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Cited by 18Stroke Rehabilitation and RecoveryTreatment of Major DepressionDementia and Cognitive Impairment Research

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Efficacy of milnacipran on cognitive dysfunction with post‐stroke depression: Preliminary open‐label study

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SATO, SHINJI, YAMAKAWA, YURIKO, TERASHIMA, YASUSHI, OHTA, HITOSHI, ASADA, TAKASHI·2006·Psychiatry and Clinical Neurosciences
DOI 10.1111/j.1440-1819.2006.01562.x
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Abstract

The aim of this study was to assess the therapeutic efficacy of the serotonin norepinephrine reuptake inhibitor (SNRI), milnacipran, on both cognitive impairment and depression in post-stroke depression (PSD) patients. A total of 18 PSD patients, approximately 3 months after stroke, were divided into two groups, milnacipran and control. A total of 10 patients were assigned to the milnaciprane group and eight were assigned to control group. Their cognitive impairment and mood symptoms were measured using the Mini-Mental State Examination (MMSE) and Hamilton Depression Rating Scale (HAM-D) both at the time of admission and at discharge, an interval of approximately 3 months. This study examined the changes in both MMSE and HAM-D scores during the study period. A significant time-by-group interaction for results of the MMSE was observed, although there was no significant difference between the two groups on the HAM-D. Amelioration of cognitive impairment was greater in the milnacipran group than the control group. For PSD patients, milnacipran is effective in improving cognitive dysfunction.

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Metadata

Authors
SATO, S., YAMAKAWA, Y., TERASHIMA, Y., OHTA, H., & ASADA, T.
Affiliations
  • University of Tsukuba (JP)
  • Ibaraki Prefectural University of Health Sciences (JP)
Corresponding author
SATO, SHINJI
ORCID
Venue
Psychiatry and Clinical Neurosciences
Publisher
Wiley
Published
2006-09-06
Volume
60
Issue
5
Pages
584-589
ISSN
  • 1323-1316 (ISSN-L)
  • 1440-1819
DOI
10.1111/j.1440-1819.2006.01562.x
OpenAlex
W1971336532
Cited by
18
References
0
Citations by year
2025: 1 · 2020: 1 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 2
FWCI
3.01
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Psychiatry and Clinical Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
milnacipran, post-stroke depression, cognitive impairment, serotonin-norepinephrine reuptake inhibitors, antidepressant efficacy, stroke, mood symptoms
MeSH terms
Milnacipran, Adult, Aged, Aged, 80 and over, Antidepressive Agents, Cognition Disorders, Cyclopropanes, Depressive Disorder, Major, Major Depressive Disorder, Depressive Disorder, Female, Humans, Functional Laterality, Male, Middle Aged, Psychiatric Status Rating Scales, Tomography, X-Ray Computed, Mood Disorders, Stroke

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SATO, S., YAMAKAWA, Y., TERASHIMA, Y., OHTA, H., & ASADA, T. (2006). Efficacy of milnacipran on cognitive dysfunction with post‐stroke depression: Preliminary open‐label study. Psychiatry and Clinical Neurosciences. https://doi.org/10.1111/j.1440-1819.2006.01562.x