virus infection and steatosis/insulin resistance
Kohgo, Y. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i35.4699 · Cited by 91
Alcohol and the liver
Reuben, A. (2007) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3280f27582 · Cited by 91
The liver: a model of organ-specific lymphocyte recruitment
Lalor, T., & Adams, D. (2002) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399402004155 · Cited by 90
PRESENCE OF PLASMA ENDOTOXIN IS CORRELATED WITH TUMOUR NECROSIS FACTOR RECEPTOR LEVELS AND DISEASE ACTIVITY IN ALCOHOLIC CIRRHOSIS
Hanck, C., Rossol, S., BOCKER, U., TOKUS, M., & SINGER, M. V. (1998) · Alcohol and Alcoholism · doi:10.1093/alcalc/33.6.606 · Cited by 89
Ethanol‐Induced Liver Injury: Potential Roles for Egr‐1
Pritchard, M. T., & Nagy, L. E. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000189286.81943.51 · Cited by 88
Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12
Teramoto, H., Castellone, M. D., Malek, R. L., Letwin, N. E., Frank, B. C., Gutkind, J. S., & Lee, N. H. (2004) · Oncogene · doi:10.1038/sj.onc.1208209 · Cited by 88
Thymocytes, Pre‐B Cells, and Organ Changes in a Mouse Model of Chronic Ethanol Ingestion—Absence of Subset‐Specific Glucocorticoid‐Induced Immune Cell Loss
Cook, R. T., Schlueter, A. J., Coleman, R. A., Tygrett, L. T., Ballas, Z. K., Jerrells, T. R., Nashelsky, M. B., Ray, N. B., Haugen, T. H., & Waldschmidt, T. J. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00478.x · Cited by 84
Role of different dietary fatty acids in the pathogenesis of experimental alcoholic liver disease
Nanji, A. A. (2004) · Alcohol · doi:10.1016/j.alcohol.2004.08.005 · Cited by 84
ICAM-1 is involved in the mechanism of alcohol-induced liver injury: studies with knockout mice
Kono, H., Uesugi, T., Froh, M., Rusyn, I., Bradford, B. U., & Thurman, R. G. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.6.g1289 · Cited by 82
Signaling pathways activated by microorganisms
Takeuchi, O., & Akira, S. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.006 · Cited by 81
Acetaldehyde stimulates the activation of latent transforming growth factor-β1 and induces expression of the type II receptor of the cytokine in rat cultured hepatic stellate cells
Chen, A. (2002) · Biochemical Journal · doi:10.1042/bj20020949 · Cited by 81
PPARα Agonists Suppress Osteopontin Expression in Macrophages and Decrease Plasma Levels in Patients With Type 2 Diabetes
Nakamachi, T., Nomiyama, T., Gizard, F., Heywood, E. B., Jones, K. L., Zhao, Y., Fuentes, L., Takebayashi, K., Aso, Y., Staels, B., et al. (2007) · Diabetes · doi:10.2337/db06-1177 · Cited by 80
The Activation State of αvβ3Regulates Platelet and Lymphocyte Adhesion to Intact and Thrombin-cleaved Osteopontin
Helluin, O., Chan, C., Vilaire, G., Mousa, S. A., DeGrado, W. F., & BENNETT, J. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001529200 · Cited by 79
Gene Expression Profiling of Alcoholic Liver Disease in the Baboon (Papio hamadryas) and Human Liver
Seth, D., Leo, M. A., McGuinness, P. H., Lieber, C. S., Brennan, Y., Williams, R. B. H., Wang, X. M., McCaughan, G. W., Gorrell, M. D., & Haber, P. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63587-0 · Cited by 78
Self-citation
Overview of an interlaboratory collaboration on evaluating the effects of model hepatotoxicants on hepatic gene expression.
Ulrich, R. G., Rockett, J. C., Gibson, G. G., & Pettit, S. D. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.6675 · Cited by 78
Osteopontin: It's Role in Regulation of Cell Motility and Nuclear Factor κB-mediated Urokinase Type Plasminogen Activator Expression
Das, R., Philip, S., Mahabeleshwar, G. H., Bulbule, A., & Kundu, G. C. (2005) · IUBMB Life · doi:10.1080/15216540500159424 · Cited by 77
Pathogenesis and management of alcoholic hepatitis
Haber, P., Warner, R. H., Seth, D., Gorrell, M. D., & McCaughan, G. W. (2003) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2003.03217.x · Cited by 76
Self-citation
Fatty acid ethyl esters: markers of alcohol abuse and alcoholism
Kaphalia, B. S., Cai, P., Khan, M. F., Okorodudu, A. O., & Ansari, G. A. S. (2004) · Alcohol · doi:10.1016/j.alcohol.2004.07.013 · Cited by 75
Lipid peroxidation and hepatic antioxidants in alcoholic liver disease.
Situnayake, R. D., Crump, B. J., Thurnham, D. I., Davies, J. A., Gearty, J., & Davis, M. (1990) · Gut · doi:10.1136/gut.31.11.1311 · Cited by 73
Genetic Polymorphisms of Interleukin-1β in Association With The Development of Alcoholic Liver Disease in Japanese Patients
Takamatsu, M., Yamauchi, M., Maezawa, Y., Saitô, S., Maeyama, S., & Uchikoshi, T. (2000) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(00)00822-4 · Cited by 72
Peroxisome Proliferator-activated Receptor α Deficiency Abolishes the Response of Lipogenic Gene Expression to Re-feeding
Hebbachi, A., Knight, B. L., Wiggins, D. K., Patel, D. D., & Gibbons, G. F. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m709471200 · Cited by 71
Fatty Liver Disease NASH and Related Disorders
Hughes, R. D. (2006) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200606000-00020 · Cited by 71
A common variant in the adiponutrin gene influences liver enzyme values
Kollerits, B., Coassin, S., Zollner-Kiechl, S., Hunt, S. C., Paulweber, B., Willeit, J., Kloss‐Brandstätter, A., Lamina, C., Adams, T. D., & Kronenberg, F. (2009) · Journal of Medical Genetics · doi:10.1136/jmg.2009.066597 · Cited by 71
Intrahepatic gene expression in human alcoholic hepatitis
Seth, D., Gorrell, M. D., Cordoba, S. P., McCaughan, G. W., & Haber, P. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.04.013 · Cited by 71
Self-citation
Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes
Norkina, O., Dolganiuc, A., Shapiro, T., Kodys, K., Mandrekar, P., & Szabó, G. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0207099 · Cited by 67
SMART amplification maintains representation of relative gene expression: quantitative validation by real time PCR and application to studies of alcoholic liver disease in primates
Seth, D., Gorrell, M. D., McGuinness, P. H., Leo, M. A., Lieber, C. S., McCaughan, G. W., & Haber, P. (2003) · Journal of Biochemical and Biophysical Methods · doi:10.1016/s0165-022x(02)00177-x · Cited by 64
Self-citation
Alcohol-induced Modulation of Signaling Pathways in Liver Parenchymal and Nonparenchymal Cells: Implications for Immunity
Nath, B., & Szabó, G. (2009) · Seminars in Liver Disease · doi:10.1055/s-0029-1214372 · Cited by 61
New role of plasminogen activator inhibitor‐1 in alcohol‐induced liver injury
Arteel, G. E. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05285.x · Cited by 61
Polymorphisms of the glutathione S-transferases mu-1 (GSTM1) and theta-1 (GSTT1) and the risk of advanced alcoholic liver disease
Ladero, J. M., Martı́nez, C., García‐Martín, E., Fernández‐Arquero, M., López‐Alonso, G., de la Concha, E. G., Díaz‐Rubio, M., & Agúndez, J. A. G. (2005) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520510012109 · Cited by 61
Hepatic stellate cells and fibrosis progression in patients with nonalcoholic fatty liver disease
Feldstein, A. E., Papouchado, B. G., Angulo, P., Sanderson, S., Adams, L. A., & Gores, G. J. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00616-0 · Cited by 60
Role for hedgehog pathway in regulating growth and function of invariant NKT cells
Syn, W., Witek, R. P., Curbishley, S. M., Jung, Y., Choi, S. S., Enrich, B., Omenetti, A., Agboola, K. M., Fearing, C. M., Tilg, H., et al. (2009) · European Journal of Immunology · doi:10.1002/eji.200838890 · Cited by 58
Self-citation
Valine-alanine manganese superoxide dismutase polymorphism is not associated with alcohol-induced oxidative stress or liver fibrosis
Stewart, S. F. (2002) · Hepatology · doi:10.1053/jhep.2002.36940 · Cited by 55
Direct effects of alcohol on hepatic fibrinolytic balance: Implications for alcoholic liver disease
Seth, D., Hogg, P. J., Gorrell, M. D., McCaughan, G. W., & Haber, P. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2007.12.015 · Cited by 55
Self-citation
Fatty Acid Ethyl Esters: Ethanol Metabolites That Reflect Ethanol Intake
Soderberg, B. L., Salem, R. O., Best-Popescu, C. A., Cluette‐Brown, J. E., & Laposata, M. (2003) · Pathology Patterns Reviews · doi:10.1309/6f39-ear2-l4gy-x5g6 · Cited by 55
Are the recent trends in liver cirrhosis mortality affected by the changes in alcohol consumption? Analysis of latency period in European countries.
Corrao, G., Ferrari, P. A., Zambon, A., & Torchio, P. (1997) · Journal of Studies on Alcohol · doi:10.15288/jsa.1997.58.486 · Cited by 54
Large-scale gene profiling of the liver in a mouse model of chronic, intragastric ethanol infusion.
Deaciuc, I., Doherty, D., Burikhanov, R., Lee, E. Y., Stromberg, A., Peng, X., & de Villiers, W. D. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2003.10.021 · Cited by 53
T-cell activation after chronic ethanol ingestion in mice
Cook, R. T., Zhu, X., Coleman, R. A., Ballas, Z. K., Waldschmidt, T. J., Ray, N. B., LaBrecque, D. R., & Cook, B. L. (2004) · Alcohol · doi:10.1016/j.alcohol.2004.06.007 · Cited by 52
Novel Differential Gene Expression in Human Cirrhosis Detected by Suppression Subtractive Hybridization
Shackel, N. A., McGuinness, P. H., Abbott, C. A., Gorrell, M. D., & McCaughan, G. W. (2003) · Hepatology · doi:10.1053/jhep.2003.50376 · Cited by 51
Ethanol inhibits hepatocyte proliferation in insulin receptor substrate 1 transgenic mice
Mohr, L., Tanaka, S., & Wands, J. R. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70036-8 · Cited by 49
Tissue plasminogen activator, plasminogen activator inhibitors, and activator-inhibitor complex in liver disease.
Leiper, K., Croll, A. M., Booth, N. A., Moore, N. R., Sinclair, T. S., & Bennett, B. (1994) · Journal of Clinical Pathology · doi:10.1136/jcp.47.3.214 · Cited by 49
Acetaldehyde regulates the gene expression of matrix-metalloproteinase-1 and -2 in human fat-storing cells
Casini, A., Ceni, E., Salzano, R., Milani, S., Schuppan, D., & Surrenti, C. (1994) · Life Sciences · doi:10.1016/0024-3205(94)00763-2 · Cited by 47
Glutathione‐S‐Transferase GST M1 “Null” Genotype and the Risk of Alcoholic Liver Disease
Savolainen, V. T., Pajarinen, J., Perola, M., Penttilä, A., & Karhunen, P. J. (1996) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb01132.x · Cited by 46
Role of osteopontin in regulating hepatic inflammatory responses and toxic liver injury
Ramaiah, S. K., & Rittling, S. R. (2007) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425225.3.4.519 · Cited by 46
Per capita alcohol consumption in Australia: will the real trend please step forward?
Chikritzhs, T. N., ALLSOP, S. J., Moodie, R., & Hall, W. (2010) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2010.tb04069.x · Cited by 45
Mortality rate of alcoholic liver disease and risk of hospitalization for alcoholic liver cirrhosis, alcoholic hepatitis and alcoholic liver failure in Australia between 1993 and 2005
Liang, W., Chikritzhs, T. N., Richard, P., & Binns, C. W. (2010) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2010.02279.x · Cited by 44
Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor
Shanmukhappa, K. S., Sabla, G. E., Degen, J. L., & Bezerra, J. A. (2006) · BMC Gastroenterology · doi:10.1186/1471-230x-6-40 · Cited by 44
Hepatic gene expression profiles associated with fibrosis progression and hepatocarcinogenesis in hepatitis C patients
Shao, R. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i13.1995 · Cited by 44
THE ROLE OF POLYMORPHISMS OF GLUTATHIONE S-TRANSFERASES GSTM1, M3, P1, T1 AND A1 IN SUSCEPTIBILITY TO ALCOHOLIC LIVER DISEASE
Brind, A. M., HURLSTONE, A., EDRISINGHE, D., Gilmore, I. T., Fisher, N. C., Pirmohamed, M., & Fryer, A. A. (2004) · Alcohol and Alcoholism · doi:10.1093/alcalc/agh105 · Cited by 44
Osteopontin expression predicts overall survival after liver transplantation for hepatocellular carcinoma in patients beyond the Milan criteria
Sieghart, W., Wang, X., Schmid, K., Pinter, M., König, F., Bodingbauer, M., Wrba, F., Rasoul‐Rockenschaub, S., & Peck‐Radosavljevic, M. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.06.030 · Cited by 43
Alcohol, Signaling, and ECM Turnover
Seth, D., D'Souza, N. B., Apte, M. V., Marı́, M., Dooley, S., Neuman, M. G., Haber, P., Kundu, G. C., Darwanto, A., de Villiers, W. J. S., et al. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01060.x · Cited by 40
Self-citation
Discriminating two classes of toxicants through expression analysis of HepG2 cells with DNA arrays
Hong, Y., Müller, U. R., & Lai, F. (2003) · Toxicology in Vitro · doi:10.1016/s0887-2333(02)00122-4 · Cited by 38
Interleukin-12 Therapy Restores Cell-Mediated Immunity in Ethanol-Consuming Mice
Peterson, J. D., Vasquez, K. O., & Waltenbaugh, C. R. (1998) · Alcoholism Clinical and Experimental Research · doi:10.1097/00000374-199802000-00034 · Cited by 38
Autocrine expression of activated transforming growth factor-β1 induces apoptosis in normal rat liver
Schrum, L. W., Bird, M. A., Salcher, O., Burchardt, E. R., Grisham, J. W., Brenner, D. A., Rippe, R. A., & Behrns, K. E. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.1.g139 · Cited by 37
Fat paradox of steatohepatitis
Tsukamoto, H., She, H., Hazra, S., Cheng, J. H., & Wang, J. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05294.x · Cited by 36
Mortality from liver disease in the West Midlands, 1993-2000: observational study
Fisher, N. C., Hanson, J., Phillips, A., Rao, J. N., & Swarbrick, E. T. (2002) · BMJ · doi:10.1136/bmj.325.7359.312 · Cited by 36
LEUCOCYTE ADHESION MOLECULES AND ALCOHOLIC LIVER DISEASE
Adams, D. (1994) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a045531 · Cited by 35
Osteopontin Small Interfering RNA Protects Mice from Fulminant Hepatitis
Saito, Y., Kon, S., Fujiwara, Y., Nakayama, Y., Kurotaki, D., Fukuda, N., Kimura, C., Kanayama, M., Ito, K., Diao, H., et al. (2007) · Human Gene Therapy · doi:10.1089/hum.2007.069 · Cited by 34
Patatin‐like phospholipase domain containing 3
Seth, D., Daly, A. K., Haber, P., & Day, C. P. (2010) · Hepatology · doi:10.1002/hep.23606 · Cited by 32
Self-citation
Roles of phosphatidylinositol 3-kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline-deficient medium
Sahai, A., Pan, X., Paul, R., Malladi, P., Kohli, R., & Whitington, P. F. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00360.2005 · Cited by 31
CYTOTOXIC T-LYMPHOCYTE ANTIGEN-4 A49G POLYMORPHISM IS ASSOCIATED WITH SUSCEPTIBILITY TO AND SEVERITY OF ALCOHOLIC LIVER DISEASE IN ITALIAN PATIENTS
Valenti, L. V. C. (2004) · Alcohol and Alcoholism · doi:10.1093/alcalc/agh047 · Cited by 30

Research works printed but not linked: 12

NAS, 2006, Towards Safer Drinking Cultures, National Alcohol Strategy 2006–2009
Chikritzh T, 2003, Patterns of Alcohol Use and Related Harms for Australian States and Territories
Haber PS, 1999, Clinical outcomes of liver transplantation for alcoholic liver disease (abst 198), J. Gastroenterol. Hepatol., 14, A130
Chikritzhs T, 2000, National Alcohol Indicators Project
Chikritzhs T, 2007, Bulletin 11: Trends in Alcohol‐Attributable Deaths Among Indigenous Australians, 1998–2004
Younossi ZM, 1998, Clinics in Liver Disease, 661
Seth D, 2006, Identification of Novel Therapeutic Targets for Alcoholic Liver Disease, 60A
10.1517/17425255.3.4.519 · DOI
Seth D, 2006, Osteopontin: An Early Marker for Alcoholic Liver Injury?, 89A
10.1111/j.1530-0277.1998.tb03645.x · DOI
10.1002/hep.1840360610 · DOI
10.1111/j.1572-0241.2000.02030.x · DOI

Sorted by citations

Pathophysiological Aspects of Alcohol Metabolism in the Liver
Hyun, J., Han, J., Lee, C., Yoon, M., & Jung, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115717 · Cited by 324
Alcoholic disease: Liver and beyond
Rocco, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i40.14652 · Cited by 260
Microglial activation is not equivalent to neuroinflammation in alcohol-induced neurodegeneration: The importance of microglia phenotype
Marshall, S. A., McClain, J. A., Kelso, M. L., Hopkins, D. M., Pauly, J. R., & Nixon, K. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.12.016 · Cited by 254
Baicalin and the liver-gut system: Pharmacological bases explaining its therapeutic effects
Hu, Q., Zhang, W., Wu, Z., Tian, X., Xiang, J., Li, L., Li, Z., Peng, X., Wei, S., Ma, X., et al. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105444 · Cited by 244
Animal models of chronic liver diseases
Liu, Y., Meyer, C., Xu, C., Weng, H., Hellerbrand, C., ten Dijke, P., & Dooley, S. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00199.2012 · Cited by 233

See all 166

Authors: Seth, D., Haber, P. S., Syn, W., Diehl, A. M., & Day, C. P.
Affiliations: The University of Sydney (AU)
University of the Basque Country (ES)
Duke Medical Center (US)
Newcastle University (GB)
Corresponding author: Seth, Devanshi
ORCID: Seth, Devanshi
Haber, Paul S
Diehl, Anna Mae
Day, Christopher P
Venue: Journal of Gastroenterology and Hepatology
Publisher: Wiley
Published: 2011-06-14
Volume: 26
Issue: 7
Pages: 1089-1105
ISSN: 0815-9319 (ISSN-L)
1440-1746
DOI: 10.1111/j.1440-1746.2011.06756.x
OpenAlex: W1574483226
Cited by: 166
References: 219
Citations by year: 2025: 10 · 2024: 3 · 2023: 10 · 2022: 6 · 2021: 16 · 2020: 22 · 2019: 4 · 2018: 4 · 2017: 8 · 2016: 12 · 2015: 16 · 2014: 21 · 2013: 17 · 2012: 15
FWCI: 2.18
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Gastroenterology and Hepatology (publishedVersion)
PubMed (publishedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Newcastle University ePrints (Newcastle Univesity)
Funders: National Institutes of Health (5r37aa010154-20)
National Institute on Alcohol Abuse and Alcoholism (R37 AA-010154)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Keywords: alcoholic liver disease, pathogenesis, alcohol metabolism, oxidative stress, endotoxin, cytokines, immune regulation, hepatic stellate cells, hepatic fibrogenesis, myofibroblast transformation, lipogenesis, liver cirrhosis, fibrinolysis, osteopontin, TGF-β/Smad signaling, Hedgehog signaling, nonalcoholic steatohepatitis, genetic polymorphism, epigenomics, animal models, therapeutic target
MeSH terms: Alcohol Drinking, Ethanol, Animals, Humans, Liver Diseases, Alcoholic, Risk Factors, Global Health, Prevalence, Oxidative Stress

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pathogenesis of alcohol‐induced liver disease: Classical concepts and recent advances

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks