The interleukin-17 pathway is involved in human alcoholic liver disease # †
Abstract
Immune dysregulations in alcoholic liver diseases are still unclear, especially regarding alcoholic hepatitis inflammatory burst. Interleukin-17 (IL-17) is known to enhance neutrophil recruitment. We studied the IL-17 pathway in alcoholic cirrhosis and alcoholic hepatitis. Patients with alcoholic liver disease were compared with patients with chronic hepatitis C virus (HCV) infection or autoimmune liver disease and with healthy controls. IL-17 plasma levels and peripheral blood mononuclear cell secretion were assessed by enzyme-linked immunosorbent assay (ELISA) and T cell phenotype by flow cytometry. IL-17 staining and co-staining with CD3 and myeloperoxidase were performed on liver biopsy specimens. IL-17 receptor expression was studied on liver biopsies and in human hepatic stellate cells as well as their response to recombinant IL-17 by chemotaxis assays. IL-17 plasma levels were dramatically increased in alcoholic liver disease patients. Peripheral blood mononuclear cells of patients with alcoholic liver disease produced higher amounts of IL-17, and their CD4 + T lymphocytes disclosed an IL-17–secreting phenotype. In the liver, IL-17–secreting cells contributed to inflammatory infiltrates in alcoholic cirrhosis, and alcoholic hepatitis foci disclosed many IL-17 + cells, including T lymphocytes and neutrophils. In alcoholic liver disease, liver IL-17 + cells infiltrates correlated to model for end-stage liver disease score, and in alcoholic hepatitis to modified discriminant function. IL-17 receptor was expressed in alcoholic liver disease by hepatic stellate cells, and these cells recruited neutrophils after IL-17 stimulation in a dose-dependent manner through IL-8 and growth related oncogen α (GRO-α) secretion in vitro . Conclusion: Human alcoholic liver disease is characterized by the activation of the IL-17 pathway. In alcoholic hepatitis, liver infiltration with IL-17–secreting cell infiltrates is a key feature that might contribute to liver neutrophil recruitment. (Clinical trials number NCT00610597). (Hepatology 2009;49:646–657.)
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Cites
Design and validation of a histological scoring system for nonalcoholic fatty liver disease†
Kleiner, D. E., Brunt, E. M., Van Natta, M., Behling, C., Contos, M. J., Cummings, O. W., Ferrell, L. D., Liu, Y., Torbenson, M. S., Unalp‐Arida, A., et al. (2005) · Hepatology · doi:10.1002/hep.20701 · Cited by 10,791 · see citing works
Steatohepatitis: A tale of two “hits”?
Day, C. P., & James, O. F. W. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70599-2 · Cited by 4,285 · see citing works
Alvarez, F., Berg, P. A., Bianchi, F. B., Bianchi, L., Burroughs, A. K., Cancado, E. L., Chapman, R. W., Cooksley, W. G. E., Czaja, A. J., Desmet, V. J., et al. (1999) · Journal of Hepatology · doi:10.1016/s0168-8278(99)80297-9 · Cited by 2,903 · see citing works
Interleukin-17 Family Members and Inflammation
Kolls, J. K., & Lindén, A. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.018 · Cited by 2,371 · see citing works
Bédossa, P. (1994) · Hepatology · doi:10.1002/hep.1840200104 · Cited by 2,189 · see citing works
Development, cytokine profile and function of human interleukin 17-producing helper T cells
Wilson, N. J., Boniface, K., Chan, J. R., McKenzie, B. S., Blumenschein, W. M., Mattson, J. D., Basham, B., Smith, K., Chen, T., Morel, F., et al. (2007) · Nature Immunology · doi:10.1038/ni1497 · Cited by 2,035 · see citing works
Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A., & Sallusto, F. (2007) · Nature Immunology · doi:10.1038/ni1496 · Cited by 1,857 · see citing works
IL-17 family cytokines and the expanding diversity of effector T cell lineages
Weaver, C. T., Hatton, R. D., Mangan, P. R., & Harrington, L. E. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141557 · Cited by 1,842 · see citing works
Increased expression of interleukin 17 in inflammatory bowel disease
Fujino, S., Andoh, A., Bamba, S., Ogawa, A., Hata, K., Araki, Y., Bamba, T., & Fujiyama, Y. (2003) · Gut · doi:10.1136/gut.52.1.65 · Cited by 1,713 · see citing works
The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation
Ouyang, W., Kolls, J. K., & Zheng, Y. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.004 · Cited by 1,697 · see citing works
The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies
Flier, J. S., Underhill, L. H., & Friedman, S. L. (1993) · New England Journal of Medicine · doi:10.1056/nejm199306243282508 · Cited by 1,433 · see citing works
Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties
Weaver, C. T., Harrington, L. E., Mangan, P. R., Gavrieli, M., & Murphy, K. M. (2006) · Immunity · doi:10.1016/j.immuni.2006.06.002 · Cited by 1,422 · see citing works
Steinman, L. (2007) · Nature Medicine · doi:10.1038/nm1551 · Cited by 1,367 · see citing works
Cytokines in Alcoholic and Nonalcoholic Steatohepatitis
Tilg, H., & Diehl, A. M. (2000) · New England Journal of Medicine · doi:10.1056/nejm200011163432007 · Cited by 935 · see citing works
TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1
Amadi‐Obi, A., Yu, C., Liu, X., Mahdi, R. M., Clarke, G., Nussenblatt, R. B., Gery, I., Lee, Y. S., & Egwuagu, C. E. (2007) · Nature Medicine · doi:10.1038/nm1585 · Cited by 861 · see citing works
Ferretti, S., Bonneau, O., Dubois, G. R., Jones, C. E., & Trifilieff, A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.4.2106 · Cited by 542 · see citing works
Increased tumor necrosis factor production by monocytes in alcoholic hepatitis
McClain, C. J., & Cohen, D. A. (1989) · Hepatology · doi:10.1002/hep.1840090302 · Cited by 540 · see citing works
Epidemiology of Alcoholic Liver Disease
Mandayam, S., Jamal, M. M., & Morgan, T. R. M. (2004) · Seminars in Liver Disease · doi:10.1055/s-2004-832936 · Cited by 527 · see citing works
van Beelen, A. J., Zelinková, Z., Taanman-Kueter, E. W., Muller, F. J. M., Hommes, D. W., Zaat, S. A. J., Kapsenberg, M. L., & de Jong, E. C. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.013 · Cited by 516 · see citing works
Methylprednisolone Therapy in Patients with Severe Alcoholic Hepatitis
Carithers, R. L., Herlong, H. F., Diehl, A. M., Shaw, E. W., Combes, B., Fallon, H. J., & Maddrey, W. C. (1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-110-9-685 · Cited by 500 · see citing works
Happel, K. I., Zheng, M., Young, E. A., Quinton, L. J., Lockhart, E., Ramsay, A. J., Shellito, J. E., Schurr, J. R., Bagby, G. J., Nelson, S., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.9.4432 · Cited by 448 · see citing works
Management of primary biliary cirrhosis
Heathcote, J. (2000) · Hepatology · doi:10.1053/he.2000.5984 · Cited by 412 · see citing works
Mookerjee, R. P., Stadlbauer, V., Lidder, S., Wright, G. A. K., Hodges, S. J., Davies, N. A., & Jalan, R. (2007) · Hepatology · doi:10.1002/hep.21737 · Cited by 332 · see citing works
Witowski, J., Pawlaczyk, K., Bręborowicz, A., Scheuren, A., Kużlan-Pawlaczyk, M., Wiśniewska, J., Połubińska, A., Friess, H., Gahl, G. M., Frei, U. A., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.10.5814 · Cited by 304 · see citing works
EPSTEIN, M. A., ACHONG, B. G., & BARR, Y. M. (1964) · The Lancet · doi:10.1016/s0140-6736(64)91529-6 · Cited by 299 · see citing works
Jones, C. E., & Chan, K. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.26.6.4757 · Cited by 289 · see citing works
Awane, M., Andres, P. G., Li, D. J., & Reinecker, H. (1999) · PubMed · Cited by 288 · see citing works
IL-17 Enhances Chemokine Gene Expression through mRNA Stabilization
Hartupee, J. C., Liu, C., Novotny, M., Li, X., & Hamilton, T. A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.4135 · Cited by 282 · see citing works
Awane, M., Andres, P. G., Li, D. J., & Reinecker, H. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.9.5337 · Cited by 272 · see citing works
Interleukin‐17 as an Effector Molecule of Innate and Acquired Immunity against Infections
Matsuzaki, G., & Umemura, M. (2007) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2007.tb04008.x · Cited by 255 · see citing works
Differential liver sensitization to Toll-like receptor pathways in mice with alcoholic fatty liver
Gustot, T., Lemmers, A., Moreno, C., Nagy, N., Quertinmont, E., Nicaise, C., Franchimont, D. P., Louis, H., Deviere, J. M., & Moine, O. L. (2006) · Hepatology · doi:10.1002/hep.21138 · Cited by 244 · see citing works
Self-citationNagy, L. E. (2003) · Experimental Biology and Medicine · doi:10.1177/153537020322800803 · Cited by 227 · see citing works
Hata, K., Andoh, A., Shimada, M., Fujino, S., Bamba, S., Araki, Y., Okuno, T., Fujiyama, Y., & Bamba, T. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00494.2001 · Cited by 218 · see citing works
Sheron, N., Bird, G. L. A., Koskinas, J. S., Portmann, B. C., Ceska, M., Lindley, I., & William, R. (1993) · Hepatology · doi:10.1002/hep.1840180108 · Cited by 211 · see citing works
Excessive In Vitro Bacterial Lipopolysaccharide–Induced Production of Monokines in Cirrhosis
Deviere, J. M. E., Content, J., Denys, C. H., Vandenbussche, P., Schandené, L., Wybran, J., & Dupont, É. (1990) · Hepatology · doi:10.1002/hep.1840110416 · Cited by 183 · see citing works
Deviere, J. M. E., Content, J., Denys, C. H., Vandenbussche, P., Schandené, L., Wybran, J., & Dupont, E. (1989) · PubMed Central · Cited by 181 · see citing works
Novel insights into the biology and physiology of the Ito cell
Pinzani, M. (1995) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(94)00072-b · Cited by 177 · see citing works
Management strategies in alcoholic liver disease
Tilg, H., & Day, C. P. (2007) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep0683 · Cited by 160 · see citing works
Hines, I. N., & Wheeler, M. D. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00094.2004 · Cited by 158 · see citing works
Neutrophil-mediated tissue injury in alcoholic hepatitis
Jaeschke, H. (2002) · Alcohol · doi:10.1016/s0741-8329(02)00200-8 · Cited by 150 · see citing works
Kishore, R., Hill, J. R., McMullen, M. R., Frenkel, J., & Nagy, L. E. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00328.2001 · Cited by 137 · see citing works
Current management of alcoholic liver disease
Tomé, S., & Lucey, M. R. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.01881.x · Cited by 126 · see citing works
Colmenero, J., Bataller, R. A., Sancho‐Bru, P., Bellot, P., Miquel, R., Moreno, M., Jares, P., Bosch, J., Arroyo, V., Caballería, J., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.12.036 · Cited by 124 · see citing works
Monocyte activation in alcoholic liver disease
McClain, C. J., Hill, D. B., Song, Z., Deaciuc, I. V., & Barve, S. S. (2002) · Alcohol · doi:10.1016/s0741-8329(02)00212-4 · Cited by 118 · see citing works
Cell-mediated hepatic injury in alcoholic liver disease
Chedid, A., Mendenhall, C. L., Moritz, T. E., French, S. W., Chen, T., Morgan, T. R. M., Roselle, G. A., Nemchausky, B. A., Tamburro, C. H., Schiff, E. R., et al. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90034-a · Cited by 117 · see citing works
McMullen, M. R., Pritchard, M. T., Wang, Q., Millward, C. A., Croniger, C. M., & Nagy, L. E. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.02.065 · Cited by 116 · see citing works
Immunologic Mechanisms of Alcoholic Liver Injury
Thiele, G. M., Freeman, T. L., & Klassen, L. W. (2004) · Seminars in Liver Disease · doi:10.1055/s-2004-832940 · Cited by 89 · see citing works
Dicing with Viruses: MicroRNAs as Antiviral Factors
Müller, S., & Imler, J. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.003 · Cited by 63 · see citing works
Calcineurin is required for translational control of protein synthesis in rat pancreatic acini
Sans, M. D., & Williams, J. A. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00534.2003 · Cited by 63 · see citing works
Antigen-induced IL-17 response in the peripheral blood mononuclear cells (PBMC) of healthy controls
Lenarczyk, A., Helsloot, J., Farmer, K. M., Peters, L., Sturgess, A. D., & Kirkham, B. W. (2000) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2000.01328.x · Cited by 58 · see citing works
Antifibrogenic effects of canrenone, an antialdosteronic drug, on human hepatic stellate cells
Caligiuri, A. (2003) · Gastroenterology · doi:10.1053/gast.2003.50058 · Cited by 52 · see citing works
Corticosteroids for alcoholic hepatitis—what's next?
Mathurin, P. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.06.003 · Cited by 49 · see citing works
T-cell activation, expression of adhesion molecules and response to ethanol in alcoholic cirrhosis
Santos, J. L., Diez‐Ruiz, A., Luna-Casado, L., Soto-Mas, J. A., WACHTER, H., Fuchs, D., & Gutierrez-Gea, F. (1996) · Immunology Letters · doi:10.1016/0165-2478(96)02541-2 · Cited by 38 · see citing works
Treatment of Alcoholic Liver Disease
Mezey, E. (1993) · Seminars in Liver Disease · doi:10.1055/s-2007-1007350 · Cited by 24 · see citing works
L-asparaginase: suppression of the immune response of mice to sheep red blood cells.
Ohno, R., Harris, J. E., & Hersh, E. M. (1970) · PubMed · Cited by 12 · see citing works
Flagged first, then by citations
1 of the 57 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Molecular and cellular mechanisms of liver fibrosis and its regression
Kisseleva, T., & Brenner, D. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00372-7 · Cited by 2,024 · see citing works
Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets
Gao, B., & Bataller, R. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.09.002 · Cited by 1,963 · see citing works
Fibrosis: from mechanisms to medicines
Henderson, N. C., Rieder, F., & Wynn, T. A. (2020) · Nature · doi:10.1038/s41586-020-2938-9 · Cited by 1,868 · see citing works
Liver inflammation and fibrosis
Koyama, Y., & Brenner, D. A. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88881 · Cited by 1,295 · see citing works
Cirrhosis-associated immune dysfunction: Distinctive features and clinical relevance
Albillos, A., Lario, M., & Álvarez-Mon, M. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.08.010 · Cited by 1,242 · see citing works
Hepatic inflammatory responses in liver fibrosis
Hammerich, L., & Tacke, F. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00807-x · Cited by 803 · see citing works
Meng, F., Wang, K., Aoyama, T., Grivennikov, S. I., Paik, Y., Scholten, D., Cong, M., Iwaisako, K., Liu, X., Zhang, M., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.05.049 · Cited by 711 · see citing works
Pathogenesis of alcoholic liver disease: Role of oxidative metabolism
Ceni, E., Mello, T., & Galli, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i47.17756 · Cited by 521 · see citing works
The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease
Gadd, V. L., Skoien, R., Powell, E. E., Fagan, K. J., Winterford, C., Horsfall, L., Irvine, K., & Clouston, A. D. (2014) · Hepatology · doi:10.1002/hep.26937 · Cited by 452 · see citing works
Ki, S. H., Park, O., Zheng, M., Morales‐Ibanez, O., Kolls, J. K., Bataller, R. A., & Gao, B. (2010) · Hepatology · doi:10.1002/hep.23837 · Cited by 433 · see citing works
Inflammatory pathways in alcoholic steatohepatitis
Gao, B., Ahmad, M. F., Nagy, L. E., & Tsukamoto, H. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2018.10.023 · Cited by 392 · see citing works
Evolving Concepts in the Pathogenesis of NASH: Beyond Steatosis and Inflammation
Peverill, W., Powell, L. W., & Skoien, R. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15058591 · Cited by 379 · see citing works
Zhang, J., Zhang, Z., Lin, F., Zou, Z., Xu, R., Jin, L., Fu, J., Shi, F., Shi, M., Wang, H., et al. (2009) · Hepatology · doi:10.1002/hep.23273 · Cited by 371 · see citing works
Pathological Features of Fatty Liver Disease
Yeh, M. M., & Brunt, E. M. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.07.056 · Cited by 339 · see citing works
de Morales, J. M. G. R., Puig, L., Daudén, E., Cañete, J. D. D., Pablos, J. L., Martín, A. O., Juanatey, C. G., Adán, A., Montalbán, X., Borruel, N., et al. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.102429 · Cited by 342 · see citing works
Wick, G., Grundtman, C., Mayerl, C., Wimpissinger, F., Feichtinger, J., Zelger, B. G., Sgonc, R., & Wolfram, D. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095937 · Cited by 336 · see citing works
Tan, Z., Qian, X., Jiang, R., Liu, Q., Wang, Y., Chen, C., Wang, X., Ryffel, B., & Sun, B. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203013 · Cited by 330 · see citing works
The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis
Bala, S., Csák, T., Saha, B., Zatsiorsky, J., Kodys, K., Catalano, D. E., Satishchandran, A., & Szabó, G. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.01.035 · Cited by 305 · see citing works
Rau, M., Schilling, A.-K., Meertens, J., Hering, I., Weiss, J., Jurowich, C., Kudlich, T., Hermanns, H. M., Bantel, H., Beyersdorf, N., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501175 · Cited by 302 · see citing works
Inflammation in Alcoholic Liver Disease
Wang, H. J., Gao, B., Zakhari, S., & Nagy, L. E. (2012) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-072610-145138 · Cited by 297 · see citing works
Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease
Tang, Y., Bian, Z., Zhao, L., Liu, Y., Liang, S., Wang, Q., Han, X., Peng, Y., Chen, X., Shen, L., et al. (2011) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2011.04471.x · Cited by 294 · see citing works
Alcoholic liver disease: pathogenesis and new targets for therapy
Altamirano, J., & Bataller, R. (2011) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2011.134 · Cited by 284 · see citing works
Alcohol, inflammation, and gut-liver-brain interactions in tissue damage and disease development
Wang, H. J. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i11.1304 · Cited by 282 · see citing works
NLRP3 inflammasome driven liver injury and fibrosis: roles of IL-17 and TNF in mice
Wree, A., McGeough, M. D., Inzaugarat, M. E., Eguchi, A., Schuster, S., Johnson, C. D., Peña, C. A., Geisler, L. J., Papouchado, B. G., Hoffman, H. M., et al. (2018) · Hepatology · doi:10.1002/hep.29523 · Cited by 266 · see citing works
Weiskirchen, R., & Tacke, F. (2014) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2304-3881.2014.11.03 · Cited by 269 · see citing works
Role of IL-17 and Th17 Cells in Liver Diseases
Hammerich, L., Heymann, F., & Tacke, F. (2010) · Clinical and Developmental Immunology · doi:10.1155/2011/345803 · Cited by 261 · see citing works
Treatment options for alcoholic and non-alcoholic fatty liver disease: A review
Singh, S., Osna, N. A., & Kharbanda, K. K. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i36.6549 · Cited by 257 · see citing works
The Effect of Inflammatory Cytokines in Alcoholic Liver Disease
Kawaratani, H., Tsujimoto, T., Douhara, A., Takaya, H., Moriya, K., Namisaki, T., Noguchi, R., Yoshiji, H., Fujimoto, M., & Fukui, H. (2013) · Mediators of Inflammation · doi:10.1155/2013/495156 · Cited by 258 · see citing works
Innate Immune Cells in Liver Inflammation
Liaskou, E., Wilson, D. V., & Oo, Y. H. (2012) · Mediators of Inflammation · doi:10.1155/2012/949157 · Cited by 255 · see citing works
Pathophysiology and Management of Alcoholic Liver Disease: Update 2016
Stickel, F., Datz, C., Hampe, J., & Bataller, R. A. (2017) · Gut and Liver · doi:10.5009/gnl16477 · Cited by 253 · see citing works
Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver
Hegde, P., Weiss, E., Paradis, V., Wan, J., Mabire, M., Sukriti, S., Rautou, P.-E., Albuquerque, M., Picq, O., Gupta, A. C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04450-y · Cited by 232 · see citing works
The Spectrum of Achalasia: Lessons From Studies of Pathophysiology and High-Resolution Manometry
Kahrilas, P. J., & Boeckxstaens, G. E. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.038 · Cited by 234 · see citing works
Alcoholic liver disease: Pathogenesis, management, and novel targets for therapy
Orman, E. S., Òdena, G., & Bataller, R. A. (2013) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12030 · Cited by 233 · see citing works
Innate immunity in alcoholic liver disease
Gao, B., Seki, E., Brenner, D. A., Friedman, S. L., Cohen, J. I., Nagy, L. E., Szabó, G., & Zakhari, S. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00537.2010 · Cited by 231 · see citing works
Zhao, L., Tang, Y., You, Z., Wang, Q., Liang, S., Han, X., Qiu, D., Wei, J., Liu, Y., Shen, L., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018909 · Cited by 227 · see citing works
The Role of Chemokines in the Recruitment of Lymphocytes to the Liver
Oo, Y. H., Shetty, S., & Adams, D. (2010) · Digestive Diseases · doi:10.1159/000282062 · Cited by 215 · see citing works
Wang, S., Wang, X., Tan, Z., Su, Y., Liu, J., Chang, M., Yan, F., Chen, J., Chen, T., Li, C., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0242-8 · Cited by 211 · see citing works
Cellular mechanisms of tissue fibrosis. 5. Novel insights into liver fibrosis
Mallat, A., & Lotersztajn, S. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00230.2013 · Cited by 211 · see citing works
CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver
Oo, Y. H., Banz, V. M., Kavanagh, D. P. J., Liaskou, E., Withers, D. R., Humphreys, E. H., Reynolds, G. M., Lee–Turner, L., Kalia, N., Hübscher, S. G., et al. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.07.008 · Cited by 210 · see citing works
Yang, Y. M., Cho, Y. E., & Hwang, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020774 · Cited by 199 · see citing works
Oxidative stress in alcohol-related liver disease
Tan, H. K., Yates, E., Lilly, K., & Dhanda, A. (2020) · World Journal of Hepatology · doi:10.4254/wjh.v12.i7.332 · Cited by 189 · see citing works
High expression of IL-17 and IL-17RE associate with poor prognosis of hepatocellular carcinoma
Liao, R., Sun, J., Wu, H., Yi, Y., Wang, J., He, H.-W., Cai, X., Zhou, J., Cheng, Y., Fan, J., et al. (2013) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-32-3 · Cited by 173 · see citing works
Pathogenesis of alcohol‐induced liver disease: Classical concepts and recent advances
Seth, D., Haber, P. S., Syn, W., Diehl, A. M., & Day, C. P. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.06756.x · Cited by 166 · see citing works
Miller, A. M., Wang, H., Bertola, A., Park, O., Horiguchi, N., Ki, S. H., Yin, S., Lafdil, F., & Gao, B. (2011) · Hepatology · doi:10.1002/hep.24517 · Cited by 162 · see citing works
Type 3 cytokines IL-17A and IL-22 drive TGF-β–dependent liver fibrosis
Fabre, T., Molina, M. F., Soucy, G., Goulet, J.-P., Willems, B., Villeneuve, J.-P., Bilodeau, M., & Shoukry, N. H. (2018) · Science Immunology · doi:10.1126/sciimmunol.aar7754 · Cited by 155 · see citing works
Cytokine production by human neutrophils: Revisiting the “dark side of the moon”
Tamassia, N., Bianchetto-Aguilera, F. M., Arruda-Silva, F., Gardiman, E., Gasperini, S., Calzetti, F., & Cassatella, M. A. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.12952 · Cited by 160 · see citing works
Th17 cells and their associated cytokines in liver diseases
Lafdil, F., Miller, A. M., Ki, S. H., & Gao, B. (2010) · Cellular and Molecular Immunology · doi:10.1038/cmi.2010.5 · Cited by 158 · see citing works
The Role of Innate Immunity in Alcoholic Liver Disease
Nagy, L. E. (2015) · Alcohol research · doi:10.35946/arcr.v37.2.08 · Cited by 153 · see citing works
Systemic effects of IL-17 in inflammatory arthritis
Beringer, A., & Miossec, P. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0243-5 · Cited by 152 · see citing works
Fabre, T., Kared, H., Friedman, S. L., & Shoukry, N. H. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400861 · Cited by 150 · see citing works
Immunopathobiology and therapeutic targets related to cytokines in liver diseases
He, Y., Hwang, S., Ahmed, Y. A., Feng, D., Li, N., Ribeiro, M. D. C., Lafdil, F., Kisseleva, T., Szabó, G., & Gao, B. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00580-w · Cited by 136 · see citing works
Khanam, A., Chua, J. V., & Kottilil, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115497 · Cited by 138 · see citing works
Gut-derived systemic inflammation as a driver of depression in chronic liver disease
Kronsten, V. T., Tranah, T. H., Pariante, C. M., & Shawcross, D. L. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.11.008 · Cited by 134 · see citing works
Targeting Inflammation by Flavonoids: Novel Therapeutic Strategy for Metabolic Disorders
Farzaei, M. H., Singh, A. K., Kumar, R., Croley, C. R., Pandey, A. K., Coy-Barrera, E. D., Patra, J. K., Das, G., Kerry, R. G., Annunziata, G., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194957 · Cited by 134 · see citing works
Guillot, A., Hamdaoui, N., Bizy, A., Zoltani, K., Souktani, R., Zafrani, E., Mallat, A., Lotersztajn, S., & Lafdil, F. (2013) · Hepatology · doi:10.1002/hep.26598 · Cited by 125 · see citing works
Chen, R.-C., Xu, L.-M., Du, S.-J., Huang, S.-S., Wu, H., Dong, J.-J., Huang, J.-R., Wang, X.-D., Feng, W.-K., & Chen, Y.-P. (2016) · Toxicology Letters · doi:10.1016/j.toxlet.2015.11.019 · Cited by 123 · see citing works
Cytokines and fatty liver diseases
Niederreiter, L., & Tilg, H. (2018) · Liver Research · doi:10.1016/j.livres.2018.03.003 · Cited by 126 · see citing works
Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice
Lazaro, R. G., Wu, R. P., Lee, S., Zhu, N., Chen, C., French, S. W., Xu, J., Machida, K., & Tsukamoto, H. (2014) · Hepatology · doi:10.1002/hep.27383 · Cited by 120 · see citing works
Sun, H. Q., Zhang, J., Zhang, H., Zou, Z., Wang, F. S., & Jia, J. (2012) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2011.01561.x · Cited by 120 · see citing works
Implication of Th17 and Th1 Cells in Patients with Chronic Active Hepatitis B
Ge, J., Wang, K., Meng, Q., Qi, Z.-X., Meng, F.-L., & Fan, Y. (2009) · Journal of Clinical Immunology · doi:10.1007/s10875-009-9328-2 · Cited by 120 · see citing works
Zhang, J., Zou, Z., Huang, A., Zhang, Z., Fu, J., Xu, X.-S., Chen, L., Li, B., & Wang, F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017484 · Cited by 118 · see citing works
Giles, D. A., Moreno-Fernandez, M. E., Stankiewicz, T. E., Cappelletti, M., Huppert, S. S., Iwakura, Y., Dong, C., Shanmukhappa, S. K., & Divanovic, S. (2016) · PLOS ONE · doi:10.1371/journal.pone.0149783 · Cited by 116 · see citing works
Lurje, I., Hammerich, L., & Tacke, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197378 · Cited by 118 · see citing works
Krueger, J. G., & Brunner, P. M. (2017) · Experimental Dermatology · doi:10.1111/exd.13467 · Cited by 113 · see citing works
Lafdil, F., Wang, H., Park, O., Zhang, W., Moritoki, Y., Yin, S., Fu, X. Y., Gershwin, M. E., Lian, Z., & Gao, B. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.08.004 · Cited by 112 · see citing works
Sepsis in alcohol-related liver disease
Gustot, T., Fernández, J., Szabó, G., Albillos, A., Louvet, A., Jalan, R., Moreau, R., & Moreno, C. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.06.013 · Cited by 108 · see citing works
Self-citationPathways of liver injury in alcoholic liver disease
Tilg, H., Moschen, A. R., & Kaneider, N. C. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.05.015 · Cited by 108 · see citing works
Xu, L., Gong, Y., Wang, B., Shi, K., Hou, Y., Wang, L., Lin, Z., Han, Y., Lu, L., Chen, D., et al. (2014) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12653 · Cited by 106 · see citing works
Osteoporosis and fractures in liver disease: Relevance, pathogenesis and therapeutic implications
Nakchbandi, I. A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i28.9427 · Cited by 105 · see citing works
Current understanding of osteoporosis associated with liver disease
Nakchbandi, I. A., & van der Merwe, S. W. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.166 · Cited by 98 · see citing works
IL-17 and IL-17-producing cells and liver diseases, with focus on autoimmune liver diseases
Beringer, A., & Miossec, P. (2018) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.06.008 · Cited by 97 · see citing works
Two Faces of Neutrophils in Liver Disease Development and Progression
Cho, Y., & Szabó, G. (2020) · Hepatology · doi:10.1002/hep.31680 · Cited by 98 · see citing works
IL-17 Axis Driven Inflammation in Non-Alcoholic Fatty Liver Disease Progression
Giles, D. A., Moreno‐Fernandez, M. E., & Divanovic, S. (2015) · Current Drug Targets · doi:10.2174/1389450116666150531153627 · Cited by 98 · see citing works
Maricic, I., Marrero, I., Eguchi, A., Nakamura, R., Johnson, C. D., Dasgupta, S., Hernandez, C. D., Nguyen, P. S., Swafford, A. D., Knight, R., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800614 · Cited by 92 · see citing works
Autophagy: A Multifaceted Partner in Liver Fibrosis
Mallat, A., Lodder, J., Teixeira-Clerc, F., Moreau, R., Codogno, P., & Lotersztajn, S. (2014) · BioMed Research International · doi:10.1155/2014/869390 · Cited by 93 · see citing works
Recent Insights Into the Role of Immune Cells in Alcoholic Liver Disease
Li, S., Tan, H., Wang, N., Feng, Y., Wang, X., & Feng, Y. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01328 · Cited by 94 · see citing works
Cell-to-cell and organ-to-organ crosstalk in the pathogenesis of alcohol-associated liver disease
Gao, H., Jiang, Y., Zeng, G., Huda, N., Thoudam, T., Yang, Z.-H., Liangpunsakul, S., & Ma, J. (2024) · eGastroenterology · doi:10.1136/egastro-2024-100104 · Cited by 85 · see citing works
Th17 cells are increased with severity of liver inflammation in patients with chronic hepatitis C
Chang, Q., Wang, Y., Zhao, Q., Wang, C. J., Hu, Y., & Wu, B. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.06782.x · Cited by 88 · see citing works
Joshi‐Barve, S., Kirpich, I., Cave, M. C., Marsano, L. S., & McClain, C. J. (2015) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2015.05.006 · Cited by 91 · see citing works
Involvement of Th17 and Th1 Effector Responses in Patients with Hepatitis B
Ye, Y., Xie, X., Yu, J.-W., Zhou, L., Xie, H., Jiang, G., Yu, X., Zhang, W., Wu, J., & Zheng, S. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9416-3 · Cited by 88 · see citing works
Mesenchymal stem cells attenuate liver fibrosis by suppressing Th17 cells - an experimental study
Milosavljević, N., Gazdic, M., Marković, B. S., Arsenijević, A., Nurković, J., Dolicanin, Z. C., Jovicic, N. U., Jeftic, I. D., Djonov, V., Arsenijević, N., et al. (2017) · Transplant International · doi:10.1111/tri.13023 · Cited by 87 · see citing works
Zeng, S.-L., Rosati, E., Saggau, C., Messner, B., Chu, H., Duan, Y., Hartmann, P., Wang, Y., Ma, S., Huang, W. J. M., et al. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.02.001 · Cited by 90 · see citing works
Tsuda, M., Zhang, W., Yang, G., Tsuneyama, K., Ando, Y., Kawata, K., Park, O., Leung, P. S. C., Coppel, R. L., Ansari, A. A., et al. (2012) · Hepatology · doi:10.1002/hep.25829 · Cited by 86 · see citing works
Foster, R. G., Golden‐Mason, L., Rutebemberwa, A., & Rosen, H. R. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1997-z · Cited by 84 · see citing works
Zhang, J., Song, C.-H., Shi, F., Zhang, Z., Fu, J., & Wang, F. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013869 · Cited by 83 · see citing works
Bias in macrophage activation pattern influences non-alcoholic steatohepatitis (NASH) in mice
Maina, V., Sutti, S., Locatelli, I., Vidali, M., Mombello, C., Bozzola, C., & Albano, E. (2011) · Clinical Science · doi:10.1042/cs20110366 · Cited by 83 · see citing works
Czaja, A. J. (2014) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12825 · Cited by 83 · see citing works
IL-17A Synergistically Enhances Bile Acid–Induced Inflammation during Obstructive Cholestasis
O'Brien, K. M., Allen, K. M., Rockwell, C. E., Towery, K., Luyendyk, J. P., & Copple, B. L. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.07.019 · Cited by 82 · see citing works
Raised interleukin-17 is immunolocalised to neutrophils in cystic fibrosis lung disease
Brodlie, M., McKean, M. C., Johnson, G. E., Anderson, A. E., Hilkens, C. M. U., Fisher, A. J., Corris, P. A., Lordan, J. L., & Ward, C. (2010) · European Respiratory Journal · doi:10.1183/09031936.00067110 · Cited by 81 · see citing works
Solari, N. E. F., Inzaugarat, M. E., Baz, P., Matteo, E. D., Lezama, C., Galoppo, M., Galoppo, C., & Cherñavsky, A. C. (2012) · Journal of Clinical Immunology · doi:10.1007/s10875-011-9635-2 · Cited by 78 · see citing works
Inflammatory status in human hepatic cirrhosis
Martinez‐Esparza, M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i41.11522 · Cited by 79 · see citing works
Milosavljević, N., Gazdic, M., Marković, B. S., Arsenijević, A., Nurković, J., Dolicanin, Z. C., Djonov, V., Lukić, M. L., & Volarević, V. (2017) · Liver Transplantation · doi:10.1002/lt.24784 · Cited by 79 · see citing works
Molecular Mechanism and Treatment of Viral Hepatitis-Related Liver Fibrosis
Su, T., Kao, J., & Liu, C. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150610578 · Cited by 77 · see citing works
Teng, S., Zhang, Y., Jin, X., Zhu, Y., Li, L., Huang, X., Wang, D., & Lin, Z. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.120453 · Cited by 76 · see citing works
Targeting inflammation for the treatment of alcoholic liver disease,
Xu, M.-J., Zhou, Z., Parker, R., & Gao, B. (2017) · Pharmacology and Therapeutics · doi:10.1016/j.pharmthera.2017.06.007 · Cited by 66 · see citing works
A review on molecular mechanism of alcoholic liver disease.
Namachivayam, A., & Gopalakrishnan, A. V. (2021) · Life Science · doi:10.1016/j.lfs.2021.119328 · Cited by 67 · see citing works
In vitro and in vivo anti-inflammatory effects of ethanol extract from Acer tegmentosum
Yu, T., Lee, J., Lee, Y. G., Byeon, S. E., Kim, M. H., Sohn, E., Lee, Y. J., Lee, S. G., & Cho, J. Y. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.12.042 · Cited by 74 · see citing works
Gut-liver axis: Recent concepts in pathophysiology in alcohol-associated liver disease
Raya Tonetti, F., Eguileor, A., Mrdjen, M., Pathak, V., Travers, J., Nagy, L. E., & Llorente, C. (2024) · Hepatology · doi:10.1097/hep.0000000000000924 · Cited by 78 · see citing works
Acute‐on‐chronic liver failure in chronic hepatitis B
Seto, W., Lai, C., & Yuen, M. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.06971.x · Cited by 69 · see citing works
Th-17 cells infiltrate the liver in human biliary atresia and are related to surgical outcome
Hill, R., Quaglia, A., Hussain, M. J., Hadžić, N., Mieli‐Vergani, G., Vergani, D., & Davenport, M. (2015) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2015.02.005 · Cited by 69 · see citing works
- Authors
- Lemmers, A., Moreno, C., Gustot, T., Maréchal, R., Degré, D., Demetter, P., de Nadai, P., Geerts, A., Quertinmont, E., Vercruysse, V., Le Moine, O., & Devière, J.
- Affiliations
- Université Libre de Bruxelles (BE)
- Vrije Universiteit Brussel (BE)
- Corresponding author
- Lemmers, Arnaud
- Venue
- Hepatology
- Published
- 2009-02
- Volume
- 49
- Issue
- 2
- Pages
- 646-657
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2086396801
- Cited by
- 394
- References
- 57
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 21 · 2023: 18 · 2022: 15 · 2021: 17 · 2020: 23 · 2019: 20 · 2018: 23 · 2017: 26 · 2016: 16 · 2015: 35 · 2014: 30 · 2013: 37 · 2012: 32
- FWCI
- 14.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Keywords
- IL-17, alcoholic liver disease, alcoholic hepatitis, alcoholic cirrhosis, neutrophil recruitment, IL-17 receptor, hepatic stellate cells, CD4+ T cells, liver inflammation, interleukin-8, CXCL1, Model for End-Stage Liver Disease, chronic hepatitis C, autoimmune liver disease
- MeSH terms
- Alanine Transaminase, Aspartate Aminotransferases, C-Reactive Protein, Female, Hepatitis, Alcoholic, Humans, Liver Cirrhosis, Liver Cirrhosis, Alcoholic, Male, Neutrophils, Reference Values, Hepatitis C, Chronic, Interleukin-17, Hepatic Stellate Cells
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