Iron imports. IV. Hepcidin and regulation of body iron metabolism

Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803 · see citing works

Hepcidin, a urinary antimicrobial peptide synthesized in the liver

Park, C. H., Valore, E. V., Waring, A. J., & Ganz, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008922200 · Cited by 2,168 · see citing works

A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload

Pigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot, P., & Loréal, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008923200 · Cited by 1,697 · see citing works

A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation

McKie, A. T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T. J., Farzaneh, F., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80425-6 · Cited by 1,422 · see citing works

Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein

Nemeth, E., Valore, E. V., Territo, M., Schiller, G., Lichtenstein, A., & Ganz, T. (2003) · Blood · doi:10.1182/blood-2002-10-3235 · Cited by 1,417 · see citing works

LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity

Krause, A., Neitz, S., Mägert, H.-J., Schulz, A., Forssmann, W.-G., Schulz-Knappe, P., & Adermann, K. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01920-7 · Cited by 1,324 · see citing works

Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 ( <i>USF2</i> ) knockout mice

Nicolas, G., Bennoun, M., Devaux, I., Beaumont, C., Grandchamp, B., Kahn, A., & Vaulont, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151179498 · Cited by 1,233 · see citing works

The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

Nicolas, G., Chauvet, C., Viatte, L., Danan, J. L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A., & Vaulont, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215686 · Cited by 1,214 · see citing works

Hereditary Hemochromatosis — A New Look at an Old Disease

Pietrangelo, A. (2004) · New England Journal of Medicine · doi:10.1056/nejmra031573 · Cited by 992 · see citing works

Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis

Papanikolaou, G., Samuels, M. E., Ludwig, E. H., MacDonald, M. L. E., Franchini, P. L., Dubé, M.-P., Andres, L., MacFarlane, J., Sakellaropoulos, N., Politou, M., et al. (2004) · Nature Genetics · doi:10.1038/ng1274 · Cited by 974 · see citing works

Severe iron deficiency anemia in transgenic mice expressing liver hepcidin

Nicolas, G., Bennoun, M., Porteu, A., Mativet, S., Beaumont, C., Grandchamp, B., Sirito, M., Sawadogo, M., Kahn, A., & Vaulont, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072632499 · Cited by 880 · see citing works

Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

Roetto, A., Papanikolaou, G., Politou, M., Alberti, F., Girelli, D., Christakis, J., Loukopoulos, D., & Camaschella, C. (2003) · Nature Genetics · doi:10.1038/ng1053 · Cited by 860 · see citing works

Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease

Weinstein, D. A., Roy, C. N., Fleming, M. D., Loda, M. F., Wolfsdorf, J. I., & Andrews, N. C. (2002) · Blood · doi:10.1182/blood-2002-04-1260 · Cited by 632 · see citing works

Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis

Bridle, K. R., Frazer, D. M., Wilkins, S. J., Dixon, J. L., Purdie, D. M., Crawford, D. H., Subramaniam, V. N., Powell, L. W., Anderson, G. J., & Ramm, G. A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12602-5 · Cited by 620 · see citing works

Hepcidin in iron overload disorders

Papanikolaou, G., Tzilianos, M., Christakis, J. I., Bogdanos, D., Tsimirika, K., MacFarlane, J., Goldberg, Y. P., Sakellaropoulos, N., Ganz, T., & Nemeth, E. (2005) · Blood · doi:10.1182/blood-2004-12-4844 · Cited by 445 · see citing works

The Solution Structure of Human Hepcidin, a Peptide Hormone with Antimicrobial Activity That Is Involved in Iron Uptake and Hereditary Hemochromatosis

Hunter, H. N., Fulton, D. B., Ganz, T., & Vogel, H. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205305200 · Cited by 400 · see citing works

Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats

Frazer, D. M., Wilkins, S. J., Becker, E., Vulpe, C. D., McKie, A. T., Trinder, D., & Anderson, G. J. (2002) · Gastroenterology · doi:10.1053/gast.2002.35353 · Cited by 342 · see citing works

Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis

Nicolas, G., Viatte, L., Lou, D.-Q., Bennoun, M., Beaumont, C., Kahn, A., Andrews, N. C., & Vaulont, S. (2003) · Nature Genetics · doi:10.1038/ng1150 · Cited by 311 · see citing works

Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs

Rivera, S., Nemeth, E., Gabayan, V., Lopez, M. A., Farshidi, D., & Ganz, T. (2005) · Blood · doi:10.1182/blood-2005-04-1766 · Cited by 308 · see citing works

Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin

Drakesmith, H., Schimanski, L. M., Ormerod, E., Merryweather-Clarke, A. T., Viprakasit, V., Edwards, J. P., Sweetland, E., Bastin, J. M., Cowley, D., Chinthammitr, Y., et al. (2005) · Blood · doi:10.1182/blood-2005-02-0561 · Cited by 264 · see citing works

Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron

Gehrke, S. G., Kulaksiz, H., Herrmann, T. R. W., Riedel, H.-D., Bents, K., Veltkamp, C., & Stremmel, W. (2003) · Blood · doi:10.1182/blood-2002-11-3610 · Cited by 244 · see citing works

The molecular basis of ferroportin-linked hemochromatosis

De Domenico, I., Ward, D. M., Nemeth, E., Vaughn, M. B., Musci, G., Ganz, T., & Kaplan, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503804102 · Cited by 230 · see citing works

The orchestration of body iron intake: how and where do enterocytes receive their cues?

Frazer, D. M., & Anderson, G. J. (2003) · Blood Cells Molecules and Diseases · doi:10.1016/s1079-9796(03)00039-1 · Cited by 211 · see citing works

Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia

Rivera, S., Liu, L., Nemeth, E., Gabayan, V., Sorensen, O. E., & Ganz, T. (2005) · Blood · doi:10.1182/blood-2004-08-3375 · Cited by 196 · see citing works

Mechanisms of Iron Accumulation in Hereditary Hemochromatosis

Fleming, R. E., & Sly, W. S. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081501.155838 · Cited by 172 · see citing works

Functional differences between hepcidin 1 and 2 in transgenic mice

Lou, D.-Q., Nicolas, G., Lesbordes, J.-C., Viatte, L., Grimber, G., Szajnert, M.-F., Kahn, A., & Vaulont, S. (2004) · Blood · doi:10.1182/blood-2003-07-2524 · Cited by 123 · see citing works

Iron bioavailability and dietary reference values

Hurrell, R., & Egli, I. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.28674f · Cited by 1,359 · see citing works

Anemia and Iron Deficiency in Heart Failure

Anand, I. S., & Gupta, P. (2018) · Circulation · doi:10.1161/circulationaha.118.030099 · Cited by 600 · see citing works

STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

Verga Falzacappa, M. V., Vujic Spasic, M., Kessler, R., Stolte, J., Hentze, M. W., & Muckenthaler, M. U. (2007) · Blood · doi:10.1182/blood-2006-07-033969 · Cited by 567 · see citing works

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554 · see citing works

Clinical practice guideline: Red blood cell transfusion in adult trauma and critical care*

Napolitano, L. M., Kurek, S. J., Luchette, F. A., Corwin, H. L., Barie, P. S., Tisherman, S. A., Hébert, P. C., Anderson, G. L., Bard, M. R., Bromberg, W. J., et al. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181b39f1b · Cited by 551 · see citing works

Immunoassay for human serum hepcidin

Ganz, T., Olbina, G., Girelli, D., Nemeth, E., & Westerman, M. (2008) · Blood · doi:10.1182/blood-2008-02-139915 · Cited by 688 · see citing works

Intracellular iron transport and storage: from molecular mechanisms to health implications

Mackenzie, E. L., Iwasaki, K., & Tsuji, Y. (2008) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2007.1893 · Cited by 526 · see citing works

The Molecular Mechanism of Hepcidin-mediated Ferroportin Down-Regulation

De Domenico, I., Ward, D. M., Langelier, C., Vaughn, M. B., Nemeth, E., Sundquist, W. I., Ganz, T., Musci, G., & Kaplan, J. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-01-0060 · Cited by 434 · see citing works

Selective iron chelation in Friedreich ataxia: biologic and clinical implications

Boddaert, N., Le Quan Sang, K. H., Rötig, A., Leroy-Willig, A., Gallet, S., Brunelle, F., Sidi, D., Thalabard, J.-C., Munnich, A., & Cabantchik, Z. I. (2007) · Blood · doi:10.1182/blood-2006-12-065433 · Cited by 409 · see citing works

Iron in fatty liver and in the metabolic syndrome: A promising therapeutic target

Dongiovanni, P., Fracanzani, A. L., Fargion, S. R., & Valenti, L. V. C. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.05.008 · Cited by 360 · see citing works

Preoperative intravenous iron to treat anaemia before major abdominal surgery (PREVENTT): a randomised, double-blind, controlled trial

Richards, T., Baikady, R. R., Clevenger, B., Butcher, A., Abeysiri, S., Chau, M., Macdougall, I. C., Murphy, G. J., Swinson, R., Collier, T. J., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31539-7 · Cited by 352 · see citing works

Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin

De Domenico, I., Ward, D. M., di Patti, M. C. B., Jeong, S. Y., David, S., Musci, G., & Kaplan, J. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601735 · Cited by 350 · see citing works

Hypoxia-inducible factors in the kidney

Haase, V. H. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00071.2006 · Cited by 329 · see citing works

Iron metabolism in the anemia of chronic disease

Weiss, G. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.08.006 · Cited by 322 · see citing works

Hepcidin: from discovery to differential diagnosis

Kemna, E., Tjalsma, H., Willems, H. L., & Swinkels, D. W. (2007) · Haematologica · doi:10.3324/haematol.11705 · Cited by 313 · see citing works

Iron deficiency and cardiovascular disease

von Haehling, S., Jankowska, E. A., van Veldhuisen, D. J., Ponikowski, P. P., & Anker, S. D. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.109 · Cited by 307 · see citing works

Iron Deficiency in Heart Failure

von Haehling, S., Ebner, N., Evertz, R., Ponikowski, P. P., & Anker, S. D. (2018) · JACC Heart Failure · doi:10.1016/j.jchf.2018.07.015 · Cited by 305 · see citing works

Oxidative mechanisms in the pathogenesis of alcoholic liver disease

Albano, E. (2007) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2007.09.004 · Cited by 303 · see citing works

Brain Iron Metabolism

Rouault, T. A., & Cooperman, S. (2006) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2006.08.002 · Cited by 280 · see citing works

A precious metal: Iron, an essential nutrient for all cells

Cairo, G., Bernuzzi, F., & Recalcati, S. (2006) · Genes & Nutrition · doi:10.1007/bf02829934 · Cited by 252 · see citing works

Synthetic and natural iron chelators: Therapeutic potential and clinical use

Hatcher, H. C., Singh, R. N., Torti, F. M., & Torti, S. V. (2009) · Future Medicinal Chemistry · doi:10.4155/fmc.09.121 · Cited by 242 · see citing works

Ferroportin‐mediated mobilization of ferritin iron precedes ferritin degradation by the proteasome

De Domenico, I., Vaughn, M. B., Li, L., Bagley, D., Musci, G., Ward, D. M., & Kaplan, J. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601409 · Cited by 235 · see citing works

Iron regulation by hepcidin

Zhao, N., Zhang, A., & Enns, C. A. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67225 · Cited by 210 · see citing works

Hepcidin levels predict nonresponsiveness to oral iron therapy in patients with iron deficiency anemia

Bregman, D. B., Morris, D., Koch, T. A., He, A., & Goodnough, L. T. (2013) · American Journal of Hematology · doi:10.1002/ajh.23354 · Cited by 187 · see citing works

Human Polymorphonuclear Leukocytes Inhibit Aspergillus fumigatus Conidial Growth by Lactoferrin-Mediated Iron Depletion

Zarember, K. A., Sugui, J. A., Chang, Y. C., Kwon-Chung, K. J., & Gallin, J. I. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.10.6367 · Cited by 184 · see citing works

Iron Homeostasis in the Neonate

Collard, K. J. (2009) · PEDIATRICS · doi:10.1542/peds.2008-1047 · Cited by 182 · see citing works

Intravenous iron sucrose is superior to oral iron sulphate for correcting anaemia and restoring iron stores in IBD patients: A randomized, controlled, evaluator-blind, multicentre study

Lindgren, S. C., Wikman, O., Befrits, R., Blom, H., Eriksson, A., Grännö, C., Ung, K., Hjortswang, H., Lindgren, A., & Unge, P. (2009) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520902839667 · Cited by 180 · see citing works

Iron in arterial plaque: A modifiable risk factor for atherosclerosis

Sullivan, J. L. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.06.005 · Cited by 176 · see citing works

Randomized, double-blind, placebo-controlled trial of iron supplementation in female soldiers during military training: Effects on iron status, physical performance, and mood

McClung, J. P., Karl, J. P., Cable, S. J., Williams, K. W., Nindl, B. C., Young, A. J., & Lieberman, H. R. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27774 · Cited by 176 · see citing works

Trace minerals intake: Risks and benefits for cardiovascular health

Mohammadifard, N., Humphries, K. H., Gotay, C. C., Mena‐Sánchez, G., Salas‐Salvadó, J., Esmaillzadeh, A., Ignaszewski, A. P., & Sarrafzadegan, N. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1406332 · Cited by 169 · see citing works

Pathogenesis of alcohol‐induced liver disease: Classical concepts and recent advances

Seth, D., Haber, P. S., Syn, W., Diehl, A. M., & Day, C. P. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.06756.x · Cited by 166 · see citing works

Iron overload syndromes and the liver

Batts, K. P. (2007) · Modern Pathology · doi:10.1038/modpathol.3800715 · Cited by 163 · see citing works

Ferroportin is a manganese‐responsive protein that decreases manganese cytotoxicity and accumulation

Yin, Z., Jiang, H., Lee, E.-S., Ni, M., Erikson, K. M., Milatović, D., Bowman, A. B., & Aschner, M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06534.x · Cited by 160 · see citing works

Haemochromatosis

Adams, P. C., & Barton, J. C. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61782-6 · Cited by 161 · see citing works

Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry

Murphy, A., Witcher, D. R., Luan, P., & Wroblewski, V. J. (2007) · Blood · doi:10.1182/blood-2006-11-057471 · Cited by 158 · see citing works

New insights into the role of iron in inflammation and atherosclerosis

Cornelissen, A., Guo, L., Sakamoto, A., Virmani, R., & Finn, A. V. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.08.014 · Cited by 160 · see citing works

Restless legs syndrome – Theoretical roles of inflammatory and immune mechanisms

Weinstock, L. B., Walters, A. S., & Paueksakon, P. (2012) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2011.09.003 · Cited by 157 · see citing works

A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells

Verga Falzacappa, M. V., Casanovas, G., Hentze, M. W., & Muckenthaler, M. U. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0313-7 · Cited by 146 · see citing works

Macrophage Iron, Hepcidin, and Atherosclerotic Plaque Stability

Sullivan, J. L. (2007) · Experimental Biology and Medicine · doi:10.3181/0703-mr-54 · Cited by 143 · see citing works

Diminished Quality of Life and Physical Function in Community-Dwelling Elderly With Anemia

Thein, M. S., Ershler, W. B., Artz, A. S., Tecson, J., Robinson, B. E., Rothstein, G., Liede, A., Gylys-Colwell, I., Lu, Z. J., & Robbins, S. (2009) · Medicine · doi:10.1097/md.0b013e31819d89d5 · Cited by 141 · see citing works

Treatment of Iron Deficiency Anemia in Pregnancy with Intravenous versus Oral Iron: Systematic Review and Meta-Analysis

Burwick, R. M., & Govindappagari, S. (2018) · American Journal of Perinatology · doi:10.1055/s-0038-1668555 · Cited by 142 · see citing works

Strong iron demand during hypoxia-induced erythropoiesis is associated with down-regulation of iron-related proteins and myoglobin in human skeletal muscle

Robach, P., Cairo, G., Gelfi, C., Bernuzzi, F., Pilegaard, H., Viganò, A., Santambrogio, P., Cerretelli, P., Calbet, J. A. L., Moutereau, S., et al. (2007) · Blood · doi:10.1182/blood-2006-08-040006 · Cited by 141 · see citing works

Mechanisms of iron loading and toxicity

Anderson, G. J. (2007) · American Journal of Hematology · doi:10.1002/ajh.21075 · Cited by 139 · see citing works

Metals in the pathogenesis of type 2 diabetes

Khan, A. R., & Awan, F. R. (2014) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/2251-6581-13-16 · Cited by 136 · see citing works

Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zinc

Mitchell, C. J., Shawki, A., Ganz, T., Nemeth, E., & Mackenzie, B. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00348.2013 · Cited by 132 · see citing works

Ethanol and liver: Recent insights into the mechanisms of ethanol-induced fatty liver

Liu, J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i40.14672 · Cited by 124 · see citing works

Anaemia, Iron Deficiency and Heart Failure in 2020: Facts and Numbers

Chopra, V., & Anker, S. D. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12797 · Cited by 124 · see citing works

Hepcidin modulation in human diseases: From research to clinic

Piperno, A., Mariani, R., Trombini, P., & Girelli, D. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.538 · Cited by 115 · see citing works

Role of iron in the pathogenesis of respiratory disease

Ali, M. K., Kim, R., Karim, R., Mayall, J., Martin, K. L., Shahandeh, A., Abbasian, F., Starkey, M. R., Loustaud-Ratti, V., Johnstone, D. M., et al. (2017) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.05.003 · Cited by 112 · see citing works

Ceruloplasmin-ferroportin system of iron traffic in vertebrates

Musci, G. (2014) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v5.i2.204 · Cited by 108 · see citing works

Anemia in COPD: A Systematic Review of the Prevalence, Quality of Life, and Mortality

Yohannes, A. M., & Ershler, W. B. (2011) · Respiratory Care · doi:10.4187/respcare.01002 · Cited by 106 · see citing works

Development of a method for the sensitive and quantitative determination of hepcidin in human serum using LC-MS/MS

Li, H., Rose, M. J., Tran, L., Zhang, J., Miranda, L. P., James, C. A., & Sasu, B. J. (2009) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2009.02.004 · Cited by 104 · see citing works

Biochemistry and Biomarkers of Inflamed Patients: Why Look, What to Assess

Kaysen, G. A. (2009) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03090509 · Cited by 100 · see citing works

Mitochondrial involvement in genetically determined transition metal toxicity

Mehta, R., Templeton, D. M., & O'Brien, P. J. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2006.05.011 · Cited by 100 · see citing works

Cellular iron transport

Garrick, M. D., & Garrick, L. M. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.03.018 · Cited by 102 · see citing works

Ironing Out the Details: How Iron Orchestrates Macrophage Polarization

Xia, Y., Li, Y., Wu, X., Zhang, Q., Chen, S., Ma, X., & Yu, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.669566 · Cited by 98 · see citing works

Iron homeostasis in osteoporosis and its clinical implications

Li, G., Pan, Y. Z., Sirois, P., Li, K., & Xu, Y. (2012) · Osteoporosis International · doi:10.1007/s00198-012-1982-1 · Cited by 99 · see citing works

Iron requirements, absorption and metabolism in infancy and childhood

Domellöf, M. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3280523aaf · Cited by 96 · see citing works

Hepcidin: clinical utility as a diagnostic tool and therapeutic target

Coyne, D. W. (2011) · Kidney International · doi:10.1038/ki.2011.141 · Cited by 97 · see citing works

H+-Coupled Divalent Metal-Ion Transporter-1

Shawki, A., Knight, P. B., Maliken, B. D., Niespodzany, E. J., & Mackenzie, B. (2012) · Current topics in membranes · doi:10.1016/b978-0-12-394316-3.00005-3 · Cited by 94 · see citing works

Changes of gene expression of iron regulatory proteins during turpentine oil-induced acute-phase response in the rat

Sheikh, N., Dudás, J., & Ramadori, G. P. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700553 · Cited by 93 · see citing works

Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors

Volke, M., Gale, D. P., Maegdefrau, U., Schley, G., Klanke, B., Bosserhoff, A.-K., Maxwell, P. H., Eckardt, K.-U., & Warnecke, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007875 · Cited by 93 · see citing works

Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe

Gnana‐Prakasam, J. P., Martin, P. M., Mysona, B. A., Roon, P., Smith, S. B., & Ganapathy, V. (2008) · Biochemical Journal · doi:10.1042/bj20071377 · Cited by 90 · see citing works

COVID-19 and iron dysregulation: distant sequence similarity between hepcidin and the novel coronavirus spike glycoprotein

Ehsani, S. (2020) · Biology Direct · doi:10.1186/s13062-020-00275-2 · Cited by 87 · see citing works

Longitudinal decrements in iron status during military training in female soldiers

McClung, J. P., Karl, J. P., Cable, S. J., Williams, K. W., Young, A., & Lieberman, H. R. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509220873 · Cited by 87 · see citing works

Fisiologia e metabolismo do ferro

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An Insight into the Relationships between Hepcidin, Anemia, Infections and Inflammatory Cytokines in Pediatric Refugees: A Cross-Sectional Study

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